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Article ; Online: Integrating genes and metabolites: unraveling mango's drought resilience mechanisms.

Hou, Xianbin / Kong, Yu / Teng, Zheng / Yang, Cuifeng / Li, Yufeng / Zhu, Zhengjie

2024 Volume 24, Issue 1, Page(s) 208

Abstract: Background: Mango (Mangifera indica L.) faces escalating challenges from increasing drought stress due to erratic climate patterns, threatening yields, and quality. Understanding mango's drought response mechanisms is pivotal for resilience and food ... ...

Abstract	Background: Mango (Mangifera indica L.) faces escalating challenges from increasing drought stress due to erratic climate patterns, threatening yields, and quality. Understanding mango's drought response mechanisms is pivotal for resilience and food security. Results: Our RNA-seq analyses unveil 12,752 differentially expressed genes linked to stress signaling, hormone regulation, and osmotic adjustment. Weighted Gene Co-expression Network Analysis identified three essential genes-WRKY transcription factor 3, polyamine oxidase 4, and protein MEI2-like 1-as drought defense components. WRKY3 having a role in stress signaling and defense validates its importance. Polyamine oxidase 4, vital in stress adaptation, enhances drought defense. Protein MEI2-like 1's significance emerges, hinting at novel roles in stress responses. Metabolite profiling illuminated Mango's metabolic responses to drought stress by presenting 990 differentially abundant metabolites, mainly related to amino acids, phenolic acids, and flavonoids, contributing to a deeper understanding of adaptation strategies. The integration between genes and metabolites provided valuable insights by revealing the correlation of WRKY3, polyamine oxidase 4 and MEI2-like 1 with amino acids, D-sphingnosine and 2,5-Dimethyl pyrazine. Conclusions: This study provides insights into mango's adaptive tactics, guiding future research for fortified crop resilience and sustainable agriculture. Harnessing key genes and metabolites holds promise for innovative strategies enhancing drought tolerance in mango cultivation, contributing to global food security efforts.
MeSH term(s)	Droughts ; Mangifera/genetics ; Resilience, Psychological ; Gene Expression Profiling ; Amino Acids ; Stress, Physiological/genetics ; Gene Expression Regulation, Plant
Chemical Substances	Amino Acids
Language	English
Publishing date	2024-03-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2059868-3
ISSN	1471-2229 ; 1471-2229
ISSN (online)	1471-2229
ISSN	1471-2229
DOI	10.1186/s12870-024-04908-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Green One-Pot Syntheses of 2-Sulfoximidoyl-3,6-dibromo Indoles Using

Chen, Xiao Yun / Tang, Yaonan / Xiang, Xinran / Tang, Yisong / Huang, Mingyang / Zheng, Shaojun / Yang, Cuifeng

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 8

Abstract: A green one-pot 2,3,6-trifunctionalization ... ...

Abstract	A green one-pot 2,3,6-trifunctionalization of
Language	English
Publishing date	2023-04-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28083380
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Article: Genome-Wide Characterization, Identification and Expression Profile of MYB Transcription Factor Gene Family during Abiotic and Biotic Stresses in Mango (

Zhang, He / Liu, Zhixin / Luo, Ruixiong / Sun, Yu / Yang, Cuifeng / Li, Xi / Gao, Aiping / Pu, Jinji

Plants (Basel, Switzerland)

2022 Volume 11, Issue 22

Abstract: Mango ( ...

Abstract	Mango (
Language	English
Publishing date	2022-11-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants11223141
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Article: Synthesis of guanidines via the I2 mediated desulfurization of N,N′-di-Boc-thiourea

Rong, Hao-Jie / Chen, Tao / Ning, Bin-Ke / Wang, Yong-Qiang / Yang, Cui-Feng

Tetrahedron letters. 2019 July 22,

2019

Abstract: The I2 mediated desulfurization of N,N′-di-Boc-thiourea was developed. Various primary amines, including sterically and electronically deactivated primary amines, were transformed into the corresponding bis-Boc protected guanidines under mild conditions. ...

Abstract	The I2 mediated desulfurization of N,N′-di-Boc-thiourea was developed. Various primary amines, including sterically and electronically deactivated primary amines, were transformed into the corresponding bis-Boc protected guanidines under mild conditions.
Keywords	chemical reactions ; chemical structure ; desulfurization ; guanidines ; primary amines
Language	English
Dates of publication	2019-0722
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ZDB-ID	204287-3
ISSN	1873-3581 ; 0040-4039
ISSN (online)	1873-3581
ISSN	0040-4039
DOI	10.1016/j.tetlet.2019.150970
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Zs.A 2837: Show issues

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Article ; Online: Ecosystem impact and dietary exposure of polychlorinated biphenyls (PCBs) and heavy metals in Chinese mitten crabs (Eriocheir sinensis) and their farming areas in Jiangsu, China.

Zhang, Hanxiaoya / Zhang, Haoran / Zhao, Ling / Zhou, Beilei / Li, Pan / Liu, Beibei / Wang, Yulong / Yang, Cuifeng / Huang, Kang / Zhang, Cunzheng

Ecotoxicology and environmental safety

2021 Volume 227, Page(s) 112936

Abstract: This study investigated the presence of 18 dioxin-like and non-dioxin-like polychlorinated biphenyls (dl- and ndl-PCBs), heavy metals (Cd, Hg, Pb, and As) in Chinese mitten crabs (Eriocheir sinensis) and their distribution in Jiangsu, China. Risk ... ...

Abstract	This study investigated the presence of 18 dioxin-like and non-dioxin-like polychlorinated biphenyls (dl- and ndl-PCBs), heavy metals (Cd, Hg, Pb, and As) in Chinese mitten crabs (Eriocheir sinensis) and their distribution in Jiangsu, China. Risk assessment and source apportionment were employed for evaluating the eco-toxicological impact and human exposure. It was found that the compositions of PCBs varied spatially, suggesting different sources of pollutants, whilst PCB 28, 105, 114, and 126 were consistently found in all sample types, suggesting a common pollution source remained, and the bio-accumulation process was in effect. The total PCBs in sediment were found much higher than in water, and brown meat had the highest and most diverse PCB congeners among all tissues. The presence of heavy metals was found in all samples in descending order of As>Cd>Pb>Hg and in the order of shell>brown meat>white meat>gill for crabs. The results of risk assessment indicated that the potential carcinogenic and non-carcinogenic risks were within the acceptable range for long-term consumption of the crabs overall. However, the highest toxic equivalent (TEQ), carcinogenic, and non-carcinogenic risks were all recorded in Location C, where dl-PCB 126, 169, and As contributed to the majority of the risks. The ecological risk posed by all HMs was low, but cases of serious point source pollution have been found in the investigated regions, and risks caused by Cd individually should raise concerns. Source apportionment study revealed that the contaminants mostly originated from anthropogenic activities. Natural deposition and transportation played an important role as well.
MeSH term(s)	Agriculture ; Animals ; Brachyura/chemistry ; China ; Dietary Exposure ; Ecosystem ; Environmental Monitoring ; Humans ; Metals, Heavy/analysis ; Polychlorinated Biphenyls/analysis ; Risk Assessment
Chemical Substances	Metals, Heavy ; Polychlorinated Biphenyls (DFC2HB4I0K)
Language	English
Publishing date	2021-10-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2021.112936
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Zs.A 1418: Show issues

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Article: Ecosystem impact and dietary exposure of polychlorinated biphenyls (PCBs) and heavy metals in Chinese mitten crabs (Eriocheir sinensis) and their farming areas in Jiangsu, China

Zhang, Hanxiaoya / Zhang, Haoran / Zhao, Ling / Zhou, Beilei / Li, Pan / Liu, Beibei / Wang, Yulong / Yang, Cuifeng / Huang, Kang / Zhang, Cunzheng

Ecotoxicology and environmental safety. 2021 Dec. 20, v. 227

2021

Abstract	This study investigated the presence of 18 dioxin-like and non-dioxin-like polychlorinated biphenyls (dl- and ndl-PCBs), heavy metals (Cd, Hg, Pb, and As) in Chinese mitten crabs (Eriocheir sinensis) and their distribution in Jiangsu, China. Risk assessment and source apportionment were employed for evaluating the eco-toxicological impact and human exposure. It was found that the compositions of PCBs varied spatially, suggesting different sources of pollutants, whilst PCB 28, 105, 114, and 126 were consistently found in all sample types, suggesting a common pollution source remained, and the bio-accumulation process was in effect. The total PCBs in sediment were found much higher than in water, and brown meat had the highest and most diverse PCB congeners among all tissues. The presence of heavy metals was found in all samples in descending order of As>Cd>Pb>Hg and in the order of shell>brown meat>white meat>gill for crabs. The results of risk assessment indicated that the potential carcinogenic and non-carcinogenic risks were within the acceptable range for long-term consumption of the crabs overall. However, the highest toxic equivalent (TEQ), carcinogenic, and non-carcinogenic risks were all recorded in Location C, where dl-PCB 126, 169, and As contributed to the majority of the risks. The ecological risk posed by all HMs was low, but cases of serious point source pollution have been found in the investigated regions, and risks caused by Cd individually should raise concerns. Source apportionment study revealed that the contaminants mostly originated from anthropogenic activities. Natural deposition and transportation played an important role as well.
Keywords	Eriocheir sinensis ; bioaccumulation ; carcinogenicity ; dietary exposure ; ecosystems ; ecotoxicology ; humans ; meat ; point source pollution ; polychlorinated biphenyls ; risk ; risk assessment ; sediments ; transportation ; China
Language	English
Dates of publication	2021-1220
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2021.112936
Database	NAL-Catalogue (AGRICOLA)

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Z 3684: Show issues

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Article: 4-Dimethylaminopyridine-catalyzed synthesis of isothiocyanates from amines and carbon disulfide

Rong, Hao-Jie / Chen, Tao / Xu, Ze-Gang / Su, Tian-Duo / Shang, Yu / Wang, Yong-Qiang / Yang, Cui-Feng

Tetrahedron letters. 2021 Mar. 30, v. 68

2021

Abstract: Isothiocyanates were synthesized by reactions between primary amines and CS₂ in the presence of 4-dimethylaminopyridine as a catalyst and tert-butyl hydroperoxide as an oxidant. Various aryl, benzyl, alkyl, and hydroxyl amines were transformed into the ... ...

Abstract	Isothiocyanates were synthesized by reactions between primary amines and CS₂ in the presence of 4-dimethylaminopyridine as a catalyst and tert-butyl hydroperoxide as an oxidant. Various aryl, benzyl, alkyl, and hydroxyl amines were transformed into the corresponding isothiocyanates in 41–82% yields.
Keywords	carbon disulfide ; catalysts ; isothiocyanates ; oxidants
Language	English
Dates of publication	2021-0330
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	204287-3
ISSN	1873-3581 ; 0040-4039
ISSN (online)	1873-3581
ISSN	0040-4039
DOI	10.1016/j.tetlet.2021.152868
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Zs.A 2837: Show issues

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Article ; Online: Precise Correction of Lhcgr Mutation in Stem Leydig Cells by Prime Editing Rescues Hereditary Primary Hypogonadism in Mice.

Xia, Kai / Wang, Fulin / Tan, Zhipeng / Zhang, Suyuan / Lai, Xingqiang / Ou, Wangsheng / Yang, Cuifeng / Chen, Hong / Peng, Hao / Luo, Peng / Hu, Anqi / Tu, Xiang'an / Wang, Tao / Ke, Qiong / Deng, Chunhua / Xiang, Andy Peng

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2023 Volume 10, Issue 29, Page(s) e2300993

Abstract: Hereditary primary hypogonadism (HPH), caused by gene mutation related to testosterone synthesis in Leydig cells, usually impairs male sexual development and spermatogenesis. Genetically corrected stem Leydig cells (SLCs) transplantation may provide a ... ...

Abstract	Hereditary primary hypogonadism (HPH), caused by gene mutation related to testosterone synthesis in Leydig cells, usually impairs male sexual development and spermatogenesis. Genetically corrected stem Leydig cells (SLCs) transplantation may provide a new approach for treating HPH. Here, a novel nonsense-point-mutation mouse model (Lhcgr
MeSH term(s)	Animals ; Humans ; Male ; Mice ; Cell Differentiation ; Hypogonadism/genetics ; Hypogonadism/therapy ; Leydig Cells/transplantation ; Mutation ; Receptors, G-Protein-Coupled ; Testosterone/metabolism ; Receptors, LH/genetics
Chemical Substances	Receptors, G-Protein-Coupled ; Testosterone (3XMK78S47O) ; LHCGR protein, mouse ; Receptors, LH
Language	English
Publishing date	2023-09-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2808093-2
ISSN	2198-3844 ; 2198-3844
ISSN (online)	2198-3844
ISSN	2198-3844
DOI	10.1002/advs.202300993
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Development of a fast-responsive and turn on fluorescent probe with large Stokes shift for specific detection of cysteine in vivo.

Yang, Cui-Feng / Zeng, Li-Yuan / Ning, Bin-Ke / Wang, Jian-Yong / Zhang, Haitao / Zhang, Zhi-Hao

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

2019 Volume 225, Page(s) 117482

Abstract: Cysteine has a great effect on the physiological and pathological processes, which could bring out various diseases such as skin lesions, edema, hair depigmentation, Alzheimer's, Parkinson's, and liver damage due to the abnormal concentrations of ... ...

Abstract	Cysteine has a great effect on the physiological and pathological processes, which could bring out various diseases such as skin lesions, edema, hair depigmentation, Alzheimer's, Parkinson's, and liver damage due to the abnormal concentrations of cysteine. Therefore, it is of great impoatance to develop a method for imaging Cys. Herein, a novel fluorescent probe was developed for imaging Cys in vivo specially. This turn-on probe exhibited favorable advantages including large Stokes shift (90 nm), fast response (10 min), good selectivity, low cytotoxicity and so on. Furthermore, the probe could be applied to monitoring cysteine in living HeLa cells, which indicates that this turn-on probe could penetrate viable cell membranes and image Cys over other analystes especially HCy and GSH.
MeSH term(s)	Cysteine/analysis ; Fluorescent Dyes/chemical synthesis ; Fluorescent Dyes/chemistry ; HeLa Cells ; Humans ; Molecular Structure ; Optical Imaging ; Single-Cell Analysis ; Spectrometry, Fluorescence
Chemical Substances	Fluorescent Dyes ; Cysteine (K848JZ4886)
Language	English
Publishing date	2019-08-22
Publishing country	England
Document type	Journal Article
ZDB-ID	210413-1
ISSN	1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
ISSN (online)	1873-3557
ISSN	0370-8322 ; 0584-8539 ; 1386-1425
DOI	10.1016/j.saa.2019.117482
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Article ; Online: Iodine-catalyzed guanylation of amines with N,N'-di-Boc-thiourea.

Rong, Hao-Jie / Yang, Cui-Feng / Chen, Tao / Xu, Ze-Gang / Su, Tian-Duo / Wang, Yong-Qiang / Ning, Bin-Ke

Organic & biomolecular chemistry

2019 Volume 17, Issue 42, Page(s) 9280–9283

Abstract: Herein, we report that iodine-catalyzed guanylation of primary amines can be accomplished with N,N'-di-Boc-thiourea and TBHP to afford the corresponding guanidines in 40-99% yields. Oxidation of the HI byproduct by TBHP eliminates the need for an extra ... ...

Abstract	Herein, we report that iodine-catalyzed guanylation of primary amines can be accomplished with N,N'-di-Boc-thiourea and TBHP to afford the corresponding guanidines in 40-99% yields. Oxidation of the HI byproduct by TBHP eliminates the need for an extra base to prevent the protonation of substrates and makes the reaction especially useful for both electronically and sterically deactivated primary anilines.
Language	English
Publishing date	2019-10-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/c9ob02014d
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