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Article ; Online: Unleashing the potential of adipose organoids: A revolutionary approach to combat obesity-related metabolic diseases.

Liu, Xingran / Yang, Jing / Yan, Yuxin / Li, Qingfeng / Huang, Ru-Lin

2024 Volume 14, Issue 5, Page(s) 2075–2098

Abstract: Obesity-related metabolic diseases, including obesity, diabetes, hyperlipidemia, and non-alcoholic fatty liver diseases pose a significant threat to health. However, comprehensive pathogenesis exploration and effective therapy development are impeded by ... ...

Abstract	Obesity-related metabolic diseases, including obesity, diabetes, hyperlipidemia, and non-alcoholic fatty liver diseases pose a significant threat to health. However, comprehensive pathogenesis exploration and effective therapy development are impeded by the limited availability of human models. Notably, advances in organoid technology enable the generation of adipose organoids that recapitulate structures and functions of native human adipose tissues to investigate mechanisms and develop corresponding treatments for obesity-related metabolic diseases. Here, we review the general principles, sources, and three-dimensional techniques for engineering adipose organoids, along with strategies to promote maturation. We also outline the application of white adipose organoids, primarily for disease modeling and drug screening, and highlight the therapeutic potential of thermogenic beige and brown adipose organoids in promoting weight loss and glucose and lipid metabolic homeostasis. We also discuss the challenges and prospects in the establishment and bench-to-bedside of adipose organoids, as well as their potential applications.
MeSH term(s)	Humans ; Adipose Tissue, Brown/metabolism ; Obesity/metabolism ; Non-alcoholic Fatty Liver Disease/metabolism ; Metabolic Diseases/metabolism ; Thermogenesis
Language	English
Publishing date	2024-02-25
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	2592097-2
ISSN	1838-7640 ; 1838-7640
ISSN (online)	1838-7640
ISSN	1838-7640
DOI	10.7150/thno.93919
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Comparison of diagnostic performance of X‑ray, CT and MRI in patients with surgically confirmed subtle Lisfranc injuries.

Tang, Lubo / Zhou, Wen / Bai, Lu / Wu, Chenxi / Xiong, Changyue / Yan, Yuxin / Chen, Sumeng

Experimental and therapeutic medicine

2024 Volume 27, Issue 4, Page(s) 174

Abstract: The present study aimed to compare the diagnostic performance of three imaging tests: X-ray, computed tomography (CT) and magnetic resonance imaging (MRI), for subtle Lisfranc injuries and three anatomical subtype injuries. The non-weight-bearing X-ray, ... ...

Abstract	The present study aimed to compare the diagnostic performance of three imaging tests: X-ray, computed tomography (CT) and magnetic resonance imaging (MRI), for subtle Lisfranc injuries and three anatomical subtype injuries. The non-weight-bearing X-ray, CT and MRI imaging results of patients with subtle Lisfranc injuries from September 2013 to March 2022 were retrospectively reviewed. Subtle Lisfranc injuries and three anatomical subtypes (first, second and cuneiform rays) were diagnosed based on the surgical reports. The diagnostic performance of X-ray, CT and MRI was compared. The sensitivity (Sn), specificity (Sp), positive predictive value, negative predictive value, area under the receiver operating characteristic curve (AUC) and κ coefficient were reported. A total of 31 patients were included in the study. The correct diagnosis was made in 48.4% (15/31), 87.1% (27/31) and 96.8% (30/31) of patients by X-ray, CT and MRI, respectively. A total of 54 different anatomical injuries were found intraoperatively in all patients, with MRI and CT having high agreement (Sn, 72.2 and 87.0%; κ, 0.69 and 0.78, respectively) and X-ray having a low agreement (Sn, 29.6%; κ, 0.26) with the surgical findings. Regarding the first-ray injuries, CT had the highest Sn (76.9%), Sp (100%) and AUC (0.885) in diagnosing subtle Lisfranc injuries. MRI showed the best Sn (88.5 and 93.3%, respectively) and AUC (0.942 and 0.904, respectively) in both second and cuneiform rays. In conclusion, non-weight-bearing X-rays had poor diagnostic accuracy for subtle Lisfranc injuries and their subtypes. CT was superior to X-rays and MRI in diagnosing first-ray injuries. Although not significantly different from CT in terms of overall diagnosis, MRI was superior to X-ray and CT in diagnosing second and cuneiform-ray injuries.
Language	English
Publishing date	2024-02-29
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2024.12462
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Article ; Online: An enhanced aquila optimization algorithm with velocity-aided global search mechanism and adaptive opposition-based learning.

Wang, Yufei / Zhang, Yujun / Yan, Yuxin / Zhao, Juan / Gao, Zhengming

Mathematical biosciences and engineering : MBE

2023 Volume 20, Issue 4, Page(s) 6422–6467

Abstract: The aquila optimization algorithm (AO) is an efficient swarm intelligence algorithm proposed recently. However, considering that AO has better performance and slower late convergence speed in the optimization process. For solving this effect of AO and ... ...

Abstract	The aquila optimization algorithm (AO) is an efficient swarm intelligence algorithm proposed recently. However, considering that AO has better performance and slower late convergence speed in the optimization process. For solving this effect of AO and improving its performance, this paper proposes an enhanced aquila optimization algorithm with a velocity-aided global search mechanism and adaptive opposition-based learning (VAIAO) which is based on AO and simplified Aquila optimization algorithm (IAO). In VAIAO, the velocity and acceleration terms are set and included in the update formula. Furthermore, an adaptive opposition-based learning strategy is introduced to improve local optima. To verify the performance of the proposed VAIAO, 27 classical benchmark functions, the Wilcoxon statistical sign-rank experiment, the Friedman test and five engineering optimization problems are tested. The results of the experiment show that the proposed VAIAO has better performance than AO, IAO and other comparison algorithms. This also means the introduction of these two strategies enhances the global exploration ability and convergence speed of the algorithm.
Language	English
Publishing date	2023-05-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2265126-3
ISSN	1551-0018 ; 1551-0018
ISSN (online)	1551-0018
ISSN	1551-0018
DOI	10.3934/mbe.2023278
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Article: TiO2-based slippery liquid-infused porous surfaces with excellent ice-phobic performance

Yan, Yuxin / Wang, Jiahui / Gao, Juan / Ma, Yurong

Colloids and surfaces. 2022 Dec. 05, v. 654

2022

Abstract: Ice formation and accretion on surfaces of instruments such as infrastructures, power lines and aircrafts can trigger serious social danger, economic loss and threaten the safety of lives. It is of practical significance to develop functionalized passive ...

Abstract	Ice formation and accretion on surfaces of instruments such as infrastructures, power lines and aircrafts can trigger serious social danger, economic loss and threaten the safety of lives. It is of practical significance to develop functionalized passive anti-icing surfaces. Herein, we synthesized titanium dioxide nanotube arrays on titanium substrate through anodic oxidation method. The TiO₂ nanotube arrays were further modified and infused with perfluoropolyether (PFPE) lubricant to form slippery liquid-infused porous surfaces (SLIPS). The relationship of the nanostructures and the slippery performance, the liquid holding property and anti-icing property of TiO₂ based SLIPS was investigated in details. The contact angle hysteresis (CAH) and sliding angles of water droplets on the TiO₂ SLIPS are as low as 1° and 4°, respectively, indicating the excellent slippery property of the SLIPS. The CAH of water droplets on TiO₂ SLIPS could be still as low as 5° after being treated with 100 mL of flowing water, which show the long term stability and superior liquid holding property of the TiO₂ SLIPS. We propose that the excellent slippery property and long term stability for holding liquid of TiO₂ SLIPS attribute to the uniform nanostructures, the small diameter of the nanotubes, the smooth surface and high capillary force of TiO₂ nanotube arrays. Both the icing delay tests and the ice adhesion force tests conducted on TiO₂ SLIPS indicate that the long-term ice-phobic stability is strongly correlated with the surface smoothness and uniformity of nanostructures. The results show that large water droplets with size about 15 μL on TiO₂ NT based SLIPS can keep as liquid phase at very low temperature (–15 ℃) for up to 24 h, which exhibits much longer icing delay time at –15 ℃ than most of the reported superhydrophobic surfaces and SLIPS. And the TiO₂ SLIPS exhibit very good icing delay effect even after being reused for 17 times at –15 ℃, indicating the superior long-term stability and anti-icing effect of TiO₂ SLIPS as passive ice-phobic surfaces. The ice adhesion force of icicles on TiO₂ SLIPS was as low as ∼50 kPa after the tenth test, further indicating their long-term stability as anti-icing surfaces. In summary, the TiO₂ nanotube arrays based SLIPS obtained in this work exhibit superior slippery property, anti-biofouling, excellent anti-icing property and long term stability after being treated with a large amount of flowing water or reused for many times under very low temperature. This work shows that SLIPS can be applied as ice-phobic surfaces with long term stability at low temperature, potentially useful for their practical applications as anti-icing and ice-phobic surfaces.
Keywords	adhesion ; contact angle ; financial economics ; hydrophobicity ; hysteresis ; ice ; liquids ; lubricants ; nanotubes ; oxidation ; temperature ; titanium ; titanium dioxide
Language	English
Dates of publication	2022-1205
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1500517-3
ISSN	0927-7757
ISSN	0927-7757
DOI	10.1016/j.colsurfa.2022.129994
Database	NAL-Catalogue (AGRICOLA)

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Article: [Research progress on joint replacement for hemiplegic femoral neck fracture].

Yan, Yu-Xin / Zhang, Zhi-Qiang

Zhongguo gu shang = China journal of orthopaedics and traumatology

2020 Volume 33, Issue 12, Page(s) 1184–1188

Abstract: With China's aging society, the number of patients with hemiplegia caused by cerebrovascular accident is increasing gradually. The risk of hip fracture in the first year after the onset of this kind of patients is 4 times higher than that of ordinary ... ...

Abstract	With China's aging society, the number of patients with hemiplegia caused by cerebrovascular accident is increasing gradually. The risk of hip fracture in the first year after the onset of this kind of patients is 4 times higher than that of ordinary people, and most of them occur in the side of hemiplegia. For senile femoral neck fracture, artificial joint replacement is almost the first choice of treatment, with mature operation technology and good curative effect. At present, it is considered that if the muscle strength of hemiplegic side can reach grade III after cerebral vascular accident, hip arthroplasty can be the first choice for hemiplegic patients with hemiplegic femoral neck fracture. However, the situation of hemiplegic patients is different from that of ordinary people. The hemiplegic limbs may have muscle atrophy, muscle strength imbalance, osteoporosis and other problems, which brings difficulties to the formulation of surgical plan. This paper mainly discusses the choice of surgical approach, the use of total hip arthroplasty or hemiarthroplasty, the use of cemented prosthesis or cementless prosthesis, and how to reduce the incidence of postoperative dislocation The purpose is to provide more reference evidence for orthopedic doctors in clinical decision-making.
MeSH term(s)	Arthroplasty, Replacement, Hip ; Femoral Neck Fractures/surgery ; Hemiarthroplasty ; Hemiplegia ; Hip Prosthesis ; Humans ; Treatment Outcome
Language	Chinese
Publishing date	2020-12-23
Publishing country	China
Document type	Journal Article
ISSN	1003-0034
ISSN	1003-0034
DOI	10.12200/j.issn.1003-0034.2020.12.019
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Dipolarophile-Controlled Regioselective 1,3-Dipolar Cycloaddition: A Switchable Divergent Access to Functionalized

Wang, Yongchao / Yan, Lijun / Yan, Yuxin / Li, Sujin / Lu, Hongying / Liu, Jia / Dong, Jianwei

International journal of molecular sciences

2023 Volume 24, Issue 4

Abstract: ... ...

Abstract	N
MeSH term(s)	Cycloaddition Reaction ; Isatin/chemistry
Chemical Substances	Isatin (82X95S7M06)
Language	English
Publishing date	2023-02-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24043771
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Article ; Online: Correction: The association between triglyceride glucose index and arthritis: a population-based study.

Yan, Yuxin / Zhou, Liyu / La, Rui / Jiang, Ming / Jiang, Dinghua / Huang, Lixin / Xu, Wu / Wu, Qian

Lipids in health and disease

2024 Volume 23, Issue 1, Page(s) 60

Language	English
Publishing date	2024-02-27
Publishing country	England
Document type	Published Erratum
ZDB-ID	2091381-3
ISSN	1476-511X ; 1476-511X
ISSN (online)	1476-511X
ISSN	1476-511X
DOI	10.1186/s12944-024-02052-w
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Article ; Online: CSCAHHO: Chaotic hybridization algorithm of the Sine Cosine with Harris Hawk optimization algorithms for solving global optimization problems.

Zhang, Yu-Jun / Yan, Yu-Xin / Zhao, Juan / Gao, Zheng-Ming

PloS one

2022 Volume 17, Issue 5, Page(s) e0263387

Abstract: Because of the No Free Lunch (NFL) rule, we are still under the way developing new algorithms and improving the capabilities of the existed algorithms. Under consideration of the simple and steady convergence capability of the sine cosine algorithm (SCA) ...

Abstract	Because of the No Free Lunch (NFL) rule, we are still under the way developing new algorithms and improving the capabilities of the existed algorithms. Under consideration of the simple and steady convergence capability of the sine cosine algorithm (SCA) and the fast convergence rate of the Harris Hawk optimization (HHO) algorithms, we hereby propose a new hybridization algorithm of the SCA and HHO algorithm in this paper, called the CSCAHHO algorithm henceforth. The energy parameter is introduced to balance the exploration and exploitation procedure for individuals in the new swarm, and chaos is introduced to improve the randomness. Updating equations is redefined and combined of the equations in the SCA and HHO algorithms. Simulation experiments on 27 benchmark functions and CEC 2014 competitive functions, together with 3 engineering problems are carried out. Comparisons have been made with the original SCA, HHO, Archimedes optimization algorithm (AOA), Seagull optimization algorithm (SOA), Sooty Tern optimization algorithm (STOA), Arithmetic optimizer (AO) and Chimp optimization algorithm (ChOA). Simulation experiments on either unimodal or multimodal, benchmark or CEC2014 functions, or real engineering problems all verified the better performance of the proposed CSAHHO, such as faster convergence rate, low residual errors, and steadier capability. Matlab code of this algorithm is shared in Gitee with the following address: https://gitee.com/yuj-zhang/cscahho.
MeSH term(s)	Algorithms ; Animals ; Benchmarking ; Birds ; Computer Simulation ; Falconiformes ; Humans ; Problem Solving
Language	English
Publishing date	2022-05-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0263387
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Bioengineering and vascularization strategies for islet organoids: advancing toward diabetes therapy.

Yang, Jing / Yan, Yuxin / Yin, Xiya / Liu, Xiangqi / Reshetov, Igor V / Karalkin, Pavel A / Li, Qingfeng / Huang, Ru-Lin

Metabolism: clinical and experimental

2024 Volume 152, Page(s) 155786

Abstract: Diabetes presents a pressing healthcare crisis, necessitating innovative solutions. Organoid technologies have rapidly advanced, leading to the emergence of bioengineering islet organoids as an unlimited source of insulin-producing cells for treating ... ...

Abstract	Diabetes presents a pressing healthcare crisis, necessitating innovative solutions. Organoid technologies have rapidly advanced, leading to the emergence of bioengineering islet organoids as an unlimited source of insulin-producing cells for treating insulin-dependent diabetes. This advancement surpasses the need for cadaveric islet transplantation. However, clinical translation of this approach faces two major limitations: immature endocrine function and the absence of a perfusable vasculature compared to primary human islets. In this review, we summarize the latest developments in bioengineering functional islet organoids in vitro and promoting vascularization of organoid grafts before and after transplantation. We highlight the crucial roles of the vasculature in ensuring long-term survival, maturation, and functionality of islet organoids. Additionally, we discuss key considerations that must be addressed before clinical translation of islet organoid-based therapy, including functional immaturity, undesired heterogeneity, and potential tumorigenic risks.
MeSH term(s)	Humans ; Organoids/blood supply ; Islets of Langerhans Transplantation ; Diabetes Mellitus, Type 1/therapy ; Bioengineering ; Insulins ; Islets of Langerhans
Chemical Substances	Insulins
Language	English
Publishing date	2024-01-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	80230-x
ISSN	1532-8600 ; 0026-0495
ISSN (online)	1532-8600
ISSN	0026-0495
DOI	10.1016/j.metabol.2024.155786
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Article ; Online: The association between remnant cholesterol and rheumatoid arthritis: insights from a large population study.

Yan, Yuxin / La, Rui / Jiang, Ming / Xu, Wu / Jiang, Dinghua / Wang, Shenghao / Huang, Lixin / Wu, Qian

Lipids in health and disease

2024 Volume 23, Issue 1, Page(s) 38

Abstract: Objectives: While lipid metabolism disorder is widely acknowledged as a contributing factor to inflammation, the association between remnant cholesterol (RC), which indicates lipid metabolism, and rheumatoid arthritis (RA) has not been investigated. ... ...

Abstract	Objectives: While lipid metabolism disorder is widely acknowledged as a contributing factor to inflammation, the association between remnant cholesterol (RC), which indicates lipid metabolism, and rheumatoid arthritis (RA) has not been investigated. Accordingly, this study evaluated whether RC is associated with RA disease events. Methods: Data were collected and specifically extracted from the National Health and Nutrition Examination Survey (NHANES) 1999-2008 database. The RC value was derived by subtracting the combined amount of low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) from the total cholesterol (TC). The association between RC and RA was evaluated using multivariate regression analysis and subgroup analysis. Results: The study analyzed 7777 patients, of which 581 patients (7.47%) were diagnosed with RA. After accounting for different covariates, the multivariate logistic regression analysis revealed a notable correlation between increased RC levels and an increased likelihood of RA (odds ratio OR = 1.54; 95% confidence interval CI: 1.11-2.13; P = 0.0092). The interaction test did not yield statistically significant effects on this association. The linear correlation between RC and RA was observed within restricted cubic spline regression model limitations. Conclusion: The results suggest that higher RC levels are associated with increased odds of RA, indicating that RC can serve as a novel and convenient index for forecasting the likelihood of RA in the United States. Additionally, these findings offer insights into early intervention strategies for susceptible populations at risk of developing RA.
MeSH term(s)	Humans ; United States/epidemiology ; Nutrition Surveys ; Arthritis, Rheumatoid/epidemiology ; Cholesterol ; Cholesterol, LDL ; Cholesterol, HDL ; Risk Factors
Chemical Substances	Cholesterol (97C5T2UQ7J) ; Cholesterol, LDL ; Cholesterol, HDL
Language	English
Publishing date	2024-02-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2091381-3
ISSN	1476-511X ; 1476-511X
ISSN (online)	1476-511X
ISSN	1476-511X
DOI	10.1186/s12944-024-02033-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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