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Article ; Online: Inhibitor of PD-1/PD-L1: a new approach may be beneficial for the treatment of idiopathic pulmonary fibrosis.

Tan, Jie / Xue, Qianfei / Hu, Xiao / Yang, Junling

2024 Volume 22, Issue 1, Page(s) 95

Abstract: Idiopathic pulmonary fibrosis (IPF) is a globally prevalent, progressive disease with limited treatment options and poor prognosis. Because of its irreversible disease progression, IPF affects the quality and length of life of patients and imposes a ... ...

Abstract	Idiopathic pulmonary fibrosis (IPF) is a globally prevalent, progressive disease with limited treatment options and poor prognosis. Because of its irreversible disease progression, IPF affects the quality and length of life of patients and imposes a significant burden on their families and social healthcare services. The use of the antifibrotic drugs pirfenidone and nintedanib can slow the progression of the disease to some extent, but it does not have a reverse effect on the prognosis. The option of lung transplantion is also limited owing to contraindications to transplantation, possible complications after transplantation, and the risk of death. Therefore, the discovery of new, effective treatment methods is an urgent need. Over recent years, various studies have been undertaken to investigate the relationship between interstitial pneumonia and lung cancer, suggesting that some immune checkpoints in IPF are similar to those in tumors. Immune checkpoints are a class of immunosuppressive molecules that are essential for maintaining autoimmune tolerance and regulating the duration and magnitude of immune responses in peripheral tissues. They can prevent normal tissues from being damaged and destroyed by the immune response. While current studies have focused on PD-1/PD-L1 and CTLA-4, PD-1/PD-L1 may be the only effective immune checkpoint IPF treatment. This review discusses the application of PD-1/PD-L1 checkpoint in IPF, with the aim of finding a new direction for IPF treatment.
MeSH term(s)	Humans ; Programmed Cell Death 1 Receptor ; B7-H1 Antigen ; Idiopathic Pulmonary Fibrosis ; Contraindications ; Immune Tolerance
Chemical Substances	Programmed Cell Death 1 Receptor ; B7-H1 Antigen
Language	English
Publishing date	2024-01-23
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2118570-0
ISSN	1479-5876 ; 1479-5876
ISSN (online)	1479-5876
ISSN	1479-5876
DOI	10.1186/s12967-024-04884-7
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Article ; Online: Household air pollution and attributable burden of disease in rural China: A literature review and a modelling study.

Yang, Junling / Lin, Zhi / Shi, Shanshan

Journal of hazardous materials

2024 Volume 470, Page(s) 134159

Abstract: Household air pollution prevails in rural residences across China, yet a comprehensive nationwide comprehending of pollution levels and the attributable disease burdens remains lacking. This study conducted a systematic review focusing on elucidating the ...

Abstract	Household air pollution prevails in rural residences across China, yet a comprehensive nationwide comprehending of pollution levels and the attributable disease burdens remains lacking. This study conducted a systematic review focusing on elucidating the indoor concentrations of prevalent household air pollutants-specifically, PM2.5, PAHs, CO, SO
MeSH term(s)	China/epidemiology ; Humans ; Air Pollution, Indoor/adverse effects ; Air Pollution, Indoor/analysis ; Rural Population/statistics & numerical data ; Cost of Illness ; Air Pollutants/analysis ; Mortality, Premature ; Models, Theoretical ; Environmental Exposure/adverse effects
Chemical Substances	Air Pollutants
Language	English
Publishing date	2024-03-29
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review ; Review
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2024.134159
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Article ; Online: Are immune checkpoint inhibitors safe and effective in lung cancer patients with pre-existing interstitial lung disease?

Zhu, Lin / Gao, Rong / Li, Han / Zheng, Yahui / Yang, Junling

Immunotherapy

2024 Volume 16, Issue 7, Page(s) 465–480

Abstract: Aim: ...

Abstract	Aim:
MeSH term(s)	Humans ; Lung Neoplasms ; Immune Checkpoint Inhibitors/adverse effects ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Lung Diseases, Interstitial/drug therapy ; Lung Diseases, Interstitial/etiology ; Pneumonia ; Retrospective Studies
Chemical Substances	Immune Checkpoint Inhibitors
Language	English
Publishing date	2024-03-21
Publishing country	England
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	2495964-9
ISSN	1750-7448 ; 1750-743X
ISSN (online)	1750-7448
ISSN	1750-743X
DOI	10.2217/imt-2023-0147
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Article ; Online: Novel gene-based therapeutic approaches for the management of hepatic complications in diabetes: Reviewing recent advances.

Yan, Qingzhu / Li, Dongfu / Jia, Shengnan / Yang, Junling / Ma, Jingru

Journal of diabetes and its complications

2024 Volume 38, Issue 2, Page(s) 108688

Abstract: Diabetes mellitus is a chronic metabolic disorder marked by hyperglycemia and systemic complications, including hepatic dysfunction, significantly contributing to disease progression and morbidity. This article reviews recent advances in gene-based ... ...

Abstract	Diabetes mellitus is a chronic metabolic disorder marked by hyperglycemia and systemic complications, including hepatic dysfunction, significantly contributing to disease progression and morbidity. This article reviews recent advances in gene-based therapeutic strategies targeting hepatic complications in diabetes, offering a promising approach for precision medicine by addressing underlying molecular mechanisms. Traditional treatments for hepatic complications in diabetes often manage symptoms rather than molecular causes, showing limited efficacy. Gene-based therapies are poised to correct dysfunctional pathways and restore hepatic function. Fundamental gene therapy approaches include gene silencing via small interfering RNAs (siRNAs) to target hepatic glucose production, lipid metabolism, and inflammation. Viral vectors can restore insulin sensitivity and reduce oxidative stress in diabetic livers. Genome editing, especially CRISPR-Cas9, allows the precise modification of disease-associated genes, offering immense potential for hepatic complication treatment. Strategies using CRISPR-Cas9 to enhance insulin receptor expression and modulate aberrant lipid regulatory genes are explored. Safety challenges in gene-based therapies, such as off-target effects and immune responses, are discussed. Advances in nanoparticle-based delivery systems and targeted gene editing techniques offer solutions to enhance specificity and minimize adverse effects. In conclusion, gene-based therapeutic approaches are a transformative direction in managing hepatic complications in diabetes. Further research is needed to optimize efficacy, safety, and long-term outcomes. Nevertheless, these innovative strategies promise to improve the lives of individuals with diabetes by addressing hepatic dysfunction's genetic root causes.
MeSH term(s)	Humans ; CRISPR-Cas Systems ; Gene Editing/methods ; Diabetes Mellitus/genetics ; Insulin/genetics
Chemical Substances	Insulin
Language	English
Publishing date	2024-01-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1105840-7
ISSN	1873-460X ; 1056-8727
ISSN (online)	1873-460X
ISSN	1056-8727
DOI	10.1016/j.jdiacomp.2024.108688
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Zs.A 2225: Show issues

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Article ; Online: The role and mechanism of action of microbiota-derived short-chain fatty acids in neutrophils: From the activation to becoming potential biomarkers.

Yan, Qingzhu / Jia, Shengnan / Li, Dongfu / Yang, Junling

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 169, Page(s) 115821

Abstract: Short-chain fatty acids (SCFAs), such as acetate, propionate, and butyrate, have emerged as critical mediators in the communication between the human microbiota and its host. As the first responder to the inflammatory site, neutrophils play an important ... ...

Abstract	Short-chain fatty acids (SCFAs), such as acetate, propionate, and butyrate, have emerged as critical mediators in the communication between the human microbiota and its host. As the first responder to the inflammatory site, neutrophils play an important role in protecting the host against bacterial infections. Recent investigations revealed that SCFAs generated from microbiota influence various neutrophil activities, including activation, migration, and generation of mediators of inflammatory processes. SCFAs have also been demonstrated to exhibit potential therapeutic benefits in a variety of disorders related to neutrophil dysfunction, including inflammatory bowel disease, viral infectious disorders, and cancer. This study aims to examine the molecular processes behind the complicated link between SCFAs and neutrophils, as well as their influence on neutrophil-driven inflammatory disorders. In addition, we will also provide an in-depth review of current research on the diagnostic and therapeutic value of SCFAs as possible biomarkers for neutrophil-related diseases.
MeSH term(s)	Humans ; Neutrophils ; Fatty Acids, Volatile/pharmacology ; Butyrates/pharmacology ; Microbiota ; Biomarkers
Chemical Substances	Fatty Acids, Volatile ; Butyrates ; Biomarkers
Language	English
Publishing date	2023-11-10
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.115821
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Article ; Online: Prognostic significance of peripheral blood S100A12, S100A8, and S100A9 concentrations in idiopathic pulmonary fibrosis.

Ding, Dongyan / Luan, Rumei / Xue, Qianfei / Yang, Junling

Cytokine

2023 Volume 172, Page(s) 156387

Abstract: Background: S100A12, S100A8, and S100A9 are inflammatory disease biomarkers whose functional significance in idiopathic pulmonary fibrosis (IPF) remains unclear. We evaluated the significance of S100A12, S100A8, and S100A9 levels in IPF development and ... ...

Abstract	Background: S100A12, S100A8, and S100A9 are inflammatory disease biomarkers whose functional significance in idiopathic pulmonary fibrosis (IPF) remains unclear. We evaluated the significance of S100A12, S100A8, and S100A9 levels in IPF development and prognosis. Methods: The dataset was collected from the Gene Expression Omnibus (GEO) database and differentially expressed genes were screened using GEO2R. We conducted a retrospective study of 106 patients with IPF to explore the relationships between different biomarkers and poor outcomes. Pearson's correlation coefficient, Kaplan-Meier, Cox regression, and functional enrichment analyses were used to evaluate relationships between these biomarkers' levels and clinical parameters or prognosis. Results: Serum levels of S100A12, S100A8, and S100A9 were significantly elevated in patients with IPF. The two most significant co-expression genes of S100A12 were S100A8 and S100A9. Patients with levels of S100A12 (median 231.21 ng/mL), S100A9 (median 57.09 ng/mL) or S100A8 (median 52.20 ng/mL), as well as combined elevated S100A12, S100A9, and S100A8 levels, exhibited shorter progression-free survival and overall survival. Serum S100A12 and S100A8, S100A12 and S100A9, S100A9 and S100A8 concentrations also displayed a strong positive correlation (r Conclusions: S100A12, S100A8, and S100A9 are promising circulating biomarkers that may aid in determining IPF patient prognosis. Multicenter clinical trials are needed to confirm their clinical value.
MeSH term(s)	Humans ; Biomarkers ; Calgranulin A/genetics ; Calgranulin B/genetics ; Idiopathic Pulmonary Fibrosis/genetics ; Prognosis ; Retrospective Studies ; S100A12 Protein
Chemical Substances	Biomarkers ; Calgranulin A ; Calgranulin B ; S100A12 Protein ; S100A12 protein, human
Language	English
Publishing date	2023-10-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1018055-2
ISSN	1096-0023 ; 1043-4666
ISSN (online)	1096-0023
ISSN	1043-4666
DOI	10.1016/j.cyto.2023.156387
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Zs.A 2840: Show issues

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Article ; Online: Overview of the immunological mechanisms in hepatitis B virus reactivation: Implications for disease progression and management strategies.

Ma, Hui / Yan, Qing-Zhu / Ma, Jing-Ru / Li, Dong-Fu / Yang, Jun-Ling

World journal of gastroenterology

2024 Volume 30, Issue 10, Page(s) 1295–1312

Abstract: Hepatitis B virus (HBV) reactivation is a clinically significant challenge in disease management. This review explores the immunological mechanisms underlying HBV reactivation, emphasizing disease progression and management. It delves into host immune ... ...

Abstract	Hepatitis B virus (HBV) reactivation is a clinically significant challenge in disease management. This review explores the immunological mechanisms underlying HBV reactivation, emphasizing disease progression and management. It delves into host immune responses and reactivation's delicate balance, spanning innate and adaptive immunity. Viral factors' disruption of this balance, as are interactions between viral antigens, immune cells, cytokine networks, and immune checkpoint pathways, are examined. Notably, the roles of T cells, natural killer cells, and antigen-presenting cells are discussed, highlighting their influence on disease progression. HBV reactivation's impact on disease severity, hepatic flares, liver fibrosis progression, and hepatocellular carcinoma is detailed. Management strategies, including anti-viral and immunomodulatory approaches, are critically analyzed. The role of prophylactic anti-viral therapy during immunosuppressive treatments is explored alongside novel immunotherapeutic interventions to restore immune control and prevent reactivation. In conclusion, this comprehensive review furnishes a holistic view of the immunological mechanisms that propel HBV reactivation. With a dedicated focus on understanding its implications for disease progression and the prospects of efficient management strategies, this article contributes significantly to the knowledge base. The more profound insights into the intricate interactions between viral elements and the immune system will inform evidence-based approaches, ultimately enhancing disease management and elevating patient outcomes. The dynamic landscape of management strategies is critically scrutinized, spanning anti-viral and immunomodulatory approaches. The role of prophylactic anti-viral therapy in preventing reactivation during immunosuppressive treatments and the potential of innovative immunotherapeutic interventions to restore immune control and proactively deter reactivation.
MeSH term(s)	Humans ; Hepatitis B virus ; Hepatitis B/drug therapy ; Immunosuppressive Agents/therapeutic use ; Immunosuppressive Agents/pharmacology ; Liver Neoplasms/drug therapy ; Antiviral Agents/pharmacology ; Disease Progression ; Virus Activation ; Hepatitis B Surface Antigens ; Hepatitis B, Chronic/drug therapy
Chemical Substances	Immunosuppressive Agents ; Antiviral Agents ; Hepatitis B Surface Antigens
Language	English
Publishing date	2024-04-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v30.i10.1295
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Zs.A 6039: Show issues

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Article ; Online: College students' knowledge, attitudes, and practices of garbage sorting and their associations: a cross-sectional study of several universities in Beijing, China.

Liu, Siyuan / Liu, Xiong / Li, Yibo / Yang, Dongli / Li, Feng / Yang, Junling

Frontiers in public health

2024 Volume 12, Page(s) 1328583

Abstract: Background: In recent years, the Chinese government has placed growing emphasis on environmental development. The implementation of effective waste separation practices in schools is crucial for establishing an ecological civilization in China.: ... ...

Abstract	Background: In recent years, the Chinese government has placed growing emphasis on environmental development. The implementation of effective waste separation practices in schools is crucial for establishing an ecological civilization in China. Objective: The present study aimed to assess the knowledge, attitude, and practice (KAP) of waste separation among Chinese university students and to understand the demographic factors influencing the KAP of the interviewed students. These sociodemographic factors include gender, age, education, and family environment. Methods: Based on the KAP theoretical model and the Lewin behavioral model (LBM), this study developed its questionnaire on college students' KAP of rubbish sorting. A survey was conducted on 1,282 college students from five colleges and universities in Beijing. A one-way ANOVA, Pearson's correlation analysis, and multiple linear stepwise regression analyzes were employed to explore the factors influencing college students' KAP scores on waste sorting. The questionnaire's reliability and validity were effectively verified through two rounds of Delphi expert consultation. Results: The scores for KAP dimensions were 55.64, 69.18, and 54.8%, respectively. The overall KAP score of university students in waste classification was 46.93 ± 9.93, with a percentage score of 62.57%. More than half of the college students lack a clear understanding of waste classification. Grade, gender, major, highest family education, and family economic status all influence college students' KAP scores on waste classification. There is a notable deficiency in school education regarding waste classification, with only 30.7% reporting having received such education. Conclusion: This study unveils the overall KAP score of waste separation among Chinese college students, which is marginally acceptable. The interviewed students exhibit a positive attitude and a willingness to participate in waste separation. However, there is room for improvement in both knowledge and practices. A lack of knowledge about waste sorting emerges as the primary influence on individual-level practices. Consideration should be given to enhancing education and management of waste separation among college students, emphasizing the cultivation of an eco-conscious culture, and guiding students to establish correct ecological values.
MeSH term(s)	Humans ; Universities ; Cross-Sectional Studies ; Beijing ; Health Knowledge, Attitudes, Practice ; Reproducibility of Results ; Students ; China
Language	English
Publishing date	2024-02-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2024.1328583
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Article ; Online: Zinc deficiency increases lung inflammation and fibrosis in obese mice by promoting oxidative stress.

Luan, Rumei / Luo, Manyu / Ding, Dongyan / Su, Xin / Yang, Junling

Biochimica et biophysica acta. General subjects

2023 Volume 1868, Issue 1, Page(s) 130518

Abstract: Background: Zinc deficiency can lead to multiple organ damage. In this study, we investigated the effects of zinc deficiency on obesity-related lung damage.: Methods: C57BL/6 J mice were fed a diet with differing amounts of zinc and fat over a 6- ... ...

Abstract	Background: Zinc deficiency can lead to multiple organ damage. In this study, we investigated the effects of zinc deficiency on obesity-related lung damage. Methods: C57BL/6 J mice were fed a diet with differing amounts of zinc and fat over a 6-month period. Palmitic acid was used to stimulate A549 cells to construct a high-fat alveolar epithelial cell model. Western blotting and histopathological staining were performed on animal tissues. Nuclear expression of nuclear factor erythroid 2-related factor 2 (Nrf2) was detected in cultured cells. A reactive oxygen species (ROS) assay kit was used to detect intracellular ROS. Furthermore, Nrf2 siRNA was used to examine zinc deficiency effects on A549 cells. Results: Pathological results showed significant damage to the lung structure of mice in the high-fat and low-zinc diet group, with a significant increase in the expression of inflammatory (IL-6, TNF-α) and fibrosis (TGFβ1, PAI-1) factors, combined with a decrease in the expression of Nrf2, HO-1 and NQO1 in the antioxidant pathway. In A549 cells, high fat and low zinc levels aggravated ROS production. Western blot and immunofluorescence results showed that high fat and zinc deficiency inhibited Nrf2 expression. After Nrf2-specific knockout in A549 cells, the protective effect of zinc on oxidant conditions induced by high fat was reduced. Phosphorylated Akt and PI3K levels were downregulated on the high-fat and low-zinc group compared with the high-fat group. Conclusions: Zinc attenuated lung oxidative damage in obesity-related lung injury and Nrf2 activation is one of the important mechanisms of this effect. General significance: Regulating zinc homeostasis through dietary modifications or supplemental nutritional therapy can contribute to the prevention and treatment of obesity-related lung injury.
MeSH term(s)	Mice ; Animals ; Reactive Oxygen Species/metabolism ; Mice, Obese ; NF-E2-Related Factor 2/metabolism ; Lung Injury ; Signal Transduction ; Mice, Inbred C57BL ; Oxidative Stress ; Pneumonia ; Fibrosis ; Zinc ; Obesity/complications
Chemical Substances	Reactive Oxygen Species ; NF-E2-Related Factor 2 ; Zinc (J41CSQ7QDS)
Language	English
Publishing date	2023-11-10
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	60-7
ISSN	1872-8006 ; 1879-2596 ; 1879-260X ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1872-8006 ; 1879-2596 ; 1879-260X ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbagen.2023.130518
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Article ; Online: Genomic Fingerprint Associated with Familial Idiopathic Pulmonary Fibrosis: A Review.

Ding, Dongyan / Gao, Rong / Xue, Qianfei / Luan, Rumei / Yang, Junling

International journal of medical sciences

2023 Volume 20, Issue 3, Page(s) 329–345

Abstract: Idiopathic pulmonary fibrosis (IPF) is a severe interstitial lung disease; although the recent introduction of two anti-fibrosis drugs, pirfenidone and Nidanib, have resulted in a significant reduction in lung function decline, IPF is still not curable. ... ...

Abstract	Idiopathic pulmonary fibrosis (IPF) is a severe interstitial lung disease; although the recent introduction of two anti-fibrosis drugs, pirfenidone and Nidanib, have resulted in a significant reduction in lung function decline, IPF is still not curable. Approximately 2-20% of patients with IPF have a family history of the disease, which is considered the strongest risk factor for idiopathic interstitial pneumonia. However, the genetic predispositions of familial IPF (f-IPF), a particular type of IPF, remain largely unknown. Genetics affect the susceptibility and progression of f-IPF. Genomic markers are increasingly being recognized for their contribution to disease prognosis and drug therapy outcomes. Existing data suggest that genomics may help identify individuals at risk for f-IPF, accurately classify patients, elucidate key pathways involved in disease pathogenesis, and ultimately develop more effective targeted therapies. Since several genetic variants associated with the disease have been found in f-IPF, this review systematically summarizes the latest progress in the gene spectrum of the f-IPF population and the underlying mechanisms of f-IPF. The genetic susceptibility variation related to the disease phenotype is also illustrated. This review aims to improve the understanding of the IPF pathogenesis and facilitate his early detection.
MeSH term(s)	Humans ; Genetic Predisposition to Disease ; Genomics ; Idiopathic Pulmonary Fibrosis/genetics ; Phenotype ; DNA Fingerprinting
Language	English
Publishing date	2023-01-31
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	2151424-0
ISSN	1449-1907 ; 1449-1907
ISSN (online)	1449-1907
ISSN	1449-1907
DOI	10.7150/ijms.80358
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