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Article ; Online: Cellular senescence in acute kidney injury: Target and opportunity.

Li, Ting / Yang, Kexin / Gao, Wei / Peng, Fujun / Zou, Xiangyu

Biochemical and biophysical research communications

2024 Volume 706, Page(s) 149744

Abstract: Acute kidney injury (AKI) is a common clinical disease with a high incidence and mortality rate. It typically arises from hemodynamic alterations, sepsis, contrast agents, and toxic drugs, instigating a series of events that culminate in tissue and renal ...

Abstract	Acute kidney injury (AKI) is a common clinical disease with a high incidence and mortality rate. It typically arises from hemodynamic alterations, sepsis, contrast agents, and toxic drugs, instigating a series of events that culminate in tissue and renal damage. This sequence of processes often leads to acute renal impairment, prompting the initiation of a repair response. Cellular senescence is an irreversible arrest of the cell cycle. Studies have shown that renal cellular senescence is closely associated with AKI through several mechanisms, including the promotion of oxidative stress and inflammatory response, telomere shortening, and the down-regulation of klotho expression. Exploring the role of cellular senescence in AKI provides innovative therapeutic ideas for both the prevention and treatment of AKI. Furthermore, it has been observed that targeted removal of senescent cells in vivo can efficiently postpone senescence, resulting in an enhanced prognosis for diseases associated with senescence. This article explores the effects of common anti-senescence drugs senolytics and senostatic and lifestyle interventions on renal diseases, and mentions the rapid development of mesenchymal stem cells (MSCs). These studies have taken senescence-related research to a new level. Overall, this article comprehensively summarizes the studies on cellular senescence in AKI, aiming is to elucidate the relationship between cellular senescence and AKI, and explore treatment strategies to improve the prognosis of AKI.
MeSH term(s)	Humans ; Acute Kidney Injury/metabolism ; Cellular Senescence ; Kidney/metabolism ; Mesenchymal Stem Cells/metabolism ; Oxidative Stress
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2024.149744
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Environment-Aware Adaptive Reinforcement Learning-Based Routing for Vehicular Ad Hoc Networks.

Jiang, Yi / Zhu, Jinlin / Yang, Kexin

Sensors (Basel, Switzerland)

2023 Volume 24, Issue 1

Abstract: With the rapid development of the intelligent transportation system (ITS), routing in vehicular ad hoc networks (VANETs) has become a popular research topic. The high mobility of vehicles in urban streets poses serious challenges to routing protocols and ...

Abstract	With the rapid development of the intelligent transportation system (ITS), routing in vehicular ad hoc networks (VANETs) has become a popular research topic. The high mobility of vehicles in urban streets poses serious challenges to routing protocols and has a significant impact on network performance. Existing topology-based routing is not suitable for highly dynamic VANETs, thereby making location-based routing protocols the preferred choice due to their scalability. However, the working environment of VANETs is complex and interference-prone. In wireless-network communication, the channel contention introduced by the high density of vehicles, coupled with urban structures, significantly increases the difficulty of designing high-quality communication protocols. In this context, compared to topology-based routing protocols, location-based geographic routing is widely employed in VANETs due to its avoidance of the route construction and maintenance phases. Considering the characteristics of VANETs, this paper proposes a novel environment-aware adaptive reinforcement routing (EARR) protocol aimed at establishing reliable connections between source and destination nodes. The protocol adopts periodic beacons to perceive and explore the surrounding environment, thereby constructing a local topology. By applying reinforcement learning to the vehicle network's route selection, it adaptively adjusts the Q table through the perception of multiple metrics from beacons, including vehicle speed, available bandwidth, signal-reception strength, etc., thereby assisting the selection of relay vehicles and alleviating the challenges posed by the high dynamics, shadow fading, and limited bandwidth in VANETs. The combination of reinforcement learning and beacons accelerates the establishment of end-to-end routes, thereby guiding each vehicle to choose the optimal next hop and forming suboptimal routes throughout the entire communication process. The adaptive adjustment feature of the protocol enables it to address sudden link interruptions, thereby enhancing communication reliability. In experiments, the EARR protocol demonstrates significant improvements across various performance metrics compared to existing routing protocols. Throughout the simulation process, the EARR protocol maintains a consistently high packet-delivery rate and throughput compared to other protocols, as well as demonstrates stable performance across various scenarios. Finally, the proposed protocol demonstrates relatively consistent standardized latency and low overhead in all experiments.
Language	English
Publishing date	2023-12-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s24010040
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Insight into Degrading Effects of Two Fungi on Polyurethane Coating Failure in a Simulated Atmospheric Environment.

Hao, Xiangping / Yang, Kexin / Zhang, Dawei / Lu, Lin

Polymers

2023 Volume 15, Issue 2

Abstract: Two different fungi, Talaromyces funiculosus (T. funiculosus) and Phanerochaete chrysosporium (P. chrysosporium), were collected from the Xishuangbanna atmospheric corrosion site and incubated on a polyurethane (PU) coating at 30 °C for two weeks under ... ...

Abstract	Two different fungi, Talaromyces funiculosus (T. funiculosus) and Phanerochaete chrysosporium (P. chrysosporium), were collected from the Xishuangbanna atmospheric corrosion site and incubated on a polyurethane (PU) coating at 30 °C for two weeks under 95% relative humidity (RH). The biodegrading effects of these fungi on the coating failure were investigated from aspects of metabolism and electrochemistry. The results showed that T. funiculosus contributed more to the degradation of the PU coating failure than P. chrysosporium, and two factors played dominant roles. First, the weight of the T. funiculosus mycelium was nearly 3 times more than that of P. chrysosporium, indicating there was more substrate mycelium of T. funiculosus deep into the coatings to get more nutrition in atmospheric during colonization. Second, T. funiculosus secreted carboxylic acids, such as citric, propanoic, succinic, and tartaric acids, and accelerated the hydrolysis of the ester and urethane bonds in the PU coatings. As a result, the mycelium of T. funiculosus readily penetrated the interface of the coating and substrate resulting in a rapid proliferation. Thus, the \|Z\|0.01Hz value of the coating decreased to 5.1 × 104 Ω·cm2 after 14 days of colonization by T. funiculosus while the value remained at 7.2 × 107 Ω·cm2 after colonization by P. chrysosporium. These insights suggest that the biodegradation process in simulated atmospheric environments would provide theoretical guidance and directions for the design of antifungal PU coatings.
Language	English
Publishing date	2023-01-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym15020328
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Article ; Online: Roll Eccentricity Detection and Application Based on SFT and Regional DFT.

Yang, Kexin / Zheng, Gang / Yang, Zhe

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 16

Abstract: Roll eccentricity disturbance is a high-frequency periodic change signal caused by the irregular shape of the roll and roll bearing, which is difficult to identify and affects the periodic deviation of the exit thickness of the strip. To achieve rapid ... ...

Abstract	Roll eccentricity disturbance is a high-frequency periodic change signal caused by the irregular shape of the roll and roll bearing, which is difficult to identify and affects the periodic deviation of the exit thickness of the strip. To achieve rapid identification of the source and a mathematical model of roll eccentricity signals, a sparse Fourier transform (SFT) and regional DFT method for roll eccentricity signal recognition and detection was proposed. This method utilizes SFT to calculate the signal FFT more quickly based on the sparsity of the signal frequency domain. Under the premise of knowing the roll diameter, the signal frequency spectrum is identified online, the amplitude and phase are identified through regional DFT, and the eccentricity disturbance is compensated on site. The simulation results show that this method can accurately identify the source of roll disturbance, quickly update and replace the problematic rolls, and improve the online recognition efficiency by more than 3000 times. This method has good results in online detection and recognition of roll eccentricity signals, greatly improving engineering application efficiency, and ultimately achieving the goal of improving the accuracy of strip outlet thickness.
Language	English
Publishing date	2023-08-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23167157
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Proteomic Analysis of Lysine Acetylation and Succinylation to Investigate the Pathogenicity of Virulent

Ding, Yongqiang / Liu, Yangxuan / Yang, Kexin / Zhao, Yiran / Wen, Chun / Yang, Yi / Zhang, Wei

Genes

2024 Volume 15, Issue 4

Abstract: Pseudomonas ... ...

Abstract	Pseudomonas syringae
MeSH term(s)	Arabidopsis/microbiology ; Arabidopsis/genetics ; Arabidopsis/metabolism ; Pseudomonas syringae/pathogenicity ; Pseudomonas syringae/metabolism ; Pseudomonas syringae/genetics ; Acetylation ; Lysine/metabolism ; Plant Diseases/microbiology ; Plant Diseases/genetics ; Proteomics/methods ; Virulence/genetics ; Bacterial Proteins/metabolism ; Bacterial Proteins/genetics ; Protein Processing, Post-Translational ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Proteome/metabolism
Chemical Substances	Lysine (K3Z4F929H6) ; Bacterial Proteins ; Arabidopsis Proteins ; Proteome
Language	English
Publishing date	2024-04-16
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes15040499
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The role of mitophagy in the development of chronic kidney disease.

Yang, Kexin / Li, Ting / Geng, Yingpu / Zou, Xiangyu / Peng, Fujun / Gao, Wei

PeerJ

2024 Volume 12, Page(s) e17260

Abstract: Chronic kidney disease (CKD) represents a significant global health concern, with renal fibrosis emerging as a prevalent and ultimate manifestation of this condition. The absence of targeted therapies presents an ongoing and substantial challenge. ... ...

Abstract	Chronic kidney disease (CKD) represents a significant global health concern, with renal fibrosis emerging as a prevalent and ultimate manifestation of this condition. The absence of targeted therapies presents an ongoing and substantial challenge. Accumulating evidence suggests that the integrity and functionality of mitochondria within renal tubular epithelial cells (RTECs) often become compromised during CKD development, playing a pivotal role in the progression of renal fibrosis. Mitophagy, a specific form of autophagy, assumes responsibility for eliminating damaged mitochondria to uphold mitochondrial equilibrium. Dysregulated mitophagy not only correlates with disrupted mitochondrial dynamics but also contributes to the advancement of renal fibrosis in CKD. While numerous studies have examined mitochondrial metabolism, ROS (reactive oxygen species) production, inflammation, and apoptosis in kidney diseases, the precise pathogenic mechanisms underlying mitophagy in CKD remain elusive. The exact mechanisms through which modulating mitophagy mitigates renal fibrosis, as well as its influence on CKD progression and prognosis, have not undergone systematic investigation. The role of mitophagy in AKI has been relatively clear, but the role of mitophagy in CKD is still rare. This article presents a comprehensive review of the current state of research on regulating mitophagy as a potential treatment for CKD. The objective is to provide fresh perspectives, viable strategies, and practical insights into CKD therapy, thereby contributing to the enhancement of human living conditions and patient well-being.
MeSH term(s)	Mitophagy ; Humans ; Renal Insufficiency, Chronic/pathology ; Renal Insufficiency, Chronic/metabolism ; Mitochondria/metabolism ; Mitochondria/pathology ; Fibrosis/pathology ; Fibrosis/metabolism ; Disease Progression ; Reactive Oxygen Species/metabolism ; Animals ; Kidney Tubules/pathology ; Kidney Tubules/metabolism
Chemical Substances	Reactive Oxygen Species
Language	English
Publishing date	2024-04-25
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2703241-3
ISSN	2167-8359 ; 2167-8359
ISSN (online)	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.17260
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Investigating Different Local Polyurethane Coatings Degradation Effects and Corrosion Behaivors by

Hao, Xiangping / Yang, Kexin / Yuan, Yiding / Zhang, Dawei / Lu, Lin

Materials (Basel, Switzerland)

2023 Volume 16, Issue 4

Abstract: The degradation effect of mold on the coating in a hot and humid environment is one of the important factors that cause layer failure. Combined with the wire beam electrode (WBE) and the traditional surface analysis technique, the local biodegradation of ...

Abstract	The degradation effect of mold on the coating in a hot and humid environment is one of the important factors that cause layer failure. Combined with the wire beam electrode (WBE) and the traditional surface analysis technique, the local biodegradation of the coatings and the corrosion behaviors of metal substrates can be characterized accurately by a WBE. Herein, a WBE was used to study the degradation impact of
Language	English
Publishing date	2023-02-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16041402
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: In vitro antioxidant activity evaluation of pine nut peptides (

Sun, Jiajia / Zhang, Zhi / Yang, Kexin / Wei, Gang / Li, Yanxia

Preparative biochemistry & biotechnology

2023 Volume 54, Issue 3, Page(s) 382–392

Abstract: In this study, we utilized the remarkable capabilities ... ...

Abstract	In this study, we utilized the remarkable capabilities of
MeSH term(s)	Antioxidants/pharmacology ; Bacillus subtilis ; Pinus ; Nut Proteins ; Nuts ; Peptides/pharmacology
Chemical Substances	Antioxidants ; Nut Proteins ; Peptides
Language	English
Publishing date	2023-08-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1322522-4
ISSN	1532-2297 ; 1082-6068
ISSN (online)	1532-2297
ISSN	1082-6068
DOI	10.1080/10826068.2023.2243507
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Does technology innovation reduce haze pollution? An empirical study based on urban innovation index in China

He, Lingyun / Yuan, Enyu / Yang, Kexin / Tao, Dongjie

Environmental science and pollution research. 2022 Apr., v. 29, no. 16

2022

Abstract: Haze pollution is one of the most concerning environmental issues, and controlling haze pollution without affecting economic development is of immense significance. Using the panel data composed of PM₂.₅ concentration and other data from 278 cities in ... ...

Abstract	Haze pollution is one of the most concerning environmental issues, and controlling haze pollution without affecting economic development is of immense significance. Using the panel data composed of PM₂.₅ concentration and other data from 278 cities in China between 2003 and 2016, this paper empirically investigates the impact of urban innovation on haze pollution and its transmission mechanism. Based on the fixed effect model, the research finds that increasing urban innovation significantly reduces haze pollution. Even after dealing with possible endogenous problems, the result still holds. Energy consumption and industrial agglomeration are two important transmission channels through which urban innovation affects haze pollution. Furthermore, time heterogeneity analysis shows that the negative effect of urban innovation on haze pollution increases with time. Spatial heterogeneity analysis shows that urban innovation has a more significant mitigation effect on haze pollution in eastern cities than in central and western cities in China. This paper indicates that technological innovation, as the main driving force for development, can provide vital support to China to improve the ecological environment.
Keywords	economic development ; empirical research ; energy ; models ; pollution ; spatial variation ; technology ; China
Language	English
Dates of publication	2022-04
Size	p. 24063-24076.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-021-17448-9
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Trivalent rare-earth metal cyclic (alkyl)(amino)carbene complexes.

Xiao, Yuyuan / Liu, Ziyu / Liang, Jiefeng / Yang, Kexin / Huang, Wenliang

Dalton transactions (Cambridge, England : 2003)

2022 Volume 51, Issue 41, Page(s) 15873–15882

Abstract: Coordination chemistry of cyclic (alkyl)(amino)carbene (CAAC) ligands has blossomed in recent years, exemplified by their strong σ-donating and π-accepting ability. However, trivalent rare-earth metal CAAC complexes remain elusive. By using M( ... ...

Abstract	Coordination chemistry of cyclic (alkyl)(amino)carbene (CAAC) ligands has blossomed in recent years, exemplified by their strong σ-donating and π-accepting ability. However, trivalent rare-earth metal CAAC complexes remain elusive. By using M(CH
Language	English
Publishing date	2022-10-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/d2dt02759c
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