LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 13820

Search options

  1. Article: A causality between fruit consumption and colorectal cancer: a two-sample Mendelian randomization analysis.

    Yang, Li

    Frontiers in oncology

    2024  Volume 14, Page(s) 1362269

    Abstract: Background: Colorectal cancer (CRC) significantly threatens human health with increasing incidence and mortality. A debate continues whether fruit consumption is associated with CRC, despite dietary habits having an impact on the disease. The study aims ...

    Abstract Background: Colorectal cancer (CRC) significantly threatens human health with increasing incidence and mortality. A debate continues whether fruit consumption is associated with CRC, despite dietary habits having an impact on the disease. The study aims to examine the causal relationship between fruit consumption and CRC based on a two-sample Mendelian randomization method (MR).
    Methods: Summary statistics for fruit consumption and CRC were obtained from the UK Biobank and the FinnGen Consortium, respectively. Analysis methods used in this study included the inverse-variance weighted (IVW), MR Egger, weighted median, simple mode, and weighted mode. Heterogeneity and horizontal pleiotropy were also assessed. Additionally, a leave-one-out analysis was performed to validate the robustness of the results.
    Results: We found that fruit consumption was associated with a reduction in CRC risk by the IVW method (
    Conclusion: Our findings suggest that a genetic predisposition for fruit consumption may be protective against CRC, underscoring the need for further research to elucidate the underlying mechanisms and dietary patterns involved.
    Language English
    Publishing date 2024-03-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2024.1362269
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Geometric phase for twisted light.

    Yang, Li-Ping

    Optics express

    2023  Volume 31, Issue 6, Page(s) 10287–10296

    Abstract: Polarization vectors of light traveling in a coiled optical fiber rotate around its propagating axis even in the absence of birefringence. This rotation was usually explained due to the Pancharatnam-Berry phase of spin-1 photons. Here, we use a purely ... ...

    Abstract Polarization vectors of light traveling in a coiled optical fiber rotate around its propagating axis even in the absence of birefringence. This rotation was usually explained due to the Pancharatnam-Berry phase of spin-1 photons. Here, we use a purely geometric method to understand this rotation. We show that similar geometric rotations also exist for twisted light carrying orbital angular momentum (OAM). The corresponding geometric phase can be applied in photonic OAM-state-based quantum computation and quantum sensing.
    Language English
    Publishing date 2023-05-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.476989
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Analysis of Erhu Performance Effect in Public Health Music Works Based on Artificial Intelligence Technology.

    Yang, Li

    publication RETRACTED

    Journal of environmental and public health

    2022  Volume 2022, Page(s) 9251793

    Abstract: With the rise of Erhu teaching in recent years, a large number of people have joined the team to learn Erhu playing. However, due to the high cost of teaching and the unique one-to-one teaching mode between teachers and students, Erhu education resources ...

    Abstract With the rise of Erhu teaching in recent years, a large number of people have joined the team to learn Erhu playing. However, due to the high cost of teaching and the unique one-to-one teaching mode between teachers and students, Erhu education resources are very scarce. Learning Erhu performance has become a luxury activity. Nowadays, with the rise of artificial intelligence, computer music is developing rapidly. Music has two important aspects: composition and performance. Different kinds of instruments convey different styles, and players inject different rhythms and dynamics into their performance, thus producing rich expressive force. The development of image style conversion, which opens people's evaluation of music performance, is an important issue in many fields of artificial intelligence (it is also known as intelligence, machine intelligence, referring to the intelligence shown by the machine made by people. Usually, artificial intelligence refers to the technique of presenting human intelligence through ordinary computer programs). For an Erhu song, there are various factors that affect its effectiveness, and there are many indexes to evaluate it, such as sense of rhythm, expressive force, musical sense, style, and so on. Using a computer to simulate the evaluation process is essential to find out the mathematical relationship between the factors that affect the performance of music and the evaluation indexes. Neural network is a kind of mathematical model proposed by simulating the way of thinking of human brain in artificial intelligence. It has the advantages of not having strict requirements on data distribution, nonlinear data processing method, strong robustness, and dynamics and is very suitable for the mathematical model of evaluation system. In addition, the neural network also has a strong theoretical basis, and their application in various industries has developed basically mature. This paper tries to introduce a deep neural network mathematical model into the evaluation system of Erhu performance, and the experimental results prove the reliability and practicality of the method in this paper. It can provide a method basis and theoretical reference for evaluation of Erhu performance effect.
    MeSH term(s) Artificial Intelligence ; Humans ; Music ; Public Health ; Reproducibility of Results ; Technology
    Language English
    Publishing date 2022-09-01
    Publishing country United States
    Document type Journal Article ; Retracted Publication
    ZDB-ID 2526611-1
    ISSN 1687-9813 ; 1687-9813
    ISSN (online) 1687-9813
    ISSN 1687-9813
    DOI 10.1155/2022/9251793
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: [Current Interventional Management of Acute Upper Gastrointestinal Bleeding].

    Yang, Li

    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

    2022  Volume 53, Issue 3, Page(s) 361–366

    Abstract: Upper gastrointestinal bleeding (UGIB), a common medical emergency, causes significant morbidity and mortality. Endoscopic evaluation and treatment remain the standard care in patients who can be hemodynamically stabilized. However, severe bleeding ... ...

    Abstract Upper gastrointestinal bleeding (UGIB), a common medical emergency, causes significant morbidity and mortality. Endoscopic evaluation and treatment remain the standard care in patients who can be hemodynamically stabilized. However, severe bleeding despite conservative medication treatment or medication combined with endoscopic intervention occurs in 5%-10% of patients, requiring interventional or surgical treatment. Endovascular embolization has emerged as an alternative to emergency operative intervention for high-risk patients with non-variceal UGIB and is now commonly considered the first-line therapy for refractory bleeding after endoscopic treatment. Child-Pugh class C or class B cirrhosis patients who have varicosity or active bleeding detected in endoscopy are at high risks for treatment failure, rebleeding, and death. A preemptive transjugular intrahepatic portosystemic shunt has been shown to reduce treatment failure and mortality significantly. Herein, we reviewed the current role of interventional treatment in the management of massive UGIB on the basis of years of clinical experience of the Department of Gastroenterology, West China Hospital, Sichuan University.
    MeSH term(s) Acute Disease ; Esophageal and Gastric Varices/complications ; Gastrointestinal Hemorrhage/etiology ; Gastrointestinal Hemorrhage/surgery ; Humans ; Liver Cirrhosis ; Portasystemic Shunt, Transjugular Intrahepatic/adverse effects
    Language Chinese
    Publishing date 2022-06-01
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2106840-9
    ISSN 1672-173X
    ISSN 1672-173X
    DOI 10.12182/20220560206
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2708: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Effects of intrinsically disordered regions in gp120 underlying HIV neutralization phenotypes.

    Li, Yi / Yang, Li / Yang, Li-Quan

    Biochemical and biophysical research communications

    2024  Volume 709, Page(s) 149830

    Abstract: HIV envelope protein gp120 is considered a primary molecular determinant of viral neutralization phenotype due to its critical role in viral entry and immune evasion. The intrinsically disordered regions (IDRs) in gp120 are responsible for their ... ...

    Abstract HIV envelope protein gp120 is considered a primary molecular determinant of viral neutralization phenotype due to its critical role in viral entry and immune evasion. The intrinsically disordered regions (IDRs) in gp120 are responsible for their extensive sequence variations and significant structural rearrangements. Despite HIV neutralization phenotype and sequence/structural information of gp120 have been experimentally characterized, there remains a gap in our understanding of the correlation between the viral phenotype and IDRs in gp120. Here, we combined machine learning (ML) techniques and molecular dynamics (MD) simulations to gain data-driven and molecule-mechanism insights into relationships between viral sequence, structure, and phenotypes from the perspective of IDRs in gp120. ML models, trained only on the length and disorder score of IDRs, achieved equivalent performance to the best baseline model using amino acid sequences to discriminate HIV neutralization phenotype, indicating that the lengths or disorder of specific IDRs are strongly related to HIV neutralization phenotypes. Comparative MD analysis reveals that gp120 with extreme neutralization phenotypes in multiple conformational states, especially some IDRs, exhibit significantly distinct structural dynamics, conformational flexibility, and thermodynamic distributions. Taken together, our study provided insights into the role of IDRs in gp120 responding to HIV neutralization phenotypes, which will advance the understanding of molecular mechanisms underlying viral function associated with HIV neutralization phenotype and help develop antiviral vaccines or drugs.
    MeSH term(s) Humans ; HIV Envelope Protein gp120/genetics ; Protein Conformation ; Amino Acid Sequence ; HIV Infections ; Phenotype ; Neutralization Tests
    Chemical Substances HIV Envelope Protein gp120
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2024.149830
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 116: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Causal associations between liver enzymes and diabetic microvascular complications

    Yang Li / Qiu Zhang

    PLoS ONE, Vol 19, Iss

    A univariable and multivariable Mendelian randomization

    2024  Volume 1

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Causal associations between liver enzymes and diabetic microvascular complications

    Yang Li / Qiu Zhang

    PLoS ONE, Vol 19, Iss 1, p e

    A univariable and multivariable Mendelian randomization.

    2024  Volume 0296894

    Abstract: Background Observational studies show that liver enzymes are diabetes risk factors. However, previous observational investigations on the relationship between liver enzymes and diabetic microvascular complications produced contradictory results. The ... ...

    Abstract Background Observational studies show that liver enzymes are diabetes risk factors. However, previous observational investigations on the relationship between liver enzymes and diabetic microvascular complications produced contradictory results. The purpose of this research is to examine the independent causal effects of liver enzymes on diabetic microvascular complications. Methods Univariable Mendelian randomization (UVMR) and multivariable Mendelian randomization (MVMR) were utilized to disentangle the causal effects. The genome-wide association study (GWAS) summary-level statistics were collected from the UK biobank and the FinnGen consortium. Single nucleotide polymorphisms (SNPs) were selected as genetic instruments with genome-wide significance (p < 5 ×10-8). Five UVMR approaches, including inverse variance weighted (IVW), Bayesian weighted Mendelian randomization, MR-Pleiotropy Residual Sum and Outlier (MR-PRESSO), weighted median, and MR-Egger, and three MVMR approaches, including the extended versions of IVW, MR-Egger, and the Q-minimization methods, were performed to evaluate the causal effects. The robustness of the MR results was further confirmed using several sensitivity analyses. Results UVMR revealed that a genetically predisposed per standard deviation increase in serum alanine aminotransferase (ALT) level increased the risk of diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM) (IVW OR = 1.489, 95% CI = 1.206-1.772, p = 0.006). Likewise, serum aspartate aminotransferase (AST) levels showed similar results (IVW OR = 1.376, 95% CI = 1.115-1.638, p = 0.017). Furthermore, these effects were consistent after controlling for glycemia and blood pressure using MVMR analysis. Additionally, sensitivity analyses further strengthened the causality. However, no significant associations were found between alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), and diabetic microvascular complications. Conclusions Robust evidence was demonstrated for an independent causal effect of serum ...
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Thesis ; Online: Genomics-assisted dissection of black rot resistance in Brassica napus

    Yang, Li

    The research aims to elucidate the genetic and molecular mechanisms underlying black rot resistance in B. napus

    2023  

    Keywords Life Science
    Language English
    Publisher Wageningen University
    Publishing country nl
    Document type Thesis ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: Spatial regulation of immunity: unmasking the secrets of abaxial immunity to powdery mildew.

    Xu, Dawei / Yang, Li

    Journal of experimental botany

    2024  Volume 75, Issue 5, Page(s) 1213–1216

    Abstract: This article comments on: Wu Y, Sexton WK, Zhang Q, Bloodgood D, Wu Y, Hooks C, Coker F, Vasquez A, Wei C-I, Xiao S. 2024. Leaf abaxial immunity to powdery mildew in Arabidopsis is conferred by multiple defense mechanisms. Journal of Experimental Botany ... ...

    Abstract This article comments on: Wu Y, Sexton WK, Zhang Q, Bloodgood D, Wu Y, Hooks C, Coker F, Vasquez A, Wei C-I, Xiao S. 2024. Leaf abaxial immunity to powdery mildew in Arabidopsis is conferred by multiple defense mechanisms. Journal of Experimental Botany 75, 1465-1478.
    MeSH term(s) Arabidopsis/genetics ; Botany ; Plant Leaves
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2976-2
    ISSN 1460-2431 ; 0022-0957
    ISSN (online) 1460-2431
    ISSN 0022-0957
    DOI 10.1093/jxb/erae019
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 55/29: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Muscle-Specific Tyrosine Kinase Antibody Positive Myasthenia Gravis With Peripheral Nerve Hyperexcitability: Case Report and Literature Review.

    Yang, Li

    Clinical neuropharmacology

    2021  Volume 44, Issue 2, Page(s) 57–61

    Abstract: Objectives: Administration of acetylcholinesterase inhibitors can bring about peripheral nerve hyperexcitability symptom in muscle-specific tyrosine kinase antibody positive myasthenia gravis, but the changes in electromyography before and after drug ... ...

    Abstract Objectives: Administration of acetylcholinesterase inhibitors can bring about peripheral nerve hyperexcitability symptom in muscle-specific tyrosine kinase antibody positive myasthenia gravis, but the changes in electromyography before and after drug withdrawal have not been described in detail.
    Methods: Electromyography was performed on a case of muscle-specific tyrosine kinase antibody positive myasthenia gravis with peripheral nerve hyperexcitability correlated with the administration of pyridostigmine bromide before and after drug withdrawal, respectively.
    Results: Afterdischarges close after M waves appeared on the tibial nerve, common peroneal nerve, median nerve, and ulnar nerve, and these presented unique characteristics in repetitive nerve stimulation. Ten days after pyridostigmine bromide withdrawal, the second electromyography examination was carried out and showed that the afterdischarges on all nerves disappeared dramatically and the amplitude of tibial nerve F waves was elevated than before.
    Conclusions: Afterdischarges can be an important indicator of muscle-specific tyrosine kinase antibody positive myasthenia gravis with peripheral nerve hyperexcitability correlated with acetylcholinesterase inhibitors.
    MeSH term(s) Acetylcholinesterase ; Electromyography ; Humans ; Myasthenia Gravis/drug therapy ; Peripheral Nerves ; Pyridostigmine Bromide/therapeutic use
    Chemical Substances Acetylcholinesterase (EC 3.1.1.7) ; Pyridostigmine Bromide (KVI301NA53)
    Language English
    Publishing date 2021-01-20
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 199293-4
    ISSN 1537-162X ; 0362-5664
    ISSN (online) 1537-162X
    ISSN 0362-5664
    DOI 10.1097/WNF.0000000000000432
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Se 437: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top