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Article ; Online: NCX2 Regulates Intracellular Calcium Homeostasis and Translocation of HIF-1α into the Nucleus to Inhibit Glioma Invasion.

Liu, Hongyuan / Yu, Ju / Yang, Liling / He, Pengcheng / Li, Zongping

2022 Volume 61, Issue 3, Page(s) 979–994

Abstract: Glioma is the most common tumor of the central nervous system, and its poor prognosis can be linked to hypoxia and gene inactivation. ... ...

Abstract	Glioma is the most common tumor of the central nervous system, and its poor prognosis can be linked to hypoxia and gene inactivation. Na
MeSH term(s)	Animals ; Mice ; Calcium/metabolism ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Glioma/genetics ; Hypoxia/genetics ; Hypoxia/metabolism ; Mice, Nude ; Neoplasm Invasiveness/genetics ; Tumor Microenvironment ; Humans
Chemical Substances	Calcium (SY7Q814VUP)
Language	English
Publishing date	2022-11-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2168-4
ISSN	1573-4927 ; 0006-2928
ISSN (online)	1573-4927
ISSN	0006-2928
DOI	10.1007/s10528-022-10274-9
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Zs.A 578: Show issues

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Article ; Online: Fulminant Guillain-Barré syndrome developed after surgical treatment of intracranial hemorrhage due to arteriovenous malformation: a case report.

Liu, Hongyuan / Yang, Liling / Li, Zongping / Cheng, Gang

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

2021 Volume 43, Issue 1, Page(s) 749–752

Abstract: Guillain-Barré syndrome (GBS) is a rare autoimmune disorder. GBS after surgical treatment of intracranial hemorrhage due to arteriovenous malformation (AVM) is even rarer. We present a 62-year-old man diagnosed with intracranial AVM and cerebral ... ...

Abstract	Guillain-Barré syndrome (GBS) is a rare autoimmune disorder. GBS after surgical treatment of intracranial hemorrhage due to arteriovenous malformation (AVM) is even rarer. We present a 62-year-old man diagnosed with intracranial AVM and cerebral hemorrhage. He developed GBS after the operation for AVM and cerebral hemorrhage. Following surgical excision of AVM and cerebral hematoma, the patient developed generalized weakness, with subsequent quadriplegia and life-threatening dyspnea. The diagnosis was confirmed to be the acute motor-sensory axonal neuropathy subtype of GBS after cerebrospinal fluid analysis and antibody tests. The patient responded poorly to immunoglobulin and steroid therapy. His family abandoned further management and signed out of the hospital against medical advice. Despite being rare, GBS can occur after intracranial hemorrhage and surgery. Clinicians should rule out GBS when patients show no improvement or develop new neurologic.
MeSH term(s)	Cerebral Hemorrhage/diagnostic imaging ; Cerebral Hemorrhage/etiology ; Cerebral Hemorrhage/surgery ; Guillain-Barre Syndrome/etiology ; Hematoma ; Humans ; Intracranial Arteriovenous Malformations/complications ; Intracranial Arteriovenous Malformations/diagnostic imaging ; Intracranial Arteriovenous Malformations/surgery ; Male ; Middle Aged ; Quadriplegia
Language	English
Publishing date	2021-07-29
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	2016546-8
ISSN	1590-3478 ; 1590-1874
ISSN (online)	1590-3478
ISSN	1590-1874
DOI	10.1007/s10072-021-05384-y
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Zs.A 1877: Show issues

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Article: The Mechanism of Sodium-Glucose Cotransporter-2 Inhibitors in Reducing Uric Acid in Type 2 Diabetes Mellitus.

Dong, Meiyuan / Chen, Huiling / Wen, Song / Yuan, Yue / Yang, Liling / Xu, Dongxiang / Zhou, Ligang

Diabetes, metabolic syndrome and obesity : targets and therapy

2023 Volume 16, Page(s) 437–445

Abstract: Hyperuricemia is a common comorbidity in patients with type 2 diabetes mellitus (T2DM), as insulin resistance (IR) or hyperinsulinemia is associated with higher serum uric acid (SUA) levels due to decreased uric acid (UA) secretion, and SUA vice versa is ...

Abstract	Hyperuricemia is a common comorbidity in patients with type 2 diabetes mellitus (T2DM), as insulin resistance (IR) or hyperinsulinemia is associated with higher serum uric acid (SUA) levels due to decreased uric acid (UA) secretion, and SUA vice versa is an important risk factor that promotes the occurrence and progression of T2DM and its complications. Growing evidence suggests that sodium-glucose cotransporter 2 inhibitors (SGLT-2i), a novel anti-diabetic drug initially developed to treat T2DM, may exert favorable effects in reducing SUA. Currently, one of the possible mechanisms is that SGLT2i increases urinary glucose excretion, probably inhibiting glucose transport 9 (GLUT9)-mediated uric acid reabsorption in the collecting duct, resulting in increased uric acid excretion in exchange for glucose reabsorption. Regardless of this possible mechanism, the underlying comprehensive mechanisms remain poorly elucidated. Therefore, in the present review, a variety of other potential mechanisms will be covered to identify the therapeutic role of SGLT-2i in hyperuricemia.
Language	English
Publishing date	2023-02-14
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2494854-8
ISSN	1178-7007
ISSN	1178-7007
DOI	10.2147/DMSO.S399343
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Article ; Online: Caregivers' experiences in the management of children with epilepsy: A Systematic synthesis of qualitative studies.

Yang, Liling / Ji, Jianlin / Lu, Qunfeng / Tang, Ping / Jiang, Yan / Yang, Hanlin / Tang, Wenjuan

Seizure

2023 Volume 106, Page(s) 117–128

Abstract: Objective: Childhood is the prime age for epilepsy onset. Adults in the family of affected children often become caregivers. Providing care for children with epilepsy may affect the caregivers' quality of life. There is a paucity of literature reviewing ...

Abstract	Objective: Childhood is the prime age for epilepsy onset. Adults in the family of affected children often become caregivers. Providing care for children with epilepsy may affect the caregivers' quality of life. There is a paucity of literature reviewing the experiences of caregivers of children with epilepsy. Therefore, we summarised the best available evidence exploring caregivers' experiences in caring for children with epilepsy. Method: Published papers in PubMed, CINAHL, Embase, Cochrane Library, Web of Science, Scopus, and PsycINFO databases were identified by two researchers. All search results were imported into EndNote X20. Two reviewers independently extracted the data using Microsoft Excel. The Critical Appraisal Skill Program systematic review checklist was used to evaluate the quality of the included articles. Data of the included studies were extracted by two independent reviewers using a standardised form. These findings were synthesised using a meta-aggregative approach. Results: A total of 12 studies were included in this meta-synthesis. In total, 260 findings were identified. These findings were aggregated into 13 categories, which were synthesised into four main themes: (i) burden experienced by caregivers, (ii) challenges experienced by caregivers, (iii) lack of social support, and (iv) adaptation to disease conditions. Significance: The synthesised studies present multiple perspectives on the burdens and challenges encountered by caregivers of children with epilepsy. Caregivers require support from a variety of sources, not only from their families but also society at large. Providing care to children with epilepsy is a dynamic experience for caregivers.
MeSH term(s)	Adult ; Child ; Humans ; Caregivers ; Quality of Life ; Qualitative Research ; Social Support ; Epilepsy/therapy
Language	English
Publishing date	2023-02-08
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1137610-7
ISSN	1532-2688 ; 1059-1311
ISSN (online)	1532-2688
ISSN	1059-1311
DOI	10.1016/j.seizure.2023.02.004
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Zs.A 3573: Show issues

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Article: Nontraumatic subdural hematoma in patients on hemodialysis with end-stage kidney disease: a systematic review and pooled analysis.

Yang, Liling / Li, Zongping / Dai, Xiaoyu / Wang, Lijun / Wang, Xiaoyi / Liu, Hongyuan

Frontiers in neurology

2023 Volume 14, Page(s) 1251652

Abstract: Background: The original treatment may aggravate when hemodialysis (HD) patients have nontraumatic subdural hematoma (NSDH). End-stage kidney disease patients are at increased risk for NSDH, but its risk factors and outcomes are not sufficiently ... ...

Abstract	Background: The original treatment may aggravate when hemodialysis (HD) patients have nontraumatic subdural hematoma (NSDH). End-stage kidney disease patients are at increased risk for NSDH, but its risk factors and outcomes are not sufficiently explored at present. Methods: Electronic databases, including PubMed, EMBASE, and Web of Science were searched by using various combinations of the keywords "Hemodialysis," "Renal Insufficiency," "Extracorporeal Dialysis," "Subdural Hematoma," "Subdural Hemorrhage," "Subdural Hematomas," and "Subdural Hemorrhages" in accordance with the PRISMA guidelines. Sixteen papers were selected. Relevant patient data were extracted, aggregated, and analyzed. Results: A total of 74 patients were analyzed, including 37 male, 26 female, and 11 with no gender data, with a mean age of 56 years (range, 16-81 years). There were 43 patients with hypertension, 36 patients with diabetes, 16 patients who used oral anticoagulants before dialysis, and 10 patients with atrial fibrillation. The diagnosis of subdural hematoma (SDH) was made by computed tomography (CT) ( Conclusion: NSDH is rare in HD, and mortality is high if NSDH occurs in dialysis patients. Surgical intervention reduces the mortality from NSDH in patients on HD (
Language	English
Publishing date	2023-09-15
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2023.1251652
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Article ; Online: Nursing perspectives on transitional care between paediatric intensive care units and general wards: A focus group study.

Ji, Jianlin / Yang, Hanlin / Yang, Liling / Jiang, Yan / Tang, Ping / Lu, Qunfeng

Journal of nursing management

2022 Volume 30, Issue 7, Page(s) 3430–3439

Abstract: Aim: We aim to explore the experiences of nursing staff in paediatric intensive care units (PICUs) and wards when transporting and caring for patients being discharged from PICU.: Background: PICU discharge is a challenging and complex procedure with ...

Abstract	Aim: We aim to explore the experiences of nursing staff in paediatric intensive care units (PICUs) and wards when transporting and caring for patients being discharged from PICU. Background: PICU discharge is a challenging and complex procedure with risks and complications for patients. Nursing staff in PICU and paediatric wards play a pivotal role in the transition and are responsible for the quality of care, but their perspectives have rarely been explored. Methods: Focus groups were conducted between December 2021 and January 2022 with purposively sampled PICU nurses and ward nurses. Four focus groups were formed, and data were analysed using qualitative content analysis. Results: The overarching themes were as follows: communication during handover, attitudes towards follow-up, a challenging transition for nurses and parents and suggestions for optimizing transitional procedure. Conclusion: Our findings provide nurses' insights and knowledge regarding the transition of patients from the PICU to the ward. Nursing strategies including the use of liaison nurses and critical training for ward nurses were considered essential to maintaining competence during transition. A well-structured handover checklist as well as interdisciplinary cooperation and transitional care units are important for the patient's quality of care. Implication for nursing management: Communication, cooperation, planning and professional care are vital during the transition process. Nurse managers should work to develop collaborative approaches to facilitate safe patient transition.
Language	English
Publishing date	2022-10-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1162321-4
ISSN	1365-2834 ; 0966-0429
ISSN (online)	1365-2834
ISSN	0966-0429
DOI	10.1111/jonm.13804
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Zs.A 3805: Show issues

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Article: The Efficacy and Safety of Roxadustat for Anemia in Patients With Chronic Kidney Disease: A Meta-Analysis.

Wang, Lijun / Yin, Heng / Yang, Liling / Zhang, Fenglian / Wang, Song / Liao, Dan

Frontiers in pharmacology

2022 Volume 13, Page(s) 779694

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2022-04-26
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.779694
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Article ; Online: Multiview Feature Fusion Representation for Interictal Epileptiform Spikes Detection.

Cheng, Chenchen / Zhou, Yuanfeng / You, Bo / Liu, Yan / Fei, Gao / Yang, Liling / Dai, Yakang

International journal of neural systems

2022 Volume 32, Issue 7, Page(s) 2250014

Abstract: Interictal epileptiform spikes (IES) of scalp electroencephalogram (EEG) signals have a strong relation with the epileptogenic region. Since IES are highly unlikely to be detected in scalp EEG signals, the primary diagnosis depends heavily on the visual ... ...

Abstract	Interictal epileptiform spikes (IES) of scalp electroencephalogram (EEG) signals have a strong relation with the epileptogenic region. Since IES are highly unlikely to be detected in scalp EEG signals, the primary diagnosis depends heavily on the visual evaluation of IES. However, visual inspection of EEG signals, the standard IES detection procedure is time-consuming, highly subjective, and error-prone. Furthermore, the highly complex, nonlinear, and nonstationary characteristics of EEG signals lead to the incomplete representation of EEG signals in existing computer-aided methods and consequently unsatisfactory detection performance. Therefore, a novel multiview feature fusion representation (MVFFR) method was developed and combined with a robustness classifier to detect EEG signals with/without IES. MVFFR comprises two steps: First, temporal, frequency, temporal-frequency, spatial, and nonlinear domain features are transformed by the IES to express the latent information effectively. Second, the unsupervised infinite feature-selection method determines the most distinct feature fusion representations. Experimental results using a balanced dataset of six patients showed that MVFFR achieved the optimal detection performance (accuracy: 89.27%, sensitivity: 89.01%, specificity: 89.54%, and precision: 89.82%) compared with other feature ranking methods, and the MVFFR-related method were complementary and indispensable. Additionally, in an independent test, MVFFR maintained excellent generalization capacity with a false detection rate per minute of 0.15 on the unbalanced dataset of one patient.
MeSH term(s)	Electroencephalography/methods ; Epilepsy/diagnosis ; Humans ; Signal Processing, Computer-Assisted
Language	English
Publishing date	2022-03-10
Publishing country	Singapore
Document type	Journal Article
ISSN	1793-6462
ISSN (online)	1793-6462
DOI	10.1142/S0129065722500149
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Article ; Online: Multilevel Feature Learning Method for Accurate Interictal Epileptiform Spike Detection.

Cheng, Chenchen / Liu, Yan / You, Bo / Zhou, Yuanfeng / Gao, Fei / Yang, Liling / Dai, Yakang

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society

2022 Volume 30, Page(s) 2506–2516

Abstract: Interictal epileptiform spike (referred to as spike) detected from electroencephalograms lasting only 20- to 200-ms can provide a reliable evidence-based indicator for clinical seizure type diagnosis. Recent feature representation approaches focus either ...

Abstract	Interictal epileptiform spike (referred to as spike) detected from electroencephalograms lasting only 20- to 200-ms can provide a reliable evidence-based indicator for clinical seizure type diagnosis. Recent feature representation approaches focus either on the concrete-level or abstract-level information mining of the spike, thus demonstrating suboptimal detection performance. Additionally, existing abstract-level information mining methods of the spike based deep learning networks have not realized the effective feature representation of long-term dependent distinguished information within similar waveform cycles caused by morphological heterogeneity, which affects detection performance. Thus, a multilevel feature learning method for accurate spike detection was proposed in this study. Specifically, the spatio-temporal-frequency multidomain information in concrete-level first are inferred the common mimetic properties of the spike using the multidomain feature extractors. Then, the effective feature representation of long-term dependent distinguished information within similar waveform cycles caused by morphological heterogeneity is suitably captured using the temporal convolutional network. Finally, the spatio-temporal-frequency multidomain long-term dependent feature representation of spike is calculated using the element-wise manner to fuse the feature representation in concrete- and abstract-levels. The experimental results indicate that the proposed method can achieve an accuracy of 90.62±1.38%, sensitivity of 90.38±1.52%, specificity of 91.00±1.60%, precision of 90.33±4.71%, and the false detection rate per minute is [Formula: see text], which are higher than when using the feature representation in the concrete-or abstract-level alone. Additionally, the detection results indicate that the proposed method avoids the subjectivity and inefficiency of visual inspection, and it enables a highly accurate detection of the spike.
MeSH term(s)	Electroencephalography ; Humans ; Seizures
Language	English
Publishing date	2022-09-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1166307-8
ISSN	1558-0210 ; 1063-6528 ; 1534-4320
ISSN (online)	1558-0210
ISSN	1063-6528 ; 1534-4320
DOI	10.1109/TNSRE.2022.3193666
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Zs.A 4726: Show issues

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Article ; Online: Parental experience of transition from a paediatric intensive care unit to a general ward: A qualitative study.

Ji, Jianlin / Yang, Liling / Yang, Hanlin / Jiang, Yan / Tang, Ping / Lu, Qunfeng

Journal of nursing management

2022 Volume 30, Issue 7, Page(s) 3578–3588

Abstract: Aim: We aim to explore parental experience in transitioning from a paediatric intensive care unit to a general ward and to investigate parental involvement in caring for their critical illness children.: Background: Parents have a major ... ...

Abstract	Aim: We aim to explore parental experience in transitioning from a paediatric intensive care unit to a general ward and to investigate parental involvement in caring for their critical illness children. Background: Parents have a major responsibility in caring for seriously ill children, but nursing staff fail to meet the expectations of parents regarding nursing care. Few studies have investigated the challenges and needs of Chinese parents during the transition from paediatric intensive care unit to general ward. Methods: Semi-structured interviews were conducted with 24 parents of children with critical illness in a paediatric hospital in Shanghai, mainland China to explore their views. Transcripts were entered into NVivo. Framework analysis was used to analyse the qualitative data. Results: Four themes were identified by data analysis: changes in the child during post paediatric intensive care unit periods; experiencing a wide range of emotions; factors involved in the transition; and suggestions for improving transitional care. Conclusions: Due to the unmet needs of parents, a more flexible visiting policy and social media support were highly desirable. Getting accurate information, establishing family integrated care, and strengthening ward-based critical support services were also listed as important needs of parents caring for critically ill children. Implications for nursing management: A profound understanding of parental experiences during the transitional period can help nursing staff to assess the effects on children and their families, improve ward-based intensive care, support parental participation, and improve visitation policies. Based on these findings, nurse managers can develop reasonable intervention programmes in order to improve nursing quality and patient outcomes.
Language	English
Publishing date	2022-07-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1162321-4
ISSN	1365-2834 ; 0966-0429
ISSN (online)	1365-2834
ISSN	0966-0429
DOI	10.1111/jonm.13716
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