Article ; Online: Association between tumor necrosis factor-α -308 Gauss/A polymorphism and risk of silicosis and coal workers pneumoconiosis in Chinese population.
2018 Volume 30, Issue 6, Page(s) 213–217
Abstract: Background: Many studies have attempted to clarify the association between TNF-a -308G/A polymorphism and pneumoconiosis, but there has been no definite consensus to date. To further assess the effects of TNF-a -308G/A polymorphism on the risk of ... ...
| Abstract | Background: Many studies have attempted to clarify the association between TNF-a -308G/A polymorphism and pneumoconiosis, but there has been no definite consensus to date. To further assess the effects of TNF-a -308G/A polymorphism on the risk of pneumoconiosis, a meta-analysis was performed in Chinese population. Methods: We searched the related literature in PubMed and Chinese databases through June 2018. The strength of the associations was assessed used pooled odds ratios (ORs) and 95% confidence intervals (CIs). Results: Nine case-control studies including 730 silicosis cases, 457 coal workers pneumoconiosis cases and 2429 controls were identified according to the inclusion criteria. In the total analyses, a significantly elevated risk was found in allelic model (OR = 1.41, 95% CI = 1.16-1.71). In the subgroup analyses by geographic area and type of pneumoconiosis, significant results were found both in North China (A versus G, OR = 1.33, CI = 1.05-1.69) and South China (A versus G, OR = 1.56, CI = 1.14-2.15); significant results were also found in silicosis (A versus G, OR = 1.40, CI = 1.11-1.78) and coal worker pneumoconiosis (A versus G, OR = 1.42, CI = 1.03-1.96). Conclusion: This meta-analysis suggested that TNF-a gene -308 G/A polymorphism is associated with increased silicosis and coal workers pneumoconiosis risk in the Chinese population, and further studies in other ethnic groups are required for definite conclusions. |
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| MeSH term(s) | Anthracosis/genetics ; Asian Continental Ancestry Group/genetics ; Case-Control Studies ; Humans ; Polymorphism, Genetic ; Risk Factors ; Silicosis/genetics ; Tumor Necrosis Factor-alpha/genetics |
| Chemical Substances | Tumor Necrosis Factor-alpha |
| Language | English |
| Publishing date | 2018-09-26 |
| Publishing country | England |
| Document type | Journal Article ; Meta-Analysis |
| ZDB-ID | 1038809-6 |
| ISSN | 1091-7691 ; 0895-8378 |
| ISSN (online) | 1091-7691 |
| ISSN | 0895-8378 |
| DOI | 10.1080/08958378.2018.1494766 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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