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Article ; Online: ASO Author Reflections: Which Technique is Superior for Segmentectomy of Small Pulmonary Nodules: Robot-Assisted or Video-Assisted?

Yang, Mu-Zi / Yang, Hao-Xian

2023 Volume 30, Issue 5, Page(s) 2765–2766

MeSH term(s)	Humans ; Pneumonectomy/methods ; Robotics ; Lung Neoplasms/surgery ; Carcinoma, Non-Small-Cell Lung/surgery ; Multiple Pulmonary Nodules/diagnostic imaging ; Multiple Pulmonary Nodules/surgery ; Thoracic Surgery, Video-Assisted/methods
Language	English
Publishing date	2023-02-10
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-023-13180-5
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Zs.A 4042: Show issues

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Article: Clinical Features and Early Recognition of 242 Cases of Autoimmune Encephalitis.

Yang, Mu / Lian, Yajun

Frontiers in neurology

2022 Volume 12, Page(s) 803752

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2022-01-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2021.803752
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Article ; Online: Integrated bioinformatics and validation reveal SOX12 as potential biomarker in colon adenocarcinoma based on an immune infiltration-related ceRNA network.

Chen, Xinyi / Yang, Mu / Tu, Jingyao / Yuan, Xianglin

Journal of cancer research and clinical oncology

2023 Volume 149, Issue 17, Page(s) 15737–15762

Abstract: Purpose: The primary objective of this study was to construct competing endogenous RNA (ceRNA) networks and evaluate the prognostic significance of tumor-infiltrating immune cells (TIICs) and key biomarkers within the ceRNA networks in colon ... ...

Abstract	Purpose: The primary objective of this study was to construct competing endogenous RNA (ceRNA) networks and evaluate the prognostic significance of tumor-infiltrating immune cells (TIICs) and key biomarkers within the ceRNA networks in colon adenocarcinoma (COAD) patients. Methods: Comprehensive bioinformatics tools were used to screen differentially expressed genes (DEGs), miRNAs (DEMs), and lncRNAs (DELs) related to COAD, leading to the creation of ceRNA networks. The CIBERSORT technique was employed to assess the significance of TIICs in COAD, and an immune-related prognosis prediction model was subsequently developed. Co-expression analyses were conducted to determine the relationship between key genes in ceRNA networks and immunologically significant TIICs. The study also utilized 5 GEO datasets and web-based databases to externally validate the findings. Results: The study revealed a statistically significant relationship between key hub genes and immune cells, as determined through co-expression analysis. Two hub regulators (SOX12 and H19) demonstrated significant prognostic value in the ceRNA-related prognostic model, and their elevated expression levels were verified across multiple CRC cell lines. Additionally, the knockdown of SOX12 led to a suppression of proliferation, migration, and invasion in colon cancer cells. Conclusion: Through the construction of ceRNA networks and evaluation of TIICs, the study successfully established two risk score models and nomograms. These models serve as valuable tools for understanding the molecular processes and predicting the prognosis of COAD patients. Further validation of hub regulators SOX12 and H19 substantiates their potential role as key biomarkers in COAD.
MeSH term(s)	Humans ; Colonic Neoplasms/genetics ; Adenocarcinoma/genetics ; Biomarkers ; MicroRNAs/genetics ; Computational Biology ; Gene Regulatory Networks ; SOXC Transcription Factors/genetics
Chemical Substances	Biomarkers ; MicroRNAs ; SOX12 protein, human ; SOXC Transcription Factors
Language	English
Publishing date	2023-09-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	134792-5
ISSN	1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
ISSN (online)	1432-1335
ISSN	0171-5216 ; 0084-5353 ; 0943-9382
DOI	10.1007/s00432-023-05316-7
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Article ; Online: The Relationship Between Fermented Dairy Consumption with Cognitive Function Among Older US Adults: Data from the NHANES 2011-2014.

Han, Yinlian / Yang, Mu / Tian, Min / Yang, Yang / Liu, Wen / Liu, Yiming

Journal of Alzheimer's disease : JAD

2024 Volume 97, Issue 4, Page(s) 1877–1887

Abstract: Background: The aging global population has led to an increased burden of cognitive impairment in older adults.: Objective: This study examined the relationship between fermented dairy intake and cognitive function in this population.: Methods: ... ...

Abstract	Background: The aging global population has led to an increased burden of cognitive impairment in older adults. Objective: This study examined the relationship between fermented dairy intake and cognitive function in this population. Methods: Yogurt, cheese, and fermented dairy consumption were assessed through two 24-hour dietary recall interviews, categorized into low, medium, and high intake groups. Multivariate linear regression was employed to examine the relationship between fermented dairy intake and cognitive tests, including the Alzheimer's Disease Word Learning Immediate Recall Test (CERAD-IRT), CERAD Delayed Recall Test (CERAD-DRT), Animal Fluency Test (AFT), Digit Symbol Substitution Test (DSST), and global cognitive z-scores, adjusting for potential confounding factors. Results: The study comprised 2,462 participants (average age 69.34±6.75 years, 52.07% female). Among yogurt consumers, global cognition and AFT z-scores are notably higher than non-consumers. Conversely, individuals who consume cheese display significantly lower CERAD-DRT z-scores. Compared to participants not intake fermented dairy, consumers of fermented dairy show significantly higher AFT and DSST z-scores and lower CERAD-DRT z-scores. Moreover, when categorizing individuals based on their intake of fermented dairy, those with low and medium consumption show significantly higher AFT and DSST z-scores, as well as significantly lower CERAD-DRT z-scores compared to non-consumers. Conclusions: Our study suggests that moderate consumption of fermented dairy products is associated with better executive function and verbal fluency in the elderly.
MeSH term(s)	Animals ; Aged ; Female ; Humans ; Adult ; Middle Aged ; Male ; Nutrition Surveys ; Cognition ; Executive Function ; Cognitive Dysfunction/epidemiology ; Learning
Language	English
Publishing date	2024-02-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-230865
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Zs.A 6084: Show issues

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Article ; Online: RUNX transcription factors: biological functions and implications in cancer.

Chen, Xinyi / Wang, Lu / Yang, Mu / Zhao, Weiheng / Tu, Jingyao / Liu, Bo / Yuan, Xianglin

Clinical and experimental medicine

2024 Volume 24, Issue 1, Page(s) 50

Abstract: Runt-related transcription factors (RUNX) are a family of transcription factors that are essential for normal and malignant hematopoietic processes. Their most widely recognized role in malignancy is to promote the occurrence and development of acute ... ...

Abstract	Runt-related transcription factors (RUNX) are a family of transcription factors that are essential for normal and malignant hematopoietic processes. Their most widely recognized role in malignancy is to promote the occurrence and development of acute myeloid leukemia. However, it is worth noting that during the last decade, studies of RUNX proteins in solid tumors have made considerable progress, suggesting that these proteins are directly involved in different stages of tumor development, including tumor initiation, progression, and invasion. RUNX proteins also play a role in tumor angiogenesis, the maintenance of tumor cell stemness, and resistance to antitumor drugs. These findings have led to the consideration of RUNX as a tumor biomarker. All RUNX proteins are involved in the occurrence and development of solid tumors, but the role of each RUNX protein in different tumors and the major signaling pathways involved are complicated by tumor heterogeneity and the interacting tumor microenvironment. Understanding how the dysregulation of RUNX in tumors affects normal biological processes is important to elucidate the molecular mechanisms by which RUNX affects malignant tumors.
MeSH term(s)	Humans ; Transcription Factors ; Neoplasms/genetics ; Core Binding Factor alpha Subunits/genetics ; Core Binding Factor alpha Subunits/metabolism ; Signal Transduction ; Tumor Microenvironment
Chemical Substances	Transcription Factors ; Core Binding Factor alpha Subunits
Language	English
Publishing date	2024-03-02
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	2053018-3
ISSN	1591-9528 ; 1591-8890
ISSN (online)	1591-9528
ISSN	1591-8890
DOI	10.1007/s10238-023-01281-0
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Zs.A 5481: Show issues

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Article ; Online: Characterization of a novel heterozygous frameshift variant in NDP gene that causes familial exudative vitreoretinopathy in female patients.

Yang, Mu / Peng, Li / Lv, Liting / Dai, Erkuan / He, Yunqi / Zhao, Rulian / Li, Shujin

Molecular genetics and genomics : MGG

2024 Volume 299, Issue 1, Page(s) 32

Abstract: Familial exudative vitreoretinopathy (FEVR) is a severe inherited disease characterized by defective retinal vascular development. With genetic and clinical heterogeneity, FEVR can be inherited in different patterns and characterized by phenotypes ... ...

Abstract	Familial exudative vitreoretinopathy (FEVR) is a severe inherited disease characterized by defective retinal vascular development. With genetic and clinical heterogeneity, FEVR can be inherited in different patterns and characterized by phenotypes ranging from moderate visual defects to complete vision loss. This study was conducted to unravel the genetic and functional etiology of a 4-month-old female FEVR patient. Targeted gene panel and Sanger sequencing were utilized for genetic evaluation. Luciferase assays, western blot, quantitive real-time PCR, and immunocytochemistry were performed to verify the functional defects in the identified candidate variant. Here, we report a 4-month-old girl with bilateral retinal folds and peripheral avascularization, and identified a novel frameshift heterozygous variant c.37dup (p.Leu13ProfsTer13) in NDP. In vitro experiments revealed that the Leu13ProfsTer13 variant led to a prominent decrease in protein levels instead of mRNA levels, resulting in compromised Norrin/β-catenin signaling activity. Human androgen receptor assay further revealed that a slight skewing of X chromosome inactivation could partially cause FEVR. Thus, the pathogenic mechanism by which heterozygous frameshift or nonsense variants in female carriers cause FEVR might largely result from a loss-of-function variant in one X chromosome allele and a slightly skewed X-inactivation. Further recruitment of more FEVR-affected females carrying NDP variants and genotype-phenotype correlation analysis can ultimately offer valuable information for the prognosis prediction of FEVR.
MeSH term(s)	Female ; Humans ; Infant ; DNA Mutational Analysis ; Eye Proteins/genetics ; Familial Exudative Vitreoretinopathies/genetics ; Heterozygote ; Mutation ; Nerve Tissue Proteins/genetics ; Pedigree ; Phenotype ; Retina/metabolism ; Retinal Diseases/genetics ; Retinal Diseases/metabolism ; Retinal Diseases/pathology
Chemical Substances	Eye Proteins ; NDP protein, human ; Nerve Tissue Proteins
Language	English
Publishing date	2024-03-13
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	2044817-X
ISSN	1617-4623 ; 1617-4615
ISSN (online)	1617-4623
ISSN	1617-4615
DOI	10.1007/s00438-024-02128-3
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Zs.A 1198: Show issues

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Article ; Online: MUC1 and MUC16: critical for immune modulation in cancer therapeutics.

Chen, Xinyi / Sandrine, Ineza Karambizi / Yang, Mu / Tu, Jingyao / Yuan, Xianglin

Frontiers in immunology

2024 Volume 15, Page(s) 1356913

Abstract: The Mucin (MUC) family, a range of highly glycosylated macromolecules, is ubiquitously expressed in mammalian epithelial cells. Such molecules are pivotal in establishing protective mucosal barriers, serving as defenses against pathogenic assaults. ... ...

Abstract	The Mucin (MUC) family, a range of highly glycosylated macromolecules, is ubiquitously expressed in mammalian epithelial cells. Such molecules are pivotal in establishing protective mucosal barriers, serving as defenses against pathogenic assaults. Intriguingly, the aberrant expression of specific MUC proteins, notably Mucin 1 (MUC1) and Mucin 16 (MUC16), within tumor cells, is intimately associated with oncogenesis, proliferation, and metastasis. This association involves various mechanisms, including cellular proliferation, viability, apoptosis resistance, chemotherapeutic resilience, metabolic shifts, and immune surveillance evasion. Due to their distinctive biological roles and structural features in oncology, MUC proteins have attracted considerable attention as prospective targets and biomarkers in cancer therapy. The current review offers an exhaustive exploration of the roles of MUC1 and MUC16 in the context of cancer biomarkers, elucidating their critical contributions to the mechanisms of cellular signal transduction, regulation of immune responses, and the modulation of the tumor microenvironment. Additionally, the article evaluates the latest advances in therapeutic strategies targeting these mucins, focusing on innovations in immunotherapies and targeted drugs, aiming to enhance customization and accuracy in cancer treatments.
MeSH term(s)	Animals ; Mucin-1/metabolism ; CA-125 Antigen/metabolism ; Mucins ; Neoplasms/drug therapy ; Immunity ; Mammals/metabolism ; Tumor Microenvironment
Chemical Substances	Mucin-1 ; CA-125 Antigen ; Mucins
Language	English
Publishing date	2024-02-01
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1356913
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Article ; Online: Under the different sectors: the relationship between low-carbon economic development, health and GDP.

Bai, Shizhen / Zhou, Jiamin / Yang, Mu / Yang, Zaoli / Cui, Yongmei

Frontiers in public health

2023 Volume 11, Page(s) 1181623

Abstract: Developing a modern low-carbon economy while protecting health is not only a current trend but also an urgent problem that needs to be solved. The growth of the national low-carbon economy is closely related to various sectors; however, it remains ... ...

Abstract	Developing a modern low-carbon economy while protecting health is not only a current trend but also an urgent problem that needs to be solved. The growth of the national low-carbon economy is closely related to various sectors; however, it remains unclear how the development of low-carbon economies in these sectors impacts the national economy and the health of residents. Using panel data on carbon emissions and resident health in 28 province-level regions in China, this study employs unit root tests, co-integration tests, and regression analysis to empirically examine the relationship between carbon emissions, low-carbon economic development, health, and GDP in industry, construction, and transportation. The results show that: First, China's carbon emissions can promote economic development. Second, low-carbon economic development can enhance resident health while improving GDP. Third, low-carbon economic development has a significant positive effect on GDP and resident health in the industrial and transportation sector, but not in the construction sector, and the level of industrial development and carbon emission sources are significant factors contributing to the inconsistency. Our findings complement existing insights into the coupling effect of carbon emissions and economic development across sectors. They can assist policymakers in tailoring low-carbon policies to specific sectors, formulating strategies to optimize energy consumption structures, improving green technology levels, and aiding enterprises in gradually reducing carbon emissions without sacrificing economic benefits, thus achieving low-carbon economic development.
MeSH term(s)	Economic Development ; Carbon/analysis ; Industry ; China ; Carbon Dioxide
Chemical Substances	Carbon (7440-44-0) ; Carbon Dioxide (142M471B3J)
Language	English
Publishing date	2023-07-20
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1181623
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Article ; Online: The COVID-19 state sales tax windfall.

Dean, Phil / Gaulin, Maclean / Seegert, Nathan / Yang, Mu-Jeung

International tax and public finance

2023 , Page(s) 1–27

Abstract: Policymakers were surprised to find increases in sales tax revenues in 2020 due to expectations that they would drop 8-20%. We investigate this puzzle and provide novel insights into consumption taxes based on this experience. Using a case study from the ...

Abstract	Policymakers were surprised to find increases in sales tax revenues in 2020 due to expectations that they would drop 8-20%. We investigate this puzzle and provide novel insights into consumption taxes based on this experience. Using a case study from the State of Utah, we document that shifts in the structure of consumption played a significant role in the robustness of sales tax revenue. Two factors stand out in our results. The first factor is the structure of the tax base for sales taxes in the USA. This tax base covers only a subset of personal consumption, excluding, for example, many services. During the pandemic, when services were restricted or shut down, this caused a shift in spending toward goods that are more likely to be in the sales tax base. The second factor is the boom in e-commerce during the pandemic, which boosted sales tax collections. This was catalyzed by recent legal changes that made the collection of sales taxes in e-commerce easier. Interestingly, this e-commerce boost also shifted the point of sale and related sales tax revenues away from urban areas toward suburban areas. Our case study of the pandemic's effect on sales taxes in the USA generally, and Utah's experience specifically, provides lessons for consumption taxes, such as the VAT more broadly, and lessons on the role of consumption taxes for tax revenue volatility.
Language	English
Publishing date	2023-05-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2016247-9
ISSN	1573-6970 ; 0927-5940
ISSN (online)	1573-6970
ISSN	0927-5940
DOI	10.1007/s10797-023-09778-w
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Article ; Online: Immunohistochemical characterization of the mandibular condyle for type I and II collagen, aggrecan, MMP-9, and MMP-13 in MMP-2-deficient mice.

Yang, Mu-Chen / Nakamura, Megumi / Mayanagi, Miyuki / Sasano, Yasuyuki

Biomedical research (Tokyo, Japan)

2023 Volume 44, Issue 2, Page(s) 65–72

Abstract: Mice devoid of matrix metalloproteinase (MMP)-2 due to gene targeting have been reported to show articular cartilage destruction in the knee joint; however, the phenotype of the mandibular condylar cartilage remains unknown. Thus, in the present study, ... ...

Abstract	Mice devoid of matrix metalloproteinase (MMP)-2 due to gene targeting have been reported to show articular cartilage destruction in the knee joint; however, the phenotype of the mandibular condylar cartilage remains unknown. Thus, in the present study, we investigated the mandibular condyle in Mmp2
MeSH term(s)	Mice ; Animals ; Aggrecans/genetics ; Aggrecans/metabolism ; Matrix Metalloproteinase 2/genetics ; Matrix Metalloproteinase 2/metabolism ; Matrix Metalloproteinase 13/genetics ; Matrix Metalloproteinase 13/metabolism ; Matrix Metalloproteinase 9/genetics ; Matrix Metalloproteinase 9/metabolism ; Chondrocytes/metabolism ; Mandibular Condyle/metabolism ; Collagen/metabolism ; Extracellular Matrix Proteins/metabolism ; Cartilage, Articular/physiology ; Collagen Type II/metabolism
Chemical Substances	Aggrecans ; Matrix Metalloproteinase 2 (EC 3.4.24.24) ; Matrix Metalloproteinase 13 (EC 3.4.24.-) ; Matrix Metalloproteinase 9 (EC 3.4.24.35) ; Collagen (9007-34-5) ; Extracellular Matrix Proteins ; Collagen Type II
Language	English
Publishing date	2023-03-24
Publishing country	Japan
Document type	Journal Article
ZDB-ID	604561-3
ISSN	1880-313X ; 0388-6107
ISSN (online)	1880-313X
ISSN	0388-6107
DOI	10.2220/biomedres.44.65
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