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  1. Article: Molecular mechanism of Hedyotis Diffusae Herba in the treatment of lupus nephritis based on network pharmacology.

    Yang, Jinfei / Li, Siying

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1118804

    Abstract: Aims: ...

    Abstract Aims:
    Language English
    Publishing date 2023-06-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1118804
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Design, synthesis and biological evaluation of Nrf2 modulators for the treatment of glioblastoma multiforme.

    Yang, Huihui / Song, Peilu / Li, Baohu / Li, Shutang / Yang, Jinfei

    Bioorganic & medicinal chemistry

    2024  Volume 103, Page(s) 117684

    Abstract: Glioblastoma multiforme (GBM) is a prevalent primary brain tumor. However, no specific therapeutic drug has been developed for it. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a crucial transcription factor involved in the cellular response to ... ...

    Abstract Glioblastoma multiforme (GBM) is a prevalent primary brain tumor. However, no specific therapeutic drug has been developed for it. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a crucial transcription factor involved in the cellular response to oxidative stress. Numerous studies have demonstrated that Nrf2 plays a pivotal role in GBM angiogenesis, and inhibiting Nrf2 can significantly enhance patient prognosis. Using virtual screening technology, we examined our in-house library and identified pinosylvin as a potential compound with high activity. Pinosylvin exhibited robust hydrogen bond and Π-Π interaction with Nrf2. Cell experiments revealed that pinosylvin effectively reduced the proliferation of U87 tumor cells by regulating Nrf2 and demonstrated greater inhibitory activity than temozolomide. Consequently, we believe that this study will offer valuable guidance for the future development of highly efficient therapeutic drugs for GBM.
    MeSH term(s) Humans ; Glioblastoma/drug therapy ; Glioblastoma/pathology ; NF-E2-Related Factor 2 ; Cell Line, Tumor ; Temozolomide ; Brain Neoplasms/drug therapy ; Brain Neoplasms/pathology ; Phytoalexins ; Stilbenes
    Chemical Substances pinosylvin (881R434AIB) ; NF-E2-Related Factor 2 ; Temozolomide (YF1K15M17Y) ; Phytoalexins ; Stilbenes
    Language English
    Publishing date 2024-03-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1161284-8
    ISSN 1464-3391 ; 0968-0896
    ISSN (online) 1464-3391
    ISSN 0968-0896
    DOI 10.1016/j.bmc.2024.117684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3815: Show issues Location:
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  3. Article ; Online: Current emerging novel therapies for Alzheimer's disease and the future prospects of magneto-mechanical force therapy.

    Shen, Yajing / Wang, Meng / Li, Shutang / Yang, Jinfei

    Journal of materials chemistry. B

    2023  Volume 11, Issue 39, Page(s) 9404–9418

    Abstract: Alzheimer's disease (AD) is the most common neurodegenerative disease among the elderly, and the morbidity increases with the aging population aggravation. The clinical symptoms of AD mainly include cognitive impairment and memory loss, which undoubtedly ...

    Abstract Alzheimer's disease (AD) is the most common neurodegenerative disease among the elderly, and the morbidity increases with the aging population aggravation. The clinical symptoms of AD mainly include cognitive impairment and memory loss, which undoubtedly bring a huge burden to families and society. Currently, the drugs in clinical use only improve the symptoms of AD but do not cure or prevent the progression of the disease. Therefore, it is urgent for us to develop novel therapeutic strategies for effective AD treatment. To provide a better theoretical basis for exploring novel therapeutic strategies in future AD treatment, this review introduces the recent AD treatment technologies from three aspects, including nanoparticle (NP) based drug therapy, biological therapy and physical therapy. The nanoparticle-mediated therapeutic approaches at the nanomaterial-neural interface and biological system are described in detail, and in particular the magneto-regulated strategies by magnetic field actuating magnetic nanoparticles are highlighted. Promising application of magneto-mechanical force regulated strategy in future AD treatment is also addressed, which offer possibilities for the remote manipulation in a precise manner. In the future, it may be possible for physicians to realize a remote, precise and effective therapy for AD using magneto-mechanical force regulated technology based on the combination of magnetic nanoparticles and an external magnetic field.
    MeSH term(s) Humans ; Aged ; Alzheimer Disease/drug therapy ; Alzheimer Disease/diagnosis ; Neurodegenerative Diseases
    Language English
    Publishing date 2023-10-11
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/d3tb01629c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Overview of the development of HBV small molecule inhibitors.

    Yang, Huihui / Yao, Weiwei / Yang, Jinfei

    European journal of medicinal chemistry

    2023  Volume 249, Page(s) 115128

    Abstract: Like tuberculosis and Acquired Immune Deficiency Syndrome (AIDS), hepatitis B is a globally recognized major public health threat. Although there are many small-molecule drugs for the treatment of hepatitis B, the approved drugs cannot eradicate the ... ...

    Abstract Like tuberculosis and Acquired Immune Deficiency Syndrome (AIDS), hepatitis B is a globally recognized major public health threat. Although there are many small-molecule drugs for the treatment of hepatitis B, the approved drugs cannot eradicate the pathogenic culprit covalently closed circular DNA in patients, so the patients need long-term medication to control HBV amplification. Driven by a high unmet medical need, many pharmaceutical companies and research institutions have been engaged in the development of anti-HBV drugs to achieve a functional cure for chronic hepatitis B as soon as possible. This review summarizes the pathogenesis of hepatitis B virus and the research progress in the development of anti-HBV small molecule drugs, and introduces the cccDNA formation and transcription inhibitors and core inhibitors in detail, especially emphasizes the role of chinese herbal medicine in the treatment of chronic hepatitis B. Furthermore, this review proposes three potential strategies for cccDNA eradication in the future. We believe this review will provide meaningful guidance to achieve a functional cure for viral hepatitis B in the future.
    MeSH term(s) Humans ; Hepatitis B, Chronic/drug therapy ; Hepatitis B, Chronic/genetics ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Virus Replication ; DNA, Viral ; Hepatitis B virus ; Hepatitis B/drug therapy
    Chemical Substances Antiviral Agents ; DNA, Viral
    Language English
    Publishing date 2023-01-26
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2023.115128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 784: Show issues Location:
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  5. Article ; Online: A review of the latest research on M

    Yang, Huihui / Yang, Jinfei

    RSC medicinal chemistry

    2021  Volume 12, Issue 7, Page(s) 1026–1036

    Abstract: Since the outbreak of COVID-19, the pandemic caused by SARS-CoV-2 infection is still spreading at an alarming rate and has caused huge loss of life and economic damage worldwide. Although more than one year has passed, effective treatments for COVID-19 ... ...

    Abstract Since the outbreak of COVID-19, the pandemic caused by SARS-CoV-2 infection is still spreading at an alarming rate and has caused huge loss of life and economic damage worldwide. Although more than one year has passed, effective treatments for COVID-19 and other pathogenic coronaviruses have not yet been developed. Therefore, the development of SARS-CoV-2 inhibitors is an urgent priority. Given that the M
    Language English
    Publishing date 2021-04-14
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2632-8682
    ISSN (online) 2632-8682
    DOI 10.1039/d1md00066g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Small-molecule drugs development for Alzheimer's disease.

    Yao, Weiwei / Yang, Huihui / Yang, Jinfei

    Frontiers in aging neuroscience

    2022  Volume 14, Page(s) 1019412

    Abstract: Alzheimer's disease (AD) is an irreversible, progressive neurodegenerative brain disorder with no effective therapeutic drugs currently. The complicated pathophysiology of AD is not well understood, although beta-amyloid (Aβ) cascade and ... ...

    Abstract Alzheimer's disease (AD) is an irreversible, progressive neurodegenerative brain disorder with no effective therapeutic drugs currently. The complicated pathophysiology of AD is not well understood, although beta-amyloid (Aβ) cascade and hyperphosphorylated tau protein were regarded as the two main causes of AD. Other mechanisms, such as oxidative stress, deficiency of central cholinergic neurotransmitters, mitochondrial dysfunction, and inflammation, were also proposed and studied as targets in AD. This review aims to summarize the small-molecule drugs that were developed based on the pathogenesis and gives a deeper understanding of the AD. We hope that it could help scientists find new and better treatments to gradually conquer the problems related to AD in future.
    Language English
    Publishing date 2022-11-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2022.1019412
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  7. Article ; Online: Fabrication of bifunctional G-quadruplex-hemin DNAzymes for colorimetric detection of apurinic/apyrimidinic endonuclease 1 and microRNA-21.

    Huang, Xiaodong / He, Zhenni / Zhou, Kejie / Zhi, Huizhen / Yang, Jinfei

    The Analyst

    2021  Volume 146, Issue 24, Page(s) 7379–7385

    Abstract: G-quadruplex-based complexes have been widely used in various analytical methods due to their outstanding capabilities of generating colorimetric, fluorescent or electrochemical signals. However, since loop sequences in traditional G-quadruplex ... ...

    Abstract G-quadruplex-based complexes have been widely used in various analytical methods due to their outstanding capabilities of generating colorimetric, fluorescent or electrochemical signals. However, since loop sequences in traditional G-quadruplex structures are quite short, it is difficult to establish biosensors solely using G-quadruplex-based complexes. Herein, we attempted to lengthen the loop sequences of G-quadruplex structures and found that G-quadruplex-hemin DNAzymes (G-DNAzymes) with long loops (even 30 nucleotides) maintain high peroxidase activity. In addition, the peroxidase activity is not affected by the hybridization of the long loop with its complementary counterpart. Consequently, G-DNAzyme can be endowed with an additional function by taking the long loop as a recognition element, which may facilitate the construction of diverse colorimetric biosensors. Furthermore, by designing an apurinic/apyrimidinic site or a complementary sequence of microRNA-21 (miRNA-21) in long loops, bifunctional G-DNAzymes can be split in the presence of apurinic/apyrimidinic endonuclease 1 (APE1) or miRNA-21, decreasing their peroxidase activities. Accordingly, APE1 and miRNA-21 are quantified using 3,3',5,5'-tetramethylbenzidine as a chromophore. Using the G-DNAzyme, APE1 can be detected in a linear range from 2.5 to 22.5 U mL
    MeSH term(s) Biosensing Techniques ; Colorimetry ; DNA, Catalytic/metabolism ; Endonucleases ; G-Quadruplexes ; Hemin ; MicroRNAs/genetics
    Chemical Substances DNA, Catalytic ; MicroRNAs ; Hemin (743LRP9S7N) ; Endonucleases (EC 3.1.-)
    Language English
    Publishing date 2021-12-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 210747-8
    ISSN 1364-5528 ; 0003-2654
    ISSN (online) 1364-5528
    ISSN 0003-2654
    DOI 10.1039/d1an01603b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2423: Show issues Location:
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  8. Article ; Online: NBMA Promotes Spermatogenesis by Mediating Oct4 Pathway.

    Yang, Jinfei / Lin, Dengfeng / Yao, Weiwei / Yun, Damin / Zhou, Liwei / Gao, Sheng / Sun, Fei

    ChemistryOpen

    2022  Volume 11, Issue 3, Page(s) e202100219

    Abstract: Non-obstructive azoospermia is one of the most common causes of male infertility, but there is still no specific treatment drug. Given that the Oct4 (Octamer-binding transcription factor 4) has an important regulatory effect on spermatogenesis, ... ...

    Abstract Non-obstructive azoospermia is one of the most common causes of male infertility, but there is still no specific treatment drug. Given that the Oct4 (Octamer-binding transcription factor 4) has an important regulatory effect on spermatogenesis, activating it can effectively promote spermatogenesis, so it is of great value to develop Oct4-targeted drug design and elucidating its mechanism of action. Here, we screened out the Oct4-targeted drug molecule NBMA (N-benzyl-4-methoxy-2-(1-(4-(trifluoromethyl)phenyl)vinyl)aniline) by computer-assisted technology, and found that it has a significant promoting effect on spermatogenesis in the established mouse azoospermia model. Subsequently, through transcriptome sequencing and enrichment analysis, real-time fluorescent quantitative PCR (qPCR) and western blot experiments revealed that NBMA promotes the differentiation of spermatogonial stem cells by activating the Oct4 pathway, thereby promoting spermatogenesis. This study proves that NBMA is a molecule with great potential to be developed as a therapeutic drug for azoospermia. It also shows that computer-assisted, chemical and biological multidisciplinary methods play a very important role in innovative drug discovery.
    MeSH term(s) Adult Germline Stem Cells/metabolism ; Animals ; Azoospermia/metabolism ; Azoospermia/therapy ; Disease Models, Animal ; Humans ; Infertility, Male/metabolism ; Male ; Mice ; Spermatogenesis ; Testis/metabolism
    Language English
    Publishing date 2022-02-09
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2655605-4
    ISSN 2191-1363 ; 2191-1363
    ISSN (online) 2191-1363
    ISSN 2191-1363
    DOI 10.1002/open.202100219
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: DsbA-L: A Promising Therapeutic Target for Metabolic Diseases.

    Yang, Ming / Luo, Shilu / Yang, Jinfei / Chen, Wei / He, Liyu / Liu, Di / Wang, Xi / Xiao, Li / Sun, Lin

    Current medicinal chemistry

    2023  

    Abstract: The increasing incidence of metabolic diseases, including obesity and diabetes, is a serious social public problem. Therefore, there is an urgent need to find effective prevention and treatment measures for these diseases. DsbA-L is a protein that is ... ...

    Abstract The increasing incidence of metabolic diseases, including obesity and diabetes, is a serious social public problem. Therefore, there is an urgent need to find effective prevention and treatment measures for these diseases. DsbA-L is a protein that is widely expressed in many tissues and is closely related to metabolism. Emerging evidence shows that DsbA-L plays an important role in antioxidative stress, promoting the synthesis and secretion of adiponectin and maintaining mitochondrial homeostasis, and the abnormalities of these functions are also closely related to the occurrence and development of metabolic diseases. Here, we reviewed the tissue expression patterns and regulatory factors of DsbA-L, summarized its biological functions and the current research progress of DsbA-L in metabolic diseases, and found that DsbA-L may be a promising target for metabolic diseases.
    Language English
    Publishing date 2023-10-24
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/0109298673252630231018044159
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4432: Show issues Location:
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  10. Article ; Online: The Potential Role of Cardiokines in Heart and Kidney Diseases.

    Yang, Ming / Luo, Shilu / Yang, Jinfei / Chen, Wei / He, Liyu / Liu, Di / Wang, Xi / Sun, Lin

    Current medicinal chemistry

    2023  

    Abstract: As the engine that maintains blood circulation, the heart is also an endocrine organ that regulates the function of distant target organs by secreting a series of cardiokines. As endocrine factors, cardiokines play an indispensable role in maintaining ... ...

    Abstract As the engine that maintains blood circulation, the heart is also an endocrine organ that regulates the function of distant target organs by secreting a series of cardiokines. As endocrine factors, cardiokines play an indispensable role in maintaining the homeostasis of the heart and other organs. Here, we summarize some of the cardiokines that have been defined thus far and explore their roles in heart and kidney diseases. Finally, we propose that cardiokines may be a potential therapeutic target for kidney diseases.
    Language English
    Publishing date 2023-10-19
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/0109298673261760231011114150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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