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Article: Early intervention with acupuncture improves the outcome of patients with Bell's palsy: A propensity score-matching analysis.

Yang, Lian-Sheng / Zhou, Dan-Feng / Zheng, Shu-Zhen / Zhao, Bai-Ming / Li, Huo-Gui / Chen, Qi-Qing / Zhong, Yun / Yang, Hong-Zhi / Zhang, Kun / Tang, Chun-Zhi

Frontiers in neurology

2022 Volume 13, Page(s) 943453

Abstract: Objective: Although acupuncture is widely used as a complementary therapy in the treatment of Bell's palsy (BP) when to initiate acupuncture is still controversial. This study aims to determine the efficacy of the early intervention by acupuncture on BP. ...

Abstract	Objective: Although acupuncture is widely used as a complementary therapy in the treatment of Bell's palsy (BP) when to initiate acupuncture is still controversial. This study aims to determine the efficacy of the early intervention by acupuncture on BP. Methods: We retrospectively gathered clinical data from the Third Affiliated Hospital of SUN-YAT SEN University between 2016 and 2021. We selected newly diagnosed patients with BP who were diagnosed by registered neurologists or acupuncturists formally. The qualified patients were divided into two groups according to whether or not initial acupuncture treatment was given within 7 days from the onset of palsy. Cohorts were balanced using 1:1 propensity score matching (PSM). Cox proportional hazards modeling and Kaplan-Meier analysis were applied to determine the differences between the two groups. The outcome included time to complete recovery of facial function, the rate of complete recovery, and the occurrence of sequelae in 24 weeks. Results: A total of 345 patients were eligible for this study and were divided into the manual acupuncture/electroacupuncture (MA/EA) group ( Conclusion: Acupuncture intervention at the acute stage of BP could shorten the time to recovery and improve the outcome. Clinical trial registration: http://www.chictr.org.cn, identifier ChiCTR 2200058060.
Language	English
Publishing date	2022-09-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2022.943453
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Traditional Chinese Medicine Syndrome Patterns and Their Association with Hepatitis B Surface Antigen Levels during the Natural History of Chronic Hepatitis B Virus Infection.

Xie, He-Ping / Liu, Zhi-Ping / Zhang, Jiong-Shan / Dai, Min / Xiao, Ge-Min / Wu, Wei-Kang / Yang, Hong-Zhi

Evidence-based complementary and alternative medicine : eCAM

2018 Volume 2018, Page(s) 7482593

Abstract: The aim of this study is to investigate traditional Chinese medicine syndrome (TCMS) patterns and their association with hepatitis B surface antigen (HBsAg) levels during the natural history of chronic hepatitis B virus infection (CHB). Patients were ... ...

Abstract	The aim of this study is to investigate traditional Chinese medicine syndrome (TCMS) patterns and their association with hepatitis B surface antigen (HBsAg) levels during the natural history of chronic hepatitis B virus infection (CHB). Patients were categorized according to the phase of CHB, as follows: immune tolerance (ITP); immune clearance (ICP); low or nonreplication (LRP); reactivation (RAP); hepatic cirrhosis (HC); and primary liver cancer (PLC). TCMS patterns were classified among the following types: spleen-kidney deficiency (SKD); liver-qi depression (LQD); damp-heat in liver-gallbladder (LGDH); liver-kidney deficiency (LKD); and blood stasis blocking collateral (BSBC). HBsAg levels and other serological indicators were quantified for all patients and their association with TCMS was statistically analyzed and determined. Two hundred and eighty-nine patients with CHB were included. During the natural history of CHB, TCMS patterns were statistically different among the different phases (
Language	English
Publishing date	2018-10-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2018/7482593
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Article: [Prevention and treatment mechanism of qingxia therapy (based on yinchenhao decoction and dachengqi decoction) on hepatocyte apoptosis in rats with acute hepatic injury induced by lipopolysaccharide/D-galactosamine].

Wang, Feng-Lin / Yang, Hong-Zhi / Li, Yang-Mei / Wu, Wei-Kang / Zou, Zeng-Cheng

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials

2014 Volume 37, Issue 5, Page(s) 848–852

Abstract: Objective: To study the prevention and treatment mechanism of Qingxia therapy (based on Yinchenhao Decoction and Dachengqi Decoction) on hepatocyte apoptosis in rats with acute hepatic injury induced by lipopolysaccharide plus D-galactosamine (LPS/D- ... ...

Abstract	Objective: To study the prevention and treatment mechanism of Qingxia therapy (based on Yinchenhao Decoction and Dachengqi Decoction) on hepatocyte apoptosis in rats with acute hepatic injury induced by lipopolysaccharide plus D-galactosamine (LPS/D-GalN). Methods: The acute hepatic injury model was established by LPS/D-GalN and then intervened with Qingxia therapy. Serum liver function, PT and liver tissue pathology were observed, hepatocyte apoptosis index was detected by Tunel, protein expressions of BCL-2, BAX and Caspase-3 were detected by Western blotting. Results: Qingxia therapy could significantly decrease serum ALT, AST and TBIL levels (P < 0.01 or 0.05), reduce hepatocyte necrosis and inflammatory cell infiltration. There were more apoptotic cells in model group, which had significant differences compared with Qingxia group and control group. Protein expressions of BAX and Caspase-3 in model group were significantly higher than those in control group and Qingxia group (P < 0.05), but BCL-2 protein expression in model group was lower (P < 0.05). Conclusion: Qingxia therapy can ameliorate the liver function and hepatic tissue pathology of rats with hepatic injury induced by LPS/D-GalN, alleviate hepatocyte apoptosis in rats, prevent and treat hepatocyte apoptosis by down-regulating the protein expressions of Caspase-3 and BAX, up-regulating the protein expression of BCL-2, and adjusting the balance of BCL-2/BAX.
MeSH term(s)	Acute Disease ; Animals ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/pharmacology ; Apoptosis/drug effects ; Caspase 3/metabolism ; Chemical and Drug Induced Liver Injury/metabolism ; Chemical and Drug Induced Liver Injury/pathology ; Chemical and Drug Induced Liver Injury/prevention & control ; Disease Models, Animal ; Drug Combinations ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacology ; Female ; Gene Expression Regulation ; Hepatocytes/drug effects ; Hepatocytes/metabolism ; Lipopolysaccharides/adverse effects ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Liver Function Tests ; Male ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Plants, Medicinal/chemistry ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Anti-Inflammatory Agents ; Drug Combinations ; Drugs, Chinese Herbal ; Lipopolysaccharides ; Plant Extracts ; Proto-Oncogene Proteins c-bcl-2 ; dachengqi decoction ; yinchenhao ; Caspase 3 (EC 3.4.22.-)
Language	Chinese
Publishing date	2014-05
Publishing country	China
Document type	Journal Article
ISSN	1001-4454
ISSN	1001-4454
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Article: Efficacy and safety of AnluoHuaxian pills on chronic hepatitis B with normal or minimally elevated alanine transaminase and early liver fibrosis: A randomized controlled trial

Journal of ethnopharmacology. 2022 Mar. 16,

2022

Abstract: The AnluoHuaxian pill (AHP) is a widely used patented medicine for chronic hepatitis B (CHB) patients withadvanced fibrosis or cirrhosisthat has been used in China for more than 15 years. However, data are lacking on whether monotherapy with AHP can be ... ...

Abstract	The AnluoHuaxian pill (AHP) is a widely used patented medicine for chronic hepatitis B (CHB) patients withadvanced fibrosis or cirrhosisthat has been used in China for more than 15 years. However, data are lacking on whether monotherapy with AHP can be effective in CHB patients with alanine aminotransferase (ALT) levels less than 2 times the upper limit of normal (ALT<2ULN) and early liver fibrosis (F ≤ 2). We aimed to investigate whether monotherapy with AHP improves liver histology in these patients. In this double-blind, randomized, placebo-controlled trial, 270 CHB patients with ALT<2ULN and F ≤ 2 were treated in 12 hospitals in China. The patients were randomly assigned to an intervention (AHP) group and a placebo group at a ratio of 2:1. Of these 270 enrolled patients, 147 had paired liver biopsies. The primary end point was histological change after 48 weeks of treatment. Per-protocol analysis revealed that the rate of histologic improvement in liver fibrosis patients in the AHP group was significantly higher than that in the placebo group (37.7% vs. 19.5%, P = 0.035) after 48 weeks of treatment, which was consistent with results from intention-to-treat and sensitivity analyses. Moreover, after adjusting for baseline characteristics, AHP was superior to placebo with respect to improving liver fibrosis (odds ratio [OR] = 2.58, 95% confidence interval [CI]: (1.01, 6.63),P = 0.049) and liver histology (OR = 3.62, 95% CI: (1.42, 9.20),P = 0.007). In noninvasive measurement of liver fibrosis (FibroScan®), the level of liver stiffness measurement (LSM) had decreased significantly at 48 weeks (5.1 kPa) compared with that at baseline (5.7 kPa) (P = 0.008) in the AHP group, whereas it did not decrease significantly in the placebo group. Cirrhosis developed in one patient in the placebo group but in no patients in the AHP group. No serious side effects occurred in the AHP-treated patients. Treatment of CHB patients who had ALT<2ULN and F ≤ 2 with the traditional Chinese medicine AHP for 48 weeks improves liver fibrosis. However, due to the short duration of treatment and the limited sample size of liver pathology, the long-term benefits of AHP in reducing fibrosis and the risk of cirrhosis and hepatocellular carcinoma in these patients need to be further studied in the future.
Keywords	Oriental traditional medicine ; alanine transaminase ; chronic hepatitis B ; confidence interval ; fibrosis ; hepatoma ; histology ; liver ; liver cirrhosis ; odds ratio ; patents ; patients ; placebos ; randomized clinical trials ; risk ; sample size ; China
Language	English
Dates of publication	2022-0316
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115210
Database	NAL-Catalogue (AGRICOLA)

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Article: Addition and Subtraction Theory of TCM Using Xiao-Chaihu-Decoction and Naturopathy in Predicting Survival Outcomes of Primary Liver Cancer Patients: A Prospective Cohort Study.

Dai, Min / Yang, Yue-Wu / Guo, Wen-Hai / Wang, Feng-Lin / Xiao, Ge-Min / Li, Yang-Mei / Yang, Hong-Zhi

Evidence-based complementary and alternative medicine : eCAM

2016 Volume 2016, Page(s) 4723530

Abstract: To investigate the therapeutic effect of combined Xiao-Chaihu-Decoction and naturopathic medicine therapy on survival outcomes of patients' PLC. In XCHD group ( ...

Abstract	To investigate the therapeutic effect of combined Xiao-Chaihu-Decoction and naturopathic medicine therapy on survival outcomes of patients' PLC. In XCHD group (
Language	English
Publishing date	2016-10-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2016/4723530
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Zs.A 5995: Show issues

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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Efficacy and safety of AnluoHuaxian pills on chronic hepatitis B with normal or minimally elevated alanine transaminase and early liver fibrosis: A randomized controlled trial.

Journal of ethnopharmacology

2022 Volume 293, Page(s) 115210

Abstract: Ethnopharmacological relevance: The AnluoHuaxian pill (AHP) is a widely used patented medicine for chronic hepatitis B (CHB) patients with advanced fibrosis or cirrhosis that has been used in China for more than 15 years. However, data are lacking on ... ...

Abstract	Ethnopharmacological relevance: The AnluoHuaxian pill (AHP) is a widely used patented medicine for chronic hepatitis B (CHB) patients with advanced fibrosis or cirrhosis that has been used in China for more than 15 years. However, data are lacking on whether monotherapy with AHP can be effective in CHB patients with alanine aminotransferase (ALT) levels less than 2 times the upper limit of normal (ALT<2ULN) and early liver fibrosis (F ≤ 2). Aim of the study: We aimed to investigate whether monotherapy with AHP improves liver histology in these patients. Materials and methods: In this double-blind, randomized, placebo-controlled trial, 270 CHB patients with ALT<2ULN and F ≤ 2 were treated in 12 hospitals in China. The patients were randomly assigned to an intervention (AHP) group and a placebo group at a ratio of 2:1. Of these 270 enrolled patients, 147 had paired liver biopsies. The primary end point was histological change after 48 weeks of treatment. Results: Per-protocol analysis revealed that the rate of histologic improvement in liver fibrosis patients in the AHP group was significantly higher than that in the placebo group (37.7% vs. 19.5%, P = 0.035) after 48 weeks of treatment, which was consistent with results from intention-to-treat and sensitivity analyses. Moreover, after adjusting for baseline characteristics, AHP was superior to placebo with respect to improving liver fibrosis (odds ratio [OR] = 2.58, 95% confidence interval [CI]: (1.01, 6.63),P = 0.049) and liver histology (OR = 3.62, 95% CI: (1.42, 9.20),P = 0.007). In noninvasive measurement of liver fibrosis (FibroScan®), the level of liver stiffness measurement (LSM) had decreased significantly at 48 weeks (5.1 kPa) compared with that at baseline (5.7 kPa) (P = 0.008) in the AHP group, whereas it did not decrease significantly in the placebo group. Cirrhosis developed in one patient in the placebo group but in no patients in the AHP group. No serious side effects occurred in the AHP-treated patients. Conclusions: Treatment of CHB patients who had ALT<2ULN and F ≤ 2 with the traditional Chinese medicine AHP for 48 weeks improves liver fibrosis. However, due to the short duration of treatment and the limited sample size of liver pathology, the long-term benefits of AHP in reducing fibrosis and the risk of cirrhosis and hepatocellular carcinoma in these patients need to be further studied in the future.
MeSH term(s)	Alanine/therapeutic use ; Alanine Transaminase ; Drugs, Chinese Herbal ; Hepatitis B, Chronic/drug therapy ; Humans ; Liver/pathology ; Liver Cirrhosis/drug therapy ; Liver Cirrhosis/pathology
Chemical Substances	Drugs, Chinese Herbal ; anluohuaxian ; Alanine Transaminase (EC 2.6.1.2) ; Alanine (OF5P57N2ZX)
Language	English
Publishing date	2022-04-07
Publishing country	Ireland
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115210
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1494: Show issues

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Article ; Online: Changes in serum alanine aminotransferase levels in telbivudine versus lamivudine treatment for chronic hepatitis B: a meta-analysis.

Dai, Min / Xiao, Ge-Min / Wang, Feng-Lin / Zhang, Jiong-Shan / Li, Yang-Mei / Yang, Hong-Zhi

The Journal of international medical research

2015 Volume 43, Issue 2, Page(s) 161–172

Abstract: Objective: A meta-analysis to compare the efficacy and safety of telbivudine (TBV) and lamivudine (LAM) in patients with chronic hepatitis B (CHB), assessed via changes in serum alanine aminotransferase (ALT) levels.: Method: The electronic ... ...

Abstract	Objective: A meta-analysis to compare the efficacy and safety of telbivudine (TBV) and lamivudine (LAM) in patients with chronic hepatitis B (CHB), assessed via changes in serum alanine aminotransferase (ALT) levels. Method: The electronic literature databases PubMed®, Embase®, Web of Science, Cochrane Library, CISCOM, CINAHL, Google Scholar, China BioMedicine and China National Knowledge Infrastructure were searched for relevant studies. The effect of TBV and LAM treatment on serum ALT was assessed using standard mean differences (SMDs) and 95% confidence intervals (CI). Results: The meta-analysis included six studies (TBV n = 202; LAM, n = 208). Post-treatment ALT levels were significantly lower than pretreatment values for both TBV and LAM (TBV: SMD = 3.00, 95%CI 1.91, 4.09; LAM: SMD = 2.33, 95%CI 1.58, 3.07). Post-treatment ALT was significantly lower after treatment with TBV than LAM (SMD = 0.58, 95%CI 0.21, 0.94). Conclusion: Both LAM and TBV are effective in normalizing ALT levels in patients with CHB, but TBV may be a better choice due to its lower rates of drug resistance.
MeSH term(s)	Alanine Transaminase/blood ; Antiviral Agents/therapeutic use ; Biomarkers/blood ; Hepatitis B, Chronic/blood ; Hepatitis B, Chronic/drug therapy ; Humans ; Lamivudine/therapeutic use ; Thymidine/analogs & derivatives ; Thymidine/therapeutic use ; Treatment Outcome
Chemical Substances	Antiviral Agents ; Biomarkers ; telbivudine (2OC4HKD3SF) ; Lamivudine (2T8Q726O95) ; Alanine Transaminase (EC 2.6.1.2) ; Thymidine (VC2W18DGKR)
Language	English
Publishing date	2015-04
Publishing country	England
Document type	Comparative Study ; Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
ZDB-ID	184023-x
ISSN	1473-2300 ; 0300-0605 ; 0142-2596
ISSN (online)	1473-2300
ISSN	0300-0605 ; 0142-2596
DOI	10.1177/0300060514556664
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 925: Show issues

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Article ; Online: Tuning optical conductivity of large-scale CVD graphene by strain engineering.

Ni, Guang-Xin / Yang, Hong-Zhi / Ji, Wei / Baeck, Seung-Jae / Toh, Chee-Tat / Ahn, Jong-Hyun / Pereira, Vitor M / Ozyilmaz, Barbaros

Advanced materials (Deerfield Beach, Fla.)

2013 Volume 26, Issue 7, Page(s) 1081–1086

Abstract: A controllable optical anisotropy in CVD graphene is shown. The transparency in the visible range of pre-strained CVD graphene exhibits a periodic modulation as a function of polarization direction. The strain sensitivity of the optical response of ... ...

Abstract	A controllable optical anisotropy in CVD graphene is shown. The transparency in the visible range of pre-strained CVD graphene exhibits a periodic modulation as a function of polarization direction. The strain sensitivity of the optical response of graphene demonstrated here can be effectively utilized towards novel ultra-thin optical devices and strain sensing applications.
MeSH term(s)	Electric Conductivity ; Graphite/chemistry ; Microscopy, Atomic Force ; Optical Devices
Chemical Substances	Graphite (7782-42-5)
Language	English
Publishing date	2013-12-11
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1474949-X
ISSN	1521-4095 ; 0935-9648
ISSN (online)	1521-4095
ISSN	0935-9648
DOI	10.1002/adma.201304156
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Hepatic resection versus transarterial chemoembolization for patients with Barcelona Clinic Liver Cancer intermediate stage Child-Pugh A hepatocellular carcinoma.

Zhao, Yin-Nong / Zhang, Yong-Quan / Ye, Jia-Zhou / Liu, Xing / Yang, Hong-Zhi / Cong, Feng-Yun / Xiang, Bang-De / Wu, Fei-Xiang / Ma, Liang / Li, Le-Qun / Ye, Hai-Hong

Experimental and therapeutic medicine

2016 Volume 12, Issue 6, Page(s) 3813–3819

Abstract: The present study aimed to compare the overall and recurrence-free survival rates following hepatic resection (HR) and transcatheter arterial chemoembolization (TACE) in patients with Barcelona Clinic Liver Cancer (BCLC) classified intermediate-stage ... ...

Abstract	The present study aimed to compare the overall and recurrence-free survival rates following hepatic resection (HR) and transcatheter arterial chemoembolization (TACE) in patients with Barcelona Clinic Liver Cancer (BCLC) classified intermediate-stage Child-Pugh A hepatocellular carcinoma (HCC). A total of 443 patients were examined, among whom 274 underwent HR, whereas 169 received TACE. The overall survival, recurrence-free survival between groups and subgroups, and risk factors with respect to mortality and recurrence, were analyzed. The 1-, 3- and 5-year overall and recurrence-free survival rates were 70, 46 and 37% and 73, 52, and 37%, respectively after HR, compared with 38, 15, and 12% and 44, 25 and 16%, respectively after TACE. Overall and recurrence-free survival rates were significantly increased following HR compared with TACE. Subgroup analysis in the multi-nodule group showed that the 1-, 3- and 5-year overall survival rates were 68, 38 and 30% after HR, compared with 36, 10 and 0% following TACE. In the solitary tumor group, 1-, 3- and 5-year overall survival rates were 71, 50 and 38% after HR, and 41, 22 and 15% after TACE. The overall survival rate after HR was significantly increased compared with that after TACE in the solitary tumor and multi-nodule groups. The risk factors for mortality include solitary tumor diameter >10 cm, multi-nodules, serum albumin level ≥35 g/l, prothrombin time >13 sec, alphafetoprotein levels >400 ng/ml, and patients with hepatitis B virus. Solitary tumor diameter >10 cm, multi-nodules, and hepatitis B virus (P<0.001) were found to be associated with higher recurrence of HCC. Overall and recurrence-free survival rates were improved after HR compared with those after TACE in BCLC stage B, Child-Pugh A, HCC patients.
Language	English
Publishing date	2016-10-17
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2016.3810
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Effects of glycyrrhizin on the expression of hepatitis B virus and Toll like receptors 2,4 in HepG2.2.15 cells expressing low HBsAg].

Li, Yong-wei / Yang, Hong-zhi / Ke, Qian-shan / Chen, Wei / Chen, Xue-juan

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials

2008 Volume 31, Issue 3, Page(s) 403–407

Abstract: Objective: To investigate the effects of glycyrrhizin (GL) on the expression of hepatitis B virus e antigen (HBeAg), HBV DNA, Toll-like receptors 2,4 (TLR2,4) and proliferation of cells in HepG2.2.15 cell line.: Methods: Real-time PCR examined HBV ... ...

Abstract	Objective: To investigate the effects of glycyrrhizin (GL) on the expression of hepatitis B virus e antigen (HBeAg), HBV DNA, Toll-like receptors 2,4 (TLR2,4) and proliferation of cells in HepG2.2.15 cell line. Methods: Real-time PCR examined HBV DNA, ELISA examined HBsAg, HBeAg and MTT examined the proliferation of cells. FCM examined the positive percent of cells expressing TLR2,4 before and after stimulated with GL, in contrast to the blank group. Results: The expression of HBsAg was low in the cell line, so e antigen was studied. The total HBeAg mean was significantly difference on the second day after stimulated (P<0.01), but only in the group with 400 microg/ml HBeAg decreased significantly in contrast to the blank group (P<0.05), the group with 800 microg/ml increased significantly in contrast to the other groups (P<0.01). The total HBV DNA mean on the third day after stimulated was significant, only the group with 50 microg/ml decreased in contrast to the blank group, but P>0.05, the other four groups increased. The intensity of TLR4 expression in the cells was significantly higher than that of the control group (P<0.05), both of total mean TLR2,4 increased significantly (P<0.01). The four groups except the group with 200 microg/ml increased significantly in no dose-dependent manner (P<0.05). GL in three goups under 200 microg/ml all could make cells proliferate, but only 200 microg/ml group had significant difference compared to the blank group (P<0.05). Both 400 and 800 microg/ml groups inhibited the growth of cells (P<0.01). The proliferation of cells were notably negative correlated with the expression of HBeAg, HBV DNA (P<0.05). Conclusion: The study suggestes GL could inhibit or promote HBV DNA replicating and e antigen secreting in mutative HepG2.2.15 cell line, the correlation between the proliferation of cells and the both are negative. GL could upregulate TLR2,4 in no dose-dependent manner. Influencing HBV maybe have no correlation to up regulating TLR2,4 by GL at least in vitro.
MeSH term(s)	Antiviral Agents/administration & dosage ; Antiviral Agents/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; DNA, Viral/genetics ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/pharmacology ; Enzyme-Linked Immunosorbent Assay ; Flow Cytometry ; Glycyrrhizic Acid/administration & dosage ; Glycyrrhizic Acid/pharmacology ; Hepatitis B Surface Antigens/metabolism ; Hepatitis B e Antigens/metabolism ; Hepatitis B virus/drug effects ; Hepatitis B virus/genetics ; Hepatitis B virus/immunology ; Humans ; Polymerase Chain Reaction ; Signal Transduction/drug effects ; Toll-Like Receptor 2/metabolism ; Toll-Like Receptor 4/metabolism
Chemical Substances	Antiviral Agents ; DNA, Viral ; Drugs, Chinese Herbal ; Hepatitis B Surface Antigens ; Hepatitis B e Antigens ; Toll-Like Receptor 2 ; Toll-Like Receptor 4 ; Glycyrrhizic Acid (6FO62043WK)
Language	Chinese
Publishing date	2008-03
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	1001-4454
ISSN	1001-4454
Database	MEDical Literature Analysis and Retrieval System OnLINE

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