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  1. Article: Bladder metastasis from epidermal growth factor receptor mutant lung cancer: A case report.

    Jin, Cai-Bao / Yang, Ling

    World journal of clinical cases

    2023  Volume 11, Issue 14, Page(s) 3356–3361

    Abstract: Background: Bladder metastasis from lung cancer with epidermal growth factor receptor (EGFR) mutation is extremely rare. Here, we report a case of bladder metastasis from lung adenocarcinoma with EGFR mutation.: Case summary: A 53-year-old female ... ...

    Abstract Background: Bladder metastasis from lung cancer with epidermal growth factor receptor (EGFR) mutation is extremely rare. Here, we report a case of bladder metastasis from lung adenocarcinoma with EGFR mutation.
    Case summary: A 53-year-old female patient was diagnosed with advanced lung adenocarcinoma with EGFR exon 19 deletion. Multiple nodules on the bladder wall were found by regular examination of the pelvic cavity through computed tomography during targeted therapy. Further cystoscopy and histological examination of bladder biopsy tissues confirmed the bladder metastasis from lung adenocarcinoma. In addition, genetic analysis of the bladder metastasis revealed EGFR T790M mutation. The patient achieved a good response to a third-generation EGFR tyrosine kinase inhibitor.
    Conclusion: During routine follow-up of lung cancer patients, imaging examination of the pelvic cavity should be performed to avoid missing bladder metastasis. The ultimate diagnosis of bladder metastasis sill depends on the pathological result of biopsy tissues.
    Language English
    Publishing date 2023-05-27
    Publishing country United States
    Document type Case Reports
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v11.i14.3356
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Current status of producing autologous hematopoietic stem cells.

    Li, Zhonglin / Yang, Ling

    Current research in translational medicine

    2023  Volume 71, Issue 1, Page(s) 103377

    Abstract: Hematopoietic stem cells (HSCs) transplantation is an established therapy for many diseases of the hematopoietic system, for example aplastic anemia, acute myeloid leukemia and acute lymphoblastic leukemia. With the development of the HSCs research, HSCs ...

    Abstract Hematopoietic stem cells (HSCs) transplantation is an established therapy for many diseases of the hematopoietic system, for example aplastic anemia, acute myeloid leukemia and acute lymphoblastic leukemia. With the development of the HSCs research, HSCs provide an attractive method for treating hereditary blood disorders and immunotherapy of cancer by introducing gene modification. Compared with allogenic HSCs transplantation, using autologous HSCs or HSCs from induced pluripotent stem cells (iPSCs) would eliminate the probability of alloimmunization and transfusion-transmitted infectious diseases. The methods for obtaining autologous HSCs include amplifying patients' HSCs or inducing patients' somatic cells to HSCs (graph abstract). However, the biggest problem is inducing HSCs to proliferate in vitro and maintaining their stemness at the same time. Although many tests have been made to transform iPSCs to HSCs, the artificially generated HSCs still have substantial disparity compared with physiological HSCs. This review summarized the application status and obstacles to implantation of autologous HSCs and iPSC-derived HSCs. Meanwhile, we summarized the latest research progress in HSCs amplification and iPSCs reprogramming methods, which will help to solve the problems mentioned above.
    MeSH term(s) Humans ; Cell Differentiation/genetics ; Hematopoietic Stem Cells ; Induced Pluripotent Stem Cells ; Hematopoietic Stem Cell Transplantation/methods ; Leukemia, Myeloid, Acute
    Language English
    Publishing date 2023-01-05
    Publishing country France
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 2452-3186
    ISSN (online) 2452-3186
    DOI 10.1016/j.retram.2023.103377
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Altered resting-state brain functional activities and networks in Crohn's disease: a systematic review.

    Yang, Ling / He, Peipei / Zhang, Lingqin / Li, Kang

    Frontiers in neuroscience

    2024  Volume 18, Page(s) 1319359

    Abstract: Background: Crohn's disease (CD) is a non-specific chronic inflammatory disease of the gastrointestinal tract and is a phenotype of inflammatory bowel disease (IBD). The current study sought to compile the resting-state functional differences in the ... ...

    Abstract Background: Crohn's disease (CD) is a non-specific chronic inflammatory disease of the gastrointestinal tract and is a phenotype of inflammatory bowel disease (IBD). The current study sought to compile the resting-state functional differences in the brain between CD patients and healthy controls.
    Methods: The online databases PubMed, Web of Science Core, and EMBASE were used to find the published neuroimage studies. The search period was from the beginning through December 15, 2023. The predetermined inclusion and exclusion criteria allowed for the identification of the studies. The studies were assembled by two impartial reviewers, who also assessed their quality and bias.
    Results: This review comprised 16 resting-state fMRI studies in total. The included studies generally had modest levels of bias. According to the research, emotional processing and pain processing were largely linked to increased or decreased brain activity in patients with CD. The DMN, CEN, and limbic systems may have abnormalities in patients with CD, according to research on brain networks. Several brain regions showed functional changes in the active CD group compared to the inactive CD group and the healthy control group, respectively. The abnormalities in brain areas were linked to changes in mood fluctuations (anxiety, melancholy) in patients with CD.
    Conclusion: Functional neuroimaging helps provide a better understanding of the underlying neuropathological processes in patients with CD. In this review, we summarize as follows: First, these findings indicate alterations in brain function in patients with CD, specifically affecting brain regions associated with pain, emotion, cognition, and visceral sensation; second, disease activity may have an impact on brain functions in patients with CD; and third, psychological factors may be associated with altered brain functions in patients with CD.
    Language English
    Publishing date 2024-01-24
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2024.1319359
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Rehabilitation strategies for trismus post oral cancer treatment: Progress in the study of mouth opening exercises.

    Yang, Ling / Hao, Guihua / Hou, Lili / Yang, Wenyu

    Journal of stomatology, oral and maxillofacial surgery

    2024  Volume 125, Issue 6, Page(s) 101796

    Abstract: Oral cancer is a significant public health issue worldwide. Although its treatment methods effectively control tumor growth, they can lead to complications, including Trismus, severely affecting patients' quality of life. The practice standards for mouth ...

    Abstract Oral cancer is a significant public health issue worldwide. Although its treatment methods effectively control tumor growth, they can lead to complications, including Trismus, severely affecting patients' quality of life. The practice standards for mouth opening exercises, a rehabilitative method to prevent and treat Trismus, are not yet clear. Therefore, this article aims to review the research progress of mouth opening exercises in the rehabilitation of Trismus post oral cancer treatment, providing a scientific and effective rehabilitation plan for oral cancer patients to improve their quality of life.
    Language English
    Publishing date 2024-02-06
    Publishing country France
    Document type Journal Article
    ZDB-ID 2916276-2
    ISSN 2468-7855 ; 2468-8509
    ISSN (online) 2468-7855
    ISSN 2468-8509
    DOI 10.1016/j.jormas.2024.101796
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The predictive value of triglyceride-glucose index for assessing the severity and MACE of premature coronary artery disease.

    Yang, Ling / Peng, Yu / Zhang, Zheng

    Cardiovascular journal of Africa

    2024  Volume 34, Page(s) 1–6

    Abstract: Objective: The aim of this study was to investigate the predictive value of the triglyceride-glucose (TyG) index to assess the severity and major adverse cardiovascular events (MACE) of patients in hospital with premature coronary artery disease (PCAD).! ...

    Abstract Objective: The aim of this study was to investigate the predictive value of the triglyceride-glucose (TyG) index to assess the severity and major adverse cardiovascular events (MACE) of patients in hospital with premature coronary artery disease (PCAD).
    Methods: A total of 300 patients with PCAD, diagnosed by coronary angiography (CAG), were enrolled in this study. According to the tertiles of TyG index, the 300 patients were divided into a T1 (
    Results: Multivariable logistic regression analysis showed that the TyG index was an independent risk factor for the severity of PCAD and MACE. The area under the ROC curve was 0.833 and 0.807, respectively (all
    Conclusion: The TyG index was independently associated with the severity of PCAD and MACE, and had a good predictive value.
    Language English
    Publishing date 2024-02-21
    Publishing country South Africa
    Document type Journal Article
    ZDB-ID 2383233-2
    ISSN 1680-0745 ; 1996-3467 ; 1015-9657 ; 1995-1892
    ISSN (online) 1680-0745 ; 1996-3467
    ISSN 1015-9657 ; 1995-1892
    DOI 10.5830/CVJA-2023-060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: A case of intracranial infection caused by

    Yang, Ling / Su, Jiacun / Zhuo, Chao

    Medical mycology case reports

    2024  Volume 44, Page(s) 100637

    Abstract: Central nervous system (CNS) aspergillosis is uncommon in immunocompetent patients. We present a 64-year-old man with chronic otitis media and uncontrolled diabetes. ...

    Abstract Central nervous system (CNS) aspergillosis is uncommon in immunocompetent patients. We present a 64-year-old man with chronic otitis media and uncontrolled diabetes.
    Language English
    Publishing date 2024-02-28
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2670415-8
    ISSN 2211-7539
    ISSN 2211-7539
    DOI 10.1016/j.mmcr.2024.100637
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Microplastics in drinking water: A review on methods, occurrence, sources, and potential risks assessment.

    Yang, Ling / Kang, Shichang / Luo, Xi / Wang, Zhaoqing

    Environmental pollution (Barking, Essex : 1987)

    2024  Volume 348, Page(s) 123857

    Abstract: Microplastics in drinking water captured widespread attention following reports of widespread detection around the world. Concerns have been raised about the potential adverse effects of microplastics in drinking water on human health. Given the ... ...

    Abstract Microplastics in drinking water captured widespread attention following reports of widespread detection around the world. Concerns have been raised about the potential adverse effects of microplastics in drinking water on human health. Given the widespread interest in this research topic, there is an urgent need to compile existing data and assess current knowledge. This paper provides a systematic review of studies on microplastics in drinking water, their evidence, key findings, knowledge gaps, and research needs. The data collected show that microplastics are widespread in drinking water, with large variations in reported concentrations. Standardized methodologies of sampling and analysis are urgently needed. There were more fibrous and fragmented microplastics, with the majority being <10 μm in size and composed of polyester, polyethylene, polypropylene, and polystyrene. Little attention has been paid to the color of microplastics. More research is needed to understand the occurrence and transfer of microplastics throughout the water supply chain and the treatment efficiency of drinking water treatment plants (DWTPs). Methods capable of analyzing microplastics <10 μm and nanoplastics are urgently needed. Potential ecological assessment models for microplastics currently in use need to be improved to take into account the complexity and specificity of microplastics.
    MeSH term(s) Humans ; Microplastics/analysis ; Plastics/analysis ; Drinking Water/analysis ; Water Pollutants, Chemical/analysis ; Environmental Monitoring
    Chemical Substances Microplastics ; Plastics ; Drinking Water ; Water Pollutants, Chemical
    Language English
    Publishing date 2024-03-25
    Publishing country England
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2024.123857
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: An improved semantic segmentation algorithm for high-resolution remote sensing images based on DeepLabv3.

    Wang, Yan / Yang, Ling / Liu, Xinzhan / Yan, Pengfei

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 9716

    Abstract: High-precision and high-efficiency Semantic segmentation of high-resolution remote sensing images is a challenge. Existing models typically require a significant amount of training data to achieve good classification results and have numerous training ... ...

    Abstract High-precision and high-efficiency Semantic segmentation of high-resolution remote sensing images is a challenge. Existing models typically require a significant amount of training data to achieve good classification results and have numerous training parameters. A novel model called MST-DeepLabv3+ was suggested in this paper for remote sensing image classification. It's based on the DeepLabv3+ and can produce better results with fewer train parameters. MST-DeepLabv3+ made three improvements: (1) Reducing the number of model parameters by substituting MobileNetV2 for the Xception in the DeepLabv3+'s backbone network. (2) Adding the attention mechanism module SENet to increase the precision of semantic segmentation. (3) Increasing Transfer Learning to enhance the model's capacity to recognize features, and raise the segmentation accuracy. MST-DeepLabv3+ was tested on international society for photogrammetry and remote sensing (ISPRS) dataset, Gaofen image dataset (GID), and practically applied to the Taikang cultivated land dataset. On the ISPRS dataset, the mean intersection over union (MIoU), overall accuracy (OA), Precision, Recall, and F1-score are 82.47%, 92.13%, 90.34%, 90.12%, and 90.23%, respectively. On the GID dataset, these values are 73.44%, 85.58%, 84.10%, 84.86%, and 84.48%, respectively. The results were as high as 90.77%, 95.47%, 95.28%, 95.02%, and 95.15% on the Taikang cultivated land dataset. The experimental results indicate that MST-DeepLabv3+ effectively improves the accuracy of semantic segmentation of remote sensing images, recognizes the edge information with more completeness, and significantly reduces the parameter size.
    Language English
    Publishing date 2024-04-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-60375-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Gut microbiota-host lipid crosstalk in Alzheimer's disease: implications for disease progression and therapeutics.

    Luo, Ya-Xi / Yang, Ling-Ling / Yao, Xiu-Qing

    Molecular neurodegeneration

    2024  Volume 19, Issue 1, Page(s) 35

    Abstract: Trillions of intestinal bacteria in the human body undergo dynamic transformations in response to physiological and pathological changes. Alterations in their composition and metabolites collectively contribute to the progression of Alzheimer's disease. ... ...

    Abstract Trillions of intestinal bacteria in the human body undergo dynamic transformations in response to physiological and pathological changes. Alterations in their composition and metabolites collectively contribute to the progression of Alzheimer's disease. The role of gut microbiota in Alzheimer's disease is diverse and complex, evidence suggests lipid metabolism may be one of the potential pathways. However, the mechanisms that gut microbiota mediate lipid metabolism in Alzheimer's disease pathology remain unclear, necessitating further investigation for clarification. This review highlights the current understanding of how gut microbiota disrupts lipid metabolism and discusses the implications of these discoveries in guiding strategies for the prevention or treatment of Alzheimer's disease based on existing data.
    MeSH term(s) Humans ; Alzheimer Disease/metabolism ; Gastrointestinal Microbiome/physiology ; Lipid Metabolism ; Disease Progression ; Lipids
    Chemical Substances Lipids
    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2244557-2
    ISSN 1750-1326 ; 1750-1326
    ISSN (online) 1750-1326
    ISSN 1750-1326
    DOI 10.1186/s13024-024-00720-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Genome-wide identification and expression analysis of ARF gene family in embryonic development of Korean pine (Pinus koraiensis).

    Zhang, Yue / Wu, Wei / Shen, Hailong / Yang, Ling

    BMC plant biology

    2024  Volume 24, Issue 1, Page(s) 267

    Abstract: Background: The Auxin Responsive Factor (ARF) family plays a crucial role in mediating auxin signal transduction and is vital for plant growth and development. However, the function of ARF genes in Korean pine (Pinus koraiensis), a conifer species of ... ...

    Abstract Background: The Auxin Responsive Factor (ARF) family plays a crucial role in mediating auxin signal transduction and is vital for plant growth and development. However, the function of ARF genes in Korean pine (Pinus koraiensis), a conifer species of significant economic value, remains unclear.
    Results: This study utilized the whole genome of Korean pine to conduct bioinformatics analysis, resulting in the identification of 13 ARF genes. A phylogenetic analysis revealed that these 13 PkorARF genes can be classified into 4 subfamilies, indicating the presence of conserved structural characteristics within each subfamily. Protein interaction prediction indicated that Pkor01G00962.1 and Pkor07G00704.1 may have a significant role in regulating plant growth and development as core components of the PkorARFs family. Additionally, the analysis of RNA-seq and RT-qPCR expression patterns suggested that PkorARF genes play a crucial role in the development process of Korean pine.
    Conclusion: Pkor01G00962.1 and Pkor07G00704.1, which are core genes of the PkorARFs family, play a potentially crucial role in regulating the fertilization and developmental process of Korean pine. This study provides a valuable reference for investigating the molecular mechanism of embryonic development in Korean pine and establishes a foundation for cultivating high-quality Korean pine.
    MeSH term(s) Phylogeny ; Pinus/genetics ; Indoleacetic Acids ; Embryonic Development ; Republic of Korea
    Chemical Substances Indoleacetic Acids
    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059868-3
    ISSN 1471-2229 ; 1471-2229
    ISSN (online) 1471-2229
    ISSN 1471-2229
    DOI 10.1186/s12870-024-04827-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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