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  1. Article: [Dao-di herbs pharmacology and new ideas of Dao-di herbs standard construction].

    Zhao, Jun-Ning / Hua, Hua / Dai, Ying / Fang, Qing-Mao / Li, Qing-Miao / Jiang, Shun-Yuan / Xie, Chun-Guang / Yang, Si-Jin / Yan, Liang-Chun / Tan, Peng / Yang, An-Dong / Wang, Shu

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2020  Volume 45, Issue 4, Page(s) 709–714

    Abstract: Guided by the basic theory of traditional Chinese medicine and using modern scientific methods, Dao-di herbs pharmacology studies the nature, performance, interaction with the body and its clinical application.It is a bridge between the basic research ... ...

    Abstract Guided by the basic theory of traditional Chinese medicine and using modern scientific methods, Dao-di herbs pharmacology studies the nature, performance, interaction with the body and its clinical application.It is a bridge between the basic research and clinical application of Dao-di herbs. It can objectively describe the law of efficacy of Dao-di herbs, scientifically explain the mechanism of efficacy of Dao-di herbs, explore and establish the standards and methods of Dao-di herbs based on biological effect and clinical efficacy, and provide scientific basis for the special properties, pharmacology and clinical value of Dao-di herbs.Furthermore, we put forward a new idea of building the standard of Dao-di herbs based on the curative effect rather than the origin.The Dao-di herbs standard should come from the systematic research of traditional Dao-di herbs producing areas and form a new characteristic system, through the extraction of environmental, genetic, character, chemical, pharmacological and other characteristics.This standard originates from the tradition, but it is higher than the tradition. It may not have the origin meaning of strict administrative division, but it can better reflect the pharmacological characteristics and excellent clinical value of Dao-di herbs.
    MeSH term(s) China ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/standards ; Medicine, Chinese Traditional ; Plants, Medicinal/chemistry
    Chemical Substances Drugs, Chinese Herbal
    Language Chinese
    Publishing date 2020-03-31
    Publishing country China
    Document type Journal Article
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    DOI 10.19540/j.cnki.cjcmm.20191226.101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3056: Show issues Location:
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  2. Article: [Pharmacokinetics and relative bioavailability of THC and THC-solid dispersion orally to mice at single dose].

    Liao, Li / Hua, Hua / Zhao, Jun-Ning / Luo, Heng / Yang, An-Dong

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2014  Volume 39, Issue 6, Page(s) 1101–1106

    Abstract: To establish a fast sensitive, reproducible LC-MS/MS method to study pharmacokinetic properties of THC, and compare relative bioavailability of THC and its solid dispersion in mice. 200 mice were divided randomly into two groups, and administered orally ... ...

    Abstract To establish a fast sensitive, reproducible LC-MS/MS method to study pharmacokinetic properties of THC, and compare relative bioavailability of THC and its solid dispersion in mice. 200 mice were divided randomly into two groups, and administered orally with THC and THC-solid dispersion after fasting (calculate on THC:400 mg x kg(-1)), used HPLC-MS/MS method to determine the THC concentration of each period at the following times: baseline ( predose ), 15, 30, 45 min, 1, 1.5, 2, 3, 4, 6, 24 h after dosing. Calculating the pharmacokinetic parameters according to the C-t curv, and then use the Phoenix WinNonlin software for data analysis. The calibration curves were linear over the range 9.06-972 microg x L(-1) for THC (R2 = 0.999). The limit of detection (LOD) was 0.7 microg x L(-1), respectively. The average extraction recoveries for THC was above 75%, The methodology recoveries were between 79% and 108%. The intra-day and inter-day RSD were less than 13%, the stability test showed that the plasma samples was stable under different conditions (RSD < 15%). The precision, accuracy, recovery and applicability were found to be adequate for pharmacokinetic studies. Pharmacokinetic parameters of THC and THC-solid dispersion orally to mice shows as fllows: T(max), were 60 and 15 min, AUC(0-t) were 44 500.43 and 57 497.81 mg x L(-1) x min, AUC(0-infinity) were 51 226.00 and 68 031.48 mg x L(-1) x min, MRT(0-infinity) were 596.915 6, 661.747 7 min, CL(z)/F were 0.007 809 and 0.005 88 L x min(-1) x kg(-1). Compared with THC, the MRT and t1/2 of the THC-solid dispersion were all slightly extended, the t(max) was significantly reduced, AUC(0-24 h), AUC(0-infinity) and C(max) were all significantly higher, the relative bioavailability of THC-solid dispersion is 1.34 times of THC. The results of the experiment shows that the precision, accuracy, recovery and applicability were found to be adequate for the pharmacokinetic studies. After oral administration to mice, the relative bioavailability of THC-solid dispersion show significant improvement compared to THC.
    MeSH term(s) Administration, Oral ; Animals ; Biological Availability ; Dronabinol/administration & dosage ; Dronabinol/chemistry ; Dronabinol/pharmacokinetics ; Female ; Male ; Mice
    Chemical Substances Dronabinol (7J8897W37S)
    Language Chinese
    Publishing date 2014-03
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3056: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article: [Generalized science of Chinese material medica-from preventive treatment of disease to Chinese medicine health industry].

    Zhao, Jun-Ning / Hua, Hua / Yang, An-Dong / Zhang, Yi-Guan / Dai, Ying / Li, Qing-Miao / Yan, Liang-Chun / Li, Xiao-Lu / Li, Li / Zeng, Jin / Ren, Si-Chong / Wang, Jian-Bo

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2018  Volume 43, Issue 21, Page(s) 4177–4181

    Abstract: Based on the systematic summary of the results of the fourth general survey of traditional Chinese medicine resources, the cultivation of large varieties of Chinese material medica and the latest research on health industrial development, the novel ... ...

    Abstract Based on the systematic summary of the results of the fourth general survey of traditional Chinese medicine resources, the cultivation of large varieties of Chinese material medica and the latest research on health industrial development, the novel concepts and scientific connotations of generalized science of Chinese material medica are put forward, and the basic ideas and methods of a new Chinese medicine academic system, the cultivation system of large varieties of Chinese medicinal materials and the application system of the large health industry are constructed. This kind of generalized science of Chinese material medica, rooted in the traditional Chinese culture and the theory of "preventive treatment of disease", can avoid the narrow prospect induced by the increasing specialization and refinement of knowledge of science of Chinese material medica. It will play an important role in the modernization, industrialization, internationalization of traditional Chinese medicine.
    MeSH term(s) Drug Industry ; Humans ; Materia Medica/therapeutic use ; Medicine, Chinese Traditional ; Research
    Chemical Substances Materia Medica
    Language Chinese
    Publishing date 2018-12-21
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    DOI 10.19540/j.cnki.cjcmm.2018.0109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article: [Studies on the preparation technology of beta-cyclodextrin inclusion compound for chuanxiong volatile oil extracted with CO2 supercritical fluid].

    Zhang, Ai-jun / Zhu, Ning / Yang, An-dong

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2004  Volume 29, Issue 1, Page(s) 39–41

    Abstract: Objective: To explore the preparation technology of beta-cyclodextrin inclusion compound for chuanxiong volatile oil.: Method: Orthogonal test was used to evaluate the influence of the 4 factors, including the proportion of volatile oil to beta- ... ...

    Abstract Objective: To explore the preparation technology of beta-cyclodextrin inclusion compound for chuanxiong volatile oil.
    Method: Orthogonal test was used to evaluate the influence of the 4 factors, including the proportion of volatile oil to beta-cyclodextrin, the mode of mixing, inclusion temperature and mixing time.
    Result: The best inclusion condition is the proportion of volatile oil to beta-cyclodextrin 1:9, the mode of mixing grinding, inclusion temperature 60 degrees C and inclusion time 90 min.
    Conclusion: The best inclusion technology of chuanxiong volatile oil is confirmed.
    MeSH term(s) Carbon Dioxide ; Chromatography, Supercritical Fluid ; Drug Carriers ; Ligusticum/chemistry ; Oils, Volatile/administration & dosage ; Oils, Volatile/isolation & purification ; Plant Roots/chemistry ; Plants, Medicinal/chemistry ; Technology, Pharmaceutical/methods ; Temperature ; Time Factors ; beta-Cyclodextrins
    Chemical Substances Drug Carriers ; Oils, Volatile ; beta-Cyclodextrins ; Carbon Dioxide (142M471B3J)
    Language Chinese
    Publishing date 2004-01
    Publishing country China
    Document type Comparative Study ; English Abstract ; Journal Article
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article: [Quantitative analysis of volatile oils and isoimperatorin in rhizoma et Radix notopterygii].

    Zhou, Yi / Jiang, Shun-Yuan / Sun, Hui / Yang, An-Dong / Ma, Yan / Ma, Xiao-Jun / Wu, Rui

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2007  Volume 32, Issue 7, Page(s) 566–569

    Abstract: Objective: To establish scientific and efficient quality control standard of Rhizoma et Radix Notopterygii through two quantitative parameters.: Method: The contents of isoimperatorin and volatile oils in 29 commercial samples from 22 localities of ... ...

    Abstract Objective: To establish scientific and efficient quality control standard of Rhizoma et Radix Notopterygii through two quantitative parameters.
    Method: The contents of isoimperatorin and volatile oils in 29 commercial samples from 22 localities of Rhizoma et Radix Notopterygii were determined by HPLC and the method in the pharmacopoeia respectively. The data were statistically analyzed.
    Result: Only 3 of 29 samples met the required standard in the Chinese Pharmacopoeia (2005 edition), 87% of samples newly produced in 2005 not met the standard. Statistics showed that the contents of volatile oils and isoimperatorin should reach 1.63% and 0.17% respectively when the samples meet requirement of criterion with more than 80% probability. The contents of volatile oil and isoimperatorin were not significantly different (P < 0.05) in the samples of 2005 and 2003, while the contents of isoimperatorin were significantly different between Notopterygium incisum and N. forbesii samples.
    Conclusion: Since the criterion of volatile oils in the Chinese Pharmacopoeia (2005 version) for Rhizoma et Radix Notopterygii is too high to satisfy for most Rhizoma et Radix Notopterygii samples, it is suggested to reduce it to 1.6% (mL x g(-1)). The content of isoimperatorin is proposed to add to the quality standard of Rhizoma et Radix Notopterygii as above 0.2% (mg x g(-1)).
    MeSH term(s) Apiaceae/chemistry ; Apiaceae/classification ; China ; Chromatography, High Pressure Liquid ; Furocoumarins/analysis ; Oils, Volatile/analysis ; Oils, Volatile/chemistry ; Oils, Volatile/isolation & purification ; Plant Roots/chemistry ; Plants, Medicinal/chemistry ; Reproducibility of Results ; Rhizome/chemistry
    Chemical Substances Furocoumarins ; Oils, Volatile ; isoimperatorin (0ZMV066080)
    Language Chinese
    Publishing date 2007-04
    Publishing country China
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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