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  1. AU="Yang, Otto O"
  2. AU="Quach, Alex"

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  1. Book: Guide to effective grant writing

    Yang, Otto O.

    how to write a successful NIH grant application

    2012  

    Institution National Institutes of Health (U.S.)
    Author's details Otto O. Yang
    Keywords Research Support as Topic ; Biomedical Research ; Writing / standards ; National Institutes of Health (U.S.)--Research grants--Handbooks, manuals, etc. ; Proposal writing for grants--United States--Handbooks, manuals, etc. ; United States
    Language English
    Size XIV, 90 S. : graph. Darst.
    Edition 2. ed.
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    Note Previous ed.: New York: Kluwer Academic/Plenum, 2005. - Includes index
    HBZ-ID HT017310372
    ISBN 978-1-4614-1580-0 ; 1-4614-1580-2 ; 9781461415817 ; 1461415810
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2012 A 2902 order for loan Magazin

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  2. Article ; Online: Understanding immune dysregulation in post-acute sequelae of COVID-19 (PASC)-The hunt for effective treatments.

    Gaylis, Norman B / Yang, Otto O

    The Journal of infection

    2024  Volume 88, Issue 5, Page(s) 106146

    MeSH term(s) Humans ; COVID-19/immunology ; COVID-19/complications ; SARS-CoV-2/immunology ; Post-Acute COVID-19 Syndrome
    Language English
    Publishing date 2024-03-24
    Publishing country England
    Document type Journal Article ; Letter
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2024.106146
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1501: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 48: Show issues

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  3. Book: War in the body

    Wick, W. David / Yang, Otto O.

    the evolutionary race between HIV and the human immune system and the implications for vaccines

    2013  

    Author's details W. David Wick ; Otto O. Yang ed
    Language English
    Size XIX, 298 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017722119
    ISBN 978-1-4614-7293-3 ; 9781461472940 ; 1-4614-7293-8 ; 1461472946
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 A 1969 available for loan (reading room) Lesesaal EG

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  4. Article: Coronavirus Disease 2019 Vaccine Dosage in Children, Adolescents, and Young Adults: Is Less More?

    Tobin, Nicole H / Yang, Otto O

    Open forum infectious diseases

    2022  Volume 9, Issue 7, Page(s) ofac222

    Abstract: The lower efficacy of the COVID-19 mRNA vaccines in 5-11 year old children was unexpected. Neutralizing antibody titers elicited by the vaccines in children, adolescents, and young adults suggest that the lower efficacy is not due to the lower dosage. ... ...

    Abstract The lower efficacy of the COVID-19 mRNA vaccines in 5-11 year old children was unexpected. Neutralizing antibody titers elicited by the vaccines in children, adolescents, and young adults suggest that the lower efficacy is not due to the lower dosage. Confirming the efficacy of these vaccines in children, determining if mRNA vaccination strategies are less effective in younger children, as well as optimizing the dosage, dosing intervals, and number of doses needed in children, adolescents, and young adults are critical to improve vaccination strategies for these populations going forward.
    Language English
    Publishing date 2022-05-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofac222
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The role of APOBEC3-induced mutations in the differential evolution of monkeypox virus.

    Li, Xiangting / Habibipour, Sara / Chou, Tom / Yang, Otto O

    Virus evolution

    2023  Volume 9, Issue 2, Page(s) vead058

    Abstract: Recent studies show that newly sampled monkeypox virus (MPXV) genomes exhibit mutations consistent with Apolipoprotein B mRNA Editing Catalytic Polypeptide-like3 (APOBEC3)-mediated editing compared to MPXV genomes collected earlier. It is unclear whether ...

    Abstract Recent studies show that newly sampled monkeypox virus (MPXV) genomes exhibit mutations consistent with Apolipoprotein B mRNA Editing Catalytic Polypeptide-like3 (APOBEC3)-mediated editing compared to MPXV genomes collected earlier. It is unclear whether these single-nucleotide polymorphisms (SNPs) result from APOBEC3-induced editing or are a consequence of genetic drift within one or more MPXV animal reservoirs. We develop a simple method based on a generalization of the General-Time-Reversible model to show that the observed SNPs are likely the result of APOBEC3-induced editing. The statistical features allow us to extract lineage information and estimate evolutionary events.
    Language English
    Publishing date 2023-10-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2818949-8
    ISSN 2057-1577
    ISSN 2057-1577
    DOI 10.1093/ve/vead058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The role of APOBEC3-induced mutations in the differential evolution of monkeypox virus.

    Li, Xiangting / Habibipour, Sara / Chou, Tom / Yang, Otto O

    ArXiv

    2023  

    Abstract: Recent studies show that newly sampled monkeypox virus (MPXV) genomes exhibit mutations consistent with Apolipoprotein B mRNA Editing Catalytic Polypeptide-like3 (APOBEC3)-mediated editing, compared to MPXV genomes collected earlier. It is unclear ... ...

    Abstract Recent studies show that newly sampled monkeypox virus (MPXV) genomes exhibit mutations consistent with Apolipoprotein B mRNA Editing Catalytic Polypeptide-like3 (APOBEC3)-mediated editing, compared to MPXV genomes collected earlier. It is unclear whether these single nucleotide polymorphisms (SNPs) result from APOBEC3-induced editing or are a consequence of genetic drift within one or more MPXV animal reservoirs. We develop a simple method based on a generalization of the General-Time-Reversible (GTR) model to show that the observed SNPs are likely the result of APOBEC3-induced editing. The statistical features allow us to extract lineage information and estimate evolutionary events.
    Language English
    Publishing date 2023-08-07
    Publishing country United States
    Document type Preprint
    ISSN 2331-8422
    ISSN (online) 2331-8422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Loss of Anti-SARS-CoV-2 Antibodies in Mild Covid-19. Reply.

    Yang, Otto O / Ibarrondo, F Javier

    The New England journal of medicine

    2020  Volume 383, Issue 17, Page(s) 1697–1698

    MeSH term(s) Antibodies, Viral ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS Virus ; SARS-CoV-2
    Chemical Substances Antibodies, Viral
    Keywords covid19
    Language English
    Publishing date 2020-09-23
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2027051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.34: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Predominantly defective CD8

    Taus, Ellie / Shino, Michael Y / Ibarrondo, F Javier / Hausner, Mary Ann / Hofmann, Christian / Yang, Otto O

    Journal of translational medicine

    2023  Volume 21, Issue 1, Page(s) 374

    Abstract: Background: Although mRNA vaccines have overall efficacy preventing morbidity/mortality from SARS-CoV-2 infection, immunocompromised persons remain at risk. Antibodies mostly prevent early symptomatic infection, but cellular immunity, particularly the ... ...

    Abstract Background: Although mRNA vaccines have overall efficacy preventing morbidity/mortality from SARS-CoV-2 infection, immunocompromised persons remain at risk. Antibodies mostly prevent early symptomatic infection, but cellular immunity, particularly the virus-specific CD8
    Methods: Comparison groups included persons with lung transplantation and no history of COVID-19 (21 and 19 persons after initial mRNA vaccination and a third booster vaccination respectively), 8 lung transplantation participants recovered from COVID-19, and 22 non-immunocompromised healthy control individuals after initial mRNA vaccination (without history of COVID-19). Anti-spike T cell responses were assayed by stimulating peripheral blood mononuclear cells (PBMCs) with pooled small overlapping peptides spanning the SARS-CoV-2 spike protein, followed by intracellular cytokine staining (ICS) and flow cytometry for release of cytokines in response to stimulation, including negative controls (no peptide stimulation) and positive controls (phorbol myristate acetate [PMA] and ionomycin stimulation). To evaluate for low frequency memory responses, PBMCs were cultured in the presence of the mRNA-1273 vaccine for 14 days before this evaluation.
    Results: Ionophore stimulation of PBMCs revealed a less inflammatory milieu in terms of interleukin (IL)-2, IL-4, and IL-10 profiling in lung transplantation individuals, reflecting the effect of immunosuppressive treatments. Similar to what we previously reported in healthy vaccinees, spike-specific responses in lung transplantation recipients were undetectable (< 0.01%) when tested 2 weeks after vaccination or later, but were detectable after in vitro culture of PBMCs with mRNA-1273 vaccine to enrich memory T cell responses. This was also seen in COVID-19-recovered lung transplantation recipients. Comparison of their enriched memory responses to controls revealed relatively similar CD4
    Conclusions: These results reveal a specific defect in CD8
    MeSH term(s) Humans ; Transplant Recipients ; CD8-Positive T-Lymphocytes ; 2019-nCoV Vaccine mRNA-1273 ; SARS-CoV-2 ; Leukocytes, Mononuclear ; COVID-19/prevention & control ; Vaccination ; Antibodies ; Cytokines ; Lung ; Antibodies, Viral
    Chemical Substances spike protein, SARS-CoV-2 ; 2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4) ; Antibodies ; Cytokines ; Antibodies, Viral
    Language English
    Publishing date 2023-06-08
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2118570-0
    ISSN 1479-5876 ; 1479-5876
    ISSN (online) 1479-5876
    ISSN 1479-5876
    DOI 10.1186/s12967-023-04234-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Correction for Balamurugan et al., "Cross-Reactivity against Multiple HIV-1 Epitopes Is Characteristic of HIV-1-Specific Cytotoxic T Lymphocyte Clones".

    Balamurugan, Arumugam / Ng, Hwee L / Yang, Otto O

    Journal of virology

    2021  Volume 95, Issue 21, Page(s) e0139721

    Language English
    Publishing date 2021-10-13
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/JVI.01397-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    ab Jg. 2022: Lesesaal (EG)

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