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Article: Angiopoietin-2 expression and its relationship with lymphangiogenesis and clinicopathological characteristics in cutaneous malignant melanoma.

Zheng, Wei / Ju, Wei / Yang, Xi-Hu / Yan, Zhi-Xin

2023 Volume 13, Page(s) 1113604

Abstract: Objective: The aim of this study was to investigate angiopoietin-2 (Ang-2/ANGPT2) expression and its relationship with lymphangiogenesis and clinicopathological characteristics in cutaneous malignant melanoma (CMM).: Methods: Gene expression ... ...

Abstract	Objective: The aim of this study was to investigate angiopoietin-2 (Ang-2/ANGPT2) expression and its relationship with lymphangiogenesis and clinicopathological characteristics in cutaneous malignant melanoma (CMM). Methods: Gene expression differences between metastatic melanoma and melanoma Results: Using the TCGA database, it was found that the gene expression level of Ang-2 in 368 cases of metastatic melanoma was significantly higher than that in 104 cases of melanoma Conclusion: An evaluation of Ang-2 expression and LVD can be used to predict the risk of tumor lymphatic metastasis and determine the prognosis of CMM. These results may also provide a new clinical treatment strategy for CMM.
Language	English
Publishing date	2023-07-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1113604
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Article ; Online: Cross‑talk between lymphangiogenesis and malignant melanoma cells: New opinions on tumour drainage and immunization (Review).

Ju, Wei / Cai, Hong-Hua / Zheng, Wei / Li, De-Ming / Zhang, Wei / Yang, Xi-Hu / Yan, Zhi-Xin

Oncology letters

2024 Volume 27, Issue 2, Page(s) 81

Abstract: Malignant melanoma (MM) is a highly aggressive tumour that can easily metastasize through the lymphatic system at the early stages. Lymph node (LN) involvement and lymphatic vessel (LV) density (LVD) represent a harbinger of an adverse prognosis, ... ...

Abstract	Malignant melanoma (MM) is a highly aggressive tumour that can easily metastasize through the lymphatic system at the early stages. Lymph node (LN) involvement and lymphatic vessel (LV) density (LVD) represent a harbinger of an adverse prognosis, indicating a strong link between the state of the lymphatic system and the advancement of MM. Permeable capillary lymphatic vessels are the optimal conduits for melanoma cell (MMC) invasion, and lymphatic endothelial cells (LECs) can also release a variety of chemokines that actively attract MMCs expressing chemokine ligands through a gradient orientation. Moreover, due to the lower oxidative stress environment in the lymph compared with the blood circulation, MMCs are more likely to survive and colonize. The number of LVs surrounding MM is associated with tumour-infiltrating lymphocytes (TILs), which is crucial for the effectiveness of immunotherapy. On the other hand, MMCs can release various endothelial growth factors such as VEGF-C/D-VEGFR3 to mediate LN education and promote lymphangiogenesis. Tumour-derived extracellular vesicles are also used to promote lymphangiogenesis and create a microenvironment that is more conducive to tumour progression. MM is surrounded by a large number of lymphocytes. However, both LECs and MMCs are highly plastic, playing multiple roles in evading immune surveillance. They achieve this by expressing inhibitory ligands or reducing antigen recognition. In recent years, tertiary lymphoid structures have been shown to be associated with response to anti-immune checkpoint therapy, which is often a positive prognostic feature in MM. The present review discusses the interaction between lymphangiogenesis and MM metastasis, and it was concluded that the relationship between LVD and TILs and patient prognosis is analogous to a dynamically tilted scale.
Language	English
Publishing date	2024-01-05
Publishing country	Greece
Document type	Journal Article ; Review
ZDB-ID	2573196-8
ISSN	1792-1082 ; 1792-1074
ISSN (online)	1792-1082
ISSN	1792-1074
DOI	10.3892/ol.2024.14215
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Book ; Online: Kernel Extreme Learning Machine Optimized by the Sparrow Search Algorithm for Hyperspectral Image Classification

Yan, Zhixin / Huang, Jiawei / Xiang, Kehua

2022

Abstract: To improve the classification performance and generalization ability of the hyperspectral image classification algorithm, this paper uses Multi-Scale Total Variation (MSTV) to extract the spectral features, local binary pattern (LBP) to extract spatial ... ...

Abstract	To improve the classification performance and generalization ability of the hyperspectral image classification algorithm, this paper uses Multi-Scale Total Variation (MSTV) to extract the spectral features, local binary pattern (LBP) to extract spatial features, and feature superposition to obtain the fused features of hyperspectral images. A new swarm intelligence optimization method with high convergence and strong global search capability, the Sparrow Search Algorithm (SSA), is used to optimize the kernel parameters and regularization coefficients of the Kernel Extreme Learning Machine (KELM). In summary, a multiscale fusion feature hyperspectral image classification method (MLS-KELM) is proposed in this paper. The Indian Pines, Pavia University and Houston 2013 datasets were selected to validate the classification performance of MLS-KELM, and the method was applied to ZY1-02D hyperspectral data. The experimental results show that MLS-KELM has better classification performance and generalization ability compared with other popular classification methods, and MLS-KELM shows its strong robustness in the small sample case. Comment: 17 pages
Keywords	Computer Science - Computer Vision and Pattern Recognition ; Computer Science - Machine Learning
Subject code	006
Publishing date	2022-04-02
Publishing country	us
Document type	Book ; Online
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Article: Circadian rhythm disorders elevate macrophages cytokines release and promote multiple tissues/organs dysfunction in mice

Sun, Zhen / Li, Lihua / Yan, Zhixin / Zhang, Lili / Zang, Guangyao / Qian, Yongjiang / Wang, Zhongqun

Physiology & behavior. 2022 May 15, v. 249

2022

Abstract: Circadian rhythm disorders are severe threats to human health. The negative impact of circadian rhythm disorders on tissues/organs has not been systematically analyzed. Therefore, there is an urgent need to evaluate the damage caused by circadian rhythm ... ...

Abstract	Circadian rhythm disorders are severe threats to human health. The negative impact of circadian rhythm disorders on tissues/organs has not been systematically analyzed. Therefore, there is an urgent need to evaluate the damage caused by circadian rhythm disorders and explore the possible mechanisms. Six-week-old male mice were divided into the control (Con) group (normal circadian rhythm), L24 group (constant light), D12L12 group (weekly shift light/dark cycle), and D24 group (constant dark). Body weight was recorded every 10 days. Ninety days after model construction, the serum lipid and cytokine level, liver function, fat accumulation, carotid artery stenosis, and cardiomyopathological changes were detected in mice. Macrophages in the liver, subscapular fat, and heart tissues were labeled with immunofluorescence staining. Mouse peritoneal macrophages were then isolated. Inflammatory cytokine levels were measured in the macrophage supernatant. The ability of macrophages to form foam cells was also tested. The supernatant from macrophages in different groups was added to AML12 (hepatocytes), 3T3-L1 (preadipocytes), or HL-1 (cardiomyocytes). Effects of conditioned media on recipient cells were determined. Body weight, serum lipids and cytokines, subscapular fat accumulation, liver enzymes, carotid artery stenosis, and myocardial fibrosis levels of the L24, D12L12, and D24 groups mice were significantly higher than those in the Con group. Macrophages were significantly increased in the liver, heart, and subscapular fat of mice with circadian rhythmdisorders. Cytokine secretion by peritoneal macrophages was enhanced in the L24, D12L12, and D24 groups. Under oxidized low density lipoprotein (oxLDL) stimulation, macrophages with circadian rhythm disorders are more likely to form foam cells. Conditioned media from the L24, D12L12, and D24 groups significantly promoted AML12 apoptosis and lipid intake, accelerated the adipogenic differentiation of 3T3-L1, and up-regulated collagen I in HL-1. These findings reveal that macrophages are increased in the tissues/organs under circadian rhythm disorders, and these macrophages could aggravate obesity, promote liver disease, accelerate atherosclerosis, and increase myocardial fibrosis through the paracrine effect.
Keywords	adipogenesis ; apoptosis ; atherosclerosis ; behavior ; blood lipids ; blood serum ; cardiomyocytes ; carotid arteries ; circadian rhythm ; collagen ; cytokines ; fat intake ; fibrosis ; fluorescent antibody technique ; foams ; hepatocytes ; human health ; liver ; liver diseases ; liver function ; low density lipoprotein ; males ; mice ; obesity ; oxidation ; secretion
Language	English
Dates of publication	2022-0515
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	3907-x
ISSN	1873-507X ; 0031-9384
ISSN (online)	1873-507X
ISSN	0031-9384
DOI	10.1016/j.physbeh.2022.113772
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Butorphanol in combination with dexmedetomidine provides efficient pain management in adult burn patients.

Ding, Xianchao / Luo, Yi / Shi, Lei / Liu, Chang / Yan, Zhixin

Burns : journal of the International Society for Burn Injuries

2021 Volume 47, Issue 7, Page(s) 1594–1601

Abstract: Objective: This study aimed to compare the sedation and analgesic effects of butorphanol alone and butorphanol in combination with dexmedetomidine on dressing changes in adult burn patients.: Method: From June 2016 to May 2019, 44 adult burn patients ...

Abstract	Objective: This study aimed to compare the sedation and analgesic effects of butorphanol alone and butorphanol in combination with dexmedetomidine on dressing changes in adult burn patients. Method: From June 2016 to May 2019, 44 adult burn patients from our department were enrolled in this prospective, double-blinded study. Their total burn surface area (TBSA) varied from 10% to 30%; and the depth of burn injury ranged from second degree to third degree. The patients were randomized into two groups. In the control group, butorphanol combined with saline was injected into the body via venous route during dressing change. In the observation group, butorphanol in combination with dexmedetomidine was injected. The variation in mean blood pressure, heart rate, respiratory rate, and peripheral oxygen saturation were recorded at various time-points of the procedure. Visual Analogue Scale (VAS) of pain and Ramsay Sedation Scores (RSS) were also recorded at different time points. Consumption of butorphanol and adverse events in these two groups were compared. Results: The mean blood pressure and heart rate were significantly decreased in the observation group before butorphanol injection (P < 0.05) and before the dressing change (P < 0.05). The respiratory rates and peripheral oxygen saturation of these two groups showed no significant differences at all time points (P > 0.05). Patients in the observation group had lower VAS scores during dressing change (P < 0.05). The RSS Scores in the observation group were higher than those in the control group during (P < 0.05) and after the dressing change (P < 0.05). The consumption of butorphanol was more in the control group (P < 0.05), and the adverse events recorded in the control group were higher (P < 0.05). Conclusion: Butorphanol combined with dexmedetomidine can reduce analgesic use of butorphanol during dressing change. This combination resulted in a higher sedation score and fewer adverse effects.
MeSH term(s)	Adult ; Burns/complications ; Burns/therapy ; Butorphanol/therapeutic use ; Dexmedetomidine/therapeutic use ; Humans ; Hypnotics and Sedatives/therapeutic use ; Oxygen Saturation ; Pain Management ; Prospective Studies
Chemical Substances	Hypnotics and Sedatives ; Dexmedetomidine (67VB76HONO) ; Butorphanol (QV897JC36D)
Language	English
Publishing date	2021-01-18
Publishing country	Netherlands
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	197308-3
ISSN	1879-1409 ; 0305-4179
ISSN (online)	1879-1409
ISSN	0305-4179
DOI	10.1016/j.burns.2020.12.025
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Article: Efficacy of dexmedetomidine versus midazolam when combined with butorphanol for sedation and analgesia during burn dressing changes: A randomized clinical trial.

Ding, Xianchao / Cui, Hengfeng / Ma, Peng / Chen, Xi / Sun, Yan / Qu, Minye / Yan, Zhixin

Frontiers in pharmacology

2022 Volume 13, Page(s) 965441

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2022-09-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.965441
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Article: Probiotics combined with zinc and selenium preparation in the treatment of child rotavirus enteritis.

Cai, Yongyan / Wang, Xiuli / Li, Cuimin / Li, Fangfang / Yan, Zhixin / Ma, Na / Sun, Mei

American journal of translational research

2022 Volume 14, Issue 2, Page(s) 1043–1050

Abstract: Objective: To investigate clinical effect of probiotics combined with zinc and selenium preparation in the treatment of child rotavirus enteritis.: Methods: In this retrospective study, the patients were divided into two groups based on treatment ... ...

Abstract	Objective: To investigate clinical effect of probiotics combined with zinc and selenium preparation in the treatment of child rotavirus enteritis. Methods: In this retrospective study, the patients were divided into two groups based on treatment method. The control group (n=42) received probiotic therapy, while the experimental group (n=43) received probiotics combined with zinc and selenium preparation. Clinical efficacy, stool frequency and incidence of adverse reactions after treatment were compared to assess the clinical effect. Results: The clinical effect was improved after intervention (P<0.05), and the total effective rate of two groups was 88.4% (38/43), 50% (21/42), respectively. Time to symptom disappearance was significantly decreased in the experimental group as compared to the control group. The myocardial zymogram indices (CK, CK-MB and AST) were decreased after treatment, and the levels in the experimental group were significantly lower than in the control group (P<0.05). Moreover, we observed that the levels of inflammatory factors (IL-6, IL-8 and hsCRP) in the experimental group were significantly lower than those of the control group after intervention (all P<0.05). Conclusion: Probiotics combined with zinc and selenium preparation can not only significantly improve the clinical effect, but also shorten the course of disease.
Language	English
Publishing date	2022-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2471058-1
ISSN	1943-8141
ISSN	1943-8141
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Article: Dynamic monitoring and a clinical correlation analysis of the serum vitamin A, D, and E levels in children with recurrent respiratory tract infections.

Sun, Mei / Yan, Zhixin / Sun, Rongrong / Tian, Wenqiu / Yi, Wenxia / Zhang, Jing

American journal of translational research

2022 Volume 14, Issue 5, Page(s) 3533–3538

Abstract: Objective: To investigate the correlation of the serum vitamin A, D, and E (VA, VD, and VE) levels with the occurrence and development of recurrent respiratory tract infections (RRTIs).: Methods: A total of 129 children with respiratory tract ... ...

Abstract	Objective: To investigate the correlation of the serum vitamin A, D, and E (VA, VD, and VE) levels with the occurrence and development of recurrent respiratory tract infections (RRTIs). Methods: A total of 129 children with respiratory tract infections (RTIs) treated in our hospital from January 2018 to February 2020 (the RTIs group) and 50 healthy children undergoing physical examinations (the control group) in our hospital were recruited as the study cohort. The serum VA, VD, and VE levels were measured upon admission (the active phase) and at two weeks after discharge (the stable phase). The serum VA, VD, and VE levels in the children with RRTIs were compared with the levels in the control group, and the correlation between these three vitamins and the occurrence and development of RRTIs was analyzed. Results: The RRTIs group and the RTIs group witnessed markedly lower serum VA, VD, VE, and humoral immunity index levels, including IgG, IgA, and IgM, compared to the control group, with an apparent lower outcome in the RRTIs group than in the RTIs group. The serum levels of the above indexes in the RRTIs children were reduced in the active phase compared with the stable phase. A Pearson correlation analysis showed a positive correlation between VA and IgA. A multivariate logistic regression analysis revealed that a low BMI (Body mass index), prematurity, VA deficiency, VD deficiency, and VE deficiency were the risk factors for RRTIs in children, and outdoor activity was the protective factor. Conclusion: The VA, VD, and VE levels are closely related to RRTIs in children. It is important to determine and supplement the VA, VD, and VE levels to prevent RTIs in children.
Language	English
Publishing date	2022-05-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2471058-1
ISSN	1943-8141
ISSN	1943-8141
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Article: Clinical Monitoring of Serum Levels of Vitamins A, D and E in Children with Recurrent Respiratory Tract Infections of Different Ages: A Clinical Controlled Trial.

Sun, Rongrong / Yan, Zhixin / Yi, Wenxia / Tian, Wenqiu / Sun, Mei / Zhang, Jing

International journal of general medicine

2022 Volume 15, Page(s) 6627–6632

Abstract: Objective: To study serum levels of vitamins A, D and E in children with recurrent respiratory tract infections of different ages and the correlation.: Methods: The clinical data of two groups of children of different ages were collected. The serum ... ...

Abstract	Objective: To study serum levels of vitamins A, D and E in children with recurrent respiratory tract infections of different ages and the correlation. Methods: The clinical data of two groups of children of different ages were collected. The serum levels and deficiencies of vitamins A, D and E in children were statistically analyzed. Results: The proportions of premature infants, low body weight infants, special physique, hospitalization history, hypocalcemia, living in a bungalow, and daily outdoor activities in less than 30 minutes in the case group were higher than those in the control group ( Conclusion: Serum levels of vitamins A, D and E, which are related to birth mode, physical fitness, hospitalization history, hypocalcemia, vitamin deficiency, living environment, and daily outdoor activity time, vary in children with recurrent respiratory tract infections of different ages, and are lower in children with recurrent respiratory tract infections than in healthy children.
Language	English
Publishing date	2022-08-17
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2452220-X
ISSN	1178-7074
ISSN	1178-7074
DOI	10.2147/IJGM.S347728
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Article ; Online: Circadian rhythm disorders elevate macrophages cytokines release and promote multiple tissues/organs dysfunction in mice.

Sun, Zhen / Li, Lihua / Yan, Zhixin / Zhang, Lili / Zang, Guangyao / Qian, Yongjiang / Wang, Zhongqun

Physiology & behavior

2022 Volume 249, Page(s) 113772

Abstract: Background: Circadian rhythm disorders are severe threats to human health. The negative impact of circadian rhythm disorders on tissues/organs has not been systematically analyzed. Therefore, there is an urgent need to evaluate the damage caused by ... ...

Abstract	Background: Circadian rhythm disorders are severe threats to human health. The negative impact of circadian rhythm disorders on tissues/organs has not been systematically analyzed. Therefore, there is an urgent need to evaluate the damage caused by circadian rhythm disorders and explore the possible mechanisms. Methods: Six-week-old male mice were divided into the control (Con) group (normal circadian rhythm), L24 group (constant light), D12L12 group (weekly shift light/dark cycle), and D24 group (constant dark). Body weight was recorded every 10 days. Ninety days after model construction, the serum lipid and cytokine level, liver function, fat accumulation, carotid artery stenosis, and cardiomyopathological changes were detected in mice. Macrophages in the liver, subscapular fat, and heart tissues were labeled with immunofluorescence staining. Mouse peritoneal macrophages were then isolated. Inflammatory cytokine levels were measured in the macrophage supernatant. The ability of macrophages to form foam cells was also tested. The supernatant from macrophages in different groups was added to AML12 (hepatocytes), 3T3-L1 (preadipocytes), or HL-1 (cardiomyocytes). Effects of conditioned media on recipient cells were determined. Results: Body weight, serum lipids and cytokines, subscapular fat accumulation, liver enzymes, carotid artery stenosis, and myocardial fibrosis levels of the L24, D12L12, and D24 groups mice were significantly higher than those in the Con group. Macrophages were significantly increased in the liver, heart, and subscapular fat of mice with circadian rhythmdisorders. Cytokine secretion by peritoneal macrophages was enhanced in the L24, D12L12, and D24 groups. Under oxidized low density lipoprotein (oxLDL) stimulation, macrophages with circadian rhythm disorders are more likely to form foam cells. Conditioned media from the L24, D12L12, and D24 groups significantly promoted AML12 apoptosis and lipid intake, accelerated the adipogenic differentiation of 3T3-L1, and up-regulated collagen I in HL-1. Conclusion: These findings reveal that macrophages are increased in the tissues/organs under circadian rhythm disorders, and these macrophages could aggravate obesity, promote liver disease, accelerate atherosclerosis, and increase myocardial fibrosis through the paracrine effect.
MeSH term(s)	Animals ; Body Weight ; Carotid Stenosis/pathology ; Chronobiology Disorders/pathology ; Circadian Rhythm ; Culture Media, Conditioned/pharmacology ; Cytokines ; Fibrosis ; Macrophages/pathology ; Male ; Mice
Chemical Substances	Culture Media, Conditioned ; Cytokines
Language	English
Publishing date	2022-03-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3907-x
ISSN	1873-507X ; 0031-9384
ISSN (online)	1873-507X
ISSN	0031-9384
DOI	10.1016/j.physbeh.2022.113772
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