LIVIVO - Search results -

Search results

Result 1 - 10 of total 63

Search options

Article ; Online: Lysosome biogenesis: Regulation and functions.

Yang, Chonglin / Wang, Xiaochen

2021 Volume 220, Issue 6

Abstract: Lysosomes are degradation centers and signaling hubs in cells and play important roles in cellular homeostasis, development, and aging. Changes in lysosome function are essential to support cellular adaptation to multiple signals and stimuli. Therefore, ... ...

Abstract	Lysosomes are degradation centers and signaling hubs in cells and play important roles in cellular homeostasis, development, and aging. Changes in lysosome function are essential to support cellular adaptation to multiple signals and stimuli. Therefore, lysosome biogenesis and activity are regulated by a wide variety of intra- and extracellular cues. Here, we summarize current knowledge of the regulatory mechanisms of lysosome biogenesis, including synthesis of lysosomal proteins and their delivery via the endosome-lysosome pathway, reformation of lysosomes from degradative vesicles, and transcriptional regulation of lysosomal genes. We survey the regulation of lysosome biogenesis in response to nutrient and nonnutrient signals, the cell cycle, stem cell quiescence, and cell fate determination. Finally, we discuss lysosome biogenesis and functions in the context of organismal development and aging.
MeSH term(s)	Animals ; Homeostasis ; Humans ; Lysosomes/physiology ; Metabolic Networks and Pathways ; Proteins/genetics ; Proteins/metabolism ; Signal Transduction
Chemical Substances	Proteins ; lysosomal proteins
Language	English
Publishing date	2021-05-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	218154-x
ISSN	1540-8140 ; 0021-9525
ISSN (online)	1540-8140
ISSN	0021-9525
DOI	10.1083/jcb.202102001
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ub I Zs.190: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: WDR91 specifies the endosomal retrieval subdomain for retromer-dependent recycling.

Liu, Nan / Liu, Kai / Yang, Chonglin

The Journal of cell biology

2022 Volume 221, Issue 12

Abstract: Retromer-dependent endosomal recycling of membrane receptors requires Rab7, sorting nexin (SNX)-retromer, and factors that regulate endosomal actin organization. It is not fully understood how these factors cooperate to form endosomal subdomains for ... ...

Abstract	Retromer-dependent endosomal recycling of membrane receptors requires Rab7, sorting nexin (SNX)-retromer, and factors that regulate endosomal actin organization. It is not fully understood how these factors cooperate to form endosomal subdomains for cargo retrieval and recycling. Here, we report that WDR91, a Rab7 effector, is the key factor that specifies the endosomal retrieval subdomain. Loss of WDR91 causes defective recycling of both intracellular and cell surface receptors. WDR91 interacts with SNXs through their PX domain, and with VPS35, thus promoting their interaction with Rab7. WDR91 also interacts with the WASH subunit FAM21. In WDR91-deficient cells, Rab7, SNX-retromer, and FAM21 fail to localize to endosomal subdomains, and endosomal actin organization is impaired. Re-expression of WDR91 enables Rab7, SNX-retromer, and FAM21 to concentrate at WDR91-specific endosomal subdomains, where retromer-mediated membrane tubulation and release occur. Thus, WDR91 coordinates Rab7 with SNX-retromer and WASH to establish the endosomal retrieval subdomains required for retromer-mediated endosomal recycling.
MeSH term(s)	Actins/metabolism ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Endosomes/genetics ; Endosomes/metabolism ; Phosphate-Binding Proteins/metabolism ; Protein Domains ; Protein Transport/physiology ; Sorting Nexins/genetics ; Sorting Nexins/metabolism
Chemical Substances	Actins ; Carrier Proteins ; Phosphate-Binding Proteins ; Sorting Nexins
Language	English
Publishing date	2022-10-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218154-x
ISSN	1540-8140 ; 0021-9525
ISSN (online)	1540-8140
ISSN	0021-9525
DOI	10.1083/jcb.202203013
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ub I Zs.190: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Clinical and MRI Donor-Site Outcomes After Autograft Harvesting From the Medial Trochlea for Talar Osteochondral Lesions: Minimum 5-Year Clinical Follow-up.

Guo, Changjun / Li, Xingchen / Zhu, Yuan / Yang, Chonglin / Xu, Xiangyang

Orthopaedic journal of sports medicine

2022 Volume 10, Issue 9, Page(s) 23259671221120075

Abstract: Background: Autologous osteochondral transplantation (AOT) is a treatment option for large or cystic osteochondral lesions of the talus (OLTs), with promising clinical results. However, donor-site morbidity (DSM) has always been a concern with this ... ...

Abstract	Background: Autologous osteochondral transplantation (AOT) is a treatment option for large or cystic osteochondral lesions of the talus (OLTs), with promising clinical results. However, donor-site morbidity (DSM) has always been a concern with this procedure. Purpose: To investigate the clinical and radiological outcomes of autograft harvesting from the medial trochlea for OLTs. Study design: Case series; Level of evidence, 4. Methods: A total of 46 consecutive patients were included after AOT procedures for OLTs, with donor autografts (single or double plugs) harvested from the medial trochlea of the ipsilateral knee. Lysholm scores were collected postoperatively at 12-month intervals to assess clinical outcomes. Postoperative magnetic resonance imaging (MRI) was used to assess the donor site using the MOCART (magnetic resonance observation of cartilage repair tissue) score. DSM was evaluated at 12-month intervals. Statistical analysis was performed to compare patients treated with single-plug and double-plug AOT procedures and establish whether there was any correlation between MOCART and Lysholm scores. Results: The mean follow-up period was 98.3 months (range, 67-144 months). The Lysholm scores for all patients were 92.5 ± 6.1 and 99.9 ± 0.2 at the 12-month and final follow-ups, respectively. MRI of the donor sites was taken at an average of 93.8 ± 20.5 (range, 61-141) months postoperatively, and the mean MOCART score was 76.2 ± 4.9. The overall incidence of DSM in this study was 4.3% at 12 months, postoperatively, which decreased to 0% at the 24-month follow-up. There was no significant difference in either the Lysholm score ( Conclusion: According to the study findings, the DSM of donor autografts harvested from the medial trochlea was low, and the number (single or double) of grafts did not affect the functional outcome.
Language	English
Publishing date	2022-09-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2706251-X
ISSN	2325-9671
ISSN	2325-9671
DOI	10.1177/23259671221120075
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Correction to: Anatomic reconstruction of the lateral ligaments using allograft tendon and suspensory fixation for chronic lateral ankle instability with poor remnant quality: results and complications.

Cao, Yongxing / Yang, Chonglin / Xu, Yang / Hong, Yuan / Xu, Xiangyang

Archives of orthopaedic and trauma surgery

2022 Volume 143, Issue 6, Page(s) 3239

Language	English
Publishing date	2022-11-24
Publishing country	Germany
Document type	Published Erratum
ZDB-ID	80407-1
ISSN	1434-3916 ; 0003-9330 ; 0344-8444
ISSN (online)	1434-3916
ISSN	0003-9330 ; 0344-8444
DOI	10.1007/s00402-022-04699-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uk I Zs.58: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Anatomic reconstruction of the lateral ligaments using allograft tendon and suspensory fixation for chronic lateral ankle instability with poor remnant quality: results and complications.

Cao, Yongxing / Yang, Chonglin / Xu, Yang / Hong, Yuan / Xu, Xiangyang

Archives of orthopaedic and trauma surgery

2022 Volume 143, Issue 6, Page(s) 3231–3237

Abstract: Purpose: Treatment of chronic lateral ankle instability (CLAI) with poor remnant quality is challenging. The aim of the present study was to evaluate clinical results and complications of anatomic reconstruction of the lateral ligaments using allograft ... ...

Abstract	Purpose: Treatment of chronic lateral ankle instability (CLAI) with poor remnant quality is challenging. The aim of the present study was to evaluate clinical results and complications of anatomic reconstruction of the lateral ligaments using allograft tendon and suspensory fixation in the treatment of such patients. Methods: One hundred and eight patients with CLAI, who were treated surgically using anatomic reconstruction with allograft tendon and suspensory fixation between April 2016 and January 2018 at our hospital, were retrospectively analysed. None of the patients had sufficient ligament remnants for the modified Broström procedure during the intraoperative evaluation. Eighteen patients were excluded. Seventeen patients were lost to follow-up and 73 patients completed the study. The mean duration of instability symptoms was 39.1 months (range, 6-480 months). The mean follow-up time was 57.5 months (range, 48-69 months). Clinical results were evaluated using the Karlsson scoring scale, American Orthopaedic Foot and Ankle Society-Ankle and Hindfoot (AOFAS-AH) score, visual analogue scale (VAS), patients' subjective satisfaction, and incidence of complications. Mechanical stability was evaluated using the varus talar tilt angle (TTA) and anterior talar displacement (ATD). Results: The AOFAS-AH scores significantly improved from 67.7 ± 8.5 points to 89.8 ± 9.5 (p < 0.001). The Karlsson scoring scales evolved from 58.8 ± 16.5 to 88.4 ± 11.2 (p < 0.001). VAS scores significantly decreased from 2.9 ± 1.3 to 1.1 ± 1.0 (p < 0.001). On stress radiographs, TTA decreased from 15.1 ± 2.5 degrees to 5.8 ± 2.1 degrees (p < 0.001), whereas ATD reduced from 13.4 ± 2.9 mm to 5.7 ± 1.5 mm (p < 0.001). Patients' subjective satisfaction indicated 46 excellent, 20 good, 5 fair, and 2 bad results. Postoperatively, 15 cases (20.5%) did not achieve complete relief of discomfort or swelling, 9 cases (12.3%) experienced joint stiffness or decreased range of motion, and 6 cases (8.2%) had soft tissue irritation. Residual instability and reoperation are rare. Allograft rejection or wound infection was not observed. Conclusion: For the CLAI patients with poor remnant quality, anatomic reconstruction of the lateral ligaments using allograft tendon and suspensory fixation is an effective procedure, while the top three complications in incidence were residual discomfort, joint stiffness, and soft tissue irritation. Levels of evidence: Level IV, retrospective case series.
MeSH term(s)	Humans ; Lateral Ligament, Ankle/surgery ; Ankle Joint/surgery ; Retrospective Studies ; Ankle ; Tendons/transplantation ; Joint Instability/surgery ; Joint Instability/diagnosis ; Allografts
Language	English
Publishing date	2022-11-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80407-1
ISSN	1434-3916 ; 0003-9330 ; 0344-8444
ISSN (online)	1434-3916
ISSN	0003-9330 ; 0344-8444
DOI	10.1007/s00402-022-04680-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uk I Zs.58: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Gain of circBRAF Represses Glioma Progression by Regulating miR-1290/FBXW7 Axis.

Zhang, Jinchao / Chen, Zhi / Liu, Xinjun / Yang, Chonglin / Xie, Donggen

Neurochemical research

2021 Volume 46, Issue 5, Page(s) 1203–1213

Abstract: Dysregulated circular RNAs (circRNAs) have been confirmed to partake in the modulation of the glioma progression. Here, we intended to explore the role of circBRAF in glioma and the possible action mechanism. The expression levels of circBRAF, microRNA ( ... ...

Abstract	Dysregulated circular RNAs (circRNAs) have been confirmed to partake in the modulation of the glioma progression. Here, we intended to explore the role of circBRAF in glioma and the possible action mechanism. The expression levels of circBRAF, microRNA (miR)-1290 and F-box and WD repeat domain containing 7 (FBXW7) were analyzed by quantitative reverse transcription polymerase chain reaction (qRT-PCR) or western blot. Cell viability was assessed by 3-(4, 5)-dimethylthiazole-2-y1)-2, 5-biphenyl tetrazolium bromide (MTT) assay. Cell cycle distribution was determined by flow cytometry. Cell migration and invasion were evaluated through Trans-well assay. Related protein levels were detected by western blot. Targeted relation among circBRAF, miR-1290 and FBXW7 was validated by dual-luciferase reporter, RNA immunoprecipitation (RIP) and pull-down assays. Xenograft model was constructed to explore the function of circBRAF in vivo. Expression of circBRAF and FBXW7 was decreased in glioma tissues and cells. Upregulation of circBRAF inhibited glioma cell proliferation and metastasis in vitro. MiR-1290 was upregulated in glioma, which was sponged by circBRAF. Besides, circBRAF elevated FBXW7 expression by targeting miR-1290. Introduction of miR-1290 or FBXW7 knockdown could counteract the inhibitory effects of circBRAF upregulation on the malignant phenotypes of glioma cells. Overexpression of circBRAF repressed the tumor growth in vivo. Upregulation of circBRAF suppressed glioma evolvement in vitro and in vivo by regulating miR-1290/FBXW7 axis, broadening the cognition of glioma progression.
MeSH term(s)	Animals ; Cell Line, Tumor ; Cell Movement/physiology ; Cell Proliferation/physiology ; Disease Progression ; F-Box-WD Repeat-Containing Protein 7/metabolism ; Gene Expression Regulation, Neoplastic/physiology ; Glioma/metabolism ; Humans ; Male ; Mice, Inbred BALB C ; Mice, Nude ; MicroRNAs/metabolism ; Neoplasm Invasiveness/physiopathology ; Neoplasm Metastasis/physiopathology ; RNA, Circular/metabolism ; Mice
Chemical Substances	F-Box-WD Repeat-Containing Protein 7 ; Fbxw7 protein, mouse ; MIRN1290 microRNA, human ; MicroRNAs ; RNA, Circular
Language	English
Publishing date	2021-03-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	199335-5
ISSN	1573-6903 ; 0364-3190
ISSN (online)	1573-6903
ISSN	0364-3190
DOI	10.1007/s11064-021-03259-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1368: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: M05B5.4 (lysosomal phospholipase A2) promotes disintegration of autophagic vesicles to maintain

Li, Yuan / Wang, Xin / Li, Meijiao / Yang, Chonglin / Wang, Xiaochen

Autophagy

2021 Volume 18, Issue 3, Page(s) 595–607

Abstract: The autophagosome has two lipid bilayer membranes. The outer membrane fuses with the lysosome, while the inner membrane is degraded to release autophagic contents for degradation. It remains unclear how the inner vesicle of the autophagosome (called the ... ...

Abstract	The autophagosome has two lipid bilayer membranes. The outer membrane fuses with the lysosome, while the inner membrane is degraded to release autophagic contents for degradation. It remains unclear how the inner vesicle of the autophagosome (called the autophagic vesicle) is disintegrated after autophagosome-lysosome fusion. Here, we identified
MeSH term(s)	Animals ; Autophagosomes/metabolism ; Autophagy/genetics ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Carrier Proteins/metabolism ; Lysosomes/metabolism ; Macroautophagy
Chemical Substances	Caenorhabditis elegans Proteins ; Carrier Proteins ; SEPA-1 protein, C elegans
Language	English
Publishing date	2021-06-30
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2454135-7
ISSN	1554-8635 ; 1554-8627
ISSN (online)	1554-8635
ISSN	1554-8627
DOI	10.1080/15548627.2021.1943178
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 6741: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Therapeutic efficacy analysis of distal tibia varus syndrome with different classification and different therapy: a cross-sectional study.

Yang, Chonglin / Liu, Ping / Cao, Yongxing / Guo, Changjun / Zhu, Yuan / Xu, Xiangyang

Annals of translational medicine

2022 Volume 10, Issue 6, Page(s) 270

Abstract: Background: We often attribute the lateral ankle impingement to the valgus calcaneus, while ignoring the varus distal tibia. The diagnostic criteria, severity and treatment of distal tibia varus syndrome (DTVS) have not been reported. This retrospective ...

Abstract	Background: We often attribute the lateral ankle impingement to the valgus calcaneus, while ignoring the varus distal tibia. The diagnostic criteria, severity and treatment of distal tibia varus syndrome (DTVS) have not been reported. This retrospective study sought to propose a diagnosis and classification system for DTVS based on patients' clinical symptoms and imaging findings. Methods: A total of 76 symptomatic patients with varus distal tibia and congruent ankle examined between 2010 and 2018 were involved to evaluate clinically based on their SF-36 scores, AOFAS ankle-hindfoot scores, and VAS scores. Each patient's history, symptoms, and MRI images were analyzed retrospectively, and their weight-bearing ankle radiographs were observed to measure the tibial anterior surface angle (TAS) and tibial tilt angle (TTA). Paired Results: Forty-three men and 33 women with an average age of 46 years (range, 28-68 years) included. Besides the same symptom of intermittent subfibular pain, 3 types of DTVS were defined: (I) Type I: a sloped surface of the distal tibia with the congruent tibiotalar joint on radiographs; (II) Type II: a sloped surface of the distal tibia with the congruent tibiotalar joint on radiographs, and soft-tissue edema inferior to the lateral malleolus on MRI images; and (III) Type III: the same symptoms as Type II, plus osteochondral lesions of the talus on MRI images. Under our proposed classification system, 26 patients were classified as Type I, requiring conservative treatment, 22 as Type II, and 28 as Type III under supramalleolar valgus osteotomy. The ankle functional evaluation scores, such as the SF-36 (74.14±12.50 preoperatively and 85.22±8.83 postoperatively), AOFAS (71.14±15.19 preoperatively and 87.53±8.62 postoperatively), and VAS (5.41±1.10 preoperatively and 1.82±1.08 postoperatively) scores for all types were significantly improved (P<0.01). The TAS (80.38°±4.80° preoperatively and 90.44°±3.96° postoperatively) and TTA (13.02°±3.41° preoperatively and 0.62°±2.67° postoperatively) of all the patients on the weight-bearing ankle radiographs were significantly improved (P<0.01). Conclusions: DTVS, causing lateral ankle impingement, can be diagnosed based on clinical manifestations and imaging findings. Our classification system can aid in the decision-making process in relation to the appropriate form of conservative or surgical treatments.
Language	English
Publishing date	2022-03-30
Publishing country	China
Document type	Journal Article
ZDB-ID	2893931-1
ISSN	2305-5847 ; 2305-5839
ISSN (online)	2305-5847
ISSN	2305-5839
DOI	10.21037/atm-22-997
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: The Metabolite Saccharopine Impairs Neuronal Development by Inhibiting the Neurotrophic Function of Glucose-6-Phosphate Isomerase.

Guo, Ye / Wu, Junjie / Wang, Min / Wang, Xin / Jian, Youli / Yang, Chonglin / Guo, Weixiang

The Journal of neuroscience : the official journal of the Society for Neuroscience

2022 Volume 42, Issue 13, Page(s) 2631–2646

Abstract: Mutations in ... ...

Abstract	Mutations in the
MeSH term(s)	Animals ; Female ; Glucose-6-Phosphate Isomerase ; Hyperlysinemias/genetics ; Hyperlysinemias/metabolism ; Lysine/analogs & derivatives ; Male ; Mice ; Saccharopine Dehydrogenases/genetics ; Saccharopine Dehydrogenases/metabolism
Chemical Substances	Saccharopine Dehydrogenases (EC 1.5.1.-) ; Glucose-6-Phosphate Isomerase (EC 5.3.1.9) ; Lysine (K3Z4F929H6) ; saccharopine (WBQ73O8W32)
Language	English
Publishing date	2022-02-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
DOI	10.1523/JNEUROSCI.1459-21.2022
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1668: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Filamin FLN-2 promotes MVB biogenesis by mediating vesicle docking on the actin cytoskeleton.

Shi, Leiling / Jian, Youli / Li, Meijiao / Hao, Tianchao / Yang, Chonglin / Wang, Xiaochen

The Journal of cell biology

2022 Volume 221, Issue 7

Abstract: Multivesicular bodies (MVBs) contain intralumenal vesicles that are delivered to lysosomes for degradation or released extracellularly for intercellular signaling. Here, we identified Caenorhabditis elegans filamin FLN-2 as a novel regulator of MVB ... ...

Abstract	Multivesicular bodies (MVBs) contain intralumenal vesicles that are delivered to lysosomes for degradation or released extracellularly for intercellular signaling. Here, we identified Caenorhabditis elegans filamin FLN-2 as a novel regulator of MVB biogenesis. FLN-2 co-localizes with V-ATPase subunits on MVBs, and the loss of FLN-2 affects MVB biogenesis, reducing the number of MVBs in C. elegans hypodermis. FLN-2 associates with actin filaments and is required for F-actin organization. Like fln-2(lf) mutation, inactivation of the V0 or V1 sector of V-ATPase or inhibition of actin polymerization impairs MVB biogenesis. Super-resolution imaging shows that FLN-2 docks V-ATPase-decorated MVBs onto actin filaments. FLN-2 interacts via its calponin-homology domains with F-actin and the V1-E subunit, VHA-8. Our data suggest that FLN-2 mediates the docking of MVBs on the actin cytoskeleton, which is required for MVB biogenesis.
MeSH term(s)	Actin Cytoskeleton/metabolism ; Actins/metabolism ; Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Filamins/genetics ; Filamins/metabolism ; Multivesicular Bodies/metabolism ; Vacuolar Proton-Translocating ATPases/metabolism
Chemical Substances	Actins ; Caenorhabditis elegans Proteins ; Filamins ; Vacuolar Proton-Translocating ATPases (EC 3.6.1.-)
Language	English
Publishing date	2022-05-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	218154-x
ISSN	1540-8140 ; 0021-9525
ISSN (online)	1540-8140
ISSN	0021-9525
DOI	10.1083/jcb.202201020
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ub I Zs.190: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito