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  1. Article ; Online: An enhanced pairing-free certificateless directed signature scheme.

    Yang, Kaiqin

    PloS one

    2022  Volume 17, Issue 2, Page(s) e0263943

    Abstract: Directed signature is a special cryptographic technique in which only the verifier designated by the signer can verify the validity of the signature. Directed signature can effectively protect the privacy of the signer's identity, so it is very suitable ... ...

    Abstract Directed signature is a special cryptographic technique in which only the verifier designated by the signer can verify the validity of the signature. Directed signature can effectively protect the privacy of the signer's identity, so it is very suitable for medical records, taxation, and other fields. To improve the security and performance of the directed signature scheme, Gayathri et al. proposed the first certificateless directed signature (CLDS) scheme without bilinear pairing and claimed that their CLDS scheme could withstand Type I and Type II attacks. In this article, we provide two attack methods to assess the security of their CLDS scheme. Unfortunately, our results indicate that their CLDS scheme is insecure against Type I and Type II attacks. That is, their CLDS scheme does not meet the unforgeability and cannot achieve the expected security goals. To resist these attacks, we present an improved CLDS scheme and give the security proof. Compared with similar schemes, our scheme has better performance and higher security.
    MeSH term(s) Algorithms ; Computer Security/standards ; Confidentiality/standards ; Humans ; Models, Theoretical ; Privacy ; Wireless Technology/instrumentation
    Language English
    Publishing date 2022-02-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0263943
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Regulation of Treg Cell Metabolism and Function in Non-Lymphoid Tissues.

    Yang, Kai

    Frontiers in immunology

    2022  Volume 13, Page(s) 909705

    Abstract: Regulator T cells (Tregs) play pivotal roles in maintaining immune tolerance and regulating immune responses against pathogens and tumors. Reprogramming of cellular metabolism has been determined as a crucial process that connects microenvironmental cues ...

    Abstract Regulator T cells (Tregs) play pivotal roles in maintaining immune tolerance and regulating immune responses against pathogens and tumors. Reprogramming of cellular metabolism has been determined as a crucial process that connects microenvironmental cues and signaling networks to influence homeostasis and function of tissue Tregs. In adaptation to a variety of non-lymphoid tissues, Tregs coordinate local immune signals and signaling networks to rewire cellular metabolic programs to sustain their suppressive function. Altered Treg metabolism in turn shapes Treg activation and function. In light of the advanced understanding of immunometabolism, manipulation of systemic metabolites has been emerging as an attractive strategy aiming to modulate metabolism and function of tissue Tregs and improve the treatment of immune-related diseases. In this review, we summarize key immune signals and metabolic programs involved in the regulation of tissue Tregs, review the mechanisms underlying the differentiation and function of Tregs in various non-lymphoid tissues, and discuss therapeutic intervention of metabolic modulators of tissue Tregs for the treatment of autoimmune diseases and cancer.
    MeSH term(s) Autoimmune Diseases/metabolism ; Homeostasis ; Humans ; Immune Tolerance ; Immunotherapy ; Neoplasms ; T-Lymphocytes, Regulatory
    Language English
    Publishing date 2022-06-02
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.909705
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  3. Article ; Online: Surface wear of attachments in patients during clear aligner therapy: a prospective clinical study.

    Li, Qiuying / Yang, Kai

    Progress in orthodontics

    2024  Volume 25, Issue 1, Page(s) 7

    Abstract: Background: This prospective clinical study aimed to quantitatively evaluate the surface wear of attachments and investigate the associated risk factors. Additionally, the wear values and regions of three types of commonly used attachments were explored. ...

    Abstract Background: This prospective clinical study aimed to quantitatively evaluate the surface wear of attachments and investigate the associated risk factors. Additionally, the wear values and regions of three types of commonly used attachments were explored.
    Methods: Participants were recruited from the population of patients who received clear aligner therapy from October to December 2022. Intraoral scanning was performed on eligible participants before treatment (T0), immediately after initial bonding of attachments (T1), and at 2 months (T2), 4 months (T3), 6 months (T4), and 8 months (T5) after starting treatment. The attachment volume, average depth and regions of attachment wear were measured using superimposed digitized models. The Kruskal-Wallis test was performed to compare data between multiple groups. Multiple linear regression analyses were performed to evaluate risk factors for the volume of attachment wear.
    Results: A total of 47 patients with 617 attachments were included. As treatment time increased, the attachment volume decreased significantly (P = 0.003). The initial attachment volume was positively related to the volume of attachment wear (β = 0.527, P < 0.001). The volume of attachment wear was significantly greater in females than in males (β = 0.147, P = 0.020) and in optimized attachments than in conventional attachments (β = 0.308, P < 0.001). The wear of 3-mm rectangular attachments progressed from edges to buccal surfaces, with the deepest wear at corners of gingival edges; the wear of the optimized attachments was primarily located on surface ridges. The wear volume ratio of the optimized root control attachments was significantly greater than that of the 3-mm rectangular attachments at T3 (P = 0.011), T4 (P < 0.001), and T5 (P < 0.001).
    Conclusions: The volume of attachment wear increased gradually with treatment time. Sex, attachment type, and initial attachment volume were risk factors for the volume of attachment wear. The deepest wear regions of 3-mm rectangular attachments were at the corners of gingival edges, while the deepest wear regions of optimized attachments were at surface ridges. Four months after treatment, optimized root control attachments showed more relative wear than 3-mm rectangular attachments.
    MeSH term(s) Male ; Female ; Humans ; Prospective Studies ; Tooth Movement Techniques ; Orthodontic Appliances, Removable
    Language English
    Publishing date 2024-02-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2040711-7
    ISSN 2196-1042 ; 1600-9975 ; 1723-7785 ; 1399-7513
    ISSN (online) 2196-1042 ; 1600-9975
    ISSN 1723-7785 ; 1399-7513
    DOI 10.1186/s40510-023-00506-y
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    Zs.A 5560: Show issues Location:
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  4. Article ; Online: Bile reflux is associated with Barrett's esophagus.

    Li, Zedong / Yang, Kun

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2024  

    Language English
    Publishing date 2024-01-08
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2023.12.016
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  5. Article: Tumor cell stemness in gastrointestinal cancer: regulation and targeted therapy.

    Yang, Kangqi / Yi, Tuo

    Frontiers in molecular biosciences

    2024  Volume 10, Page(s) 1297611

    Abstract: The cancer stem cells are a rare group of self-renewable cancer cells capable of the initiation, progression, metastasis and recurrence of tumors, and also a key contributor to the therapeutic resistance. Thus, understanding the molecular mechanism of ... ...

    Abstract The cancer stem cells are a rare group of self-renewable cancer cells capable of the initiation, progression, metastasis and recurrence of tumors, and also a key contributor to the therapeutic resistance. Thus, understanding the molecular mechanism of tumor stemness regulation, especially in the gastrointestinal (GI) cancers, is of great importance for targeting CSC and designing novel therapeutic strategies. This review aims to elucidate current advancements in the understanding of CSC regulation, including CSC biomarkers, signaling pathways, and non-coding RNAs. We will also provide a comprehensive view on how the tumor microenvironment (TME) display an overall tumor-promoting effect, including the recruitment and impact of cancer-associated fibroblasts (CAFs), the establishment of an immunosuppressive milieu, and the induction of angiogenesis and hypoxia. Lastly, this review consolidates mainstream novel therapeutic interventions targeting CSC stemness regulation.
    Language English
    Publishing date 2024-02-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2023.1297611
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  6. Article ; Online: Association between cooking fuel exposure and respiratory health: Longitudinal evidence from the China Health and Retirement Longitudinal Study (CHARLS).

    Yang, Kai / Chen, Rongchang

    Ecotoxicology and environmental safety

    2024  Volume 275, Page(s) 116247

    Abstract: The epidemiological evidences for the association between cooking fuel exposure and respiratory health were inconsistent, and repeated-measures prospective evaluation of cooking fuel exposure was still lacking. We assessed the longitudinal association of ...

    Abstract The epidemiological evidences for the association between cooking fuel exposure and respiratory health were inconsistent, and repeated-measures prospective evaluation of cooking fuel exposure was still lacking. We assessed the longitudinal association of chronic lung disease (CLD) and lung function with cooking fuel types among Chinese adults aged ≥ 40 years. In this prospective, nationwide representative cohort of the China Health and Retirement Longitudinal Study from 2011 to 2018, 9004 participants from 28 provinces in China were included. CLD was identified based on self-reported physician diagnosis in 2018. Lung function was assessed by peak expiratory flow (PEF) in 2011, 2013 and 2015. Multivariable logistic and linear mixed-effects repeated-measures models were conducted to measure the associations of CLD and PEF with cooking fuel types. Three-level mixed-effects model was performed as sensitivity analysis. Among the participants, 3508 and 3548 participants used persistent solid and clean cooking fuels throughout the survey, and 1948 participants who used solid cooking fuels at baseline switched to clean cooking fuels. Use of persistent clean cooking fuels (adjusted odds ratio [aOR] = 0.73, 95 % confidence interval [CI]: 0.61, 0.88) and switch of solid fuels to clean fuels (aOR = 0.81, 95 % CI: 0.67, 0.98) were associated with lower risk of CLD. The use of clean cooking fuels throughout the survey and switch of solid fuels to clean fuels in 2013 were also significantly associated with higher PEF level. Similar results were observed in stratified analyses and different statistical models. The evidence from CHARLS cohort suggested that reducing solid cooking fuel exposure was associated with lower risk of CLD and better lung function. Given the recent evidence, improving household air quality will reduce the burden of chronic lung diseases.
    MeSH term(s) Adult ; Humans ; Longitudinal Studies ; Retirement ; Prospective Studies ; Lung Diseases/chemically induced ; Lung Diseases/epidemiology ; Cooking/methods ; Air Pollution, Indoor/adverse effects ; Air Pollution, Indoor/analysis ; China/epidemiology
    Language English
    Publishing date 2024-03-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 436536-7
    ISSN 1090-2414 ; 0147-6513
    ISSN (online) 1090-2414
    ISSN 0147-6513
    DOI 10.1016/j.ecoenv.2024.116247
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1418: Show issues Location:
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  7. Article ; Online: Exploring the Impact of Antireflux Treatment on Risk of Esophageal Adenocarcinoma in Patients With Barrett's Esophagus: Insights from a Mendelian Randomization Study.

    Li, Zedong / Yang, Kun

    Gastroenterology

    2024  Volume 166, Issue 5, Page(s) 944–945

    MeSH term(s) Humans ; Barrett Esophagus/genetics ; Esophageal Neoplasms/genetics ; Mendelian Randomization Analysis ; Adenocarcinoma/genetics ; Gastroesophageal Reflux/diagnosis ; Gastroesophageal Reflux/drug therapy ; Risk Factors ; Proton Pump Inhibitors/therapeutic use ; Proton Pump Inhibitors/adverse effects ; Risk Assessment ; Treatment Outcome ; Polymorphism, Single Nucleotide
    Chemical Substances Proton Pump Inhibitors
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Research Support, Non-U.S. Gov't ; Journal Article ; Letter
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2024.01.020
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  8. Article ; Online: Secondary amenorrhea in a β-thalassemia major patient treated with thalidomide.

    Yu, Yang / Yang, Kun

    Pediatric blood & cancer

    2024  Volume 71, Issue 6, Page(s) e30982

    MeSH term(s) Humans ; beta-Thalassemia/drug therapy ; beta-Thalassemia/complications ; Female ; Thalidomide/adverse effects ; Thalidomide/therapeutic use ; Amenorrhea/chemically induced ; Adolescent
    Chemical Substances Thalidomide (4Z8R6ORS6L)
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.30982
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  9. Article ; Online: Author's reply: ABCA8, a tumour suppressor in colorectal cancer.

    Yang, Kun / Jiang, Zheng

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2024  Volume 56, Issue 5, Page(s) 904

    MeSH term(s) Humans ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; ATP-Binding Cassette Transporters/genetics ; ATP-Binding Cassette Transporters/metabolism ; Genes, Tumor Suppressor
    Chemical Substances ATP-Binding Cassette Transporters
    Language English
    Publishing date 2024-02-09
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2024.01.205
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  10. Article ; Online: Internet use, employment performance and the health of Chinese residents.

    Yang, Kewen

    International health

    2021  Volume 14, Issue 3, Page(s) 222–235

    Abstract: Using data from the China Labor-force Dynamics Survey 2016, this study examines the effects of Internet use on Chinese resident health and the role of employment performance in this process. The results show that Internet use had a significant positive ... ...

    Abstract Using data from the China Labor-force Dynamics Survey 2016, this study examines the effects of Internet use on Chinese resident health and the role of employment performance in this process. The results show that Internet use had a significant positive effect on the health of Chinese residents. After addressing potential endogeneity by applying appropriate instrumental variable estimation, the main findings remain robust. Heterogeneity analysis found that the Internet is conducive to improving the health of older, less-educated and female residents, which suggests that the Internet can narrow the health gap of residents with different ages, education levels and genders. Through the analysis of the impact mechanism, it was found that although Chinese residents can improve their health by enhancing their employment performance with the help of the Internet, the mediating effect accounts for <20%, indicating that the role of employment performance in the process of improving the health of Chinese residents through Internet use is very limited. Finally, suggestions are given to promote the healthy development of China via the effects of Internet use.
    MeSH term(s) China ; Employment ; Female ; Health Status ; Humans ; Internet Use ; Male ; Surveys and Questionnaires
    Language English
    Publishing date 2021-06-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2526175-7
    ISSN 1876-3405 ; 1876-3413
    ISSN (online) 1876-3405
    ISSN 1876-3413
    DOI 10.1093/inthealth/ihab034
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