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  1. Book ; Thesis: Der Einfluss von intranasal appliziertem Insulin auf den Geschmackssinn des Menschen

    Yang, Huan

    2018  

    Author's details vorgelegt von Huan Yang
    Language German
    Size 72 Seiten, Illustrationen, Diagramme
    Publishing place Aachen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Rheinisch-Westfälische Technische Hochschule Aachen, 2018
    Note Deutsche und englische Zusammenfassung
    HBZ-ID HT020004603
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2019 D 809 order for loan Magazin

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  2. Article ; Online: Mesonephric-like adenocarcinoma of the uterine corpus involving cervix

    Yang Huan, Mou Yanlin, Li Tao

    Xin yixue, Vol 54, Iss 6, Pp 452-

    a case report

    2023  Volume 456

    Abstract: Mesonephric-like adenocarcinoma （MLA） is a rare malignant tumor occurring in the uterine corpus and ovary. MLA of the uterine corpus shows similar histological，immunophenotypic and molecular pathological features with mesonephric adenocarcinoma （MA） of ... ...

    Abstract Mesonephric-like adenocarcinoma （MLA） is a rare malignant tumor occurring in the uterine corpus and ovary. MLA of the uterine corpus shows similar histological，immunophenotypic and molecular pathological features with mesonephric adenocarcinoma （MA） of the cervix. In addition，MLA of the uterine corpus can present with a variety of growth patterns，which is likely to be misinterpreted and misdiagnosed as low-grade endometrioid adenocarcinoma，clear cell carcinoma and serous carcinoma. Hence，the diagnosis of MLA of the uterine corpus is rather challenging. Here，we reported a 58-year-old woman diagnosed with MLA of the uterine corpus. It was difficult to make the diagnosis of this extremely rare disease. Moreover，MLA was involved with the cervix，which increased the difficulty of differential diagnosis from MA of the cervix. In this article，clinical characteristics of this rare case were analyzed and literature review was conducted on the pathology，clinical symptoms，diagnosis，treatment and prognosis of MLA of the uterine corpus，aiming to increase the awareness of this disease among clinicians and pathologists，thus avoiding the misdiagnosis and ineffective treatment.
    Keywords |mesonephric-like adenocarcinoma|mesonephric adenocarcinoma|endometrium|diagnosis ; Medicine ; R
    Subject code 610
    Language Chinese
    Publishing date 2023-06-01T00:00:00Z
    Publisher Editorial Office of Journal of New Medicine
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Effects of near-bed turbulence on microplastics fate and transport in streams.

    Yang, Huan / Foroutan, Hosein

    The Science of the total environment

    2023  Volume 905, Page(s) 167173

    Abstract: Quantifying the impact of hyporheic exchange is crucial for understanding the transport and fate of microplastics in streams. In this study, we conducted several Computational Fluid Dynamics (CFD) simulations to investigate near-bed turbulence and ... ...

    Abstract Quantifying the impact of hyporheic exchange is crucial for understanding the transport and fate of microplastics in streams. In this study, we conducted several Computational Fluid Dynamics (CFD) simulations to investigate near-bed turbulence and analyze vertical hyporheic exchange. Different arranged spheres were used to represent rough and permeable sediment beds in natural rivers. The velocities associated with vertical hyporheic flux and the gravitational force were compared to quantify the susceptibility of microplastics to hyporheic exchange. Four scenario cases representing different channel characteristics were studied and their effects on microplastics movements through hyporheic exchange were quantitatively studied. Results show that hyporheic exchange flow can significantly influence the fate and transport of microplastics of small and light-weighted microplastics. Under certain conditions, hyporheic exchange flow can dominate the behavior of microplastics with sizes up to around 800 μm. This dominance is particularly evident near the sediment-water interface, especially at the top layer of sediments. Higher bed porosity enhances the exchange of microplastics between water and sediment, while increased flow conditions extend the vertical exchange zone into deeper layers of the bed. Changes in the bedform lead to the most pronounced vertical hyporheic exchange, emphasizing the control of morphological features on microplastics transport. Furthermore, it is found that sweep-ejection events are prevailing near the bed surface, serving as a mechanism for microplastics transport in rivers. As moving from the water column to deeper layers in the sediment bed, there's a shift from sweeps dominance to ejections dominance, indicating changes of direction in microplastics movement at different locations.
    Language English
    Publishing date 2023-09-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.167173
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: High conductivity characteristics of phosphorus-doped nanocrystalline silicon thin films by KrF pulsed excimer laser irradiation method.

    Wang, Xiang / Song, Chao / Xu, Boxu / Yang, Huan

    RSC advances

    2024  Volume 14, Issue 15, Page(s) 10697–10702

    Abstract: The microstructure and high conductivity properties of phosphorus-doped nanocrystalline silicon films were investigated on samples prepared by a plasma-enhanced chemical vapor deposition technique and the KrF pulsed excimer laser irradiation method. The ... ...

    Abstract The microstructure and high conductivity properties of phosphorus-doped nanocrystalline silicon films were investigated on samples prepared by a plasma-enhanced chemical vapor deposition technique and the KrF pulsed excimer laser irradiation method. The results of Fourier transform infrared spectroscopy and Raman spectroscopy show that Si nanocrystallites with an average diameter of 2 nm to 3 nm are formed in the film. The degree of crystallinity increases with the increase of laser radiation intensity, while the content of hydrogen decreases gradually. More phosphorus atoms are substitutionally incorporated into the nc-Si dots under higher laser irradiation fluence, which is responsible for the high dark conductivity. By controlling the laser fluence at 1.0 J cm
    Language English
    Publishing date 2024-04-02
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d4ra00040d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Two-dimensional Janus SbTeBr/SbSI heterostructures as multifunctional optoelectronic systems with efficient carrier separation.

    Liu, Hong-Yao / Yang, Huan / Zheng, Yujun

    Physical chemistry chemical physics : PCCP

    2024  Volume 26, Issue 7, Page(s) 6228–6234

    Abstract: The stacking of two-dimensional (2D) materials is a highly effective approach in the design of high-performance optoelectronic devices. In this study, we propose a novel Janus monolayer-based 2D/2D van der Waals heterostructure (vdWH) called SbTeBr/SbSI. ...

    Abstract The stacking of two-dimensional (2D) materials is a highly effective approach in the design of high-performance optoelectronic devices. In this study, we propose a novel Janus monolayer-based 2D/2D van der Waals heterostructure (vdWH) called SbTeBr/SbSI. Starting from its most stable binding configuration, we systematically examined its electronic, optical, mechanical and dynamical properties. The SbTeBr/SbSI vdWH exhibits a type II band arrangement, with an indirect bandgap of 1.28 eV and strong light absorption capabilities in the visible range, achieving an absorption coefficient of 4 × 10
    Language English
    Publishing date 2024-02-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp04087a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: HMGB1 is a critical molecule in the pathogenesis of Gram-negative sepsis.

    Andersson, Ulf / Yang, Huan

    Journal of intensive medicine

    2022  Volume 2, Issue 3, Page(s) 156–166

    Abstract: Gram-negative sepsis is a severe clinical syndrome associated with significant morbidity and mortality. Lipopolysaccharide (LPS), expressed on Gram-negative bacteria, is a potent pro-inflammatory toxin that induces inflammation and coagulation via two ... ...

    Abstract Gram-negative sepsis is a severe clinical syndrome associated with significant morbidity and mortality. Lipopolysaccharide (LPS), expressed on Gram-negative bacteria, is a potent pro-inflammatory toxin that induces inflammation and coagulation via two separate receptor systems. One is Toll-like receptor 4 (TLR4), expressed on cell surfaces and in endosomes, and the other is the cytosolic receptor caspase-11 (caspases-4 and -5 in humans). Extracellular LPS binds to high mobility group box 1 (HMGB1) protein, a cytokine-like molecule. The HMGB1-LPS complex is transported via receptor for advanced glycated end products (RAGE)-endocytosis to the endolysosomal system to reach the cytosolic LPS receptor caspase-11 to induce HMGB1 release, inflammation, and coagulation that may cause multi-organ failure. The insight that LPS needs HMGB1 assistance to generate severe inflammation has led to successful therapeutic results in preclinical Gram-negative sepsis studies targeting HMGB1. However, to date, no clinical studies have been performed based on this strategy. HMGB1 is also actively released by peripheral sensory nerves and this mechanism is fundamental for the initiation and propagation of inflammation during tissue injury. Homeostasis is achieved when other neurons actively restrict the inflammatory response via monitoring by the central nervous system and the vagus nerve through the cholinergic anti-inflammatory pathway. The neuronal control in Gram-negative sepsis needs further studies since a deeper understanding of the interplay between HMGB1 and acetylcholine may have beneficial therapeutic implications. Herein, we review the synergistic overlapping mechanisms of LPS and HMGB1 and discuss future treatment opportunities in Gram-negative sepsis.
    Language English
    Publishing date 2022-03-09
    Publishing country China
    Document type Journal Article ; Review
    ISSN 2667-100X
    ISSN (online) 2667-100X
    DOI 10.1016/j.jointm.2022.02.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Genetic prediction of antihyperglycemic drug targets and risk of epilepsy: a mendelian randomisation study.

    Zhou, Kaiping / Yang, Huan / Xie, Zhihao / Wang, Weiping / Qu, Zhenzhen

    BMC pharmacology & toxicology

    2024  Volume 25, Issue 1, Page(s) 1

    Abstract: A connection between diabetes and an increased risk of epilepsy has been suggested by observational studies. Animal studies have also shown that antihyperglycemic drugs can improve seizures. However, it is unclear whether antihyperglycemic drugs have a ... ...

    Abstract A connection between diabetes and an increased risk of epilepsy has been suggested by observational studies. Animal studies have also shown that antihyperglycemic drugs can improve seizures. However, it is unclear whether antihyperglycemic drugs have a causal role in epilepsy in humans. To investigate this potential causal relationship, a Mendelian randomisation study was conducted using International League Against Epilepsy data as the discovery set and FinnGen data as the replication set. It was discovered that three antidiabetic drug target genes, ETFDH, CYP21A2 and CYP2D6, were involved in the occurrence of epilepsy. In particular, ETFDH was identified as a target gene in both the discovery set (inverse variance weighting [IVW], odds ratio [OR] = 1.018, 95% confidence interval [CI], 1.004-1.033, p = 0.009) and replication set (IVW, OR = 1.074, 95% CI, 1.034-1.114, p = 0.00016), and CYP21A2 was identified in the discovery set (IVW, OR = 1.029, 95% CI, 1.005-1.053, p = 0.016) and replication set (IVW, OR = 1.057, 95% CI, 1.001-1.116, p = 0.045) as having a causal association with an increased risk of epilepsy. Conversely, the CYP2D6 gene was found to be a protective factor for epilepsy in both the discovery set (IVW, OR = 0.0984, 95% CI, 0.969-0.998, p = 0.025) and replication set (IVW, OR = 0.977, 95% CI, 0.955-1.000, p = 0.046). A search of DrugBank revealed that metformin, an anti-glucose drug, is an inhibitor of the ETFDH gene and may have a potential therapeutic effect on epilepsy.
    MeSH term(s) Animals ; Humans ; Hypoglycemic Agents/therapeutic use ; Cytochrome P-450 CYP2D6 ; Epilepsy/drug therapy ; Epilepsy/genetics ; Metformin ; Seizures ; Steroid 21-Hydroxylase
    Chemical Substances Hypoglycemic Agents ; Cytochrome P-450 CYP2D6 (EC 1.14.14.1) ; Metformin (9100L32L2N) ; CYP21A2 protein, human (EC 1.14.14.16) ; Steroid 21-Hydroxylase (EC 1.14.14.16)
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2680259-4
    ISSN 2050-6511 ; 2050-6511
    ISSN (online) 2050-6511
    ISSN 2050-6511
    DOI 10.1186/s40360-023-00718-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The molecular mechanisms regulating the assembly of the autophagy initiation complex.

    Yao, Weijing / Feng, Yuyao / Zhang, Yi / Yang, Huan / Yi, Cong

    BioEssays : news and reviews in molecular, cellular and developmental biology

    2024  , Page(s) e2300243

    Abstract: The autophagy initiation complex is brought about via a highly ordered and stepwise assembly process. Two crucial signaling molecules, mTORC1 and AMPK, orchestrate this assembly by phosphorylating/dephosphorylating autophagy-related proteins. Activation ... ...

    Abstract The autophagy initiation complex is brought about via a highly ordered and stepwise assembly process. Two crucial signaling molecules, mTORC1 and AMPK, orchestrate this assembly by phosphorylating/dephosphorylating autophagy-related proteins. Activation of Atg1 followed by recruitment of both Atg9 vesicles and the PI3K complex I to the PAS (phagophore assembly site) are particularly crucial steps in its formation. Ypt1, a small Rab GTPase in yeast cells, also plays an essential role in the formation of the autophagy initiation complex through multiple regulatory pathways. In this review, our primary focus is to discuss how signaling molecules initiate the assembly of the autophagy initiation complex, and highlight the significant roles of Ypt1 in this process. We end by addressing issues that need future clarification.
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 50140-2
    ISSN 1521-1878 ; 0265-9247
    ISSN (online) 1521-1878
    ISSN 0265-9247
    DOI 10.1002/bies.202300243
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  9. Article ; Online: Genome-Wide Identification and Expression Analysis of the MYB Transcription Factor Family in

    Yang, Huan / Chen, Chen / Han, Limin / Zhang, Xiao / Yue, Ming

    Genes

    2024  Volume 15, Issue 1

    Abstract: The MYB transcription factor gene family is among the most extensive superfamilies of transcription factors in plants and is involved in various essential functions, such as plant growth, defense, and pigment formation. ...

    Abstract The MYB transcription factor gene family is among the most extensive superfamilies of transcription factors in plants and is involved in various essential functions, such as plant growth, defense, and pigment formation.
    MeSH term(s) Transcription Factors/genetics ; Salvia/genetics ; Anthocyanins/genetics ; Phylogeny ; Plant Breeding
    Chemical Substances Transcription Factors ; Anthocyanins
    Language English
    Publishing date 2024-01-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes15010110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: High-purity C

    Yang, Huan / Han, Changdao / Jiang, Jie / Li, Pei / Chen, Liang

    RSC advances

    2024  Volume 14, Issue 15, Page(s) 10749–10754

    Abstract: A new type of two-dimensional layered material, namely ... ...

    Abstract A new type of two-dimensional layered material, namely C
    Language English
    Publishing date 2024-04-02
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d4ra00887a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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