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  1. Book ; Online ; E-Book: Targeting autophagy in cancer therapy

    Yang, Jin-Ming

    (Current cancer research)

    2016  

    Author's details Jin-Ming Yang editor
    Series title Current cancer research
    Keywords Neoplasms / genetics ; Neoplasms / therapy ; Autophagy / drug effects ; Antineoplastic Agents / therapeutic use
    Language English
    Size 1 Online-Ressource (vii, 141 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019436148
    ISBN 978-3-319-42740-9 ; 9783319427386 ; 3-319-42740-7 ; 3319427385
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: TMSOTf-Promoted Cyclization of Indole-2-methyl-α-aminoketones: Access to 4-Aryl-Substituted β-Carbolines.

    Yang, Xin-Yu / Yang, Jin-Ming / Wu, Bin

    Organic letters

    2024  Volume 26, Issue 5, Page(s) 1105–1109

    Abstract: An efficient method to construct 4-aryl-substituted β-carbolines from indole-2-methyl-α-aminoketones via a TMSOTf-promoted annulation reaction was reported. High yield along with wide substrate scope and functional group tolerance make this reaction ... ...

    Abstract An efficient method to construct 4-aryl-substituted β-carbolines from indole-2-methyl-α-aminoketones via a TMSOTf-promoted annulation reaction was reported. High yield along with wide substrate scope and functional group tolerance make this reaction applicable to build various highly potential bioactive β-carboline derivatives.
    Language English
    Publishing date 2024-01-30
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.3c04382
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cascade hydroarylation/Diels-Alder cycloaddition of alkynylindoles with electron-deficient alkynes and alkenes.

    Feng, Guang-Chao / Li, Jun-Chi / Huang, Xiang / Liu, Ji-Kai / Wu, Bin / Yang, Jin-Ming

    Chemical communications (Cambridge, England)

    2024  Volume 60, Issue 3, Page(s) 328–331

    Abstract: Herein, a novel cascade gold(I)-catalyzed hydroarylation of alkynylindoles and subsequent Diels-Alder cycloaddition with electron-deficient alkynes and alkenes is described. A variety of azepino-fused hydrocarbazoles and carbazoles were obtained in ... ...

    Abstract Herein, a novel cascade gold(I)-catalyzed hydroarylation of alkynylindoles and subsequent Diels-Alder cycloaddition with electron-deficient alkynes and alkenes is described. A variety of azepino-fused hydrocarbazoles and carbazoles were obtained in moderate to excellent yields. Key features of this methodology are low catalyst loadings, high regioselectivity, broad functional group tolerances, access to important heterocycles, and 100% atom economy.
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc05210a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Role and clinical implication of autophagy in COVID-19.

    Shan, Tianjiao / Li, Lan-Ya / Yang, Jin-Ming / Cheng, Yan

    Virology journal

    2023  Volume 20, Issue 1, Page(s) 125

    Abstract: The ongoing coronavirus disease 2019 (COVID-19) pandemic constitutes a serious public health concern worldwide. Currently, more than 6 million deaths have occurred despite drastic containment measures, and this number is still increasing. Currently, no ... ...

    Abstract The ongoing coronavirus disease 2019 (COVID-19) pandemic constitutes a serious public health concern worldwide. Currently, more than 6 million deaths have occurred despite drastic containment measures, and this number is still increasing. Currently, no standard therapies for COVID-19 are available, which necessitates identifying effective preventive and therapeutic agents against COVID-19. However, developing new drugs and vaccines is a time-consuming process, and therefore, repurposing the existing drugs or redeveloping related targets seems to be the best strategy to develop effective therapeutics against COVID-19. Autophagy, a multistep lysosomal degradation pathway contributing to nutrient recycling and metabolic adaptation, is involved in the initiation and progression of numerous diseases as a part of an immune response. The key role of autophagy in antiviral immunity has been extensively studied. Moreover, autophagy can directly eliminate intracellular microorganisms by selective autophagy, that is, "xenophagy." However, viruses have acquired diverse strategies to exploit autophagy for their infection and replication. This review aims to trigger the interest in the field of autophagy as an antiviral target for viral pathogens (with an emphasis on COVID-19). We base this hypothesis on summarizing the classification and structure of coronaviruses as well as the process of SARS-CoV-2 infection and replication; providing the common understanding of autophagy; reviewing interactions between the mechanisms of viral entry/replication and the autophagy pathways; and discussing the current state of clinical trials of autophagy-modifying drugs in the treatment of SARS-CoV-2 infection. We anticipate that this review will contribute to the rapid development of therapeutics and vaccines against COVID-19.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; COVID-19 Vaccines ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Antiviral Agents/chemistry ; Autophagy
    Chemical Substances COVID-19 Vaccines ; Antiviral Agents
    Language English
    Publishing date 2023-06-16
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2160640-7
    ISSN 1743-422X ; 1743-422X
    ISSN (online) 1743-422X
    ISSN 1743-422X
    DOI 10.1186/s12985-023-02069-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Correction to "Iron-Mediated Reductive Amidation of Triazine Esters with Nitroarenes".

    Wang, Qing-Dong / Liu, Xiang / Zheng, Ya-Wen / Wu, Yuan-Shuai / Zhou, Xiaocong / Yang, Jin-Ming / Shen, Zhi-Liang

    Organic letters

    2024  Volume 26, Issue 5, Page(s) 1122

    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Published Erratum
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.4c00259
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Rhodium(III)-catalyzed intermolecular [3+3] annulation of benzoxazines with quinone compounds: access to spiro-heterocyclic scaffolds.

    Wei, Qing-Yi / Zhou, Ze / Yao, Meng-Lian / Liu, Ji-Kai / Wu, Bin / Yang, Jin-Ming

    Chemical communications (Cambridge, England)

    2023  Volume 59, Issue 77, Page(s) 11520–11523

    Abstract: A rhodium(III)-catalyzed redox-neutral spiroannulation approach to access the spiro[benzo[ ...

    Abstract A rhodium(III)-catalyzed redox-neutral spiroannulation approach to access the spiro[benzo[
    Language English
    Publishing date 2023-09-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc03609j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book: Targeting autophagy in cancer therapy

    Yang, Jin-Ming

    (Current cancer research,)

    2016  

    Author's details Jin-Ming Yang, editor
    Series title Current cancer research,
    MeSH term(s) Neoplasms/genetics ; Neoplasms/therapy ; Autophagy/drug effects ; Antineoplastic Agents/therapeutic use
    Language English
    Size vii, 141 pages :, illustrations.
    Document type Book
    ISBN 9783319427386 ; 9783319427409 ; 3319427385 ; 3319427407
    Database Catalogue of the US National Library of Medicine (NLM)

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  8. Article: Access to Azepino-Annulated Benzo[c]carbazoles Enabled by Gold-Catalyzed Hydroarylation of Alkynylindoles and Subsequent Oxidative Cyclization

    Yang, Jin-Ming / Yao, Meng-Lian / Li, Jun-Chi / Liu, Ji-Kai / Wu, Bin

    Organic letters. 2022 Sept. 01, v. 24, no. 36

    2022  

    Abstract: Herein, we report a facile and efficient synthetic method to construct azepino[1,2-a]indoles through a novel gold(I)-catalyzed intramolecular hydroarylation of alkynylindoles. A wide range of functional groups can be well tolerated in this transformation, ...

    Abstract Herein, we report a facile and efficient synthetic method to construct azepino[1,2-a]indoles through a novel gold(I)-catalyzed intramolecular hydroarylation of alkynylindoles. A wide range of functional groups can be well tolerated in this transformation, and the corresponding highly functionalized azepino[1,2-a]indole skeletons were obtained in moderate to excellent yields. Subsequent oxidation of the products gave the interesting and valuable polycyclic carbazoles, which were widely used as the key building blocks in materials science.
    Keywords carbazoles ; gold ; indoles ; oxidation
    Language English
    Dates of publication 2022-0901
    Size p. 6505-6509.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1523-7052
    DOI 10.1021/acs.orglett.2c02293
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Access to Azepino-Annulated Benzo[

    Yang, Jin-Ming / Yao, Meng-Lian / Li, Jun-Chi / Liu, Ji-Kai / Wu, Bin

    Organic letters

    2022  Volume 24, Issue 36, Page(s) 6505–6509

    Abstract: Herein, we report a facile and efficient synthetic method to construct azepino[1,2- ...

    Abstract Herein, we report a facile and efficient synthetic method to construct azepino[1,2-
    Language English
    Publishing date 2022-09-01
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.2c02293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Spatiotemporal evolution of NO

    Zhang, Zhe / He, Hong-Di / Yang, Jin-Ming / Wang, Hong-Wei / Xue, Yu / Peng, Zhong-Ren

    Chemosphere

    2022  Volume 293, Page(s) 133631

    Abstract: The COVID-19 pandemic and the corresponding lockdown measures have been confirmed to reduce the air pollution in major megacities worldwide. Especially at some monitoring hotspots, ... ...

    Abstract The COVID-19 pandemic and the corresponding lockdown measures have been confirmed to reduce the air pollution in major megacities worldwide. Especially at some monitoring hotspots, NO
    MeSH term(s) Air Pollutants/analysis ; Air Pollution/analysis ; Beijing ; COVID-19 ; Cities ; Communicable Disease Control ; Environmental Monitoring ; Humans ; Nitrogen Dioxide/analysis ; Pandemics ; Particulate Matter/analysis ; SARS-CoV-2
    Chemical Substances Air Pollutants ; Particulate Matter ; Nitrogen Dioxide (S7G510RUBH)
    Language English
    Publishing date 2022-01-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2022.133631
    Database MEDical Literature Analysis and Retrieval System OnLINE

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