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Article ; Online: Qualitative analysis of licorice and strychnine decoction before and after combination using UPLC-QE-Orbitrap-MS.

Guo, Yuyan / Wei, Yuxin / Sun, Shuang / Yang, Dayu / Lv, Shaowa

2024

Abstract: Background and objective: Glycyrrhiza glabra L. (GG) and Strychnos nux-vomica L. (NV) are traditional Chinese medicines (TCMs). Changes in the chemical composition may occur before and after the GG-NV compatibility. Ultra-performance liquid ... ...

Abstract	Background and objective: Glycyrrhiza glabra L. (GG) and Strychnos nux-vomica L. (NV) are traditional Chinese medicines (TCMs). Changes in the chemical composition may occur before and after the GG-NV compatibility. Ultra-performance liquid chromatography Q-exactive Orbitrap mass spectrometry (UPLC-QE-Orbitrap-MS) was applied here to study the difference in the components of the GG and NV decoctions before and after they were combined. The changes in the chemical composition of GG and NV before and after the combination were determined. Methods: The precise molecular weight, retention time, and fragment ion peak of the different components of the decoctions before and after compatibility were obtained through UPLC-QE-Orbitrap-MS. Differential analysis methods, such as principal component analysis, were used for comparison. Results: In the positive ion mode, 200 new components were added, whereas six components were lost. In the negative ion mode, 144 new compounds were identified, whereas three components were missing. Conclusions: The compatibility difference between GG and NV was studied through UPLC-QE-Orbitrap-MS. The chemical composition of GG and NV changed before and after compatibility, and a class of compounds different from GG and NV was identified in the co-decoction. This study provides an experimental basis for subsequent research into detoxification mechanisms of the GG-NV combination and offers a new analytical method for investigating the compatibility of various other TCM pairs.
Language	English
Publishing date	2024-05-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1073576-8
ISSN	1099-1565 ; 0958-0344
ISSN (online)	1099-1565
ISSN	0958-0344
DOI	10.1002/pca.3366
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Book ; Online: An Exploration Study of Mixed-initiative Query Reformulation in Conversational Passage Retrieval

Yang, Dayu / Zhang, Yue / Fang, Hui

2023

Abstract: In this paper, we report our methods and experiments for the TREC Conversational Assistance Track (CAsT) 2022. In this work, we aim to reproduce multi-stage retrieval pipelines and explore one of the potential benefits of involving mixed-initiative ... ...

Abstract	In this paper, we report our methods and experiments for the TREC Conversational Assistance Track (CAsT) 2022. In this work, we aim to reproduce multi-stage retrieval pipelines and explore one of the potential benefits of involving mixed-initiative interaction in conversational passage retrieval scenarios: reformulating raw queries. Before the first ranking stage of a multi-stage retrieval pipeline, we propose a mixed-initiative query reformulation module, which achieves query reformulation based on the mixed-initiative interaction between the users and the system, as the replacement for the neural reformulation method. Specifically, we design an algorithm to generate appropriate questions related to the ambiguities in raw queries, and another algorithm to reformulate raw queries by parsing users' feedback and incorporating it into the raw query. For the first ranking stage of our multi-stage pipelines, we adopt a sparse ranking function: BM25, and a dense retrieval method: TCT-ColBERT. For the second-ranking step, we adopt a pointwise reranker: MonoT5, and a pairwise reranker: DuoT5. Experiments on both TREC CAsT 2021 and TREC CAsT 2022 datasets show the effectiveness of our mixed-initiative-based query reformulation method on improving retrieval performance compared with two popular reformulators: a neural reformulator: CANARD-T5 and a rule-based reformulator: historical query reformulator(HQE). Comment: The Thirty-First Text REtrieval Conference (TREC 2022) Proceedings
Keywords	Computer Science - Information Retrieval
Subject code	006
Publishing date	2023-07-17
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Zero-shot Query Reformulation for Conversational Search

Yang, Dayu / Zhang, Yue / Fang, Hui

2023

Abstract: As the popularity of voice assistants continues to surge, conversational search has gained increased attention in Information Retrieval. However, data sparsity issues in conversational search significantly hinder the progress of supervised conversational ...

Abstract	As the popularity of voice assistants continues to surge, conversational search has gained increased attention in Information Retrieval. However, data sparsity issues in conversational search significantly hinder the progress of supervised conversational search methods. Consequently, researchers are focusing more on zero-shot conversational search approaches. Nevertheless, existing zero-shot methods face three primary limitations: they are not universally applicable to all retrievers, their effectiveness lacks sufficient explainability, and they struggle to resolve common conversational ambiguities caused by omission. To address these limitations, we introduce a novel Zero-shot Query Reformulation (ZeQR) framework that reformulates queries based on previous dialogue contexts without requiring supervision from conversational search data. Specifically, our framework utilizes language models designed for machine reading comprehension tasks to explicitly resolve two common ambiguities: coreference and omission, in raw queries. In comparison to existing zero-shot methods, our approach is universally applicable to any retriever without additional adaptation or indexing. It also provides greater explainability and effectively enhances query intent understanding because ambiguities are explicitly and proactively resolved. Through extensive experiments on four TREC conversational datasets, we demonstrate the effectiveness of our method, which consistently outperforms state-of-the-art baselines. Comment: Accepted by ICTIR 2023
Keywords	Computer Science - Information Retrieval ; Computer Science - Computation and Language
Subject code	006
Publishing date	2023-07-18
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Effects of Exogenous Abscisic Acid on the Physiological and Biochemical Responses of

Yang, Dayu / Chen, Yongzhong / Wang, Rui / He, Yimin / Ma, Xiaofan / Shen, Jiancai / He, Zhilong / Lai, Hanggui

Plants (Basel, Switzerland)

2024 Volume 13, Issue 2

Abstract: This study comprehensively investigates the physiological and molecular regulatory mechanisms ... ...

Abstract	This study comprehensively investigates the physiological and molecular regulatory mechanisms of
Language	English
Publishing date	2024-01-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants13020225
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Article ; Online: Anthocyanin: a review of plant sources, extraction, stability, content determination and modifications

Guo, Yuyan / Zhang, Huan / Shao, Shuang / Sun, Shuang / Yang, Dayu / Lv, Shaowa

International Journal of Food Science & Technology. 2022 Dec., v. 57, no. 12 p.7573-7591

2022

Abstract: Anthocyanins are flavonoids of the polyphenol family, which are secondary metabolites of natural products synthesised by blueberries, mulberry and other plants. As a natural edible pigment, it is not only plentiful, non‐toxic and safe, but also has high ... ...

Abstract	Anthocyanins are flavonoids of the polyphenol family, which are secondary metabolites of natural products synthesised by blueberries, mulberry and other plants. As a natural edible pigment, it is not only plentiful, non‐toxic and safe, but also has high nutritional value and pharmacological effects. Several studies have shown that anthocyanins have many health benefits such as improving vision, promoting antioxidant activity, capturing free radicals and treating cancer in humans. They are becoming increasingly popular in the fields of food and medicine. However, in terms of their structures, natural anthocyanins are unstable, easily deteriorating under the influence of their own structures and external factors, which greatly limits their application. Therefore, it is particularly important to use appropriate extraction methods and techniques to enhance the stability of anthocyanins. This article summarises the current research on anthocyanins in terms of plant sources, extraction, stability, content determination and structural modifications, and provides a reference for improving their application in the fields of food and medicine.
Keywords	anthocyanins ; antioxidant activity ; medicine ; mulberries ; nutritive value ; polyphenols ; secondary metabolites ; technology ; vision
Language	English
Dates of publication	2022-12
Size	p. 7573-7591.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	REVIEW
ZDB-ID	883561-5
ISSN	0950-5423
ISSN	0950-5423
DOI	10.1111/ijfs.16132
Database	NAL-Catalogue (AGRICOLA)

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Article: Self-assembly of core–shell structured multiwalled nanotubes@covalent organic frameworks composite for solid-phase extraction of four phytohormones from fruit juices

Yang, Dayu / Huang, Rui / Hu, Biqing / Chen, Ziying / Zhang, Sunxian / Pang, Jie / lv, Feng / Yan, Zhiming

Journal of chromatography. 2022 Feb. 08, v. 1664

2022

Abstract: Covalent organic frameworks (COFs) have attracted considerable attention in sample pretreatment because of their unique characteristics. However, the submicron or micron size of COFs has restricted their wider applications in solid-phase extraction (SPE). ...

Abstract	Covalent organic frameworks (COFs) have attracted considerable attention in sample pretreatment because of their unique characteristics. However, the submicron or micron size of COFs has restricted their wider applications in solid-phase extraction (SPE). Herein, multiwalled nanotubes (MWNTs) were used as substrate materials to synthesize core–shell structured MWNTs@COFs composites (MWNTs@SNW-1) using a simple self-assembly method. The as-prepared MWNTs@SNW-1 composite exhibited a high BET surface area, good thermal stability, and good adsorption capacity. The MWNTs@SNW-1 composite was used as an adsorbent in cartridge-based SPE to extract four phytohormones before determining their levels by high-performance liquid chromatography. The experimental parameters affecting extraction efficiency, including the amount of adsorbents, solution pH, ionic strength, eluent type, and eluent volume, were investigated. The developed method showed a wide linear range (0.37–100 ng mL⁻¹), low detection limits (0.11–0.32 ng mL⁻¹), low limits of quantification (0.37–1.07 ng mL⁻¹), high enrichment factors (45.9–49.3), and good reproducibility (<4.8%) for phytohormones. The developed analytical method was used to analyze trace phytohormones in fruit juices with good recoveries, highlighting the potential of the MWNTs@SNW-1 composite as an adsorbent in sample preparation.
Keywords	adsorbents ; adsorption ; fruits ; high performance liquid chromatography ; ionic strength ; nanotubes ; pH ; plant hormones ; solid phase extraction ; surface area ; thermal stability
Language	English
Dates of publication	2022-0208
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	218139-3
ISSN	0021-9673 ; 0378-4355 ; 0376-737X
ISSN	0021-9673 ; 0378-4355 ; 0376-737X
DOI	10.1016/j.chroma.2022.462807
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Article ; Online: A novel polymer micelle as a targeted drug delivery system for 10-hydroxycamptothecin with high drug-loading properties and anti-tumor efficacy.

Guo, Yuyan / Gao, Tao / Fang, Fang / Sun, Shuang / Yang, Dayu / Li, Yongji / Lv, Shaowa

Biophysical chemistry

2021 Volume 279, Page(s) 106679

Abstract: A novel polyethylene glycol-polycaprolactone-poly-l-tyrosine (MPEG-PCL-PTyr) amphiphilic triblock copolymer micelle was synthesized for the first time. 10-hydroxycamptothecin (HCPT) was embedded in MPEG-PCL-PTyr nanomicelles using the emulsion solvent ... ...

Abstract	A novel polyethylene glycol-polycaprolactone-poly-l-tyrosine (MPEG-PCL-PTyr) amphiphilic triblock copolymer micelle was synthesized for the first time. 10-hydroxycamptothecin (HCPT) was embedded in MPEG-PCL-PTyr nanomicelles using the emulsion solvent evaporation method. A series of was conducted to confirm the structure of the compound and to evaluate the physical properties of the MPEG-PCL-PTyr nanomicelles. Cellular uptake, cytotoxicity, and apoptosis were assessed using flow cytometry and MTT assays. Confocal microscopy and flow cytometry results demonstrated that the nanocapsules carrying HCPT had significantly increased anti-tumor activity against HepG2 cells and could target HepG2 cell lysosomes with obvious liver targeting. In addition, the drug-loaded nanomicelles could significantly block the S phase of cancer cells and induce apoptosis; thus, they could be potential carriers for future 10-HCPT delivery and cancer treatment.
MeSH term(s)	Camptothecin/analogs & derivatives ; Drug Carriers/chemistry ; Drug Delivery Systems/methods ; Micelles ; Particle Size ; Polyethylene Glycols/chemistry ; Polymers/chemistry
Chemical Substances	Drug Carriers ; Micelles ; Polymers ; Polyethylene Glycols (3WJQ0SDW1A) ; 10-hydroxycamptothecin (9Z01632KRV) ; Camptothecin (XT3Z54Z28A)
Language	English
Publishing date	2021-09-17
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	185052-0
ISSN	1873-4200 ; 0301-4622
ISSN (online)	1873-4200
ISSN	0301-4622
DOI	10.1016/j.bpc.2021.106679
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Article ; Online: Content Determination and Release Characteristics of Six Components in the Different Phases of "

Guo, Yuyan / Shao, Shuang / Zhang, Wenjun / Li, Chuncheng / Meng, Zejun / Sun, Shuang / Yang, Dayu / Lü, Shaowa

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 19

Abstract: The decoction turns into a complex multiphase system following exposure to high temperature and a complex chemical environment. However, the differences in the concentration of key active ingredients in different phase states and the release of drugs in ... ...

Abstract	The decoction turns into a complex multiphase system following exposure to high temperature and a complex chemical environment. However, the differences in the concentration of key active ingredients in different phase states and the release of drugs in sedimentary phase have yet to be elucidated. A simple ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed and validated for the simultaneous quantitative determination of brucine, strychnine, liquiritin, isoliquiritin, isoliquiritigenin and glycyrrhizic acid concentrations and it was applied to compare the content of different phases and measure the release characteristics of the sedimentary phase in "
MeSH term(s)	Chromatography, High Pressure Liquid ; Chromatography, Liquid ; Glycyrrhizic Acid/analysis ; Seeds/chemistry ; Strychnine/chemistry ; Strychnos nux-vomica/chemistry ; Tandem Mass Spectrometry
Chemical Substances	Glycyrrhizic Acid (6FO62043WK) ; Strychnine (H9Y79VD43J)
Language	English
Publishing date	2022-09-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27196180
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Article: [Contributions of flavonoids from citri reticulatae pericarpium to gastric hormones, CD3~+ and TFF3 mRNA expression in rats with spleen deficiency intervened by Liujunzi Decoction].

Lyu, Shao-Wa / Li, Ying / Yu, Xin / Guo, Yu-Yan / Yang, Da-Yu / Sun, Shuang / Shang, Er-Yu

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2022 Volume 47, Issue 4, Page(s) 951–958

Abstract: The present study established the spectrum-effect relationship model of flavonoids in Citri Reticulatae Pericarpium(CRP) from 15 batches of Liujunzi Decoction and statistically analyzed the correlation between chemical peaks and efficacy to identify the ... ...

Abstract	The present study established the spectrum-effect relationship model of flavonoids in Citri Reticulatae Pericarpium(CRP) from 15 batches of Liujunzi Decoction and statistically analyzed the correlation between chemical peaks and efficacy to identify the main effective components. HPLC fingerprints of flavonoids in CRP from 15 batches of Liujunzi Decoction were established. HPLC analysis was carried out on the Venusil XBP C_(18)(L) column(4.6 mm×250 mm, 5 μm) at 30 ℃ with acetonitrile-water(containing 0.1% formic acid) as mobile phase for gradient elution, a flow rate of 1.0 mL·min~(-1), and detection wavelength of 300 nm to obtain chemical fingerprints. Additionally, the effects of flavonoids from CRP in 15 batches of Liujunzi Decoction on the content of GAS, MTL, and VIP, TFF3 mRNA expression, and percentage of CD3~+ T-cells of model rats with spleen deficiency were determined. The spectrum-effect relationship model was established by gray correlation analysis. The results showed that the main characteristic peaks with great contribution to the regulation of gastrointestinal tract were peak 16(vicenin-2), peak 63(sinensetin), peak 64(isosinensetin), peak 65(nobiletin), peak 67(3,5,6,7,8,3',4'-heptemthoxyflavone), peak 68(tangeretin), and peak 69(5-desmethylnobiletin). Therefore, there was a linear correlation between flavonoids from CRP in Liujunzi Decoction and the efficacy, and the medicinal effect was achieved by multi-component action. This study is expected to provide a new idea for exploring the material basis of the effect, i.e., regulating qi prior to replenishing qi, of CRP in Liujunzi Decoction.
MeSH term(s)	Animals ; Citrus/chemistry ; Drugs, Chinese Herbal ; Flavonoids/chemistry ; Flavonoids/pharmacology ; Hormones ; RNA, Messenger/genetics ; Rats ; Spleen
Chemical Substances	Drugs, Chinese Herbal ; Flavonoids ; Hormones ; RNA, Messenger ; liujunzi
Language	Chinese
Publishing date	2022-03-13
Publishing country	China
Document type	Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20210901.301
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Article ; Online: Self-assembly of core-shell structured multiwalled nanotubes@covalent organic frameworks composite for solid-phase extraction of four phytohormones from fruit juices.

Yang, Dayu / Huang, Rui / Hu, Biqing / Chen, Ziying / Zhang, Sunxian / Pang, Jie / Lv, Feng / Yan, Zhiming

Journal of chromatography. A

2022 Volume 1664, Page(s) 462807

Abstract	Covalent organic frameworks (COFs) have attracted considerable attention in sample pretreatment because of their unique characteristics. However, the submicron or micron size of COFs has restricted their wider applications in solid-phase extraction (SPE). Herein, multiwalled nanotubes (MWNTs) were used as substrate materials to synthesize core-shell structured MWNTs@COFs composites (MWNTs@SNW-1) using a simple self-assembly method. The as-prepared MWNTs@SNW-1 composite exhibited a high BET surface area, good thermal stability, and good adsorption capacity. The MWNTs@SNW-1 composite was used as an adsorbent in cartridge-based SPE to extract four phytohormones before determining their levels by high-performance liquid chromatography. The experimental parameters affecting extraction efficiency, including the amount of adsorbents, solution pH, ionic strength, eluent type, and eluent volume, were investigated. The developed method showed a wide linear range (0.37-100 ng mL
MeSH term(s)	Adsorption ; Chromatography, High Pressure Liquid ; Fruit and Vegetable Juices ; Limit of Detection ; Metal-Organic Frameworks ; Nanotubes ; Plant Growth Regulators ; Reproducibility of Results ; Solid Phase Extraction
Chemical Substances	Metal-Organic Frameworks ; Plant Growth Regulators
Language	English
Publishing date	2022-01-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1171488-8
ISSN	1873-3778 ; 0021-9673
ISSN (online)	1873-3778
ISSN	0021-9673
DOI	10.1016/j.chroma.2022.462807
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