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Article ; Online: Analysis on key parameters in subretinal injection facilitating a predictable and automated robot-assisted treatment in gene therapy.

Huang, Ching-Wen / Yang, Hung-Yu / Chen, Ta-Ching / Chen, Cheng-Wei

The international journal of medical robotics + computer assisted surgery : MRCAS

2023 Volume 19, Issue 6, Page(s) e2560

Abstract: Background: Subretinal injection (SRI) has become an important surgical method for treating vitreoretinal diseases. Nevertheless, the optimisation of bleb formation in SRI, for the attainment of desired therapeutic outcomes, still requires further ... ...

Abstract	Background: Subretinal injection (SRI) has become an important surgical method for treating vitreoretinal diseases. Nevertheless, the optimisation of bleb formation in SRI, for the attainment of desired therapeutic outcomes, still requires further investigation. Methods: This study analysed the influence of surgical parameters on SRI using a robotic setup. The surgical procedure was automated using visual guidance. A predictive model for bleb formation was established through regression analysis. To validate the model, we compared the clinical data's target area with the simulated SRI's actual area using parameters determined by the predictive model. Results: The insertion angle dominated the eccentricity and area of the bleb. The injection speed dominated the axial angle. Automated SRI increased success rate and produced predictable outcomes. Conclusions: We could provide accurate SRI on phantom models by adjusting surgical parameters based on the patient's clinical information. Automatic robot-assisted SRI is a promising surgical technique with highly predictable results.
MeSH term(s)	Humans ; Robotics ; Injections ; Genetic Therapy ; Robotic Surgical Procedures
Language	English
Publishing date	2023-08-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2151860-9
ISSN	1478-596X ; 1478-5951
ISSN (online)	1478-596X
ISSN	1478-5951
DOI	10.1002/rcs.2560
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Article: Manipulating Topological Phases in Magnetic Topological Insulators.

Qiu, Gang / Yang, Hung-Yu / Chong, Su Kong / Cheng, Yang / Tai, Lixuan / Wang, Kang L

Nanomaterials (Basel, Switzerland)

2023 Volume 13, Issue 19

Abstract: Magnetic topological insulators (MTIs) are a group of materials that feature topological band structures with concurrent magnetism, which can offer new opportunities for technological advancements in various applications, such as spintronics and quantum ... ...

Abstract	Magnetic topological insulators (MTIs) are a group of materials that feature topological band structures with concurrent magnetism, which can offer new opportunities for technological advancements in various applications, such as spintronics and quantum computing. The combination of topology and magnetism introduces a rich spectrum of topological phases in MTIs, which can be controllably manipulated by tuning material parameters such as doping profiles, interfacial proximity effect, or external conditions such as pressure and electric field. In this paper, we first review the mainstream MTI material platforms where the quantum anomalous Hall effect can be achieved, along with other exotic topological phases in MTIs. We then focus on highlighting recent developments in modulating topological properties in MTI with finite-size limit, pressure, electric field, and magnetic proximity effect. The manipulation of topological phases in MTIs provides an exciting avenue for advancing both fundamental research and practical applications. As this field continues to develop, further investigations into the interplay between topology and magnetism in MTIs will undoubtedly pave the way for innovative breakthroughs in the fundamental understanding of topological physics as well as practical applications.
Language	English
Publishing date	2023-09-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano13192655
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Article ; Online: Engineering Anomalously Large Electron Transport in Topological Semimetals.

Plisson, Vincent M / Yao, Xiaohan / Wang, Yaxian / Varnavides, George / Suslov, Alexey / Graf, David / Choi, Eun Sang / Yang, Hung-Yu / Wang, Yiping / Romanelli, Marisa / McNamara, Grant / Singh, Birender / McCandless, Gregory T / Chan, Julia Y / Narang, Prineha / Tafti, Fazel / Burch, Kenneth S

Advanced materials (Deerfield Beach, Fla.)

2024 , Page(s) e2310944

Abstract: Anomalous transport of topological semimetals has generated significant interest for applications in optoelectronics, nanoscale devices, and interconnects. Understanding the origin of novel transport is crucial to engineering the desired material ... ...

Abstract	Anomalous transport of topological semimetals has generated significant interest for applications in optoelectronics, nanoscale devices, and interconnects. Understanding the origin of novel transport is crucial to engineering the desired material properties, yet their orders of magnitude higher transport than single-particle mobilities remain unexplained. This work demonstrates the dramatic mobility enhancements result from phonons primarily returning momentum to electrons due to phonon-electron dominating over phonon-phonon scattering. Proving this idea, proposed by Peierls in 1932, requires tuning electron and phonon dispersions without changing symmetry, topology, or disorder. This is achieved by combining de Haas - van Alphen (dHvA), electron transport, Raman scattering, and first-principles calculations in the topological semimetals MX
Language	English
Publishing date	2024-03-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1474949-X
ISSN	1521-4095 ; 0935-9648
ISSN (online)	1521-4095
ISSN	0935-9648
DOI	10.1002/adma.202310944
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Article ; Online: Emergent ferromagnetism with superconductivity in Fe(Te,Se) van der Waals Josephson junctions.

Qiu, Gang / Yang, Hung-Yu / Hu, Lunhui / Zhang, Huairuo / Chen, Chih-Yen / Lyu, Yanfeng / Eckberg, Christopher / Deng, Peng / Krylyuk, Sergiy / Davydov, Albert V / Zhang, Ruixing / Wang, Kang L

Nature communications

2023 Volume 14, Issue 1, Page(s) 6691

Abstract: Ferromagnetism and superconductivity are two key ingredients for topological superconductors, which can serve as building blocks of fault-tolerant quantum computers. Adversely, ferromagnetism and superconductivity are typically also two hostile orderings ...

Abstract	Ferromagnetism and superconductivity are two key ingredients for topological superconductors, which can serve as building blocks of fault-tolerant quantum computers. Adversely, ferromagnetism and superconductivity are typically also two hostile orderings competing to align spins in different configurations, and thus making the material design and experimental implementation extremely challenging. A single material platform with concurrent ferromagnetism and superconductivity is actively pursued. In this paper, we fabricate van der Waals Josephson junctions made with iron-based superconductor Fe(Te,Se), and report the global device-level transport signatures of interfacial ferromagnetism emerging with superconducting states for the first time. Magnetic hysteresis in the junction resistance is observed only below the superconducting critical temperature, suggesting an inherent correlation between ferromagnetic and superconducting order parameters. The 0-π phase mixing in the Fraunhofer patterns pinpoints the ferromagnetism on the junction interface. More importantly, a stochastic field-free superconducting diode effect was observed in Josephson junction devices, with a significant diode efficiency up to 10%, which unambiguously confirms the spontaneous time-reversal symmetry breaking. Our work demonstrates a new way to search for topological superconductivity in iron-based superconductors for future high T
Language	English
Publishing date	2023-10-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-42447-4
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Article ; Online: Nonlinear optical diode effect in a magnetic Weyl semimetal.

Nature communications

2024 Volume 15, Issue 1, Page(s) 3017

Abstract: Diode effects are of great interest for both fundamental physics and modern technologies. Electrical diode effects (nonreciprocal transport) have been observed in Weyl systems. Optical diode effects arising from the Weyl fermions have been theoretically ... ...

Abstract	Diode effects are of great interest for both fundamental physics and modern technologies. Electrical diode effects (nonreciprocal transport) have been observed in Weyl systems. Optical diode effects arising from the Weyl fermions have been theoretically considered but not probed experimentally. Here, we report the observation of a nonlinear optical diode effect (NODE) in the magnetic Weyl semimetal CeAlSi, where the magnetization introduces a pronounced directionality in the nonlinear optical second-harmonic generation (SHG). We demonstrate a six-fold change of the measured SHG intensity between opposite propagation directions over a bandwidth exceeding 250 meV. Supported by density-functional theory, we establish the linearly dispersive bands emerging from Weyl nodes as the origin of this broadband effect. We further demonstrate current-induced magnetization switching and thus electrical control of the NODE. Our results advance ongoing research to identify novel nonlinear optical/transport phenomena in magnetic topological materials and further opens new pathways for the unidirectional manipulation of light.
Language	English
Publishing date	2024-04-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-47291-8
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Book ; Online: Stripe Helical Magnetism and Two Regimes of Anomalous Hall Effect in NdAlGe

Yang, Hung-Yu / Gaudet, Jonathan / Verma, Rahul / Baidya, Santu / Bahrami, Faranak / Yao, Xiaohan / Huang, Cheng-Yi / DeBeer-Schmitt, Lisa / Aczel, Adam A. / Xu, Guangyong / Lin, Hsin / Bansil, Arun / Singh, Bahadur / Tafti, Fazel

2023

Abstract: We report the magnetic and electronic transport properties of the inversion and time-reversal symmetry breaking Weyl semimetal NdAlGe. This material is analogous to NdAlSi, whose helical magnetism presents a rare example of a Weyl-mediated collective ... ...

Abstract	We report the magnetic and electronic transport properties of the inversion and time-reversal symmetry breaking Weyl semimetal NdAlGe. This material is analogous to NdAlSi, whose helical magnetism presents a rare example of a Weyl-mediated collective phenomenon, but with a larger spin-orbit coupling. Our neutron diffraction experiments revealed that NdAlGe, similar to NdAlSi, supports an incommensurate Ising spin density wave ($T_{\text{inc}}=6.8$ K) with a small helical spin canting of 3$^\circ$ and a long-wavelength of $\sim$ 35 nm, which transitions to a commensurate ferrimagnetic state below $T_{\text{com}}=5.1$ K. Using small-angle neutron scattering, we showed that the zero-field cooled ferrimagnetic domains form stripes in real space with characteristic length scales of 18 nm and 72 nm parallel and perpendicular to the [110] direction, respectively. Interestingly, for the transport properties, NdAlSi does not exhibit an anomalous Hall effect (AHE) that is commonly observed in magnetic Weyl semimetals. In contrast to NdAlSi, we identify two different AHE regimes in NdAlGe that are respectively governed by intrinsic Berry curvature and extrinsic disorders/spin fluctuations. Our study suggests that Weyl-mediated magnetism prevails in this group of noncentrosymmetric magnetic Weyl semimetals NdAl$X$, but transport properties including AHE are affected by material-specific extrinsic effects such as disorders, despite the presence of prominent Berry curvature. Comment: Preprint, 16 pages, 6 main figures, 6 supplementary figures
Keywords	Condensed Matter - Materials Science ; Condensed Matter - Mesoscale and Nanoscale Physics ; Condensed Matter - Strongly Correlated Electrons
Subject code	530
Publishing date	2023-01-12
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Concurrent Ferromagnetism and Superconductivity in Fe(Te,Se) van der Waals Josephson Junctions

Qiu, Gang / Yang, Hung-Yu / Hu, Lunhui / Zhang, Huairuo / Chen, Chih-Yen / Lyu, Yanfeng / Eckberg, Christopher / Deng, Peng / Krylyuk, Sergiy / Davydov, Albert V. / Zhang, Ruixing / Wang, Kang L.

2023

Abstract: Ferromagnetism and superconductivity are two key ingredients to create non-Abelian quasiparticle excitations that are expected as building blocks to construct topological quantum computers. Adversely, ferromagnetism and superconductivity are typically ... ...

Abstract	Ferromagnetism and superconductivity are two key ingredients to create non-Abelian quasiparticle excitations that are expected as building blocks to construct topological quantum computers. Adversely, ferromagnetism and superconductivity are typically also two hostile orderings competing to align spins in different configurations, making the material design and experimental implementation extremely challenging. Recently, iron-based superconductor Fe(Te,Se) has emerged as a connate topological superconductor (TSC), which differentiates itself from other hybrid TSCs by self-proximitizing its Dirac surface states with bulk superconductivity. So far, the efforts to search for Majorana states in this material are prevalently focused on spectroscopy techniques. In this paper, we present the global transport signature of interfacial magnetism coexisting with superconductivity. Time-reversal symmetry breaking superconducting states are confirmed through device level transport measurements for the first time in a van der Waals (vdW) Josephson junction structure. Magnetic hysteresis is observed in this device scheme, which only appears below the superconducting critical temperature, leading to potential Fulde-Ferrell (FF) superconducting pairing mechanisms. The 0-{\pi} phase mixing in the Fraunhofer patterns pinpoints the ferromagnetic state dwelling on the surface. Furthermore, a stochastic field-free superconducting diode effect also confirms the spontaneous time-reversal symmetry breaking which reflects the behavior of the ferromagnetism. Our work paves a new way to explore topological superconductivity in iron-based superconductors for future high Tc fault-tolerant qubit implementations from a device perspective. Comment: 23 pages, 5 figures
Keywords	Condensed Matter - Superconductivity ; Condensed Matter - Materials Science
Subject code	539
Publishing date	2023-03-01
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: WMJ-S-001, a Novel Aliphatic Hydroxamate-Based Compound, Suppresses Lymphangiogenesis Through p38mapk-p53-survivin Signaling Cascade.

Huang, Shiu-Wen / Yang, Hung-Yu / Huang, Wei-Jan / Chen, Wei-Chuan / Yu, Meng-Chieh / Wang, Shih-Wei / Hsu, Ya-Fen / Hsu, Ming-Jen

Frontiers in oncology

2019 Volume 9, Page(s) 1188

Abstract: Background and purpose: ...

Abstract	Background and purpose:
Language	English
Publishing date	2019-11-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2019.01188
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Article: Weyl-mediated helical magnetism in NdAlSi.

Gaudet, Jonathan / Yang, Hung-Yu / Baidya, Santu / Lu, Baozhu / Xu, Guangyong / Zhao, Yang / Rodriguez-Rivera, Jose A / Hoffmann, Christina M / Graf, David E / Torchinsky, Darius H / Nikolić, Predrag / Vanderbilt, David / Tafti, Fazel / Broholm, Collin L

Nature materials

2021 Volume 20, Issue 12, Page(s) 1650–1656

Abstract: Emergent relativistic quasiparticles in Weyl semimetals are the source of exotic electronic properties such as surface Fermi arcs, the anomalous Hall effect and negative magnetoresistance, all observed in real materials. Whereas these phenomena highlight ...

Abstract	Emergent relativistic quasiparticles in Weyl semimetals are the source of exotic electronic properties such as surface Fermi arcs, the anomalous Hall effect and negative magnetoresistance, all observed in real materials. Whereas these phenomena highlight the effect of Weyl fermions on the electronic transport properties, less is known about what collective phenomena they may support. Here, we report a Weyl semimetal, NdAlSi, that offers an example. Using neutron diffraction, we found a long-wavelength helical magnetic order in NdAlSi, the periodicity of which is linked to the nesting vector between two topologically non-trivial Fermi pockets, which we characterize using density functional theory and quantum oscillation measurements. We further show the chiral transverse component of the spin structure is promoted by bond-oriented Dzyaloshinskii-Moriya interactions associated with Weyl exchange processes. Our work provides a rare example of Weyl fermions driving collective magnetism.
Language	English
Publishing date	2021-08-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2088679-2
ISSN	1476-4660 ; 1476-1122
ISSN (online)	1476-4660
ISSN	1476-1122
DOI	10.1038/s41563-021-01062-8
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Article ; Online: Thermodynamic Evidence of Proximity to a Kitaev Spin Liquid in Ag_{3}LiIr_{2}O_{6}.

Bahrami, Faranak / Lafargue-Dit-Hauret, William / Lebedev, Oleg I / Movshovich, Roman / Yang, Hung-Yu / Broido, David / Rocquefelte, Xavier / Tafti, Fazel

Physical review letters

2019 Volume 123, Issue 23, Page(s) 237203

Abstract: Kitaev magnets are materials with bond-dependent Ising interactions between localized spins on a honeycomb lattice. Such interactions could lead to a quantum spin-liquid (QSL) ground state at zero temperature. Recent theoretical studies suggest two ... ...

Abstract	Kitaev magnets are materials with bond-dependent Ising interactions between localized spins on a honeycomb lattice. Such interactions could lead to a quantum spin-liquid (QSL) ground state at zero temperature. Recent theoretical studies suggest two potential signatures of a QSL at finite temperatures, namely, a scaling behavior of thermodynamic quantities in the presence of quenched disorder, and a two-step release of the magnetic entropy. Here, we present both signatures in Ag_{3}LiIr_{2}O_{6} which is synthesized from α-Li_{2}IrO_{3} by replacing the interlayer Li atoms with Ag atoms. In addition, the dc susceptibility data confirm the absence of a long-range order, and the ac susceptibility data rule out a spin-glass transition. These observations suggest a closer proximity to the QSL in Ag_{3}LiIr_{2}O_{6} compared to its parent compound α-Li_{2}IrO_{3} that orders at 15 K. We discuss an enhanced spin-orbit coupling due to a mixing between silver d and oxygen p orbitals as a potential underlying mechanism.
Language	English
Publishing date	2019-12-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.123.237203
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