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  1. Article ; Online: 영상의학과의 한글 명칭과 한글 의학용어의 변천 과정: 의학용어집 제6판의 출간에 붙임.

    Yang, Ik

    Taehan Yongsang Uihakhoe chi

    2020  Volume 82, Issue 1, Page(s) 66–81

    Abstract: The author was a member of the Medical Terminology Committee of the Korean Society of Radiology and the Korean Medical Association Working Committee on Medical Terms for the publication of the sixth edition of the Korean Medical Association. The author ... ...

    Title translation Transition of the Korean Name for the Department of Radiology and Korean Medical Terminology: A Note Ahead of Publication for the Sixth Edition of the Korean Medical Terminology.
    Abstract The author was a member of the Medical Terminology Committee of the Korean Society of Radiology and the Korean Medical Association Working Committee on Medical Terms for the publication of the sixth edition of the Korean Medical Association. The author participated in the revision of the sixth-edition medical terminology from July 2015 to January 2020. Based on that experience, this special article was written to share the changes in the Korean medical terminology and the name of the department of radiology.
    Language Korean
    Publishing date 2020-09-15
    Publishing country Korea (South)
    Document type English Abstract ; Journal Article ; Review
    ISSN 2288-2928
    ISSN (online) 2288-2928
    DOI 10.3348/jksr.2020.0088
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  2. Article ; Online: Biomimic Zwitterionic Polyamide/Polyurethane Elastic Blending Fabrics.

    Chou, Ying-Nien / Yang, I-Hsun

    Biomimetics (Basel, Switzerland)

    2023  Volume 8, Issue 2

    Abstract: This study developed an epoxy-type biomimic zwitterionic copolymer, poly(glycidyl methacrylate) (PGMA)-poly(sulfobetaine acrylamide) (SBAA) (poly(GMA-co-SBAA)), to modify the surface of polyamide elastic fabric using a hydroxylated pretreatment ... ...

    Abstract This study developed an epoxy-type biomimic zwitterionic copolymer, poly(glycidyl methacrylate) (PGMA)-poly(sulfobetaine acrylamide) (SBAA) (poly(GMA-co-SBAA)), to modify the surface of polyamide elastic fabric using a hydroxylated pretreatment zwitterionic copolymer and dip-coating method. X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy confirmed successful grafting, while scanning electron microscopy revealed changes in the surface pattern. Optimization of coating conditions included controlling reaction temperature, solid concentration, molar ratio, and base catalysis. The modified fabric exhibited good biocompatibility and anti-biofouling performance, as evidenced by contact angle measurements and evaluation of protein adsorption, blood cell, and bacterial attachment. This simple, cost-effective zwitterionic modification technology has high commercial value and is a promising approach for surface modification of biomedical materials.
    Language English
    Publishing date 2023-05-10
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2313-7673
    ISSN (online) 2313-7673
    DOI 10.3390/biomimetics8020198
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  3. Article ; Online: Predicting RNA splicing from DNA sequence using Pangolin

    Tony Zeng / Yang I Li

    Genome Biology, Vol 23, Iss 1, Pp 1-

    2022  Volume 18

    Abstract: Abstract Recent progress in deep learning has greatly improved the prediction of RNA splicing from DNA sequence. Here, we present Pangolin, a deep learning model to predict splice site strength in multiple tissues. Pangolin outperforms state-of-the-art ... ...

    Abstract Abstract Recent progress in deep learning has greatly improved the prediction of RNA splicing from DNA sequence. Here, we present Pangolin, a deep learning model to predict splice site strength in multiple tissues. Pangolin outperforms state-of-the-art methods for predicting RNA splicing on a variety of prediction tasks. Pangolin improves prediction of the impact of genetic variants on RNA splicing, including common, rare, and lineage-specific genetic variation. In addition, Pangolin identifies loss-of-function mutations with high accuracy and recall, particularly for mutations that are not missense or nonsense, demonstrating remarkable potential for identifying pathogenic variants.
    Keywords Biology (General) ; QH301-705.5 ; Genetics ; QH426-470
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
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  4. Article ; Online: Patient Sex Mediates the Influence of Patient Age on Superior Canal Dehiscence Repair Outcome.

    Yang, Hong-Ho / Yang, Isaac / Gopen, Quinton S

    The Laryngoscope

    2024  

    Abstract: Objective: To investigate the independent and interactive effects of patient age and sex on superior canal dehiscence (SCD) repair outcomes.: Methods: This was a cohort study of consecutive SCD repairs via the middle fossa approach at an institution ... ...

    Abstract Objective: To investigate the independent and interactive effects of patient age and sex on superior canal dehiscence (SCD) repair outcomes.
    Methods: This was a cohort study of consecutive SCD repairs via the middle fossa approach at an institution between 2011 and 2022. We constructed multivariable regression models assessing surgical outcomes with age and sex as the primary predictors. Models controlled for surgery duration, follow-up duration, and relevant surgical and medical history. Subsequently, we repeated each model with the incorporation of an interaction term between patient age and sex.
    Results: Among 402 repairs, average age was 50 years, and 63% of cases were females. There was a significant interaction between patient age and sex with respect to symptom resolution score (SRS) (adj. β 0.80, 95% C.I. 0.04-1.56). Older age was associated with lower SRS among females (-0.84, -1.29 to -0.39 point per year) but not significantly associated with SRS among males (0.04, -0.65 to 0.56 point per year). Furthermore, older age independently predicted a greater magnitude of increase in air conduction at 8000 Hz following surgery regardless of sex (adj. β 2.1, 0.2-4.0 dB per 10-year increase).
    Conclusions: This is the first study on the interactive effect between patient age and sex with respect to SCD repair outcomes. Older age predicted poorer symptomatic response among female patients but did not predict symptomatic response among male patients. Furthermore, older age predicted more severe high-frequency hearing loss following SCD repairs among both female and male patients.
    Level of evidence: 3 Laryngoscope, 2024.
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.31356
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  5. Article ; Online: Predicting RNA splicing from DNA sequence using Pangolin.

    Zeng, Tony / Li, Yang I

    Genome biology

    2022  Volume 23, Issue 1, Page(s) 103

    Abstract: Recent progress in deep learning has greatly improved the prediction of RNA splicing from DNA sequence. Here, we present Pangolin, a deep learning model to predict splice site strength in multiple tissues. Pangolin outperforms state-of-the-art methods ... ...

    Abstract Recent progress in deep learning has greatly improved the prediction of RNA splicing from DNA sequence. Here, we present Pangolin, a deep learning model to predict splice site strength in multiple tissues. Pangolin outperforms state-of-the-art methods for predicting RNA splicing on a variety of prediction tasks. Pangolin improves prediction of the impact of genetic variants on RNA splicing, including common, rare, and lineage-specific genetic variation. In addition, Pangolin identifies loss-of-function mutations with high accuracy and recall, particularly for mutations that are not missense or nonsense, demonstrating remarkable potential for identifying pathogenic variants.
    MeSH term(s) Animals ; Base Sequence ; Mutation ; Pangolins ; RNA Splice Sites ; RNA Splicing
    Chemical Substances RNA Splice Sites
    Language English
    Publishing date 2022-04-21
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2040529-7
    ISSN 1474-760X ; 1474-760X
    ISSN (online) 1474-760X
    ISSN 1474-760X
    DOI 10.1186/s13059-022-02664-4
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  6. Article: Predicting RNA splicing from DNA sequence using Pangolin

    Zeng, Tony / Li, Yang I

    Genome biology. 2022 Dec., v. 23, no. 1

    2022  

    Abstract: Recent progress in deep learning has greatly improved the prediction of RNA splicing from DNA sequence. Here, we present Pangolin, a deep learning model to predict splice site strength in multiple tissues. Pangolin outperforms state-of-the-art methods ... ...

    Abstract Recent progress in deep learning has greatly improved the prediction of RNA splicing from DNA sequence. Here, we present Pangolin, a deep learning model to predict splice site strength in multiple tissues. Pangolin outperforms state-of-the-art methods for predicting RNA splicing on a variety of prediction tasks. Pangolin improves prediction of the impact of genetic variants on RNA splicing, including common, rare, and lineage-specific genetic variation. In addition, Pangolin identifies loss-of-function mutations with high accuracy and recall, particularly for mutations that are not missense or nonsense, demonstrating remarkable potential for identifying pathogenic variants.
    Keywords RNA ; genetic variation ; genome ; loss-of-function mutation ; models ; nucleotide sequences ; prediction
    Language English
    Dates of publication 2022-12
    Size p. 103.
    Publishing place BioMed Central
    Document type Article
    ZDB-ID 2040529-7
    ISSN 1474-760X
    ISSN 1474-760X
    DOI 10.1186/s13059-022-02664-4
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  7. Article ; Online: Genetic and molecular architecture of complex traits.

    Lappalainen, Tuuli / Li, Yang I / Ramachandran, Sohini / Gusev, Alexander

    Cell

    2024  Volume 187, Issue 5, Page(s) 1059–1075

    Abstract: Human genetics has emerged as one of the most dynamic areas of biology, with a broadening societal impact. In this review, we discuss recent achievements, ongoing efforts, and future challenges in the field. Advances in technology, statistical methods, ... ...

    Abstract Human genetics has emerged as one of the most dynamic areas of biology, with a broadening societal impact. In this review, we discuss recent achievements, ongoing efforts, and future challenges in the field. Advances in technology, statistical methods, and the growing scale of research efforts have all provided many insights into the processes that have given rise to the current patterns of genetic variation. Vast maps of genetic associations with human traits and diseases have allowed characterization of their genetic architecture. Finally, studies of molecular and cellular effects of genetic variants have provided insights into biological processes underlying disease. Many outstanding questions remain, but the field is well poised for groundbreaking discoveries as it increases the use of genetic data to understand both the history of our species and its applications to improve human health.
    MeSH term(s) Humans ; Genetic Variation ; Multifactorial Inheritance ; Phenotype ; Human Genetics
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2024.01.023
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  8. Book ; Online: Distributionally Robust Differential Dynamic Programming with Wasserstein Distance

    Hakobyan, Astghik / Yang, Insoon

    2023  

    Abstract: Differential dynamic programming (DDP) is a popular technique for solving nonlinear optimal control problems with locally quadratic approximations. However, existing DDP methods are not designed for stochastic systems with unknown disturbance ... ...

    Abstract Differential dynamic programming (DDP) is a popular technique for solving nonlinear optimal control problems with locally quadratic approximations. However, existing DDP methods are not designed for stochastic systems with unknown disturbance distributions. To address this limitation, we propose a novel DDP method that approximately solves the Wasserstein distributionally robust control (WDRC) problem, where the true disturbance distribution is unknown but a disturbance sample dataset is given. Our approach aims to develop a practical and computationally efficient DDP solution. To achieve this, we use the Kantrovich duality principle to decompose the value function in a novel way and derive closed-form expressions of the distributionally robust control and worst-case distribution policies to be used in each iteration of our DDP algorithm. This characterization makes our method tractable and scalable without the need for numerically solving any minimax optimization problems. The superior out-of-sample performance and scalability of our algorithm are demonstrated through kinematic car navigation and coupled oscillator problems.
    Keywords Electrical Engineering and Systems Science - Systems and Control ; Mathematics - Optimization and Control
    Subject code 510
    Publishing date 2023-05-16
    Publishing country us
    Document type Book ; Online
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  9. Article ; Online: Audiometric Outcomes After the Middle Cranial Fossa Repair of Superior Semicircular Canal Dehiscence.

    Yang, Hong-Ho / Yang, Isaac / Gopen, Quinton S

    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

    2023  Volume 44, Issue 6, Page(s) 593–599

    Abstract: Objective: To evaluate the audiometric outcomes after the middle cranial fossa approach (MCF) for superior canal dehiscence (SCD) repair.: Study design: Retrospective review.: Setting: Tertiary referral center.: Patients: SCD cases presented to ...

    Abstract Objective: To evaluate the audiometric outcomes after the middle cranial fossa approach (MCF) for superior canal dehiscence (SCD) repair.
    Study design: Retrospective review.
    Setting: Tertiary referral center.
    Patients: SCD cases presented to a single institution between 2012 and 2022.
    Interventions: The MCF repair of SCD.
    Main outcome measures: Air conduction (AC) threshold (250-8,000 Hz), bone conduction threshold (BC) (250-4,000 Hz), and air bone gap (ABG) (250-4,000 Hz) at each frequency, pure tone average (PTA) (500, 1,000, 2,000, 3,000 Hz).
    Results: Among 202 repairs, 57% were bilateral SCD disease and 9% had previous surgery on the affected ear. The approach significantly narrowed ABG at 250, 500, and 1,000 Hz. The narrowing of ABG was achieved by both decreased AC and increased BC at 250 Hz, but mediated primarily by increased BC at 500 Hz and 1,000 Hz. Among cases without previous ear surgery, mean PTA remained in the normal hearing range (mean: preop, 21 dB; postop, 24 dB) and clinically important hearing loss (PTA increased by ≥10 dB) after the approach was noted in 15% of cases. Among cases with previous ear surgery, mean PTA remained in the mild hearing loss range (mean: preop, 33 dB; postop, 35 dB) and clinically important hearing loss after the approach was noted in 5% of cases.
    Conclusion: This is the largest study to date examining the audiometric outcomes after the middle cranial fossa approach for SCD repair. Findings of this investigation support that the approach is effective and safe with long-term hearing preservation for most.
    MeSH term(s) Humans ; Semicircular Canal Dehiscence ; Cranial Fossa, Middle/surgery ; Audiometry, Pure-Tone ; Hearing ; Hearing Loss/surgery ; Retrospective Studies ; Treatment Outcome ; Semicircular Canals/surgery
    Language English
    Publishing date 2023-05-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2036790-9
    ISSN 1537-4505 ; 1531-7129
    ISSN (online) 1537-4505
    ISSN 1531-7129
    DOI 10.1097/MAO.0000000000003905
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  10. Article ; Online: Current Role and Potential of Polymeric Biomaterials in Clinical Obesity Treatment.

    Tang, Rui-Chian / Yang, I-Hsuan / Lin, Feng-Huei

    Biomacromolecules

    2023  Volume 24, Issue 8, Page(s) 3438–3449

    Abstract: The rise of obesity and associated fatal diseases has taken a massive toll worldwide. Despite the existing pharmaceuticals and bariatric surgeries, these approaches manifest limited efficacy or accompany various side effects. Therefore, researchers seek ... ...

    Abstract The rise of obesity and associated fatal diseases has taken a massive toll worldwide. Despite the existing pharmaceuticals and bariatric surgeries, these approaches manifest limited efficacy or accompany various side effects. Therefore, researchers seek to facilitate the prolonged and specific delivery of therapeutics. Or else, to mimic the essential part of "gastric bypass" by physically blocking excessive absorption via less invasive methods. To achieve these goals, polymeric biomaterials have gained tremendous interest recently. They are known for synthesizing hydrogels, microneedle patches, mucoadhesive coatings, polymer conjugates, and so forth. In this Review, we provide insights into the current studies of polymeric biomaterials in the prevention and treatment of obesity, inspiring future improvements in this regime of study.
    MeSH term(s) Humans ; Biocompatible Materials ; Obesity/drug therapy ; Drug Delivery Systems/methods ; Hydrogels/therapeutic use ; Polymers/therapeutic use
    Chemical Substances Biocompatible Materials ; Hydrogels ; Polymers
    Language English
    Publishing date 2023-07-13
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 1526-4602
    ISSN (online) 1526-4602
    DOI 10.1021/acs.biomac.3c00388
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