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Article ; Online: Major adverse cardiac and cerebrovascular events (MACCEs) in patients with acute ST-segment elevation myocardial infarction(STEMI) treated with pharmaco-invasive strategy with half-dose recombinant human prourokinase (PHDP): Two-year outcomes.

Yang, Hui-Hui / Dou, Jie / Liu, Yong-Hua / Luo, Dong-Lei

2024

Language	English
Publishing date	2024-03-15
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2024.03.036
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Article ; Online: Prognostic bleeding events in patients with acute ST-segment elevation myocardial infarction (STEMI) treated with pharmaco-invasive strategy with half-dose recombinant human prourokinase: 2-year follow-up.

Dou, Jie / Yang, Hui-Hui / Wang, Xue-Yan / Luo, Dong-Lei

Asian journal of surgery

2024

Language	English
Publishing date	2024-02-27
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2024.02.110
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Article ; Online: A preliminary study of changes in carotid artery elasticity in type 2 diabetes mellitus.

Jin, Chun-Xiang / Tian, Jing / Yang, Hui-Hui / He, Yu

Clinical physiology and functional imaging

2023 Volume 43, Issue 3, Page(s) 181–191

Abstract: Background: Carotid stiffening is found to be present in patients with type 2 diabetes mellitus (T2DM) together with endothelial dysfunction and it remains unclear about the role of carotid elasticity in the development of diabetic vascular damage. The ... ...

Abstract	Background: Carotid stiffening is found to be present in patients with type 2 diabetes mellitus (T2DM) together with endothelial dysfunction and it remains unclear about the role of carotid elasticity in the development of diabetic vascular damage. The aim of the study was to investigate changes and significance of carotid artery elasticity in diabetic patients with or without microvascular complications using velocity vector imaging (VVI) analysis. Methods: Fifty participants were enrolled and divided into health Control group, the uncomplicated DM (uDM) group and the complicated DM (cDM) group. All of them underwent carotid ultrasound examinations. VVI was used to evaluate the common carotid artery (CCA) elasticity and intima-media thickness (IMT) was also measured. Flow-mediated dilation (FMD) was performed to detect the vascular endothelial function. Then differences and correlations of variables between three groups were compared and analyzed. Results: CCA elasticity measured by VVI decreased significantly between three groups (p < 0.05), while FMD decreased significantly only in cDM group (p < 0.01) and only IMT in cDM group was significantly thicker than that of Control group (p < 0.05). Representative VVI variables were independently, negatively related to the known duration and microalbuminuria (p < 0.05). All VVI variables were significantly correlated with FMD (0.5 ≤ \|r \| <0.8, p < 0.001), and just a small part of VVI variables were significantly correlated with IMT (0.3 ≤ \|r \| <0.5, p < 0.05). Conclusion: Compared with FMD, CCA elasticity measured by VVI showed more obvious changes in diabetic patients with different levels of vascular damage and may be considered as an alternative indicator in evaluating arterial status of T2DM.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/complications ; Carotid Intima-Media Thickness ; Carotid Arteries/diagnostic imaging ; Carotid Artery, Common/diagnostic imaging ; Elasticity ; Endothelium, Vascular/diagnostic imaging ; Brachial Artery/diagnostic imaging ; Ultrasonography ; Vasodilation
Language	English
Publishing date	2023-01-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2071203-0
ISSN	1475-097X ; 1475-0961
ISSN (online)	1475-097X
ISSN	1475-0961
DOI	10.1111/cpf.12808
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Zs.A 1650: Show issues

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Article: Clinical Value of the Diagonal Earlobe Crease in Patients with Chest Pain for Diagnosing Coronary Heart Disease.

Gao, Jie / Dou, Jie / Yang, Hui-Hui / Guo, Ruo-Ling / Jiang, Chao / Tse, Gary / Liu, Tong / Liu, Jian-Wei / Luo, Dong-Lei

International journal of general medicine

2024 Volume 17, Page(s) 1557–1569

Abstract: Purpose: To investigate the clinical application value of diagonal earlobe crease (DELC) in patients with chest pain for the diagnosis of coronary heart disease (CHD) and to construct a risk model by multivariate logistic regression.: Patients and ... ...

Abstract	Purpose: To investigate the clinical application value of diagonal earlobe crease (DELC) in patients with chest pain for the diagnosis of coronary heart disease (CHD) and to construct a risk model by multivariate logistic regression. Patients and methods: Our trial enrolled prospectively and consecutively 706 chest pain patients with suspected CHD between January 2021 to June 2023 from Chengde Central Hospital. According to coronary angiography results, they were categorized into the CHD (n=457) and non-CHD groups (n=249). Results: The trial demonstrated a significant positive relationship between DELC and CHD. Independent risk factors were sex, age, hypertension, diabetes mellitus, LP (a), Cys C, and DELC, whilst HDL-C was a protective factor, for CHD. Patients with-DELC were older than those in the without-DELC arm ( Conclusion: DELC is an independent risk factor for CHD after adjusting for sex, age, hypertension, diabetes mellitus, smoking index, LP (a), Cys C, and HDL-C. Our model can be used clinically for assessing the risk of CHD.
Language	English
Publishing date	2024-04-23
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2452220-X
ISSN	1178-7074
ISSN	1178-7074
DOI	10.2147/IJGM.S454888
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Article ; Online: Lipocalin family proteins and their diverse roles in cardiovascular disease.

Yang, Hui-Hui / Wang, Xiaohong / Li, Siru / Liu, Yueying / Akbar, Rubab / Fan, Guo-Chang

Pharmacology & therapeutics

2023 Volume 244, Page(s) 108385

Abstract: The lipocalin (LCN) family members, a group of small extracellular proteins with 160-180 amino acids in length, can be detected in all kingdoms of life from bacteria to human beings. They are characterized by low similarity of amino acid sequence but ... ...

Abstract	The lipocalin (LCN) family members, a group of small extracellular proteins with 160-180 amino acids in length, can be detected in all kingdoms of life from bacteria to human beings. They are characterized by low similarity of amino acid sequence but highly conserved tertiary structures with an eight-stranded antiparallel β-barrel which forms a cup-shaped ligand binding pocket. In addition to bind small hydrophobic ligands (i.e., fatty acids, odorants, retinoids, and steroids) and transport them to specific cells, lipocalins (LCNs) can interact with specific cell membrane receptors to activate their downstream signaling pathways, and with soluble macromolecules to form the complex. Consequently, LCNs exhibit great functional diversity. Accumulating evidence has demonstrated that LCN family proteins exert multiple layers of function in the regulation of many physiological processes and human diseases (i.e., cancers, immune disorders, metabolic disease, neurological/psychiatric disorders, and cardiovascular disease). In this review, we firstly introduce the structural and sequence properties of LCNs. Next, six LCNs including apolipoprotein D (ApoD), ApoM, lipocalin 2 (LCN2), LCN10, retinol-binding protein 4 (RBP4), and Lipocalin-type prostaglandin D synthase (L-PGDS) which have been characterized so far are highlighted for their diagnostic/prognostic values and their potential effects on coronary artery disease and myocardial infarction injury. The roles of these 6 LCNs in cardiac hypertrophy, heart failure, diabetes-induced cardiac disorder, and septic cardiomyopathy are also summarized. Finally, their therapeutic potential for cardiovascular disease is discussed in each section.
MeSH term(s)	Humans ; Cardiovascular Diseases ; Lipocalins/chemistry ; Lipocalins/metabolism ; Amino Acid Sequence ; Receptors, Cell Surface/metabolism ; Ligands ; Retinol-Binding Proteins, Plasma/metabolism
Chemical Substances	Lipocalins ; Receptors, Cell Surface ; Ligands ; RBP4 protein, human ; Retinol-Binding Proteins, Plasma
Language	English
Publishing date	2023-03-24
Publishing country	England
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural
ZDB-ID	194735-7
ISSN	1879-016X ; 0163-7258
ISSN (online)	1879-016X
ISSN	0163-7258
DOI	10.1016/j.pharmthera.2023.108385
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Article ; Online: Cytoplasm Hydrogelation-Mediated Cardiomyocyte Sponge Alleviated Coxsackievirus B3 Infection.

Wang, Jingzhe / Liu, Tonggong / Gu, Siyao / Yang, Hui-Hui / Xie, Weidong / Gao, Cheng / Gu, Dayong

Nano letters

2023 Volume 23, Issue 19, Page(s) 8881–8890

Abstract: Viral myocarditis (VMC), commonly caused by coxsackievirus B3 (CVB3) infection, lacks specific treatments and leads to serious heart conditions. Current treatments, such as IFNα and ribavirin, show limited effectiveness. Herein, rather than inhibiting ... ...

Abstract	Viral myocarditis (VMC), commonly caused by coxsackievirus B3 (CVB3) infection, lacks specific treatments and leads to serious heart conditions. Current treatments, such as IFNα and ribavirin, show limited effectiveness. Herein, rather than inhibiting virus replication, this study introduces a novel cardiomyocyte sponge, intracellular gelated cardiomyocytes (GCs), to trap and neutralize CVB3 via a receptor-ligand interaction, such as CAR and CD55. By maintaining cellular morphology, GCs serve as sponges for CVB3, inhibiting infection.
Language	English
Publishing date	2023-09-26
Publishing country	United States
Document type	Journal Article
ISSN	1530-6992
ISSN (online)	1530-6992
DOI	10.1021/acs.nanolett.3c01983
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Article ; Online: Functional differentiation of two general odorant-binding proteins to sex pheromones in Spodoptera frugiperda.

Yang, Hui-Hui / Li, Shu-Peng / Yin, Mao-Zhu / Zhu, Xiu-Yun / Li, Jin-Bu / Zhang, Ya-Nan / Li, Xiao-Ming

Pesticide biochemistry and physiology

2023 Volume 191, Page(s) 105348

Abstract: A precise chemosensory system can help insects complete various important behavioral responses by accurately identifying different external odorants. Therefore, deeply understanding the mechanism of insect recognition of important odorants will help us ... ...

Abstract	A precise chemosensory system can help insects complete various important behavioral responses by accurately identifying different external odorants. Therefore, deeply understanding the mechanism of insect recognition of important odorants will help us develop efficient and environmentally-friendly behavioral inhibitors. Spodoptera frugiperda is a polyphagous pest that feeds on >350 different host plants worldwide and also harms maize production in China. However, the molecular mechanism of the first step for males to use odorant-binding proteins (OBPs) to recognize sex pheromones remains unclear. Here, we obtained 50 OBPs from the S. frugiperda genome, and the expression level of SfruGOBP1 in females was significantly higher than that in males, whereas SfruGOBP2 displayed male-biased expression. Fluorescence competitive binding assays showed that only SfruGOBP2 showed binding affinities for the four sex pheromones of female S. frugiperda. Subsequently, we identified some key amino acid residues that can participate in the interaction between SfruGOBP2 and sex pheromones using molecular docking and site-directed mutagenesis methods. These findings will help us explore the interaction mechanism between GOBPs and sex pheromones in moths, and provide important target genes for developing new mating inhibitors of S. frugiperda in the future.
MeSH term(s)	Animals ; Female ; Male ; Sex Attractants/metabolism ; Spodoptera/genetics ; Spodoptera/metabolism ; Odorants ; Molecular Docking Simulation ; Insect Proteins/metabolism ; Moths/metabolism ; Pheromones/metabolism
Chemical Substances	Sex Attractants ; Insect Proteins ; Pheromones
Language	English
Publishing date	2023-01-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	184819-7
ISSN	1095-9939 ; 0048-3583 ; 0048-3575
ISSN (online)	1095-9939
ISSN	0048-3583 ; 0048-3575
DOI	10.1016/j.pestbp.2023.105348
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Article ; Online: Functional differentiation of two general odorant-binding proteins to sex pheromones in Spodoptera frugiperda

Yang, Hui-Hui / Li, Shu-Peng / Yin, Mao-Zhu / Zhu, Xiu-Yun / Li, Jin-Bu / Zhang, Ya-Nan / Li, Xiao Ming

Pesticide Biochemistry and Physiology. 2023 Apr., v. 191 p.105348-

2023

Abstract	A precise chemosensory system can help insects complete various important behavioral responses by accurately identifying different external odorants. Therefore, deeply understanding the mechanism of insect recognition of important odorants will help us develop efficient and environmentally-friendly behavioral inhibitors. Spodoptera frugiperda is a polyphagous pest that feeds on >350 different host plants worldwide and also harms maize production in China. However, the molecular mechanism of the first step for males to use odorant-binding proteins (OBPs) to recognize sex pheromones remains unclear. Here, we obtained 50 OBPs from the S. frugiperda genome, and the expression level of SfruGOBP1 in females was significantly higher than that in males, whereas SfruGOBP2 displayed male-biased expression. Fluorescence competitive binding assays showed that only SfruGOBP2 showed binding affinities for the four sex pheromones of female S. frugiperda. Subsequently, we identified some key amino acid residues that can participate in the interaction between SfruGOBP2 and sex pheromones using molecular docking and site-directed mutagenesis methods. These findings will help us explore the interaction mechanism between GOBPs and sex pheromones in moths, and provide important target genes for developing new mating inhibitors of S. frugiperda in the future.
Keywords	Spodoptera frugiperda ; amino acids ; corn ; females ; fluorescence ; genome ; insects ; odor compounds ; pesticides ; pests ; physiology ; site-directed mutagenesis ; China ; Odorant-binding protein ; Sex pheromone ; Fluorescence competitive binding assay
Language	English
Dates of publication	2023-04
Publishing place	Elsevier Inc.
Document type	Article ; Online
ZDB-ID	184819-7
ISSN	1095-9939 ; 0048-3583 ; 0048-3575
ISSN (online)	1095-9939
ISSN	0048-3583 ; 0048-3575
DOI	10.1016/j.pestbp.2023.105348
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Article ; Online: CGRP is essential for protection against alveolar epithelial cell necroptosis by activating the AMPK/L-OPA1 signaling pathway during acute lung injury.

Jiang, Hui-Ling / Yang, Hui-Hui / Liu, Yu-Biao / Duan, Jia-Xi / Guan, Xin-Xin / Zhang, Chen-Yu / Zhong, Wen-Jing / Jin, Ling / Li, Dai / Li, Qing / Zhou, Yong / Guan, Cha-Xiang

Journal of cellular physiology

2024 Volume 239, Issue 2, Page(s) e31169

Abstract: Alveolar epithelial cell (AEC) necroptosis is critical to disrupt the alveolar barrier and provoke acute lung injury (ALI). Here, we define calcitonin gene-related peptide (CGRP), the most abundant endogenous neuropeptide in the lung, as a novel ... ...

Abstract	Alveolar epithelial cell (AEC) necroptosis is critical to disrupt the alveolar barrier and provoke acute lung injury (ALI). Here, we define calcitonin gene-related peptide (CGRP), the most abundant endogenous neuropeptide in the lung, as a novel modulator of AEC necroptosis in lipopolysaccharide (LPS)-induced ALI. Upon LPS-induced ALI, overexpression of Cgrp significantly mitigates the inflammatory response, alleviates lung tissue damage, and decreases AEC necroptosis. Similarly, CGRP alleviated AEC necroptosis under the LPS challenge in vitro. Previously, we identified that long optic atrophy 1 (L-OPA1) deficiency mediates mitochondrial fragmentation, leading to AEC necroptosis. In this study, we discovered that CGRP positively regulated mitochondrial fusion through stabilizing L-OPA1. Mechanistically, we elucidate that CGRP activates AMP-activated protein kinase (AMPK). Furthermore, the blockade of AMPK compromised the protective effect of CGRP against AEC necroptosis following the LPS challenge. Our study suggests that CRGP-mediated activation of the AMPK/L-OPA1 axis may have potent therapeutic benefits for patients with ALI or other diseases with necroptosis.
MeSH term(s)	Animals ; Male ; Mice ; Acute Lung Injury/chemically induced ; Acute Lung Injury/genetics ; Acute Lung Injury/drug therapy ; Alveolar Epithelial Cells/metabolism ; AMP-Activated Protein Kinases/genetics ; AMP-Activated Protein Kinases/metabolism ; Calcitonin Gene-Related Peptide/genetics ; Calcitonin Gene-Related Peptide/pharmacology ; Calcitonin Gene-Related Peptide/metabolism ; Cell Line ; GTP Phosphohydrolases/metabolism ; Lipopolysaccharides/pharmacology ; Lipopolysaccharides/metabolism ; Lung/metabolism ; Mice, Inbred C57BL ; Necroptosis ; Signal Transduction
Chemical Substances	AMP-Activated Protein Kinases (EC 2.7.11.31) ; Calcitonin Gene-Related Peptide (JHB2QIZ69Z) ; GTP Phosphohydrolases (EC 3.6.1.-) ; Lipopolysaccharides
Language	English
Publishing date	2024-01-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	3116-1
ISSN	1097-4652 ; 0021-9541
ISSN (online)	1097-4652
ISSN	0021-9541
DOI	10.1002/jcp.31169
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Article ; Online: Macrophage-enriched Sectm1a promotes efficient efferocytosis to attenuate ischemia/reperfusion-induced cardiac injury.

Wang, Xiaohong / Du, Wa / Li, Yutian / Yang, Hui-Hui / Zhang, Yu / Akbar, Rubab / Morgan, Hannah / Peng, Tianqing / Chen, Jing / Sadayappan, Sakthivel / Hu, Yueh-Chiang / Fan, Yanbo / Huang, Wei / Fan, Guo-Chang

JCI insight

2024 Volume 9, Issue 5

Abstract: Efficient clearance and degradation of apoptotic cardiomyocytes by macrophages (collectively termed efferocytosis) is critical for inflammation resolution and restoration of cardiac function after myocardial ischemia/reperfusion (I/R). Here, we define ... ...

Abstract	Efficient clearance and degradation of apoptotic cardiomyocytes by macrophages (collectively termed efferocytosis) is critical for inflammation resolution and restoration of cardiac function after myocardial ischemia/reperfusion (I/R). Here, we define secreted and transmembrane protein 1a (Sectm1a), a cardiac macrophage-enriched gene, as a modulator of macrophage efferocytosis in I/R-injured hearts. Upon myocardial I/R, Sectm1a-KO mice exhibited impaired macrophage efferocytosis, leading to massive accumulation of apoptotic cardiomyocytes, cardiac inflammation, fibrosis, and consequently, exaggerated cardiac dysfunction. By contrast, therapeutic administration of recombinant SECTM1A protein significantly enhanced macrophage efferocytosis and improved cardiac function. Mechanistically, SECTM1A could elicit autocrine effects on the activation of glucocorticoid-induced TNF receptor (GITR) at the surface of macrophages, leading to the upregulation of liver X receptor α (LXRα) and its downstream efferocytosis-related genes and lysosomal enzyme genes. Our study suggests that Sectm1a-mediated activation of the Gitr/LXRα axis could be a promising approach to enhance macrophage efferocytosis for the treatment of myocardial I/R injury.
MeSH term(s)	Mice ; Animals ; Phagocytosis ; Efferocytosis ; Apoptosis ; Macrophages/metabolism ; Inflammation/metabolism ; Membrane Proteins/metabolism ; Myocardial Reperfusion Injury/metabolism ; Reperfusion
Chemical Substances	Membrane Proteins ; SECTM1A protein, mouse
Language	English
Publishing date	2024-03-08
Publishing country	United States
Document type	Journal Article
ISSN	2379-3708
ISSN (online)	2379-3708
DOI	10.1172/jci.insight.173832
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