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  1. Article: Astragaloside IV reduces lung injury in lethal sepsis via promoting treg cells expansion and inhibiting inflammatory responses.

    Yang, Haihao / Yin, Na / Gu, Qianlan / Wu, Zhao / Xu, Ying / Gao, Jie / Qin, Dongdong / Wan, Chunping

    Pakistan journal of pharmaceutical sciences

    2023  Volume 36, Issue 6, Page(s) 1709–1718

    Abstract: Sepsis is a systemic inflammatory response syndrome caused by an infection progressing to sepsis-associated organ failure (such as lung injury). Our previous review revealed that Astragaloside IV (ASI-IV), one of the primary bioactive ingredients in ... ...

    Abstract Sepsis is a systemic inflammatory response syndrome caused by an infection progressing to sepsis-associated organ failure (such as lung injury). Our previous review revealed that Astragaloside IV (ASI-IV), one of the primary bioactive ingredients in Astragalus membranaceus (Fisch) Bge (Huang-Qi), had been shown to exert anti-inflammatory and immunomodulatory effects. Nevertheless, it is still unclear whether ASI-IV could attenuate septic lung injury via activating regulatory T-cells (Tregs). This study was designed to evaluate the therapeutic potential of ASI-IV on sepsis-induced lung injury and to further explore its underlying mechanism. In the murine models of cecal ligation and puncture (CLP) and lipopolysaccharide (LPS) induced sepsis, ASI-IV can markedly improve the survival rate and reduce inflammatory lung injury, protect mice against exacerbated inflammatory responses by decreasing myeloid cell infiltration and down-regulating IL-6 and TNF-α in lung tissue. Meanwhile, Treg cell-related gene expression, including Foxp3 and IL-10, significantly increased after ASI-IV treatment. Furthermore, ASI-IV notably promoted the differentiation of naïve CD4
    MeSH term(s) Mice ; Animals ; Lung Injury ; T-Lymphocytes, Regulatory ; Sepsis/drug therapy ; Saponins/pharmacology ; Saponins/therapeutic use ; Saponins/metabolism ; Disease Models, Animal
    Chemical Substances astragaloside A (3A592W8XKE) ; Saponins
    Language English
    Publishing date 2023-12-20
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 885131-1
    ISSN 1011-601X
    ISSN 1011-601X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: A third (booster) dose of the inactivated SARS-CoV-2 vaccine elicits immunogenicity and T follicular helper cell responses in people living with HIV.

    Lv, Zhengchao / Lv, Songqin / Li, Qin / Xia, Yafei / Feng, Zaineng / Zhang, Haohong / Yang, Haihao / Wu, Zhao / Zou, Nanting / Mo, Qingyan / Gu, Qianlan / Ying, Sai / Wang, Xicheng / Qin, Dongdong / Wan, Chunping

    Frontiers in immunology

    2023  Volume 14, Page(s) 1264160

    Abstract: Introduction: This study sought to explore the immunogenicity of a booster dose of an inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine in people living with human immunodeficiency virus (HIV) and identify the factors ... ...

    Abstract Introduction: This study sought to explore the immunogenicity of a booster dose of an inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine in people living with human immunodeficiency virus (HIV) and identify the factors affecting the magnitude of anti-SARS-CoV-2 antibody levels.
    Materials and methods: A total of 34 people living with HIV (PLWH) and 34 healthy donors (HD) were administered a booster dose of the same SARS-CoV-2 vaccine. Anti-SARS-CoV-2 antibody and immunoglobulin G (IgG) levels were measured using the SARS-CoV-2 S protein neutralizing antibody Enzyme-Linked Immunosorbent Assay (ELISA) and 2019-nCov IgG Chemiluminescent Immunoassay Microparticles, respectively. Spearman correlation analysis was used to measure the correlation between laboratory markers and neutralizing antibody and IgG levels. Peripheral blood mononuclear cells (PBMCs) were extracted from each subject using density gradient centrifugation and the numbers of memory T and T follicular helper (Tfh) cells were determined using flow cytometry.
    Results: PLWH had a marked reduction in CD4 and B cell levels that was accompanied by a lower CD4/CD8 T cell ratio. However, those who received a supplementary dose of inactivated SARS-CoV-2 vaccines exhibited antibody positivity rates that were analogous to levels previously observed. The booster vaccine led to a reduction in IgG and neutralizing antibody levels and the amplitude of this decline was substantially higher in the PLWH than HD group. Correlation analyses revealed a strong correlation between neutralizing antibody levels and the count and proportion of CD4 cells. Anti-SARS-CoV-2 IgG antibody levels followed a similar trend. The expression of memory T and Tfh cells was considerably lower in the PLWH than in the HD group.
    Discussion: PLWH had an attenuated immune response to a third (booster) administration of an inactivated SARS-CoV-2 vaccine, as shown by lower neutralizing antibody and IgG levels. This could be attributed to the reduced responsiveness of CD4 cells, particularly memory T and cTfh subsets. CD4 and cTfh cells may serve as pivotal markers of enduring and protective antibody levels. Vaccination dose recalibration may be critical for HIV-positive individuals, particularly those with a lower proportion of CD4 and Tfh cells.
    MeSH term(s) Humans ; COVID-19 Vaccines ; HIV ; T Follicular Helper Cells ; Leukocytes, Mononuclear ; COVID-19/prevention & control ; SARS-CoV-2 ; HIV Seropositivity ; Antibodies, Neutralizing ; Antibodies, Viral ; Immunoglobulin G
    Chemical Substances COVID-19 Vaccines ; spike protein, SARS-CoV-2 ; Antibodies, Neutralizing ; Antibodies, Viral ; Immunoglobulin G
    Language English
    Publishing date 2023-11-15
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1264160
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: MW‑9, a chalcones derivative bearing heterocyclic moieties, attenuates experimental autoimmune encephalomyelitis via suppressing pathogenic T

    Liu, Bei / Mao, Zewei / Yin, Na / Gu, Qianlan / Qi, Yan / Li, Xiaosi / Yang, Haihao / Wu, Zhao / Zou, Nanting / Ying, Sai / Wan, Chunping

    Molecular medicine reports

    2022  Volume 26, Issue 4

    Abstract: Previous studies have indicated that MW‑9, a chalcones derivative bearing heterocyclic moieties, has considerable anti‑inflammatory ... ...

    Abstract Previous studies have indicated that MW‑9, a chalcones derivative bearing heterocyclic moieties, has considerable anti‑inflammatory activity
    MeSH term(s) Animals ; Cell Differentiation ; Chalcones/pharmacology ; Cytokines/metabolism ; Encephalomyelitis, Autoimmune, Experimental ; Female ; Immunoglobulin G/pharmacology ; Interleukin-17/pharmacology ; Mice ; Mice, Inbred C57BL ; Th1 Cells ; Th17 Cells
    Chemical Substances Chalcones ; Cytokines ; Immunoglobulin G ; Interleukin-17
    Language English
    Publishing date 2022-08-12
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2469505-1
    ISSN 1791-3004 ; 1791-2997
    ISSN (online) 1791-3004
    ISSN 1791-2997
    DOI 10.3892/mmr.2022.12824
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Jian Pi Shen Shi formula alleviates hyperuricemia and related renal fibrosis in uricase-deficient rats via suppression of the collagen-binding pathway.

    Yin, Na / Li, Xiaosi / Liu, Weichao / Qi, Yan / Wu, Runfang / Li, Zhaofu / Ying, Sai / Yang, Haihao / Gu, Qianlan / Wu, Zhao / Zou, Nanting / Duan, Weigang / Peng, Jiangyun / Wan, Chunping

    International journal of rheumatic diseases

    2022  Volume 25, Issue 12, Page(s) 1395–1407

    Abstract: Aim: Jian Pi Shen Shi Formula (JPSSF) is a beneficial treatment for hyperuricemia and related tissue damage in the clinical setting. This study was designed to investigate its therapeutic potential and underlying mechanisms in uricase-deficient rats ( ... ...

    Abstract Aim: Jian Pi Shen Shi Formula (JPSSF) is a beneficial treatment for hyperuricemia and related tissue damage in the clinical setting. This study was designed to investigate its therapeutic potential and underlying mechanisms in uricase-deficient rats (Uox
    Methods: Uox
    Results: JPSSF significantly decreased renal function indices and alleviated renal injuries. The action of JPSSF was manifested by down-regulation of col6a1 and interleukin-1 receptor-associated kinase-like 2, which blocked the binding sites on collagen and further prevented kidney injury. The anti-renal fibrosis effect of JPSSF was confirmed by reducing the collagen deposition and hydroxyproline concentrations. JPSSF treatment also intensely down-regulated the mRNA and protein expressions of col6a1, col1a1, and α-smooth muscle actin, which inhibited the function of the collagen-binding-related signaling pathway.
    Conclusion: Our results indicated that JPSSF notably ameliorated hyperuricemia and related renal fibrosis in Uox
    MeSH term(s) Rats ; Animals ; Hyperuricemia/complications ; Hyperuricemia/drug therapy ; Urate Oxidase/metabolism ; Urate Oxidase/pharmacology ; Urate Oxidase/therapeutic use ; Actins/metabolism ; Proteomics ; Kidney Diseases/drug therapy ; Kidney Diseases/etiology ; Kidney Diseases/prevention & control ; Fibrosis ; Kidney/pathology ; Signal Transduction ; Collagen/metabolism
    Chemical Substances Urate Oxidase (EC 1.7.3.3) ; Actins ; Collagen (9007-34-5)
    Language English
    Publishing date 2022-09-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2426924-4
    ISSN 1756-185X ; 1756-1841
    ISSN (online) 1756-185X
    ISSN 1756-1841
    DOI 10.1111/1756-185X.14434
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6098: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  5. Article ; Online: Inactivated SARS-CoV-2 vaccines elicit immunogenicity and T-cell responses in people living with HIV.

    Lv, Zhengchao / Li, Qin / Feng, Zaixiong / Zheng, Xi / NaYin / Yang, Haihao / Gu, Qianlan / Ying, Sai / Qi, Yan / Li, Xiaosi / Wu, Runfang / Wu, Zhao / Yu, Xiyu / Zou, Nanting / Qin, Dongdong / Wan, Chunping

    International immunopharmacology

    2021  Volume 102, Page(s) 108383

    Abstract: Backgrounds: To date, the effects of SARS-CoV-2 vaccines on people living with HIV (PLWH) were mainly focused on messenger RNA (mRNA) and adenovirus vector-based vaccines, and little is known about the effects of inactivated virus-based vaccine. This ... ...

    Abstract Backgrounds: To date, the effects of SARS-CoV-2 vaccines on people living with HIV (PLWH) were mainly focused on messenger RNA (mRNA) and adenovirus vector-based vaccines, and little is known about the effects of inactivated virus-based vaccine. This study was designed to determine the effects of inactivated SARS-CoV-2 vaccines on PLWH.
    Methods: Twenty-four HIV-positive individuals and 24 healthy donors (HD) were respectively recruited from Malipo Country People's Hospital and community in Kunming city. Enumeration of lymphocyte and CD4
    Results: CD4, B cells, CD4
    Conclusions: PLWH and HD have comparable neutralizing antibodies positive rates, but PLWH display weaker responses to inactivated SARS-CoV-2 vaccines in magnitude, which suggests that a booster dose or dose adjustment are required for HIV-infected individuals, especially for those with lower counts of CD4 T and B cells.
    MeSH term(s) Adult ; Antibodies, Neutralizing/blood ; Antibodies, Viral/blood ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19/virology ; COVID-19 Vaccines/administration & dosage ; COVID-19 Vaccines/immunology ; Female ; HIV Infections/blood ; HIV Infections/complications ; HIV Infections/immunology ; Healthy Volunteers ; Humans ; Immunogenicity, Vaccine ; Male ; Memory T Cells/immunology ; Middle Aged ; SARS-CoV-2/immunology ; Th17 Cells/immunology ; Th2 Cells/immunology ; Vaccines, Inactivated/administration & dosage ; Vaccines, Inactivated/immunology
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines ; SARS-CoV-2 inactivated vaccines ; Vaccines, Inactivated
    Language English
    Publishing date 2021-11-18
    Publishing country Netherlands
    Document type Clinical Trial ; Journal Article
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2021.108383
    Database MEDical Literature Analysis and Retrieval System OnLINE

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