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Article ; Online: Role of LINC00240 on T-helper 9 differentiation in allergic rhinitis through influencing DNMT1-dependent methylation of PU.1.

Liu, JianGuo / Jiang, XunShuo / Liu, Ke / Deng, JianJian / Qiu, Yi / Wei, Wan / Yang, ChunPing

2023 Volume 72, Issue 2, Page(s) 197–211

Abstract: Background: Allergic rhinitis (AR) is a common allergic disease with increasing prevalence globally. However, the molecular mechanism underlying AR pathogenesis remains largely undefined.: Methods: Peripheral blood and nasal mucosa samples obtained ... ...

Abstract	Background: Allergic rhinitis (AR) is a common allergic disease with increasing prevalence globally. However, the molecular mechanism underlying AR pathogenesis remains largely undefined. Methods: Peripheral blood and nasal mucosa samples obtained from patients with AR (n = 22), and ovalbumin-induced AR mouse model (n = 8 per group) were prepared for subsequent detection. qRT-PCR and western blot were used to detect the expression of LINC00240, miR-155-5p, PU.1 and other key molecules. ELISA assay and flow cytometry were employed to evaluate the secretion of IL-9 and T-helper 9 (Th9) cell ratio, respectively. Bioinformatics analysis, RNA immunoprecipitation (RIP), chromatin immunoprecipitation (ChIP) and luciferase reporter assays were employed to further elucidate the regulatory network of LINC00240/miR-155-5p/DNMT1. The methylation of PU.1 promoter was assessed by methylation-specific PCR (MSP). This signaling axis was further validated in the mouse model of AR. Results: LINC00240 was downregulated, while miR-155-5p and PU.1 were upregulated in the peripheral blood and nasal mucosa of AR patients, as well as in AR mice. This was accompanied with the increased ratio of Th9 cells and elevated IL-9 secretion. Mechanistically, LINC00240 served as a miR-155-5p sponge, and DNMT1 was a target of miR-155-5p. In addition, DNMT1 mediated the methylation of PU.1 promoter. In vivo studies verified that LINC00240 mitigated AR progression, possibly via miR-155-5p/DNMT1/PU.1-dependent Th9 differentiation. Conclusion: The involvement of LINC00240 in AR pathogenesis is closely associated with Th9 differentiation through modulating DNMT1-dependent methylation of PU.1 by sponging miR-155-5p.
MeSH term(s)	Animals ; Humans ; Mice ; Interleukin-9/genetics ; Interleukin-9/metabolism ; Methylation ; MicroRNAs/genetics ; Nasal Mucosa/metabolism ; Rhinitis, Allergic/genetics
Chemical Substances	Interleukin-9 ; MicroRNAs ; proto-oncogene protein Spi-1 ; DNMT1 protein, human (EC 2.1.1.37) ; Dnmt1 protein, mouse (EC 2.1.1.37)
Language	English
Publishing date	2023-11-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	632857-x
ISSN	1559-0755 ; 0257-277X
ISSN (online)	1559-0755
ISSN	0257-277X
DOI	10.1007/s12026-023-09435-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Isolation and structural identification of insecticidal compounds from Tripterygium wilfordii

Qian, Yong / Yang, Chun-Ping / Weng, Ping / Zhang, Min / Pan, Xue-Ge / Wang, Yan-Mei / Chen, Hua-Bao

Journal of Asian natural products research. 2022 July 3, v. 24, no. 7

2022

Abstract: Five compounds were identified from Tripterygium wilfordii, including two novel compounds and three previously known compounds. Two newly discovered compounds are celangulin CY (1α,2α,3β,4β,6β,8α,13-hepacetoxy-9β-benzoyloxy-β-dihydroagarofuran) and ... ...

Abstract	Five compounds were identified from Tripterygium wilfordii, including two novel compounds and three previously known compounds. Two newly discovered compounds are celangulin CY (1α,2α,3β,4β,6β,8α,13-hepacetoxy-9β-benzoyloxy-β-dihydroagarofuran) and celangulin CQ (1α-nicotinoyloxy-2α,3β,6β-triacetoxy-9β-furancarbonyloxy-13-isobutanoyloxy-4β-hydroxy-β-dihydroagarofuran). Their structures were determined using nuclear magnetic resonance (NMR), mass spectrometry (MS), and high-pressure liquid chromatography (HPLC). The isolated compounds were tested for insecticidal activity against the third instar larvae of Spodoptera frugiperda. Both celangulin CY and celangulin CQ exhibited significantly higher oral toxicity in the larvae than that exhibited by the three known compounds.
Keywords	Spodoptera frugiperda ; Tripterygium wilfordii ; high performance liquid chromatography ; insecticidal properties ; instars ; mass spectrometry ; nuclear magnetic resonance spectroscopy ; research ; toxicity
Language	English
Dates of publication	2022-0703
Size	p. 648-656.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	2077926-4
ISSN	1477-2213 ; 1028-6020
ISSN (online)	1477-2213
ISSN	1028-6020
DOI	10.1080/10286020.2021.1948535
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Isolation and structural identification of insecticidal compounds from

Qian, Yong / Yang, Chun-Ping / Weng, Ping / Zhang, Min / Pan, Xue-Ge / Wang, Yan-Mei / Chen, Hua-Bao

Journal of Asian natural products research

2021 Volume 24, Issue 7, Page(s) 648–656

Abstract: Five compounds were identified ... ...

Abstract	Five compounds were identified from
MeSH term(s)	Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacology ; Insecticides/pharmacology ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Sesquiterpenes/chemistry ; Tripterygium
Chemical Substances	Drugs, Chinese Herbal ; Insecticides ; Sesquiterpenes
Language	English
Publishing date	2021-07-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2077926-4
ISSN	1477-2213 ; 1028-6020
ISSN (online)	1477-2213
ISSN	1028-6020
DOI	10.1080/10286020.2021.1948535
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Relationships Among Longitude, Latitude and Elevation of Occurrence of Parocneria orienta Chao (Lepidoptera: Erebidae) in China

Zhou, Xing-Yu / Wang, Jia-Wen / Zhang, Jing / Yang, Hua / Yang, Wei / Yang, Chun-Ping / Zhou, Wei / Li, Tao / Wang, Ru-Lin

Journal of the Kansas Entomological Society. 2020 June 8, v. 92, no. 3

2020

Abstract: Parocneria orienta Chao (Lepidoptera: Erebidae) is the primary defoliator of members of the conifer family Cupressaceae in China. Research is needed to identify the geographic distribution of P. orienta and its major areas of occurrence and to formulate ... ...

Abstract	Parocneria orienta Chao (Lepidoptera: Erebidae) is the primary defoliator of members of the conifer family Cupressaceae in China. Research is needed to identify the geographic distribution of P. orienta and its major areas of occurrence and to formulate measures for early warning, monitoring and control of this pest. Data on the occurrence P. orienta were collected from 4,688 monitoring sites in Sichuan Province, China from 2012 to 2016. Analyses of the spatial distribution and model fit were carried out using ArcGIS and Matlab software. We found that the occurrence of P. orienta complied with a normal distribution law (α = 1% confidence level) in terms of longitude and latitude and belonged to a generalized extreme-value distribution (α = 1% confidence level) in terms of elevation. According to the double factor variance analysis taking year-month as the time variance and longitude, latitude and elevation as the space variance, the hazard centroid shifted significantly by 6 minutes of longitude in March (105°46′37″E) and July (105°40′30″E) of the same year. The regions of greatest damage by P. orienta were located in eastern and southeastern parts of Sichuan Province (105.7°E–31.1°N, elevation 400 m), an area that features plains and low mountains with lush vegetation and abundant Cupressus funebris individuals.
Keywords	Cupressus funebris ; Erebidae ; computer software ; conifers ; defoliating insects ; geographical distribution ; latitude ; longitude ; normal distribution ; variance ; vegetation ; China ; Kansas
Language	English
Dates of publication	2020-0608
Size	p. 549-560.
Publishing place	Kansas Entomological Society
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2210268-1
ISSN	0022-8567
ISSN	0022-8567
DOI	10.2317/0022-8567-92.3.549
Database	NAL-Catalogue (AGRICOLA)

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Article: Molecular Characterization, Expression and Binding Specificity Analysis of the Odorant-Binding Proteins of Scleroderma sichuanensis Xiao (Hymenoptera: Bethylidae)

Tao, Yuan-Yuan / Zhu, Xiao-Qing / Yang, Wei / Yang, Hua / Yang, Chun-Ping / Guan, Feng-Rong / Han, Qing-Long

Journal of the Kansas Entomological Society. 2020 Jan. 8, v. 92, no. 2

2020

Abstract: Odorant-binding proteins (OBPs) play an important role in the sense of smell in parasitoid wasps, especially for locating hosts and mates. Clarifying the role of OBPs in information exchanges between parasitoid wasps and their environment is beneficial ... ...

Abstract	Odorant-binding proteins (OBPs) play an important role in the sense of smell in parasitoid wasps, especially for locating hosts and mates. Clarifying the role of OBPs in information exchanges between parasitoid wasps and their environment is beneficial for understanding the sense of smell in parasitoid wasps. To this end, we cloned the OBPs, SsicOBP1 and SsicOBP2 (GenBank accession numbers: AKP80533.1 and AKP80534.1), of Scleroderma sichuanensis Xiao and then proceeded to conduct prokaryotic expression and qPCR analysis, and determine the binding capacity of SsicOBP1 and SsicOBP2 with 18 types of volatiles from Pinus massoniana Lambert using competitive binding (with 1-NPN as fluorescent probes). We found that SsicOBP1 and SsicOBP2 are expressed at high levels in the antennae of Scleroderma sichuanensis Xiao. Of the 18 types of P. massoniana volatiles, SsicOBP1 could bind effectively with ocimene (binding constant of 12.82 μM) and β-pinene (binding constant of 15.57 μM). SsicOBP2 could bind effectively with α-pinene (with a binding constant of 13.52 μM), ocimene (binding constant of 14.38 μM) and β-pinene (binding constant of 14.51 μM). From this, we could infer that SsicOBP1 and SsicOBP2 are general odorant-binding proteins, which play an important role in sensing plant volatiles.
Keywords	Pinus massoniana ; Scleroderma sichuanensis ; alpha-pinene ; antennae ; beta-pinene ; binding capacity ; fluorescent dyes ; hosts ; ocimene ; odorant receptors ; parasitic wasps ; quantitative polymerase chain reaction ; smell
Language	English
Dates of publication	2020-0108
Size	p. 459-479.
Publishing place	Kansas Entomological Society
Document type	Article
ZDB-ID	2210268-1
ISSN	0022-8567
ISSN	0022-8567
DOI	10.2317/0022-8567-92.2.459
Database	NAL-Catalogue (AGRICOLA)

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Article: The effects of local variation in light availability on pollinator visitation, pollen and resource limitation of female reproduction in Hosta ventricosa.

Cao, Guo-Xing / Wu, Bi-Xian / Xu, Xu-Jian / Wang, Xie / Yang, Chun-Ping

Botanical studies

2017 Volume 58, Issue 1, Page(s) 24

Abstract: Background: Light availability may have direct effects on reproduction through resource availability, and indirect effects on female reproduction by influencing plant-pollinator interactions. Floral display size, pollinator visitation per flower, ... ...

Abstract	Background: Light availability may have direct effects on reproduction through resource availability, and indirect effects on female reproduction by influencing plant-pollinator interactions. Floral display size, pollinator visitation per flower, resource and pollen limitation of fruit and seed production were quantified in a forested patch and an adjacent open patch of two populations of the perennial herb Hosta ventricosa. Results: Plants in the open patch produced significantly larger floral displays than those in the forested patch in both populations. Floral display size had a positive effect on pollinator visitation rate per flower in one population, but no effect in the other. Plants in the open patch received approximately 8-11 times more visitation rates and produced significantly more fruit and seeds per flower than those in the forested patch. However, supplemental pollination resulted in significantly more fruit and seed production per flower compared to natural pollination in the forested patch but not in the open patch in one population, and did not enhance fruit and seed production in either the forested or the open patch in the other. In both populations, supplementally pollinated plants in the open patch produced significantly more fruit and seeds per flower than supplementally pollinated plants in the forested patch. Conclusions: In H. ventricosa, local variation in light conditions could affect pollinator activity and influence female reproduction through resource availability; however differences in the degree of pollen limitation between local habitats were found to be population-specific.
Language	English
Publishing date	2017-06-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2432110-2
ISSN	1999-3110 ; 1817-406X
ISSN (online)	1999-3110
ISSN	1817-406X
DOI	10.1186/s40529-017-0180-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Scale-dependent effects of habitat fragmentation on reproduction in the annual Circaeaster agristis, a narrow endemic and threatened species.

Zhao, Jie-Cai / Luo, Jun / Yang, Chun-Ping / Cao, Guo-Xing

Botanical studies

2015 Volume 56, Issue 1, Page(s) 15

Abstract: Background: Habitat fragmentation and the resulting decline in population size and density commonly reduce the reproduction of rare and threatened species. We investigated the impacts of population size and density on reproduction in more than 30 ... ...

Abstract	Background: Habitat fragmentation and the resulting decline in population size and density commonly reduce the reproduction of rare and threatened species. We investigated the impacts of population size and density on reproduction in more than 30 populations of Circaeaster agristis, a narrow endemic and threatened species, in 2010 and 2011. We also examined the effects of NND (nearest neighbor distance) and LNS (local neighbor size), within radii of 0.1 m, 0.2 m and 0.3 m, on reproduction in two of the populations in 2011. Results: Population size did not affect fruit (seed) number and fruit set in either year studied. Population density had an indirect negative effect on fruit number and fruit set as a consequence of a negative effect on plant size in 2010, but had no effect on fruit number and fruit set in 2011. Within populations, individual fruit number did not change, and individual fruit set increased independent of plant size, in response to increasing NND. Both individual fruit number and individual fruit set increased, independent of plant size, with increases in LNS within a 0.1 m radius, but did not change with increases in LNS within radii of between 0.1 m and 0.2 m radii or between 0.2 m and 0.3 m. Conclusions: The effect of habitat fragmentation on reproduction of C. agristis is scale-dependent. In contrast to the generally accepted idea that fragmentation reduces plant reproduction, reproductive success may increase in sparse populations or increase in response to decreases in LNS in C. agristis.
Language	English
Publishing date	2015-06-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2432110-2
ISSN	1999-3110 ; 1817-406X
ISSN (online)	1999-3110
ISSN	1817-406X
DOI	10.1186/s40529-015-0095-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Role of Vision in Host-Orientation and Mate-Finding Behaviors of the White-Striped Longhorned Beetle, Batocera lineolata

Yang, Hua / Chen Zhang-Ming / Lu Lin / Wang Bao-Xin / Yang Chun-Ping / Yang Wei

Entomological news. 2017 Apr., v. 126, no. 5

2017

Abstract: The roles of vision in host orientation and mate finding were investigated in a major coleopteran pest of broad-leaved plants, the white-striped longhorned beetle Batocera lineolata, in the laboratory. Adults oriented strongly to host-related wavelengths ...

Abstract	The roles of vision in host orientation and mate finding were investigated in a major coleopteran pest of broad-leaved plants, the white-striped longhorned beetle Batocera lineolata, in the laboratory. Adults oriented strongly to host-related wavelengths (560â600 nm), and preferred different target wavelengths under different light sources (artificial light and natural light). The combined effect of color and volatile organic compounds from host plants were significantly attractive to B. lineolata adults (P<0.05). Blinded adults could find mates by olfaction alone, but needed more time (P<0.05). Our findings will help to understand visual and volatile attraction in this longhorned beetle and may present potential novel approaches for sustainable management.
Keywords	adults ; Batocera ; color ; host plants ; pests ; smell ; solar radiation ; vision ; volatile organic compounds ; wavelengths
Language	English
Dates of publication	2017-04
Size	p. 358-371.
Publishing place	American Entomological Society
Document type	Article
ZDB-ID	427420-9
ISSN	0013-872X
ISSN	0013-872X
DOI	10.3157%2F021.126.0504
Database	NAL-Catalogue (AGRICOLA)

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Article: Scale-dependent effects of habitat fragmentation on reproduction in the annual Circaeaster agristis, a narrow endemic and threatened species

Zhao, Jie-Cai / Luo, Jun / Yang, Chun-Ping / Cao, Guo-Xing

Botanical studies. 2015 Dec., v. 56, no. 1

2015

Abstract: BACKGROUND: Habitat fragmentation and the resulting decline in population size and density commonly reduce the reproduction of rare and threatened species. We investigated the impacts of population size and density on reproduction in more than 30 ... ...

Abstract	BACKGROUND: Habitat fragmentation and the resulting decline in population size and density commonly reduce the reproduction of rare and threatened species. We investigated the impacts of population size and density on reproduction in more than 30 populations of Circaeaster agristis, a narrow endemic and threatened species, in 2010 and 2011. We also examined the effects of NND (nearest neighbor distance) and LNS (local neighbor size), within radii of 0.1 m, 0.2 m and 0.3 m, on reproduction in two of the populations in 2011. RESULTS: Population size did not affect fruit (seed) number and fruit set in either year studied. Population density had an indirect negative effect on fruit number and fruit set as a consequence of a negative effect on plant size in 2010, but had no effect on fruit number and fruit set in 2011. Within populations, individual fruit number did not change, and individual fruit set increased independent of plant size, in response to increasing NND. Both individual fruit number and individual fruit set increased, independent of plant size, with increases in LNS within a 0.1 m radius, but did not change with increases in LNS within radii of between 0.1 m and 0.2 m radii or between 0.2 m and 0.3 m. CONCLUSIONS: The effect of habitat fragmentation on reproduction of C. agristis is scale-dependent. In contrast to the generally accepted idea that fragmentation reduces plant reproduction, reproductive success may increase in sparse populations or increase in response to decreases in LNS in C. agristis.
Keywords	fruit set ; habitat fragmentation ; plant reproduction ; population density ; population dynamics ; population size ; reproductive success ; threatened species
Language	English
Dates of publication	2015-12
Size	p. 15.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	2432110-2
ISSN	1999-3110 ; 1817-406X
ISSN (online)	1999-3110
ISSN	1817-406X
DOI	10.1186/s40529-015-0095-5
Database	NAL-Catalogue (AGRICOLA)

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Article: Effects of Scleroderma sichuanensis Xiao (Hymenoptera: Bethylidae) venom and parasitism on nutritional content regulation in host Tenebrio molitor L. (Coleoptera: Tenebrionidae).

Zhuo, Zhi-Hang / Yang, Wei / Xu, Dan-Ping / Yang, Chun-Ping / Yang, Hua

SpringerPlus

2016 Volume 5, Issue 1, Page(s) 1017

Abstract: To explore the mechanisms by which the wasp Scleroderma sichuanensis Xiao regulates the physiology and biochemistry of its host, effects of S. sichuanensis venom and parasitism on host the Tenebrio molitor L. pupae were examined. Significant differences ... ...

Abstract	To explore the mechanisms by which the wasp Scleroderma sichuanensis Xiao regulates the physiology and biochemistry of its host, effects of S. sichuanensis venom and parasitism on host the Tenebrio molitor L. pupae were examined. Significant differences in nutritional content were noted between parasitized and non-parasitized pupae and between venom- and phosphate buffered saline-injected pupae. When pupae were injected with venom, the fat body could not be disintegrated into granules; however, when pupae were parasitized, fat-body disintegration occurred. Electrophoresis showed no differences in hemolymph protein content between parasitized pupae and those injected with venom, indicating that the wasp did not have narrow-spectrum peptides. These findings confirmed that S. sichuanensis was a typical idiobiont ectoparasitoid wasp, and that nutrient regulation was similar between idiobiont and koinobiont wasps. The strong similarities between the two treatments suggest that venom injection is a major factor responsible for changes in host nutrient content. The wasp fed mainly on reducing sugars, free amino acids, and fat-body tissues; larval fat bodies were derived from hemolymph and from host tissue. Our findings suggest that lipid catabolism might be accelerated, and that lipid biosynthesis might be inhibited, when host pupae are parasitized or injected with venom. In addition to venom, physiological and biochemical changes that occur during the parasitic process might be caused by venom, ovarian proteins, saliva, or secretions.
Language	English
Publishing date	2016-07-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661116-8
ISSN	2193-1801
ISSN	2193-1801
DOI	10.1186/s40064-016-2732-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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