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Article ; Online: Construction of C-P Bonds from Free Cyclobutanone Oximes and Chlorophosphines via Radical-Radical Coupling.

Yang, LuLu / Wu, Jiale / Li, Yang / Tang, Yuhai / Li, Jing / Xu, Silong

Organic letters

2024 Volume 26, Issue 15, Page(s) 3208–3212

Abstract: Herein, we report a catalyst-free reaction of cyclobutanone oximes with chlorophosphines ( ... ...

Abstract	Herein, we report a catalyst-free reaction of cyclobutanone oximes with chlorophosphines (R
Language	English
Publishing date	2024-04-10
Publishing country	United States
Document type	Journal Article
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.4c00799
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Response surface methodology optimization of extraction and enrichment conditions of total triterpenoid saponins from Celosiae Semen and evaluation of its lipid-lowering activity.

Yang, Lu-Lu / Zhou, Qi-Qi / Fan, Song / Liu, Chun-Lu / Li, Hui-Jun

Biomedical chromatography : BMC

2024 Volume 38, Issue 5, Page(s) e5835

Abstract: The saponin-enriched extract from Celosiae Semen is a promising resource owing to its lipid-lowering activity. However, triterpenoid saponins are difficult to extract owing to their high molecular weight and strong water solubility. The aim of this paper ...

Abstract	The saponin-enriched extract from Celosiae Semen is a promising resource owing to its lipid-lowering activity. However, triterpenoid saponins are difficult to extract owing to their high molecular weight and strong water solubility. The aim of this paper was to explore an eco-friendly and effective technology of extraction and enrichment of total triterpenoid saponins to obtain high lipid-lowering fractions. Initially, Box-Behnken design experiments were employed to optimize the heat reflux extraction process on the basic of mono-factor experiments. Afterwards, the crude extract was further purified using D-101 resin, and the purification parameters were investigated based on adsorption/desorption experiments and biological activity assay. Under optimal conditions, the purity of the finally obtained total triterpenoid saponins was increased by 7.28-fold. The lipid-lowering activities of the six main triterpenoid saponins were evaluated in HepG2 cells induced by palmitic acid. The results of Oil Red O staining showed that the compounds all exhibited potential lipid-lowering activity. The structure-activity relationship analysis suggested that the oligosaccharide chain at C-28 played an essential role in their lipid-lowering activity and the substituent group at C-23 site also showed important effects. The optimal extraction and purification methods may facilitate the utilization of Celosiae Semen for the industrial production as a functional food and drug.
MeSH term(s)	Saponins/isolation & purification ; Saponins/pharmacology ; Saponins/chemistry ; Humans ; Triterpenes/isolation & purification ; Triterpenes/chemistry ; Triterpenes/pharmacology ; Hep G2 Cells ; Hypolipidemic Agents/chemistry ; Hypolipidemic Agents/pharmacology ; Hypolipidemic Agents/isolation & purification ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Plant Extracts/isolation & purification ; Chromatography, High Pressure Liquid/methods ; Structure-Activity Relationship
Chemical Substances	Saponins ; Triterpenes ; Hypolipidemic Agents ; Plant Extracts
Language	English
Publishing date	2024-02-02
Publishing country	England
Document type	Journal Article
ZDB-ID	632848-9
ISSN	1099-0801 ; 0269-3879
ISSN (online)	1099-0801
ISSN	0269-3879
DOI	10.1002/bmc.5835
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Article: Comparative morphology and plant volatile responses of antennal sensilla in

Yang, Lu-Lu / Wang, Bing / Shen, Jie / Wang, Gui-Rong

Frontiers in cellular neuroscience

2023 Volume 17, Page(s) 1162349

Abstract: Olfaction is important for mediating aphid behaviors and is involved in host location and mating. Antennal primary rhinaria play a key role in the chemoreception of aphids. The function of the peripheral olfactory system in the subfamily Aphidinae has ... ...

Abstract	Olfaction is important for mediating aphid behaviors and is involved in host location and mating. Antennal primary rhinaria play a key role in the chemoreception of aphids. The function of the peripheral olfactory system in the subfamily Aphidinae has been intensively studied, but little is known about other subfamilies of Aphididae. Therefore, three aphid species were selected to study the olfactory reception of plant volatiles:
Language	English
Publishing date	2023-04-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452963-1
ISSN	1662-5102
ISSN	1662-5102
DOI	10.3389/fncel.2023.1162349
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Article ; Online: Ultrasonography in the evaluation of various factors of developmental dysplasia of the hip in infants: Results from a retrospective study in a large hospital of northwest China.

Dong, Tian-Tian / Nie, Fang / Yang, Lu-Lu / Wang, Ting

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association

2023

Abstract: Background: The occurrence and development of developmental dysplasia of the hip (DDH) are related to a variety of factors, which have been reported in the literature, but the literature does not mention factors related to the severity of DDH. The ... ...

Abstract	Background: The occurrence and development of developmental dysplasia of the hip (DDH) are related to a variety of factors, which have been reported in the literature, but the literature does not mention factors related to the severity of DDH. The purpose of this study is to analyze the related factors of the occurrence and severity of DDH in combination with the Graf ultrasonic diagnostic classification. Methods: This study was a monocentric retrospective study describing the factors associated with DDH in a large hospital of northwest China. A total of 3046 infants (6092 hips) within 6 months after birth using the Graf method were admitted to our department between 2014 and 2018. We analyzed data of DDH. After reviewing medical charts and diagnostic examination results, we assessed whether factors such as ethnicity, gender, gestational age, birth weight, diagnosis age, maternal age, mode of delivery, fetal presentation, amniotic fluid volume and birth order, had any effect on development of hip. Result: ① Analysis showed that DDH mostly occurs in female and left hip joint, related to intrauterine fetal presentation, amniotic fluid volume, gestational age, mode of delivery, prenatal weight, and diagnosis age after birth, and the occurrence of DDH is also related to maternal age (All P＜0.05). Ethnicity and first born showed have no obvious correlation with DDH incidence (p = 0.718, 0.147, respectively). ② The strongest correlation was found with amniotic fluid, followed by birth weight. ③ The severity of DDH was correlated with ethnicity, births, prenatal weight, gestational age, diagnosis age and maternal age (All P＜0.05, respectively). ④ There were significant differences in treatment methods, duration and prognosis among different types of DDH. Conclusions: The occurrence and development of DDH are related to a variety of factors. Ultrasound examination can provide an early assessment of the hip development status of infants and may play an important role in establishing an early clinical diagnosis treatment and monitoring and prognosis.
Language	English
Publishing date	2023-06-02
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1314243-4
ISSN	1436-2023 ; 0949-2658
ISSN (online)	1436-2023
ISSN	0949-2658
DOI	10.1016/j.jos.2023.05.009
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Zs.A 4484: Show issues

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Article ; Online: Experience of IVIG Treatment in an Overweight 14-year-old Child With Kawasaki Disease: A Case Report.

Shi, Hui / Qiu, Jian-Li / Xu, Yan / Yang, Lu-Lu

Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners

2023

Abstract: Kawasaki disease, or mucocutaneous lymph node syndrome, is an acute systemic vasculitis involving small and medium-sized vessels. It can be complicated by varying degrees of cardiac damage, especially coronary artery disease. The disease mainly occurs in ...

Abstract	Kawasaki disease, or mucocutaneous lymph node syndrome, is an acute systemic vasculitis involving small and medium-sized vessels. It can be complicated by varying degrees of cardiac damage, especially coronary artery disease. The disease mainly occurs in children aged < 5 years, with rarer cases in older children and adults. Intravenous immunoglobulin combined with aspirin is the widely accepted treatment regimen in the acute phase, but the dosage recommended by the American Heart Association guidelines is not suitable for heavier children. This article reports the successful management of an overweight 14-year-old child with Kawasaki disease.
Language	English
Publishing date	2023-10-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	1036356-7
ISSN	1532-656X ; 0891-5245
ISSN (online)	1532-656X
ISSN	0891-5245
DOI	10.1016/j.pedhc.2023.10.004
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Zs.A 2641: Show issues

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Article ; Online: Pulmonary rehabilitation for patients with coronavirus disease 2019 (COVID-19).

Yang, Lu-Lu / Yang, Ting

Chronic diseases and translational medicine

2020 Volume 6, Issue 2, Page(s) 79–86

Abstract: As a highly infectious respiratory tract disease, coronavirus disease 2019 (COVID-19) can cause respiratory, physical, and psychological dysfunction in patients. Therefore, pulmonary rehabilitation is crucial for both admitted and discharged patients of ... ...

Abstract	As a highly infectious respiratory tract disease, coronavirus disease 2019 (COVID-19) can cause respiratory, physical, and psychological dysfunction in patients. Therefore, pulmonary rehabilitation is crucial for both admitted and discharged patients of COVID-19. In this study, based on the newly released pulmonary rehabilitation guidelines for patients with COVID-19, as well as evidence from the pulmonary rehabilitation of patients with severe acute respiratory syndrome, we investigated pulmonary rehabilitation for patients with COVID-19 having complications, such as chronic pulmonary disease, and established an intelligent respiratory rehabilitation model for these patients.
Keywords	covid19
Language	English
Publishing date	2020-05-14
Publishing country	China
Document type	Journal Article ; Review
ISSN	2589-0514
ISSN (online)	2589-0514
DOI	10.1016/j.cdtm.2020.05.002
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Article: Iodine-125 seeds insertion with trans-arterial chemical infusion for advanced lung cancer: a meta-analysis.

Hong, Jiao / Shi, Yi-Bing / Fu, Yu-Fei / Yang, Lu-Lu

Journal of contemporary brachytherapy

2022 Volume 14, Issue 4, Page(s) 403–410

Abstract: Purpose: Local treatments, including iodine-125 (: Material and methods: This meta-analysis was performed according to preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement. Relevant studies were searched in PubMed, ... ...

Abstract	Purpose: Local treatments, including iodine-125 ( Material and methods: This meta-analysis was performed according to preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement. Relevant studies were searched in PubMed, Embase, Cochrane Library, CINK, Wanfang, and VIP (until October 2021) databases, using the following key words: (((((Iodine-125) OR (I125)) OR (125I)) OR (brachytherapy)) AND ((lung cancer) OR (NSCLC))) AND (chemotherapy). Outcomes included complete response rate (CRR), treatment success rate (TSR), disease control rate (DCR), 1-year survival rate, 2-year survival rate, overall survival (OS), and treatment-related toxicity. RevMan v. 5.3 and Stata v. 12.0 were applied for meta-analysis. Results: Eight studies were included in the evaluation. Three hundred and seventy-seven patients underwent combined TAI and ISI treatment (combined group), while 397 patients underwent TAI alone (TAI alone group). The pooled CRR ( Conclusions: ISI can enhance TAI clinical efficacy in clinical cases of advanced LC, excluding severe adverse events.
Language	English
Publishing date	2022-07-13
Publishing country	Poland
Document type	Journal Article ; Review
ZDB-ID	2627721-9
ISSN	2081-2841 ; 1689-832X
ISSN (online)	2081-2841
ISSN	1689-832X
DOI	10.5114/jcb.2022.118117
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Article: Congenital nephrogenic diabetes insipidus arginine vasopressin receptor 2 gene mutation at new site: A case report.

Yang, Lu-Lu / Xu, Yan / Qiu, Jian-Li / Zhao, Qian-Yi / Li, Man-Man / Shi, Hui

World journal of clinical cases

2023 Volume 10, Issue 36, Page(s) 13443–13450

Abstract: Background: Congenital nephrogenic diabetes insipidus (CNDI) is a rare hereditary disorder. It is associated with mutations in the arginine vasopressin receptor 2 (AVPR2) gene and aquaporin 2 (AQP2) gene, and approximately 270 different mutation sites ... ...

Abstract	Background: Congenital nephrogenic diabetes insipidus (CNDI) is a rare hereditary disorder. It is associated with mutations in the arginine vasopressin receptor 2 (AVPR2) gene and aquaporin 2 (AQP2) gene, and approximately 270 different mutation sites have been reported for AVPR2. Therefore, new mutations and new manifestations are crucial to complement the clinical deficiencies in the diagnosis of this disease. We report a case of a novel AVPR2 gene mutation locus and a new clinical mani-festation. Case summary: We describe the case of a 48-d-old boy who presented with recurrent fever and diarrhea 5 d after birth. Laboratory tests showed electrolyte disturbances and low urine specific gravity, and imaging tests showed no abnormalities. Genetic testing revealed a novel X-linked recessive missense mutation, c.283 (exon 2) C>T (p.P95S). This mutation results in the substitution of a proline residue with a serine residue in the AVPR2 protein sequence. The diagnosis of CNDI was confirmed based on the AVPR2 gene mutation. The treatment strategy for this patient was divided into two stages, including physical cooling supplemented with appropriate amounts of water in the early stage and oral hydrochlorothia-zide (1-2 mg/kg) after a clear diagnosis. After follow-up of one and a half years, the patient gradually improved. Conclusion: AVPR2 gene mutations in new loci and new clinical symptoms help clinicians understand this disease and shorten the diagnosis cycle.
Language	English
Publishing date	2023-01-18
Publishing country	United States
Document type	Case Reports
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v10.i36.13443
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Article: Stent insertion for hilar cholangiocarcinoma: a meta-analysis of comparison between unilateral and bilateral stenting.

Wang, Ying / Liu, Pei-Pei / Yang, Lu-Lu

Przeglad gastroenterologiczny

2021 Volume 16, Issue 4, Page(s) 383–389

Abstract: Introduction: Metal stenting can be used as a primary treatment option for alleviating malignant hilar biliary obstruction (MHBO) symptoms. Although many studies have focused on the topic of unilateral or bilateral stenting for MHBO, there is a clear ... ...

Abstract	Introduction: Metal stenting can be used as a primary treatment option for alleviating malignant hilar biliary obstruction (MHBO) symptoms. Although many studies have focused on the topic of unilateral or bilateral stenting for MHBO, there is a clear need for a study comparing these two stenting types in patients with a single type of cancer. Aim: This meta-analysis was conducted to evaluate the relative clinical efficacy of unilateral and bilateral metal stent insertion for hilar cholangiocarcinoma (HCCA). Material and methods: The PubMed, Embase, and Cochrane Library databases were searched to identify all relevant studies. This meta-analysis was conducted using RevMan v5.3. Results: We initially identified 154 studies, seven of which were included in the final meta-analysis. These studies contained 524 HCCA patients treated by either unilateral ( Conclusions: Compared to bilateral metal stenting, unilateral metal stenting could provide a similar clinical efficacy for patients with HCCA with a lower complication rate.
Language	English
Publishing date	2021-04-06
Publishing country	Poland
Document type	Journal Article ; Review
ZDB-ID	2596134-2
ISSN	1897-4317 ; 1895-5770
ISSN (online)	1897-4317
ISSN	1895-5770
DOI	10.5114/pg.2021.105022
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Article ; Online: Integration of untargeted and pseudotargeted metabolomics reveals specific markers for authentication and adulteration detection of Fritillariae Bulbus using tandem mass spectrometry and chemometrics.

Jiang, Yan / Li, Xin / Zhao, Wen-Jing / Liu, Feng-Jie / Yang, Lu-Lu / Li, Ping / Li, Hui-Jun

Journal of pharmaceutical and biomedical analysis

2024 Volume 242, Page(s) 116013

Abstract: Authentication and adulteration detection of closely related herbal medicines is a thorny issue in the quality control and market standardization of traditional Chinese medicine. Taking Fritillariae Bulbus (FB) as a case study, we herein proposed a three- ...

Abstract	Authentication and adulteration detection of closely related herbal medicines is a thorny issue in the quality control and market standardization of traditional Chinese medicine. Taking Fritillariae Bulbus (FB) as a case study, we herein proposed a three-step strategy that integrates mass spectrometry-based metabolomics and multivariate statistical analysis to identify specific markers, thereby accurately identifying FBs and determining the adulteration level. First, an ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry-based untargeted metabolomics method was employed to profile steroid alkaloids in five sorts of FB and screen potential differential markers. Then, the reliability of the screened markers was further verified by the distribution in different FB groups acquired from ultra-high performance liquid chromatography triple quadrupole mass spectrometry-based pseudotargeted metabolomics analysis. As a result, a total of 16 compounds were screened out to be the specific markers, which were successfully applied to distinguish five FBs by using discriminant analysis model. Besides, partial least squares regression models based on specific markers allowed accurate prediction of three sets of adulterated FBs. All the models afforded good linearity and good predictive ability with regression coefficient of prediction (R
MeSH term(s)	Tandem Mass Spectrometry/methods ; Chemometrics ; Reproducibility of Results ; Chromatography, High Pressure Liquid/methods ; Metabolomics/methods ; Plants, Medicinal ; Plant Extracts
Chemical Substances	Plant Extracts
Language	English
Publishing date	2024-02-06
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2024.116013
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