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Article ; Online: Topical BCl-2 inhibitor (ABT-737) attenuates skin photoaging in mice.

Yang, Bingyi / Jiang, Jiao / Wu, Haijing / Lu, Qianjin

2024 Volume 33, Issue 3, Page(s) e15051

MeSH term(s)	Mice ; Animals ; Skin Aging ; Antineoplastic Agents/pharmacology ; Proto-Oncogene Proteins c-bcl-2 ; Sulfonamides/pharmacology ; Biphenyl Compounds ; Nitrophenols ; Piperazines
Chemical Substances	ABT-737 ; Antineoplastic Agents ; Proto-Oncogene Proteins c-bcl-2 ; Sulfonamides ; Biphenyl Compounds ; Nitrophenols ; Piperazines
Language	English
Publishing date	2024-03-21
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1130936-2
ISSN	1600-0625 ; 0906-6705
ISSN (online)	1600-0625
ISSN	0906-6705
DOI	10.1111/exd.15051
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Zs.A 3508: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Accuracy for key parameters in modelling study.

Yang, Bingyi / Lin, Yun / Cowling, Benjamin J

The Lancet. Public health

2022 Volume 7, Issue 6, Page(s) e494

Language	English
Publishing date	2022-06-05
Publishing country	England
Document type	Letter ; Comment
ISSN	2468-2667
ISSN (online)	2468-2667
DOI	10.1016/S2468-2667(22)00085-8
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Article ; Online: Limited impact of lifting universal masks on SARS-COV-2 transmission in schools: The crucial role of outcome measurements

Li, Mingwei / Yang, Bingyi / Cowling, Benjamin J

medRxiv

Abstract: As the pandemic9s dynamics changed, many municipalities lifted face wearing requirement in school which was initially implemented to mitigate the transmission of COVID-19. This study examines the effects of lifting mask mandates on COVID-19 transmission ... ...

Abstract	As the pandemic9s dynamics changed, many municipalities lifted face wearing requirement in school which was initially implemented to mitigate the transmission of COVID-19. This study examines the effects of lifting mask mandates on COVID-19 transmission within Massachusetts school districts. We first replicated previous research by Cowger et al. (2022) utilizing a Difference-in-Difference (DID) model. Then, we back project the case infection and calculate the Rt value to redo the DID analysis. However, when shifting the outcome measurement to the reproductive number (Rt), our findings suggest that lifting mask mandates can only significantly influence the Rt first two weeks post-intervention. This implies that while mask mandate plays a role in mitigation, its lifting does not drastically influence COVID-19 transmissibility in the long term.
Keywords	covid19
Language	English
Publishing date	2023-08-28
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2023.08.26.23294658
Database	COVID19

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Article ; Online: Corrigendum to "Association of public health and social measures on the hand-foot-mouth epidemic in South Korea" [J Infect Public Health 16 (2023) 859-64].

Ryu, Sukhyun / Han, Changhee / Ali, Sheikh Taslim / Achangwa, Chiara / Yang, Bingyi / Pei, Sen

Journal of infection and public health

2023 Volume 16, Issue 11, Page(s) 1891

Language	English
Publishing date	2023-08-07
Publishing country	England
Document type	Published Erratum
ZDB-ID	2467587-8
ISSN	1876-035X ; 1876-0341
ISSN (online)	1876-035X
ISSN	1876-0341
DOI	10.1016/j.jiph.2023.07.022
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Article ; Online: Association of public health and social measures on the hand-foot-mouth epidemic in South Korea.

Ryu, Sukhyun / Han, Changhee / Ali, Sheikh Taslim / Achangwa, Chiara / Yang, Bingyi / Pei, Sen

Journal of infection and public health

2023 Volume 16, Issue 6, Page(s) 859–864

Abstract: Background: School based-measures such as school closure and school holidays have been considered a viable intervention during the hand-foot-mouth disease (HFMD) epidemic. The aim of this study was to explore the association of nationwide public health ... ...

Abstract	Background: School based-measures such as school closure and school holidays have been considered a viable intervention during the hand-foot-mouth disease (HFMD) epidemic. The aim of this study was to explore the association of nationwide public health and social measures (PHSMs) including planned school vacation on the transmissibility and attack rate of the HFMD epidemic in South Korea. Methods: In this study, we used Korean national surveillance data on HFMD from 2014 to 2019 to estimate the temporal changes in HFMD transmissibility (instantaneous reproductive number, R Results: We found that school vacations and 2015 PHSMs were associated with the reduced R Conclusions: PHSMs likely have a larger association with reduced HFMD transmissibility than school-based measures alone (i.e. school vacations). Preventive measures targeting preschoolers could be considered as potential options for reducing the future burden of HFMD.
MeSH term(s)	Humans ; Public Health ; Epidemics ; Hand, Foot and Mouth Disease/epidemiology ; Incidence ; Mouth ; China/epidemiology
Language	English
Publishing date	2023-03-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2467587-8
ISSN	1876-035X ; 1876-0341
ISSN (online)	1876-035X
ISSN	1876-0341
DOI	10.1016/j.jiph.2023.03.029
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Article ; Online: Bach2 in CD4

Long, Di / Yang, Bingyi / Yang, Ming / Xiong, Feng / Zhu, Xuejing / Tan, Yixin / Wu, Haijing

European journal of immunology

2023 Volume 53, Issue 4, Page(s) e2250109

Abstract: T and B cells participate in the development of systemic lupus erythematosus (SLE). BTB and CNC homology 2 (Bach2) is an irreplaceable regulator in the T and B lineages that helps to maintain immune homeostasis. However, the function of Bach2 in the ... ...

Abstract	T and B cells participate in the development of systemic lupus erythematosus (SLE). BTB and CNC homology 2 (Bach2) is an irreplaceable regulator in the T and B lineages that helps to maintain immune homeostasis. However, the function of Bach2 in the pathogenesis of SLE has not been studied in depth. Flow cytometry and qRT-PCR were used to assess Bach2 levels, bisulfite sequencing PCR was used to measure the methylation level, and silencing by electroporation and stimulation with a cytokine concentration gradient were used to investigate the effect of Bach2 on T cells. Bach2 expression was elevated in the helper T-cell subsets (T follicular helper, Th1, Th2, Th17, and Treg cells) of SLE patients and negatively correlated with disease severity and autoantibody levels. CD4
MeSH term(s)	Humans ; Basic-Leucine Zipper Transcription Factors/genetics ; Basic-Leucine Zipper Transcription Factors/metabolism ; Cell Differentiation ; Cytokines ; Immunoglobulin G ; Lupus Erythematosus, Systemic ; T-Lymphocyte Subsets ; T-Lymphocytes, Regulatory ; CD4-Positive T-Lymphocytes ; B-Lymphocytes
Chemical Substances	BACH2 protein, human ; Basic-Leucine Zipper Transcription Factors ; Cytokines ; Immunoglobulin G
Language	English
Publishing date	2023-02-25
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120108-6
ISSN	1521-4141 ; 0014-2980
ISSN (online)	1521-4141
ISSN	0014-2980
DOI	10.1002/eji.202250109
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Zs.A 489: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Knockdown of Linc00052 alleviated spinal nerve ligation-triggered neuropathic pain through regulating miR-448 and JAK1.

Wang, Li / Zhu, Kairun / Yang, Bingyi / Cai, Yi

Journal of cellular physiology

2020 Volume 235, Issue 10, Page(s) 6528–6535

Abstract: The dysfunction of the nervous system contributes to neuropathic pain. Long noncoding RNAs are reported to participate in neuropathic pain. Recently, Linc00052 is implicated to be closely associated with multiple diseases. Nevertheless, the mechanisms of ...

Abstract	The dysfunction of the nervous system contributes to neuropathic pain. Long noncoding RNAs are reported to participate in neuropathic pain. Recently, Linc00052 is implicated to be closely associated with multiple diseases. Nevertheless, the mechanisms of Linc00052 remain barely explored in neuropathic pain development. Currently, spinal nerve ligation (SNL) triggered neuropathic pain was employed in our investigation. Here, we assessed the function of Linc00052 in SNL rat models. Interestingly, we reported Linc00052 was significantly elevated in SNL rats. Loss of Linc00052 could reduce neuropathic pain progression via regulating the behaviors of neuropathic pain. Additionally, knockdown of Linc00052 repressed the processes of neuroinflammation. Interleukin (IL)-6 and tumor necrosis factor α level were inhibited while IL-10 was induced by the silence of Linc00052. Moreover, we predicted miR-448 can serve as a target of Linc00052. miR-448 exerts a crucial power in several diseases. Currently, we exhibited miR-448 was remarkably downregulated in SNL rats. RNA immunoprecipitation experiments validated the association between miR-448 and Linc00052. Inhibition of Linc00052 could reverse the roles of miR-448 on neuropathic pain development. Furthermore, Janus kinase 1 (JAK1) was displayed as the putative target of miR-448 in the present investigation. It was showed that JAK1 was induced in SNL rats. Loss of miR-448 could dramatically induce the expression of JAK1, which was rescued by knockdown of Linc00052. Taken these together, our study implied that Linc00052 functioned as a novel target of neuropathic pain via sponging miR-448 and regulating JAK1.
MeSH term(s)	Animals ; Cell Line, Tumor ; Disease Progression ; Down-Regulation/genetics ; Inflammation/genetics ; Inflammation/pathology ; Interleukin-6/genetics ; Janus Kinase 1/genetics ; Male ; MicroRNAs/genetics ; Neuralgia/genetics ; PC12 Cells ; RNA, Long Noncoding/genetics ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/genetics ; Spinal Nerves/physiology
Chemical Substances	Interleukin-6 ; MIRN448 microRNA, rat ; MicroRNAs ; RNA, Long Noncoding ; Jak1 protein, rat (EC 2.7.10.2) ; Janus Kinase 1 (EC 2.7.10.2)
Language	English
Publishing date	2020-02-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	3116-1
ISSN	1097-4652 ; 0021-9541
ISSN (online)	1097-4652
ISSN	0021-9541
DOI	10.1002/jcp.29465
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Uc I Zs.212: Show issues

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Article ; Online: A Comprehensive Review of Biological Agents for Lupus: Beyond Single Target.

Yang, Bingyi / Zhao, Ming / Wu, Haijing / Lu, Qianjin

Frontiers in immunology

2020 Volume 11, Page(s) 539797

Abstract: Systemic lupus erythematosus (SLE) is an autoimmune disease that involves multiple immune cells. Due to its complex pathogenesis, the effectiveness of traditional treatment methods is limited. Many patients have developed resistance to conventional ... ...

Abstract	Systemic lupus erythematosus (SLE) is an autoimmune disease that involves multiple immune cells. Due to its complex pathogenesis, the effectiveness of traditional treatment methods is limited. Many patients have developed resistance to conventional treatment or are not sensitive to steroid and immunosuppressant therapy, and so emerging therapeutic antibodies have become an alternative and have been shown to work well in many patients with moderate and severe SLE. This review summarizes the biological agents that are in the preclinical and clinical trial study of SLE. In addition to the various monoclonal antibodies that have been studied for a long time, such as belimumab and rituximab, we focused on another treatment for SLE, bispecific antibodies (BsAbs) such as tibulizumab, which simultaneously targets multiple pathogenic cytokines or pathways. Although the application of BsAbs in cancer has been intensively studied, their application in autoimmune diseases is still in the infant stage. This unique combined mechanism of action may provide a novel therapeutic strategy for SLE.
MeSH term(s)	Antibodies, Bispecific/immunology ; Antibodies, Bispecific/therapeutic use ; Antibodies, Monoclonal, Humanized/immunology ; Antibodies, Monoclonal, Humanized/therapeutic use ; Humans ; Lupus Erythematosus, Systemic/drug therapy ; Lupus Erythematosus, Systemic/immunology ; Lupus Erythematosus, Systemic/pathology ; Rituximab/immunology ; Rituximab/therapeutic use
Chemical Substances	Antibodies, Bispecific ; Antibodies, Monoclonal, Humanized ; Rituximab (4F4X42SYQ6) ; belimumab (73B0K5S26A)
Language	English
Publishing date	2020-10-02
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.539797
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Comparison of the effect of oral megestrol acetate with or without levonorgestrel-intrauterine system on fertility-preserving treatment in patients with early-stage endometrial cancer: a prospective, open-label, randomized controlled phase II trial (ClinicalTrials.gov NCT03241914).

Xu, Zhiying / Yang, Bingyi / Guan, Jun / Shan, Weiwei / Liao, Jiongbo / Shao, Wenyu / Chen, Xiaojun

Journal of gynecologic oncology

2022 Volume 34, Issue 1, Page(s) e32

Abstract: Objective: To evaluate the effect of levonorgestrel-releasing intrauterine system (LNG-IUS) plus oral megestrol acetate (MA) as fertility-preserving treatment in patients with early-stage endometrial cancer (EEC).: Methods: In this single-center, ... ...

Abstract	Objective: To evaluate the effect of levonorgestrel-releasing intrauterine system (LNG-IUS) plus oral megestrol acetate (MA) as fertility-preserving treatment in patients with early-stage endometrial cancer (EEC). Methods: In this single-center, phase II study with open-label, randomized and controlled design, young patients (18-45 years) diagnosed with primary EEC were screened, who strongly required fertility-preserving treatment. Patients were randomly assigned (1:1) into MA group (160 mg oral daily) or MA (160 mg oral daily) plus LNG-IUS group. Pathologic evaluation on endometrium retrieved by hysteroscopy was performed every 3 months. The primary endpoint was complete response (CR) rate within 16 weeks of treatment. The secondary endpoints were CR rate within 32 weeks of treatment, adverse events, recurrent and pregnancy rate. Results: Between July 2017 and June 2020, 63 patients were enrolled and randomly assigned. Totally 56 patients (26 in MA group; 28 in MA + LNG-IUS group) were included into primary-endpoint analyses. The median follow-up was 31.6 months (range, 3.1-94.0). No significant difference in 16-week CR rate were found between MA and MA + LNG-IUS groups (19.2% vs. 25.0%, p=0.610; odds ratio=1.40; 95% confidence interval=0.38-5.12), while the 32-week CR rates were also similar (57.1% and 61.5%, p=0.743), accordingly. More women in MA + LNG-IUS group experienced vaginal hemorrhage (46.4% vs. 16.1%; p=0.012) compared with MA group. No intergroup difference was found regarding recurrence or pregnancy rate. Conclusion: Compared with MA alone, the addition of LNG-IUS may not improve the early CR rate for EEC, and may produce more adverse events instead. Trial registration: ClinicalTrials.gov Identifier: NCT03241914.
MeSH term(s)	Humans ; Female ; Levonorgestrel/adverse effects ; Megestrol Acetate ; Prospective Studies ; Endometrium ; Endometrial Neoplasms/drug therapy
Chemical Substances	Levonorgestrel (5W7SIA7YZW) ; Megestrol Acetate (TJ2M0FR8ES)
Language	English
Publishing date	2022-12-15
Publishing country	Korea (South)
Document type	Randomized Controlled Trial ; Clinical Trial, Phase II ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2478405-9
ISSN	2005-0399 ; 2005-0380
ISSN (online)	2005-0399
ISSN	2005-0380
DOI	10.3802/jgo.2023.34.e32
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Article ; Online: Immunogenicity, efficacy, and safety of SARS-CoV-2 vaccine dose fractionation: a systematic review and meta-analysis.

Yang, Bingyi / Huang, Xiaotong / Gao, Huizhi / Leung, Nancy H / Tsang, Tim K / Cowling, Benjamin J

BMC medicine

2022 Volume 20, Issue 1, Page(s) 409

Abstract: Background: Dose fractionation of a coronavirus disease 2019 (COVID-19) vaccine could effectively accelerate global vaccine coverage, while supporting evidence of efficacy, immunogenicity, and safety are unavailable, especially with emerging variants.!## ...

Abstract	Background: Dose fractionation of a coronavirus disease 2019 (COVID-19) vaccine could effectively accelerate global vaccine coverage, while supporting evidence of efficacy, immunogenicity, and safety are unavailable, especially with emerging variants. Methods: We systematically reviewed clinical trials that reported dose-finding results and estimated the dose-response relationship of neutralizing antibodies (nAbs) of COVID-19 vaccines using a generalized additive model. We predicted the vaccine efficacy against both ancestral and variants, using previously reported correlates of protection and cross-reactivity. We also reviewed and compared seroconversion to nAbs, T cell responses, and safety profiles between fractional and standard dose groups. Results: We found that dose fractionation of mRNA and protein subunit vaccines could induce SARS-CoV-2-specific nAbs and T cells that confer a reasonable level of protection (i.e., vaccine efficacy > 50%) against ancestral strains and variants up to Omicron. Safety profiles of fractional doses were non-inferior to the standard dose. Conclusions: Dose fractionation of mRNA and protein subunit vaccines may be safe and effective, which would also vary depending on the characteristics of emerging variants and updated vaccine formulations.
MeSH term(s)	Humans ; Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Protein Subunits ; RNA, Messenger ; SARS-CoV-2 ; Viral Vaccines
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines ; Protein Subunits ; RNA, Messenger ; Viral Vaccines
Language	English
Publishing date	2022-10-25
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2131669-7
ISSN	1741-7015 ; 1741-7015
ISSN (online)	1741-7015
ISSN	1741-7015
DOI	10.1186/s12916-022-02600-0
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