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Article ; Online: Sources and spatial variations of heavy metals in offshore sediments of the western Pearl River Estuary.

Zhao, Jianru / Yang, Kehong / Chu, Fengyou / Ge, Qian / Xu, Dong / Han, Xibin / Ye, Liming

2023 Volume 188, Page(s) 114599

Abstract: The concentrations of six heavy metals (Cd, Cr, Cu, Pb, Zn, and As) in offshore surface sediments of western Pearl River Estuary were analyzed to investigate their sources and spatial variations using factorial kriging analysis. Three-scale spatial ... ...

Abstract	The concentrations of six heavy metals (Cd, Cr, Cu, Pb, Zn, and As) in offshore surface sediments of western Pearl River Estuary were analyzed to investigate their sources and spatial variations using factorial kriging analysis. Three-scale spatial variations in heavy metal concentrations were identified and separated: nugget, local, and regional scale, which indicated sample errors, anthropogenic pollution and natural variation, respectively. Anthropogenic heavy metals varied sharply and heterogeneous at range of 60 km. Maoming Port, Hailing Bay and coastal area northeastern Hainan Island were potential polluted areas of Cd, Cr, Cu, Pb, Zn and As, also the Nandu River, Baoling River and Wanquan River estuaries were potential polluted areas of As. These polluted areas ranged up to 60 km in size and tended to extend with currents. The natural heavy metals varied continuously and relatively homogeneous at range of 180 km, which was dominated by riverine input and paleo-sea-level changes.
MeSH term(s)	Estuaries ; Rivers ; Cadmium/analysis ; Lead/analysis ; Water Pollutants, Chemical/analysis ; Geologic Sediments/analysis ; Environmental Monitoring ; Metals, Heavy/analysis ; China ; Risk Assessment
Chemical Substances	Cadmium (00BH33GNGH) ; Lead (2P299V784P) ; Water Pollutants, Chemical ; Metals, Heavy
Language	English
Publishing date	2023-02-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2001296-2
ISSN	1879-3363 ; 0025-326X
ISSN (online)	1879-3363
ISSN	0025-326X
DOI	10.1016/j.marpolbul.2023.114599
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Economic burden of advanced lung cancer patients treated by gefitinib alone and combined with chemotherapy in two regions of China.

Yang, Kehong / Hua, Susan / Wei, Wenting / Yang, Congyan / Zhu, Xinhai / Li, Shu Chuen

Journal of medical economics

2023 Volume 26, Issue 1, Page(s) 1424–1431

Abstract: Aim: To assess the economic burden of different chemotherapies for lung cancer patients and influencing factors in China.: Materials and methods: The economic burden of lung cancer, including direct, indirect and intangible costs was measured within ... ...

Abstract	Aim: To assess the economic burden of different chemotherapies for lung cancer patients and influencing factors in China. Materials and methods: The economic burden of lung cancer, including direct, indirect and intangible costs was measured within three months after diagnosis and treatment. Direct cost included the cost of hospitalization, outpatient visits, out-of-pocket drug purchases, costs of transportation, accommodation and meal expenses while seeking treatments in hospitals. Cost information was attained from questionnaire and patients' medical record. Indirect cost was measured by the patients' and their caregivers' productive days lost due to outpatient visits and hospitalization for lung cancer treatment. Intangible cost was obtained through the willingness-to-pay method from a questionnaire completed by the patient. Results: Among the total cost of CNY71,401.92, direct cost, indirect cost and intangible cost constituted 89.02%, 4.29%, and 6.69% respectively. Educational level, occupation, family income, lung cancer classification, and the city of residence significantly influenced the total cost. Limitations: Limitations in our study included: First, our follow-up period of three months was relatively short compared to the whole survival period of lung cancer patients. Second, the sample size of the chemotherapy combined with targeted therapy group was not large enough, and the cost data obtained would need confirmation in future studies. Third, participants came from only two localities, which may somewhat limit the representativeness of the study results for the whole of China. Conclusions: The economic burden of lung cancer treatment mainly came from the cost of the drugs. Patients taking chemotherapy had significantly higher cost compared to patients using targeted therapy. The cost was generally higher for those with higher educational level, those with higher family income, and those living in an economically more developed city. Patients with NSCLC had higher cost compared to patients with SCLC.
MeSH term(s)	Humans ; Lung Neoplasms/drug therapy ; Gefitinib/therapeutic use ; Financial Stress ; Carcinoma, Non-Small-Cell Lung/drug therapy ; China
Chemical Substances	Gefitinib (S65743JHBS)
Language	English
Publishing date	2023-10-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2270945-9
ISSN	1941-837X ; 1369-6998
ISSN (online)	1941-837X
ISSN	1369-6998
DOI	10.1080/13696998.2023.2272536
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Petrology and geochemistry of cold seep carbonates from the northern Okinawa Trough, East China Sea: implications to early diagenesis

Yang, Kehong / Zhu, Zhimin / Dong, Yanhui / Zhang, Weiyan / Chu, Fengyou

Journal of oceanology and limnology. 2022 July, v. 40, no. 4

2022

Abstract: Carbonate samples were collected from the northern Okinawa Trough in the East China Sea in 2013. The petrology, mineralogy, carbon and oxygen isotopes, and rare earth elements (REEs) of these samples were analyzed. Aragonite, high-Mg calcite, and ... ...

Abstract	Carbonate samples were collected from the northern Okinawa Trough in the East China Sea in 2013. The petrology, mineralogy, carbon and oxygen isotopes, and rare earth elements (REEs) of these samples were analyzed. Aragonite, high-Mg calcite, and dolomite were the main carbonate minerals, the contents of which varied greatly among the carbonate samples. Petrological observations revealed the common occurrence of framboidal pyrites. The δ¹³C values of carbonates varied from −53.7‰ to −39.39‰ (average of −47.3‰ based on Vienna Pee Dee Belemnite (V-PDB), n=9), and the δ¹⁸O values ranged from 0.6‰ to 3.4‰ (average of 1.9‰; V-PDB, n=9). The carbon and oxygen isotope characteristics indicated that the carbonates precipitated during the anaerobic oxidation of methane. The carbon source was a mixture of thermogenic methane and biogenic methane, possibly with a greater contribution from the former. The oxygen isotope data showed that gas hydrate dissociation occurred during carbonate precipitation. The Ce anomalies suggested that the carbonates precipitated in an anoxic environment. A slight enrichment of middle REEs (MREEs) could be attributable to the early diagenesis. The structures, minerals, oxygen isotopes, and MREEs all indicated that the carbonates experienced some degree of early diagenesis. Therefore, the influence of early diagenesis should be considered when using geological and geochemical proxies to reconstruct original methane seepage environments.
Keywords	Ryukyu Archipelago ; anaerobic conditions ; aragonite ; calcite ; carbon ; carbonates ; cold ; diagenesis ; dissociation ; dolomite ; gas hydrate ; geochemistry ; limnology ; methane ; methane production ; oceanography ; oxidation ; oxygen ; oxygen isotopes ; seepage ; East China Sea
Language	English
Dates of publication	2022-07
Size	p. 1388-1403.
Publishing place	Science Press
Document type	Article
ISSN	2096-5508
DOI	10.1007/s00343-021-1148-0
Database	NAL-Catalogue (AGRICOLA)

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Article: [Effect of low-molecular-weight heparin combined with doxorubicin on hepatocellular cancer cell migration in vitro].

Yang, Kehong / Ma, Linyan / Cheng, Xiu / Chen, Chao / Zhang, Mengxiao / Liu, Hao / Jiang, Zhiwen

Nan fang yi ke da xue xue bao = Journal of Southern Medical University

2014 Volume 34, Issue 7, Page(s) 1048–1052

Abstract: Objective: To investigate the anti-cancer effect of low-molecular-weight heparin (LMWH) combined with doxorubicin and explore the mechanism.: Methods: Hepatocellular cancer HepG2 cells exposed to LMWH, doxorubicin, or both were evaluated for cell ... ...

Abstract	Objective: To investigate the anti-cancer effect of low-molecular-weight heparin (LMWH) combined with doxorubicin and explore the mechanism. Methods: Hepatocellular cancer HepG2 cells exposed to LMWH, doxorubicin, or both were evaluated for cell viability with MTT assay and for changes in their migration ability using wound healing assay and Transwell migration assay. The changes in cellular expressions of matrix metalloproteinase-9 (MMP-9) and MMP-2 mRNA and proteins were analyzed with quantitative real-time PCR (qRT-PCR) and Western blotting, and ELISA was used to determine heparanase (HPA) concentration in the cell culture medium. Results: HepG2 cells exhibited suppressed proliferation in response to LMWH and doxorubicin treatments. The combined treatment caused a significantly higher inhibition rate of cell migration than LMWH and doxorubicin alone. LMWH enhanced doxorubicin-induced down-regulation of MMP-9, MMP-2 and HPA in the cells. Conclusions: LMWH can enhance the inhibitory effect of doxorubicin on the migration of HepG2 cells, the mechanism of which may involve the down-regulation of MMP-9, MMP-2 and HPA expressions.
MeSH term(s)	Cell Movement/drug effects ; Cell Survival ; Down-Regulation ; Doxorubicin/pharmacology ; Glucuronidase/chemistry ; Hep G2 Cells ; Heparin, Low-Molecular-Weight/pharmacology ; Humans ; Liver Neoplasms/pathology ; Matrix Metalloproteinase 2/metabolism ; Matrix Metalloproteinase 9/metabolism ; Neoplasm Invasiveness ; RNA, Messenger ; Real-Time Polymerase Chain Reaction
Chemical Substances	Heparin, Low-Molecular-Weight ; RNA, Messenger ; Doxorubicin (80168379AG) ; heparanase (EC 3.2.1.-) ; Glucuronidase (EC 3.2.1.31) ; MMP2 protein, human (EC 3.4.24.24) ; Matrix Metalloproteinase 2 (EC 3.4.24.24) ; MMP9 protein, human (EC 3.4.24.35) ; Matrix Metalloproteinase 9 (EC 3.4.24.35)
Language	Chinese
Publishing date	2014-06
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2250951-3
ISSN	1673-4254
ISSN	1673-4254
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Origin and nature of cold seep in northeastern Dongsha area, South China Sea: Evidence from chimney-like seep carbonates

Han, XiQiu / Yang, KeHong / Huang, YongYang

Chinese science bulletin Kexue tongbao.. 2013 Oct., v. 58, no. 30

2013

Abstract: The occurrence of seep carbonates is one of the characteristic features for cold seep sites at continental margins. The carbonates documented the venting history of methane-rich fluid. Compared to the chemoherm carbonates and carbonate pavements which ... ...

Abstract	The occurrence of seep carbonates is one of the characteristic features for cold seep sites at continental margins. The carbonates documented the venting history of methane-rich fluid. Compared to the chemoherm carbonates and carbonate pavements which formed on the sediment-water interface, chimney-like seep carbonates precipitated around fluid conduits below the sediment-water interface therefore better recording information of the past fluid flow and composition. Here the chimney-like seep carbonate samples from the northeastern Dongsha area of the South China Sea were studied to understand the origin and nature of the venting fluids and their potential relationship with gas hydrate deposits underneath the seafloor. Based on the occurrence, morphology, petrology, mineralogy and C- and O- isotope compositions, combined with present and past bottom water temperatures and the timing of methane release events, the oxygen isotopic fractionation between calcite and water were used to estimate the equilibrium δ ¹⁸O values of the precipitating fluids. The δ ¹³C values ranging from −56.33‰ to −42.70‰ V-PDB and thus clearly show that the studied chimneys were mainly derived from biogenic methane oxidation. The calculated equilibrium δ ¹⁸O values of the precipitating fluids ranged from 1.9‰ ± 0.3‰ to 0.6‰ ± 0.3‰ V-SMOW, with an average of 1.4‰ ± 0.3‰ V-SMOW which is heavier than those of seawater even at the last glacial maximum. It is considered that the formation of chimney-like carbonates was closely related to methane hydrate dissociation in the area. The methane hydrates contributed as much as 45.7% of water to the venting fluids. It is suggested that the climate and environmental changes (e.g. sea-level lowering, down-cutting canyons and mass wasting) are the major mechanisms maybe responsible for the destabilization of methane hydrates in the study area. The extensive occurrence of seep carbonates indicates that a large amount of the methane released from methane hydrate dissociation has been effectively captured and sequestered by microbial anaerobic oxidation of methane (AOM) before it escapes into the water column.
Keywords	calcite ; canyons ; carbon ; carbonates ; climate ; cold ; dissociation ; fractionation ; methane ; methane production ; oxidation ; oxygen ; sea level ; seawater ; stable isotopes ; water temperature ; South China Sea
Language	English
Dates of publication	2013-10
Size	p. 3689-3697.
Publishing place	Springer-Verlag
Document type	Article
ZDB-ID	1021576-1
ISSN	1861-9541 ; 1001-6538 ; 0250-7862
ISSN (online)	1861-9541
ISSN	1001-6538 ; 0250-7862
DOI	10.1007/s11434-013-5819-x
Database	NAL-Catalogue (AGRICOLA)

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Article: [Variation of BDNF mRNA on focalcerebral ischemia reperfusion injury in rats with notogisenoside-Rg1].

Yang, Ke-hong / Ge, Shu-xing / Xu, Bing-ying / Yan, Jun-ling / Wu, Lan-ou

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials

2007 Volume 30, Issue 3, Page(s) 313–316

Abstract: Objective: To study the effect of notoginsenoside-Rg, on expression of BDNF mRNA (brain-derived neurotrophic factor messenger ribonucleic acid) in cerebrum cortex after MCAO/R (middle cerebral artery occlusion reperfusion) injury in rat by real-time ... ...

Abstract	Objective: To study the effect of notoginsenoside-Rg, on expression of BDNF mRNA (brain-derived neurotrophic factor messenger ribonucleic acid) in cerebrum cortex after MCAO/R (middle cerebral artery occlusion reperfusion) injury in rat by real-time quantitative polymerase chain reaction. Methods: 36 SD male rats were randomly divided into MCAO/R model group, notogisenoside-Rg1 therapy group (100 mg/kg) and the positive medicine control group (nimodipine 1 mg/kg). The MCAO/R model were made by thread-occluded method. The four rats were randomly taken from each groups and were killed to be breaken out brain tissues as specimens after which were treated with medicine in 1,3, 5 days. Total RNA was isolated from cerebrum cortex. Specific oligonucleotide primers of BDNF mRNA gene fragments were amplificated by RT-PCR to construct recombinant plasmid and sequence. To dilute recombinant plasmid didploidly and a quantitative standard curve was completed. Taqman fluorogenic quantitative RT-PCR (FQ-PCR) was set up to detect the BDNF mRNA variety of cerebrum cortex. Results: Compared with the model group and the postive control group, notogisenoside-Rg1 treated groups could obviously improve some nervous deficit symptoms in the cerebral ischemia and increase BDNF mRNA amount that in the cerebrum cortex at different period after rat MCAO/R injury. Conclusion: Notoginsenoside-Rg1 can promote to generating internal BDNF protein in brain by up-regulation the expression of BDNF mRNA amount in the cerebrum cortex. BDNF bind in TrkB, which can give rise to protective effects for ischemic neurons by generating corresponding domino effect molecules. Accordingly it can be as a therapy method in cerebral ischemia injury.
MeSH term(s)	Animals ; Brain Ischemia/drug therapy ; Brain Ischemia/genetics ; Brain-Derived Neurotrophic Factor/genetics ; Ginsenosides/pharmacology ; Male ; RNA, Messenger/genetics ; Rats ; Rats, Sprague-Dawley ; Real-Time Polymerase Chain Reaction ; Reperfusion Injury/drug therapy ; Reperfusion Injury/genetics ; Reverse Transcriptase Polymerase Chain Reaction ; Up-Regulation
Chemical Substances	Brain-Derived Neurotrophic Factor ; Ginsenosides ; RNA, Messenger
Language	Chinese
Publishing date	2007-03
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	1001-4454
ISSN	1001-4454
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Origin and nature of cold seep in northeastern Dongsha area, South China Sea: Evidence from chimney-like seep carbonates

Han, XiQiu / Yang, KeHong / Huang, YongYang

Chinese science bulletin Kexue tongbao

Volume v. 58,, Issue no. 3

Abstract	The occurrence of seep carbonates is one of the characteristic features for cold seep sites at continental margins. The carbonates documented the venting history of methane-rich fluid. Compared to the chemoherm carbonates and carbonate pavements which formed on the sediment-water interface, chimney-like seep carbonates precipitated around fluid conduits below the sediment-water interface therefore better recording information of the past fluid flow and composition. Here the chimney-like seep carbonate samples from the northeastern Dongsha area of the South China Sea were studied to understand the origin and nature of the venting fluids and their potential relationship with gas hydrate deposits underneath the seafloor. Based on the occurrence, morphology, petrology, mineralogy and C- and O- isotope compositions, combined with present and past bottom water temperatures and the timing of methane release events, the oxygen isotopic fractionation between calcite and water were used to estimate the equilibrium δ ¹⁸O values of the precipitating fluids. The δ ¹³C values ranging from −56.33‰ to −42.70‰ V-PDB and thus clearly show that the studied chimneys were mainly derived from biogenic methane oxidation. The calculated equilibrium δ ¹⁸O values of the precipitating fluids ranged from 1.9‰ ± 0.3‰ to 0.6‰ ± 0.3‰ V-SMOW, with an average of 1.4‰ ± 0.3‰ V-SMOW which is heavier than those of seawater even at the last glacial maximum. It is considered that the formation of chimney-like carbonates was closely related to methane hydrate dissociation in the area. The methane hydrates contributed as much as 45.7% of water to the venting fluids. It is suggested that the climate and environmental changes (e.g. sea-level lowering, down-cutting canyons and mass wasting) are the major mechanisms maybe responsible for the destabilization of methane hydrates in the study area. The extensive occurrence of seep carbonates indicates that a large amount of the methane released from methane hydrate dissociation has been effectively captured and sequestered by microbial anaerobic oxidation of methane (AOM) before it escapes into the water column.
Keywords	seawater ; dissociation ; methane ; oxygen ; oxidation ; canyons ; stable isotopes ; calcite ; methane production ; cold ; carbon ; sea level ; water temperature ; carbonates ; climate ; fractionation
Language	English
Document type	Article
ISSN	1001-6538
Database	AGRIS - International Information System for the Agricultural Sciences and Technology

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Article ; Online: Sources and spatial variations of heavy metals in offshore sediments of the western Pearl River Estuary.

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Article ; Online: Economic burden of advanced lung cancer patients treated by gefitinib alone and combined with chemotherapy in two regions of China.

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Article: Petrology and geochemistry of cold seep carbonates from the northern Okinawa Trough, East China Sea: implications to early diagenesis

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Article: [Effect of low-molecular-weight heparin combined with doxorubicin on hepatocellular cancer cell migration in vitro].

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Article: Origin and nature of cold seep in northeastern Dongsha area, South China Sea: Evidence from chimney-like seep carbonates

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Article: [Variation of BDNF mRNA on focalcerebral ischemia reperfusion injury in rats with notogisenoside-Rg1].

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Article: Origin and nature of cold seep in northeastern Dongsha area, South China Sea: Evidence from chimney-like seep carbonates

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