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Article ; Online: Assessment of optimal combinations of therapeutic probiotics for depression, anxiety, and stress.

Yang, Yafang / Yang, Ligang / Wan, Min / Pan, Da / Sun, Guiju / Yang, Chao

2024 , Page(s) 1–15

Abstract: Background: Accumulating data show that probiotics may be beneficial for reducing depressive, anxiety, and stress symptoms. However, the best combinations and species of probiotics have not been identified. The objective of our study was to assess the ... ...

Abstract	Background: Accumulating data show that probiotics may be beneficial for reducing depressive, anxiety, and stress symptoms. However, the best combinations and species of probiotics have not been identified. The objective of our study was to assess the most effective combinations and components of different probiotics through network meta-analysis. Method: A systematic search of four databases, PubMed, Web of Science, Cochrane, and Embase, was conducted from inception to 11 January 2024. The GRADE framework was used to assess the quality of evidence contributing to each network estimate. Results: We deemed 45 trials eligible, these included 4053 participants and 10 types of interventions. The quality of evidence was rated as high or moderate. The NMA revealed that Conclusion: The NMA revealed that
Language	English
Publishing date	2024-03-18
Publishing country	England
Document type	Journal Article
ZDB-ID	217420-0
ISSN	1469-8978 ; 0033-2917
ISSN (online)	1469-8978
ISSN	0033-2917
DOI	10.1017/S0033291724000679
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Zs.B 1003: Show issues

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Article ; Online: Azithromycin, minocycline, moxifloxacin and spectinomycin failure in a case with persistent

Yang, Ligang / Ke, Wujian

International journal of STD & AIDS

2020 Volume 31, Issue 11, Page(s) 1106–1109

Abstract: We report a case ... ...

Abstract	We report a case of
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Azithromycin/pharmacology ; Azithromycin/therapeutic use ; DNA Gyrase/genetics ; DNA, Bacterial/genetics ; Humans ; Middle Aged ; Minocycline/pharmacology ; Minocycline/therapeutic use ; Moxifloxacin/pharmacology ; Moxifloxacin/therapeutic use ; Mycoplasma Infections/drug therapy ; Mycoplasma Infections/genetics ; Mycoplasma Infections/microbiology ; Mycoplasma genitalium/drug effects ; Mycoplasma genitalium/genetics ; Mycoplasma genitalium/isolation & purification ; RNA, Ribosomal, 23S/genetics ; Sequence Analysis, DNA ; Spectinomycin/pharmacology ; Spectinomycin/therapeutic use ; Treatment Failure ; Urethritis/drug therapy ; Urethritis/microbiology
Chemical Substances	Anti-Bacterial Agents ; DNA, Bacterial ; RNA, Ribosomal, 23S ; Azithromycin (83905-01-5) ; Spectinomycin (93AKI1U6QF) ; DNA Gyrase (EC 5.99.1.3) ; Minocycline (FYY3R43WGO) ; Moxifloxacin (U188XYD42P)
Language	English
Publishing date	2020-08-25
Publishing country	England
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1018089-8
ISSN	1758-1052 ; 0956-4624
ISSN (online)	1758-1052
ISSN	0956-4624
DOI	10.1177/0956462420905269
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Zs.A 2829: Show issues

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Article ; Online: The perceptions of sexuality and sexually transmitted diseases (STDs) among adolescent STD patients: A qualitative study.

Liu, Han / Ke, Wujian / Chen, Huiru / Liang, Chunmei / Yang, Ligang

Journal of pediatric nursing

2022 Volume 66, Page(s) e54–e60

Abstract: Purpose: To explore the causes and outcomes of sexually transmitted diseases (STDs) in the adolescent STD patients (ASPs) in relation to their access to and interpretation of sexual and STD knowledge, their attitudes towards premarital sex, and their ... ...

Abstract	Purpose: To explore the causes and outcomes of sexually transmitted diseases (STDs) in the adolescent STD patients (ASPs) in relation to their access to and interpretation of sexual and STD knowledge, their attitudes towards premarital sex, and their feelings and thoughts after getting STDs. Methods: A qualitative study was conducted to interview 16 ASPs (12 males, 4 females) using convenience sampling. One-on-one, semi-structured, and confidential interviews were conducted in an outpatient clinic room at a dermatology hospital in Guangzhou, China. Data were analysed via thematic analysis with NVivo 12 software. Results: Four main themes were derived from the data: sex education before getting STDs, cognition of the definition of STDs and their transmission, attitude towards premarital sex, and impact of infection with STDs. Most of the participants had very limited information about sexuality from their families or schools, lacked STD knowledge, and considered premarital sex as normal or common. Infection with STDs had a negative influence on all the participants, especially on female participants, as they felt ashamed and some even did not want to get married in the future. Conclusion: Limited sex education, lack of sexual knowledge, and an open attitude towards premarital sex led to STDs among adolescents. This study highlights the importance of providing effective sex education. In addition, specific and targeted health guidance and suggestions should be provided to ASPs to help them deal with STDs and the life experience with STDs objectively and correctly.
MeSH term(s)	Adolescent ; Female ; Humans ; Male ; Qualitative Research ; Sex Education ; Sexual Behavior ; Sexuality ; Sexually Transmitted Diseases
Language	English
Publishing date	2022-06-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	632731-x
ISSN	1532-8449 ; 0882-5963
ISSN (online)	1532-8449
ISSN	0882-5963
DOI	10.1016/j.pedn.2022.05.018
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Zs.B 2871: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 375: Show issues

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Article ; Online: Optimal probiotic combinations for treating nonalcoholic fatty liver disease: A systematic review and network meta-analysis.

Yang, Yafang / Yang, Ligang / Wu, Jiale / Hu, Jing / Wan, Min / Bie, Jindi / Li, Jiaxin / Pan, Da / Sun, Guiju / Yang, Chao

Clinical nutrition (Edinburgh, Scotland)

2024 Volume 43, Issue 6, Page(s) 1224–1239

Abstract: Background: Probiotic administration is a promising therapy for improving conditions in NAFLD patients. This network meta-analysis aimed to compare and estimate the relative effects of probiotic interventions and identify the optimal probiotic species ... ...

Abstract	Background: Probiotic administration is a promising therapy for improving conditions in NAFLD patients. This network meta-analysis aimed to compare and estimate the relative effects of probiotic interventions and identify the optimal probiotic species for the treatment of NAFLD (Nonalcoholic fatty liver disease) patients. Methods: The PubMed, Web of Science, Embase, and Cochrane databases were searched from inception to 29 January 2024 to identify RCTs that were published in English. The GRADE framework was used to assess the quality of evidence contributing to each network estimate. Results: A total of 35 RCTs involving 2212 NAFLD patients were included in the analysis. For primary outcomes, Lactobacillus + Bifidobacterium + Streptococcus exhibited the highest probability of being the finest probiotic combination in terms of enhancing acceptability as well as reducing AST (SMD: -1.95 95% CI: -2.90, -0.99), ALT (SMD = -1.67, 95% CI: -2.48, -0.85), and GGT levels (SMD = -2.17, 95% CI: -3.27, -1.06). In terms of the secondary outcomes, Lactobacillus + Bifidobacterium + Streptococcus was also the best probiotic combination for reducing BMI (SMD = -0.45, 95% CI: -0.86, -0.04), LDL levels (SMD = -0.45, 95% CI: -0.87, -0.02), TC levels (SMD = -1.09, 95% CI: -1.89, -0.29), and TNF-α levels (SMD = -1.73, 95% CI: -2.72, -0.74). Conclusion: This network meta-analysis revealed that Lactobacillus + Bifidobacterium + Streptococcus may be the most effective probiotic combination for the treatment of liver enzymes, lipid profiles, and inflammation factors. These findings can be used to guide the development of a probiotics-based treatment guideline for NAFLD since there are few direct comparisons between different therapies.
Language	English
Publishing date	2024-04-13
Publishing country	England
Document type	Journal Article
ZDB-ID	604812-2
ISSN	1532-1983 ; 0261-5614
ISSN (online)	1532-1983
ISSN	0261-5614
DOI	10.1016/j.clnu.2024.04.004
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Zs.A 1774: Show issues

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Article ; Online: Meet the Editors.

Bell, Stephen / Newman, Christy / Yang, Ligang

Sexual health

2021 Volume 18, Issue 2, Page(s) i–ii

MeSH term(s)	Editorial Policies ; Humans ; Publishing
Language	English
Publishing date	2021-05-06
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2256731-8
ISSN	1449-8987 ; 1448-5028
ISSN (online)	1449-8987
ISSN	1448-5028
DOI	10.1071/SHv18n2_MeetED
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Zs.A 6421: Show issues

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Article ; Online: Analysis of Chemical Constituents of

Chen, Lin / Sun, Jihan / Pan, Zhengyu / Lu, Yifei / Wang, Zhaodan / Yang, Ligang / Sun, Guiju

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 2

Abstract: Chrysanthemum extract possesses antioxidant potential and carbohydrate and fat digestive enzyme inhibitory in vitro. However, no evidence supporting chrysanthemum in modulation of postprandial lipemia and antioxidant status in humans presently exists. ... ...

Abstract	Chrysanthemum extract possesses antioxidant potential and carbohydrate and fat digestive enzyme inhibitory in vitro. However, no evidence supporting chrysanthemum in modulation of postprandial lipemia and antioxidant status in humans presently exists. This study was to analyze the composition of Imperial Chrysanthemum (IC) extract and determine the effect on changes in postprandial glycemic and lipemic response and antioxidant status in adults after consumption of a high-fat (HF) meal. UHPLC-MS method was used to analyze the components of two kinds of IC extracts (IC-P/IC-E) and in vitro antioxidant activities were evaluated using 1,1-diphenyl-2-picrylhydraxyl (DPPH), 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) and Hydroxyl radical (HR) radical scavenging assays. Following a randomized design, 37 healthy adults (age, 25.2 ± 2.6 years, and BMI, 20.9 ± 1.5 kg/m2) were assigned to two groups that consumed the HF meal, or HF meal supplemented by IC extract. Blood samples were collected at fasting state and then at 0.5, 1, 2, 4, 6 and 8 h after the meal consumption. There were 12 compounds with relative content of more than 1% of the extracts, of which amino acid and derivatives, flavonoids, carboxylic acids and derivatives were the main components. Compared with IC-E, the contents of flavonoids in IC-P increased significantly (p < 0.05), and the cynaroside content exceeded 30%. In addition, IC-P showed strong free radical scavenging activity against DPPH, ABTS and HR radicals. Furthermore, according to repeated−measures ANOVA, significant differences were observed in the maximal changes for postprandial glucose, TG, T-AOC and MDA among the two groups. Postprandial glucose has significant difference between the two groups at 1 h after meal and the level in IC group was significantly lower than that in control group. No significant differences were observed in the incremental area under the curve (iAUC) among the two groups. IC significantly improved the serum antioxidant status, as characterized by increased postprandial serum T-AOC, SOD, GSH and decreased MDA. This finding suggests that IC can be used as a natural ingredient for reducing postprandial lipemia and improving the antioxidant status after consuming a HF meal.
MeSH term(s)	Adult ; Humans ; Young Adult ; Antioxidants/chemistry ; Chrysanthemum/chemistry ; Flavonoids/chemistry ; Glucose ; Lipid Metabolism ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Postprandial Period
Chemical Substances	Antioxidants ; Flavonoids ; Glucose (IY9XDZ35W2) ; Plant Extracts
Language	English
Publishing date	2023-01-06
Publishing country	Switzerland
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28020579
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Zs.MO 81: Show issues

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Article ; Online: Effects of flaxseed powder in improving non-alcoholic fatty liver by regulating gut microbiota-bile acids metabolic pathway through FXR/TGR5 mediating.

Yang, Chao / Yang, Ligang / Yang, Yafang / Wan, Min / Xu, Dengfeng / Pan, Da / Sun, Guiju

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 163, Page(s) 114864

Abstract: Non-alcoholic fatty liver disease (NAFLD) is gradually becoming one of the most common and health-endangering diseases. Flaxseed powder (FLA) is rich in α-linolenic acid, dietary fiber, lignans, and other active ingredients, which have lipid-lowering and ...

Abstract	Non-alcoholic fatty liver disease (NAFLD) is gradually becoming one of the most common and health-endangering diseases. Flaxseed powder (FLA) is rich in α-linolenic acid, dietary fiber, lignans, and other active ingredients, which have lipid-lowering and anti-inflammatory effects. Here, we investigated whether the FLA improves host metabolism by gut bacteria modulation and further bile acid modulation in mice fed a high-fat diet. At the end of the experiment, we found that FLA can significantly reduce the body weight, body fat content, and serum TG, LDL-C, and TNF-α levels of mice, and improve liver steatosis. FLA intervention has a significant effect on preventing and regulating the gut flora disturbance caused by HFD. FLA intervention affects bile acid metabolism in the intestine and causes significant changes in functional bile acids, which can play a lipid-lowering and anti-inflammatory role by activating the intestinal Fxr- Fgfr4-Cyp7a1 and Tgr5-Tlr4-Tnfα pathways.
MeSH term(s)	Mice ; Animals ; Non-alcoholic Fatty Liver Disease/metabolism ; Gastrointestinal Microbiome ; Bile Acids and Salts/metabolism ; Flax ; Powders/pharmacology ; Diet, High-Fat/adverse effects ; Metabolic Networks and Pathways ; Lipids/pharmacology ; Mice, Inbred C57BL ; Liver/metabolism
Chemical Substances	Bile Acids and Salts ; Powders ; Lipids
Language	English
Publishing date	2023-05-09
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.114864
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Article: Tissue distribution of Lycium barbarum polysaccharides in rat tissue by fluorescein isothiocyanate labeling

Yang, Chao / Xia, Hui / Tang, Huali / Yang, Ligang / Sun, Guiju

Food science and human wellness. 2022 July, v. 11, no. 4

2022

Abstract: To date, in vivo investigations of polysaccharide’s pharmacokinetics are significantly restricted by the difficulty in their detection. This study was conducted to establish the quantitative determination of Lycium barbarum polysaccharides (LBPs) based ... ...

Abstract	To date, in vivo investigations of polysaccharide’s pharmacokinetics are significantly restricted by the difficulty in their detection. This study was conducted to establish the quantitative determination of Lycium barbarum polysaccharides (LBPs) based on fluorescein isothiocyanate (FITC) pre-labeling and to investigate their tissue distribution in rat. We obtained the calibration curves linear over the range of 0–25µg/mL in rat tissue samples with correlation coefficients greater than 0.99. The inter-day and intra-day precisions (RSD, %) were within 15%, and the relative recovery ranged 95.2%–102.4%, with RSD range 1.48%–9.58%, indicating that this experiment was suitable for the determination of LBPs. The fluorescence intensity was measured after 24h storage at room temperature, 3 times of freeze-cycle and cryopreservation at –20 °C for 15 day, these results indicated that the stability of the samples was good. LBP-FITC was mainly absorbed by the small intestine and stomach, and mainly excreted in the urine through the kidney; this distinct difference in the tissue distribution of LBPs could be attributed to the size of these LBPs in relation to the pore sizes of the vascular beds in the kidney and liver. Results showed in this study enable us to comprehensively understand the biological effects of LBPs following its oral ingestion.
Keywords	Lycium barbarum ; ambient temperature ; cryopreservation ; fluorescein ; fluorescence ; food science ; humans ; isothiocyanates ; kidneys ; liver ; pharmacokinetics ; polysaccharides ; quantitative analysis ; rats ; small intestine ; stomach ; tissue distribution ; urine
Language	English
Dates of publication	2022-07
Size	p. 837-844.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2712869-6
ISSN	2213-4530
ISSN	2213-4530
DOI	10.1016/j.fshw.2022.03.004
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The Effect of Lycium Barbarum Polysaccharide on the Glucose and Lipid Metabolism: A Systematic Review and Meta-Analysis

Zhou, Beijia / Xia, Hui / Yang, Ligang / Wang, Shaokang / Sun, Guiju

Journal of the American Nutrition Association. 2022 Aug. 18, v. 41, no. 6 p.617-625

2022

Abstract: Goji berry has been used in China more than 2,000 years as a traditional medicinal herb and food supplement. Lycium barbarum polysaccharide (LBP), the chief active component in goji berry, has been used to treat hypertension, atherosclerosis and other ... ...

Abstract	Goji berry has been used in China more than 2,000 years as a traditional medicinal herb and food supplement. Lycium barbarum polysaccharide (LBP), the chief active component in goji berry, has been used to treat hypertension, atherosclerosis and other cardiovascular diseases in Chinese traditional medicine. However, the underlying effects of LBP- mediated activity in blood glucose and lipid metabolism remain poorly understood. The present study aims to apply the meta-analysis to explore the healthy effects of LBP. Eligible studies published up to November 15, 2020, were searched and identified from CNKI, Pubmed, Web of Science, Cocharane library detabases. A total of 315 publications were retrieved and 7 articles were included. The STATA (version 11.0) was applied to process the meta-analysis. The pooled estimate showed that daily consumption of LBP played significant effects on regulating serum triglyceride (TG), fasting blood glucose, and low-density lipoprotein (LDL) and high-density lipoprotein (HDL) concentrations (p < 0.05), while it was effect-free on the total cholesterol (TC). The present study provided a better understanding of current research status and suggested that LBP could play potential role in prevention and therapy for non-communicable chronic diseases, and more scientific evidence are required in the future.Key teaching pointsGoji berry and LBP, its main biologically active ingredient, have a wide range of health promotion effects. The supplement of LBP may played significant effects on regulating serum TG, HDL, LDL and FBG concentrations. Goji may serve as a potential drug to prevent and treat chronic non-communicable diseases in the future. Healthy dietary patterns containing goji berries will be a new choice for consumers in the future.
Keywords	Lycium barbarum ; Oriental traditional medicine ; active ingredients ; atherosclerosis ; blood glucose ; blood serum ; cholesterol ; dietary supplements ; drugs ; glucose ; health promotion ; high density lipoprotein ; hypertension ; lipid metabolism ; low density lipoprotein ; medicinal plants ; meta-analysis ; polysaccharides ; systematic review ; therapeutics ; triacylglycerols ; China ; Goji berry ; Lycium barbarum polysaccharide ; glucose and lipid metabolism ; chronic non-communicable diseases
Language	English
Dates of publication	2022-0818
Size	p. 617-625.
Publishing place	Taylor & Francis
Document type	Article ; Online
ISSN	2769-707X
DOI	10.1080/07315724.2021.1925996
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The Effect of Lycium Barbarum Polysaccharide on the Glucose and Lipid Metabolism: A Systematic Review and Meta-Analysis.

Zhou, Beijia / Xia, Hui / Yang, Ligang / Wang, Shaokang / Sun, Guiju

Journal of the American Nutrition Association

2021 Volume 41, Issue 6, Page(s) 618–626

Abstract	Goji berry has been used in China more than 2,000 years as a traditional medicinal herb and food supplement. Lycium barbarum polysaccharide (LBP), the chief active component in goji berry, has been used to treat hypertension, atherosclerosis and other cardiovascular diseases in Chinese traditional medicine. However, the underlying effects of LBP- mediated activity in blood glucose and lipid metabolism remain poorly understood. The present study aims to apply the meta-analysis to explore the healthy effects of LBP. Eligible studies published up to November 15, 2020, were searched and identified from CNKI, Pubmed, Web of Science, Cocharane library detabases. A total of 315 publications were retrieved and 7 articles were included. The STATA (version 11.0) was applied to process the meta-analysis. The pooled estimate showed that daily consumption of LBP played significant effects on regulating serum triglyceride (TG), fasting blood glucose, and low-density lipoprotein (LDL) and high-density lipoprotein (HDL) concentrations (
MeSH term(s)	Blood Glucose/metabolism ; Drugs, Chinese Herbal ; Glucose ; Lipid Metabolism ; Lycium/metabolism
Chemical Substances	Blood Glucose ; Drugs, Chinese Herbal ; lycium barbarum polysaccharide ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2021-07-02
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ISSN	2769-707X
ISSN (online)	2769-707X
DOI	10.1080/07315724.2021.1925996
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