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  1. Article ; Online: Editorial: The role of essential trace elements in health and disease.

    Guan, Dong-Xing / Yang, Chunguang / Nriagu, Jerome O

    Frontiers in public health

    2024  Volume 11, Page(s) 1285603

    MeSH term(s) Humans ; Female ; Trace Elements/analysis ; Maternal Exposure
    Chemical Substances Trace Elements
    Language English
    Publishing date 2024-01-03
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1285603
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Novel Antibacterial Metals as Food Contact Materials: A Review.

    Zhang, Xinrui / Yang, Chunguang / Yang, Ke

    Materials (Basel, Switzerland)

    2023  Volume 16, Issue 8

    Abstract: Food contamination caused by microorganisms is a significant issue in the food field that not only affects the shelf life of food, but also threatens human health, causing huge economic losses. Considering that the materials in direct or indirect contact ...

    Abstract Food contamination caused by microorganisms is a significant issue in the food field that not only affects the shelf life of food, but also threatens human health, causing huge economic losses. Considering that the materials in direct or indirect contact with food are important carriers and vectors of microorganisms, the development of antibacterial food contact materials is an important coping strategy. However, different antibacterial agents, manufacturing methods, and material characteristics have brought great challenges to the antibacterial effectiveness, durability, and component migration associated with the use security of materials. Therefore, this review focused on the most widely used metal-type food contact materials and comprehensively presents the research progress regarding antibacterial food contact materials, hoping to provide references for exploring novel antibacterial food contact materials.
    Language English
    Publishing date 2023-04-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma16083029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Preoperative accuracy of diagnostic evaluation of urachal carcinoma.

    Ke, Chunjin / Hu, Zhiquan / Yang, Chunguang

    Cancer medicine

    2023  Volume 12, Issue 8, Page(s) 9106–9115

    Abstract: Background: We analyzed the clinical data of patients with urachal carcinoma (UrC) in order to strengthen urologists' understanding of UrC and improve preoperative diagnosis.: Methods: The clinical data of 37 patients with UrC admitted to our ... ...

    Abstract Background: We analyzed the clinical data of patients with urachal carcinoma (UrC) in order to strengthen urologists' understanding of UrC and improve preoperative diagnosis.
    Methods: The clinical data of 37 patients with UrC admitted to our hospital from October 2005 to April 2022 were retrospectively analyzed, and 40 patients with urothelial carcinoma (UCa) of bladder were enrolled as the control group. We compared and analyzed the imaging, cystoscopy and immunohistochemistry, serum tumor markers, fluorescence in situ hybridization (FISH) of UrC and bladder UCa for early diagnosis and evaluation of diagnostic accuracy.
    Results: A total of 37 patients with UrC were enrolled in this study, including 30 males and seven females, with a median age of 52.00 (44.50-63.50) years. Imaging and cystoscopy suggest that UrC grows primarily outside the bladder cavity and is found in the middle line of the dome or anterior wall of the bladder. There was a significant difference in tumor location between the UrC group and the UCa group (10.13 mm vs. -7.06 mm, p < 0.001). Immunohistochemistry revealed that CK20 and CDX-2 were both diffusely and strongly positive. β-catenin was strongly positive in cytoplasm and membrane, but negative in nuclear staining. Carcinoembryonic antigen (CEA) and carbohydrate antigen 72-4 (CA724) expression levels were significantly higher in the UrC group than in the UCa group (p < 0.05). In the diagnosis of UrC, the area under the curve (AUC) of CEA combined with CA724 was the greatest. FISH's sensitivity in diagnosing UrC (5/7, 71.43%) was not significantly different from that of UCa (71.43% vs. 77.50%, p = 0.659). Imaging examination has the highest sensitivity and specificity among the accuracy evaluation of different diagnostic methods.
    Conclusions: Imaging and cystoscopy are the powerful diagnostic methods for UrC. Serum tumor markers may assist in diagnosis, prognosis, and monitoring. Positive urine FISH can easily misdiagnose UrC as UCa.
    MeSH term(s) Male ; Female ; Humans ; Urinary Bladder Neoplasms/diagnosis ; Urinary Bladder Neoplasms/surgery ; Urinary Bladder Neoplasms/pathology ; Carcinoma, Transitional Cell ; Carcinoembryonic Antigen ; Retrospective Studies ; In Situ Hybridization, Fluorescence ; Biomarkers, Tumor
    Chemical Substances Carcinoembryonic Antigen ; Biomarkers, Tumor
    Language English
    Publishing date 2023-02-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2659751-2
    ISSN 2045-7634 ; 2045-7634
    ISSN (online) 2045-7634
    ISSN 2045-7634
    DOI 10.1002/cam4.5648
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Trace element zinc and skin disorders.

    Zou, Pan / Du, Yuxin / Yang, Chunguang / Cao, Yuchun

    Frontiers in medicine

    2023  Volume 9, Page(s) 1093868

    Abstract: Zinc is a necessary trace element and an important constituent of proteins and other biological molecules. It has many biological functions, including antioxidant, skin and mucous membrane integrity maintenance, and the promotion of various enzymatic and ...

    Abstract Zinc is a necessary trace element and an important constituent of proteins and other biological molecules. It has many biological functions, including antioxidant, skin and mucous membrane integrity maintenance, and the promotion of various enzymatic and transcriptional responses. The skin contains the third most zinc in the organism. Zinc deficiency can lead to a range of skin diseases. Except for acrodermatitis enteropathic, a rare genetic zinc deficiency, it has also been reported in other diseases. In recent years, zinc supplementation has been widely used for various skin conditions, including infectious diseases (viral warts, genital herpes, cutaneous leishmaniasis, leprosy), inflammatory diseases (hidradenitis suppurativa, acne vulgaris, rosacea, eczematous dermatitis, seborrheic dermatitis, psoriasis, Behcet's disease, oral lichen planus), pigmentary diseases (vitiligo, melasma), tumor-associated diseases (basal cell carcinoma), endocrine and metabolic diseases (necrolytic migratory erythema, necrolytic acral erythema), hair diseases (alopecia), and so on. We reviewed the literature on zinc application in dermatology to provide references for better use.
    Language English
    Publishing date 2023-01-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.1093868
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Sequential Dearomatization/Rearrangement of Quinazoline-Derived Azomethine Imines for the Synthesis of Nitrogen-Rich Three-Dimensional Cage-Like Molecules.

    Wang, Yu-Jiao / Yang, Chun-Guang / Wang, Shuang / Wu, Han / Zhao, Li-Ming

    Organic letters

    2024  Volume 26, Issue 17, Page(s) 3557–3562

    Abstract: A sequential dearomatization/rearrangement reaction between quinazoline-derived azomethine imines and crotonate sulfonium salts has been developed to provide a series of three-dimensional cage-like molecules. The reaction involves two dearomatizations, ... ...

    Abstract A sequential dearomatization/rearrangement reaction between quinazoline-derived azomethine imines and crotonate sulfonium salts has been developed to provide a series of three-dimensional cage-like molecules. The reaction involves two dearomatizations, two cyclizations, and two C-C bond and three C-N bond formations in one step. The new transformation has a broad substrate scope, does not require any added reagents, and proceeds under room temperature in a short time. A mechanistic rationale for the sequential dearomatization/rearrangement is also presented. Furthermore, the synthetic compounds are evaluated for their glucose control effect. Compounds
    Language English
    Publishing date 2024-04-23
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.4c00952
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: A case report of sustained remission after radiotherapy combined with ICI in NEPC with primary drug resistance to chemotherapy.

    Li, Tengfei / Wang, Yanan / Jiang, Yueqiang / Wu, Zixi / Hu, Zhiquan / Wang, Zhihua / Yang, Chunguang

    Frontiers in oncology

    2024  Volume 14, Page(s) 1360956

    Abstract: Advanced prostate cancer (PCa) is usually treated initially with androgen deprivation therapy (ADT). Although they experience a period of disease regression, most patients progress to metastatic castration-resistant prostate cancer (mCRPC). Patients with ...

    Abstract Advanced prostate cancer (PCa) is usually treated initially with androgen deprivation therapy (ADT). Although they experience a period of disease regression, most patients progress to metastatic castration-resistant prostate cancer (mCRPC). Patients with mCRPC now have an unprecedented number of approved treatment options, including chemotherapies, hormone therapies, targeted therapies, etc. However, the improvement of overall survival (OS) in patients with mCRPC and its special subtype neuroendocrine prostate cancer (NEPC) is limited. In recent years, with the use of immune checkpoint inhibitors (ICIs), such as PD1/PDL1 and CTLA4 inhibitors, immunotherapy has once again become a promising treatment choice to stimulate antitumor immunity. However, the efficacy of NEPC receiving ICI has not been reported. Here, we describe a patient with mCRPC who developed primary resistance to current endocrine and chemotherapy regimens and progressed to mCRPC with NEPC as the main component, showing a significant and lasting response to PD1 monoclonal antibody combined with radiotherapy.
    Language English
    Publishing date 2024-04-26
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2024.1360956
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: UroVysion

    Ke, Chunjin / Liu, Xuguang / Wan, Jie / Hu, Zhiquan / Yang, Chunguang

    Frontiers in molecular biosciences

    2023  Volume 10, Page(s) 1250442

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-10-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2023.1250442
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: UroVysion

    Ke, Chunjin / Hu, Zhiquan / Yang, Chunguang

    Cancers

    2022  Volume 14, Issue 21

    Abstract: ... ...

    Abstract UroVysion
    Language English
    Publishing date 2022-11-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14215423
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Neoadjuvant therapy with Disitamab vedotin in treating muscle-invasive bladder cancer: A case report

    Huang, Haijun / Zhang, Yucong / Chen, Zhi / Zeng, Xing / Hu, Zhiquan / Yang, Chunguang

    Heliyon. 2023 Apr. 03, p.e15157-

    2023  

    Abstract: Platinum-based regimens are regarded as the preferred alternative for neoadjuvant chemotherapy for muscle-invasive bladder cancer (MIBC) patients. However, some patients cannot tolerate platinum-based regimens. We report an MIBC case with severe renal ... ...

    Abstract Platinum-based regimens are regarded as the preferred alternative for neoadjuvant chemotherapy for muscle-invasive bladder cancer (MIBC) patients. However, some patients cannot tolerate platinum-based regimens. We report an MIBC case with severe renal insufficiency treated by neoadjuvant therapy with gemcitabine and Disitamab Vedotin. A 68-year-old man with severe renal insufficiency was admitted to our department and diagnosed with cT3N0M0 MIBC. Immunohistochemical staining of the biopsy tissues showed human epidermal growth factor receptor 2 expression (1+). This patient received neoadjuvant therapy with gemcitabine 1600 mg and DV 120 mg intravenously every three weeks 3 times. We compared the imaging results of the patient before and after neoadjuvant therapy. In addition, the white blood cell count, alanine aminotransferase, aspartate aminotransferase, and serum creatinine were followed up during neoadjuvant therapy. Abnormal symptoms such as hair loss, fatigue, and hypoesthesia were also recorded. According to the imaging examinations, the lesions were significantly reduced after receiving neoadjuvant therapy. Significant adverse side effects did not occur during neoadjuvant therapy. In this T3N0M0 cisplatin-ineligible patient, gemcitabine combined with DV as neoadjuvant therapy achieved radiological partial response, and no significant adverse events were observed during neoadjuvant therapy.
    Keywords alanine transaminase ; alopecia ; aspartate transaminase ; biopsy ; blood serum ; case studies ; creatinine ; erbB-2 receptor ; immunohistochemistry ; intravenous injection ; leukocyte count ; patients ; renal failure ; somatosensory disorders ; urinary bladder neoplasms ; Neoadjuvant therapy ; Muscle-invasive bladder cancer ; Disitamab vedotin ; HER2-Targeted ; Antibody‒drug conjugates
    Language English
    Dates of publication 2023-0403
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Pre-press version ; Use and reproduction
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e15157
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: Prognostic indicators for survival in renal cell carcinoma with venous thrombus and development of predictive nomograms.

    Tian, Jihua / Zeng, Xing / Guan, Wei / Hu, Zhiquan / Yang, Chunguang

    Translational andrology and urology

    2022  Volume 11, Issue 10, Page(s) 1374–1388

    Abstract: Background: Previous predictive models of prognosis of patients with renal cell carcinoma (RCC) and venous tumour thrombus (VTT) didn't included patients have not undergoing radical nephrectomy (RN). We analysed both patients receive RN or not to ... ...

    Abstract Background: Previous predictive models of prognosis of patients with renal cell carcinoma (RCC) and venous tumour thrombus (VTT) didn't included patients have not undergoing radical nephrectomy (RN). We analysed both patients receive RN or not to investigate the prognostic factors of survival for patients with RCC and VTT comprehensively.
    Methods: The clinical data of patients with RCC and VTT diagnosed from 2000-2018 in the Surveillance Epidemiology and End Results (SEER) database were downloaded and compared with the clinical data of patients with VTT admitted to the Department of Urology of the Tongji Hospital (TJH) from 2004-2020. The matched cases were divided into a training set and a validation set. The training set was used to establish nomograms based on key prognostic factors. The reliability of the nomograms for predicting the survival of patients in the training set, those in the validation set and TJH patients and was evaluated by C-indexes, ROC curves and calibration curves.
    Results: Multivariate Cox regression analysis identified nine prognostic factors for overall survival (OS): age, tumour size, histologic classification, nuclear grade, location of VTT, N stage, M stage, surgery, and systemic treatments (P<0.001). Nomograms for OS and cancer specific survival (CSS) were established based on key prognostic factors obtained from the multivariate analysis. The C-indexes of the nomogram for predicting OS in the training set, validation set, TJH cohort were 0.762 (95% CI: 0.746-0.778), 0.718 (95% CI: 0.687-0.749), and 0.819 (95% CI: 0.745-0.893), respectively. The calibration curves are all close to a straight line with a slope of 1. Based on the ROC curves, the nomograms had greater areas under the curve (AUCs) than the tumor, node and metastasis (TNM) staging system in predicting the 3-year OS and CSS. All three validations showed that the nomograms established based on key prognostic factors have reliable accuracy in predicting the survival of both TJH and SEER patients who developed RCCs with VTT.
    Conclusions: Beside the location of VTT, the tumour size can also predict the survival of patients with RCC and VTT. Nomograms based on key prognostic factors can predict the survival of patients from both America and central China with reliable accuracy.
    Language English
    Publishing date 2022-11-11
    Publishing country China
    Document type Journal Article
    ZDB-ID 2851630-8
    ISSN 2223-4691 ; 2223-4691 ; 2223-4683
    ISSN (online) 2223-4691
    ISSN 2223-4691 ; 2223-4683
    DOI 10.21037/tau-22-128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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