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Article ; Online: A prediction model for differentiating recurrent Kawasaki disease from other febrile illnesses.

Yang, Penghui / Zhang, Jing / Feng, Siqi / Yi, Qijian

2024

Language	English
Publishing date	2024-03-21
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1038679-8
ISSN	1879-0828 ; 0953-6205
ISSN (online)	1879-0828
ISSN	0953-6205
DOI	10.1016/j.ejim.2024.03.020
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Zs.A 2608: Show issues

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Article ; Online: A prediction model for coronary artery abnormalities in children with Kawasaki disease older than 5 years.

Yang, Penghui / Zhang, Jing / Chen, Zhuo / Yi, Qijian

Jornal de pediatria

2024 Volume 100, Issue 3, Page(s) 318–326

Abstract: Objective: Reliably prediction models for coronary artery abnormalities (CAA) in children aged >5 years with Kawasaki disease (KD) are still lacking. This study aimed to develop a nomogram model for predicting CAA at 4 to 8 weeks of illness in children ... ...

Abstract	Objective: Reliably prediction models for coronary artery abnormalities (CAA) in children aged >5 years with Kawasaki disease (KD) are still lacking. This study aimed to develop a nomogram model for predicting CAA at 4 to 8 weeks of illness in children with KD older than 5 years. Methods: A total of 644 eligible children were randomly assigned to a training cohort (n = 450) and a validation cohort (n = 194). The least absolute shrinkage and selection operator (LASSO) analysis was used for optimal predictors selection, and multivariate logistic regression was used to develop a nomogram model based on the selected predictors. Area under the receiver operating characteristic curve (AUC), calibration curves, Hosmer-Lemeshow test, Brier score, and decision curve analysis (DCA) were used to assess model performance. Results: Neutrophil to lymphocyte ratio, intravenous immunoglobulin resistance, and maximum baseline z-score ≥ 2.5 were identified by LASSO as significant predictors. The model incorporating these variables showed good discrimination and calibration capacities in both training and validation cohorts. The AUC of the training cohort and validation cohort were 0.854 and 0.850, respectively. The DCA confirmed the clinical usefulness of the nomogram model. Conclusions: A novel nomogram model was established to accurately assess the risk of CAA at 4-8 weeks of onset among KD children older than 5 years, which may aid clinical decision-making.
MeSH term(s)	Humans ; Mucocutaneous Lymph Node Syndrome/complications ; Mucocutaneous Lymph Node Syndrome/diagnosis ; Male ; Female ; Nomograms ; Child ; Child, Preschool ; Coronary Vessel Anomalies ; ROC Curve ; Logistic Models ; Risk Assessment/methods
Language	English
Publishing date	2024-01-02
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	731324-x
ISSN	1678-4782 ; 0021-7557
ISSN (online)	1678-4782
ISSN	0021-7557
DOI	10.1016/j.jped.2023.12.002
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Zs.B 1265: Show issues

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Article ; Online: Efficient Production of a Thermostable Mutant of Transglutaminase by

Ye, Jiacai / Yang, Penghui / Zhou, Jingwen / Du, Guocheng / Liu, Song

Journal of agricultural and food chemistry

2024 Volume 72, Issue 8, Page(s) 4207–4216

Abstract: The transglutaminase (TGase) ... ...

Abstract	The transglutaminase (TGase) from
MeSH term(s)	Transglutaminases/genetics ; Transglutaminases/metabolism ; Streptomyces/metabolism ; Bacterial Proteins/metabolism
Chemical Substances	Transglutaminases (EC 2.3.2.13) ; Bacterial Proteins
Language	English
Publishing date	2024-02-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.3c07621
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Zs.A 1172: Show issues

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Article ; Online: A nomogram for predicting cancer-specific survival of mediastinal primary large B-cell lymphoma: A population-based study.

Yang, Penghui / Zhang, Kaijun / Zhang, Jing / Yi, Qijian

Asian journal of surgery

2023 Volume 46, Issue 10, Page(s) 4493–4494

MeSH term(s)	Adult ; Humans ; Nomograms ; Lymphoma, Large B-Cell, Diffuse ; Thymus Neoplasms
Language	English
Publishing date	2023-05-11
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2023.04.125
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Zs.B 2831: Show issues

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Article ; Online: A recombinant oncolytic influenza virus expressing a PD-L1 antibody induces CD8

Sun, Fang / Xu, Yan / Deng, Zhuoya / Yang, Penghui

International immunopharmacology

2023 Volume 120, Page(s) 110323

Abstract: Objective: To evaluate targeted killing of hepatocellular carcinoma (HCC) cells by a recombinant oncolytic influenza virus expressing a PD-L1 antibody (rgFlu/PD-L1) and to develop a novel immunotherapy for HCC.: Methods: Using influenza virus reverse ...

Abstract	Objective: To evaluate targeted killing of hepatocellular carcinoma (HCC) cells by a recombinant oncolytic influenza virus expressing a PD-L1 antibody (rgFlu/PD-L1) and to develop a novel immunotherapy for HCC. Methods: Using influenza virus reverse genetics, a recombinant oncolytic virus was generated in the background of the A/Puerto Rico/8/34 (PR8) virus, then identified via screening and passage in specific pathogen-free chicken embryos. Hepatocellular carcinoma cell killing by rgFlu/PD-L1 was confirmed in vitro and in vivo. Transcriptome analyses were used to explore PD-L1 expression and function. Western blotting revealed that PD-L1 activated the cGas-STING pathway. Results: rgFlu/PD-L1 expressed the PD-L1 heavy and light chain in PB1 and PA, respectively; PR8 served as the backbone. The hemagglutinin titer of rgFlu/PD-L1 was 2 Conclusion: rgFlu/PD-L1 activated the cGas-STING pathway in CD8
MeSH term(s)	Chick Embryo ; Animals ; Mice ; Carcinoma, Hepatocellular ; Liver Neoplasms ; CD8-Positive T-Lymphocytes ; Oncolytic Viruses/genetics ; Oncolytic Viruses/metabolism ; B7-H1 Antigen/metabolism ; Antibodies ; Orthomyxoviridae
Chemical Substances	B7-H1 Antigen ; Antibodies
Language	English
Publishing date	2023-05-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2023.110323
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Zs.A 5408: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Serum levels of PDGF-CC as a potential biomarker for the diagnosis of Kawasaki disease.

Zhang, Jing / Yang, Penghui / Liu, Yihao / Chen, Zhuo / Wu, Jinhui / Feng, Siqi / Yi, Qijian

Italian journal of pediatrics

2024 Volume 50, Issue 1, Page(s) 16

Abstract: Background: Kawasaki disease (KD) is an acute systemic vasculitis of unknown etiology that predominantly affects children, and no specific diagnostic biomarkers for KD are available. Platelet-derived growth factor CC (PDGF-CC) is a peptide with ... ...

Abstract	Background: Kawasaki disease (KD) is an acute systemic vasculitis of unknown etiology that predominantly affects children, and no specific diagnostic biomarkers for KD are available. Platelet-derived growth factor CC (PDGF-CC) is a peptide with angiogenic properties that has been amply demonstrated to play a critical role in the cardiovascular system. This study aimed to investigate the serum expression of PDGF-CC in children with KD and to evaluate the ability of PDGF-CC to diagnose KD. Methods: A total of 96 subjects, including 59 KD patients, 17 febrile controls (FC), and 20 healthy controls (HC), were enrolled. Serum levels of PDGF-CC were measured via enzyme-linked immunosorbent assay. The associations between PDGF-CC and clinical laboratory parameters were investigated by correlation analysis. The diagnostic performance was assessed by receiver operating characteristic (ROC) curve analysis. Results: Serum PDGF-CC levels in the KD group were significantly higher than in the FC and HC groups. Serum PDGF-CC levels in the KD group were positively correlated with white blood cell counts, percentage of neutrophils, IL-2, IL-12p70, TNF-α, and IL-1β levels, and negatively correlated with the percentage of lymphocytes. In the analysis of ROC curves, the area under the curve was 0.796 (95% confidence interval 0.688-0.880; P < 0.0001) for PDGF-CC and increased to 0.900 (95% confidence interval 0.808-0.957; P < 0.0001) in combination with white blood cell counts and C-reactive protein. Conclusions: PDGF-CC is a potential biomarker for KD diagnosis, and the combination with white blood cell counts and C-reactive protein can further improve diagnostic performance.
MeSH term(s)	Child ; Humans ; Mucocutaneous Lymph Node Syndrome/diagnosis ; C-Reactive Protein/analysis ; Biomarkers ; Platelet-Derived Growth Factor ; Fever ; Lymphokines
Chemical Substances	platelet-derived growth factor C ; C-Reactive Protein (9007-41-4) ; Biomarkers ; Platelet-Derived Growth Factor ; Lymphokines
Language	English
Publishing date	2024-01-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2088556-8
ISSN	1824-7288 ; 1720-8424
ISSN (online)	1824-7288
ISSN	1720-8424
DOI	10.1186/s13052-024-01580-6
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Zs.A 1961: Show issues

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Article ; Online: Pediatric malignant pheochromocytoma with atypical presentation as vision changes, lung metastasis, and recurrence: a case report.

Zhang, Kaijun / Yang, Penghui / Li, Mi / Xiang, Ping / Cheng, Zhenli / Zhou, Xue

Journal of medical case reports

2024 Volume 18, Issue 1, Page(s) 134

Abstract: Background: This case report documents a case of malignant pheochromocytoma manifested as vision changes with lung metastasis and recurrence.: Case presentation: A 10-year-old Han Chinese girl presented with vision changes and was eventually ... ...

Abstract	Background: This case report documents a case of malignant pheochromocytoma manifested as vision changes with lung metastasis and recurrence. Case presentation: A 10-year-old Han Chinese girl presented with vision changes and was eventually diagnosed with pheochromocytoma by contrast-enhanced computed tomography, urine vanillylmandelic acid. After medication for hypertension and surgery, clinical symptoms disappeared. Malignant pheochromocytoma with lung metastasis was confirmed histologically using the Pheochromocytoma of the Adrenal Gland Scaled Score scoring system and genetically with succinate dehydrogenase complex iron sulfur subunit B mutation, and 3 months later, unplanned surgery was performed because of the high risks and signs of recurrence. She is asymptomatic as of the writing of this case report. Our patient's case highlights the importance of considering a diagnosis of malignant pheochromocytoma, and long-term follow-up for possible recurrence. Conclusion: Although there are well-recognized classic clinical manifestations associated with pheochromocytoma, atypical presentation, such as vision changes in children, should be considered. In addition, malignant pheochromocytoma children with a high Pheochromocytoma of the Adrenal Gland Scaled Score and succinate dehydrogenase complex iron sulfur subunit B mutation require a long-term follow-up or even unplanned surgery because of the higher risk of recurrence.
MeSH term(s)	Female ; Humans ; Child ; Pheochromocytoma/diagnosis ; Pheochromocytoma/surgery ; Succinate Dehydrogenase/genetics ; Adrenal Gland Neoplasms ; Lung Neoplasms ; Sulfur ; Iron
Chemical Substances	Succinate Dehydrogenase (EC 1.3.99.1) ; Sulfur (70FD1KFU70) ; Iron (E1UOL152H7)
Language	English
Publishing date	2024-03-05
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2269805-X
ISSN	1752-1947 ; 1752-1947
ISSN (online)	1752-1947
ISSN	1752-1947
DOI	10.1186/s13256-023-04329-7
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Article ; Online: High throughput screening of pure silica zeolites for CF

Zhang, Hui-Dong / Li, Xiao-Dong / Xie, Yan-Yu / Yang, Peng-Hui / Yu, Jing-Xin

Physical chemistry chemical physics : PCCP

2024 Volume 26, Issue 15, Page(s) 11570–11581

Abstract: The capture and separation of ... ...

Abstract	The capture and separation of CF
Language	English
Publishing date	2024-04-17
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d4cp00171k
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Article ; Online: Prediction of Coronary Artery Lesions in Patients With Recurrent Kawasaki Disease.

Yang, Penghui / Zhang, Jing / Liu, Yihao / Feng, Siqi / Yi, Qijian

The Pediatric infectious disease journal

2023

Abstract: Background: A subset of patients with Kawasaki disease (KD) will suffer recurrence. However, there is still a lack of accurate prediction models for coronary artery lesions (CAL) in recurrent KD patients. It is necessary to establish a new nomogram ... ...

Abstract	Background: A subset of patients with Kawasaki disease (KD) will suffer recurrence. However, there is still a lack of accurate prediction models for coronary artery lesions (CAL) in recurrent KD patients. It is necessary to establish a new nomogram model for predicting CAL in patients with recurrent KD. Methods: Data from patients with recurrent KD between 2015 and 2021 were retrospectively reviewed. After splitting the patients into training and validation cohorts, the least absolute shrinkage and selection operator was used to select the predictors of CAL and multivariate logistic regression was used to construct a nomogram based on the selected predictors. The application of area under the receiver operating characteristic curve (AUC), calibration curves, Hosmer-Lemeshow test, Brier score and decision curve analysis were used to assess the model performance. Results: A total of 159 recurrent KD patients were enrolled, 66 (41.5%) of whom had CAL. Hemoglobin levels, CAL at the first episode, and intravenous immunoglobulin resistance at recurrence were identified by the least absolute shrinkage and selection operator regression analysis as significant predictors. The model incorporating these predictors showed good discrimination (AUC, 0.777) and calibration capacities (Hosmer-Lemeshow P value, 0.418; Brier score, 0.190) in the training cohort. Application of the model to the validation cohort yielded an AUC of 0.741, a Hosmer-Lemeshow P value of 0.623 and a Brier score of 0.190. The decision curve analysis demonstrated that the nomogram model was clinically useful. Conclusions: The proposed nomogram model could help clinicians assess the risk of CAL in patients with recurrent KD.
Language	English
Publishing date	2023-10-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	392481-6
ISSN	1532-0987 ; 0891-3668
ISSN (online)	1532-0987
ISSN	0891-3668
DOI	10.1097/INF.0000000000004146
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Article: mRNA vaccines: A novel weapon to control infectious diseases.

Tian, Yuying / Deng, Zhuoya / Yang, Penghui

Frontiers in microbiology

2022 Volume 13, Page(s) 1008684

Abstract: Infectious diseases have always threatened human life, but with the development of vaccines, effective strategies for preventing and controlling these diseases have become available. The global outbreak of COVID-19 ushered in the advent of mRNA vaccine ... ...

Abstract	Infectious diseases have always threatened human life, but with the development of vaccines, effective strategies for preventing and controlling these diseases have become available. The global outbreak of COVID-19 ushered in the advent of mRNA vaccine technologies, which quickly led to the introduction of mRNA vaccines effective against SARS-CoV-2. The success of this approach has stimulated research into the use of mRNA vaccines in the fight against other emerging as well as remerging infectious diseases. This review examines the constructive strategies and delivery systems used in mRNA vaccines and provides an overview of current clinical trials of those vaccines in the prevention of infectious diseases. The underlying mechanisms of mRNA vaccines are also discussed, including the double-edged sword of the innate immune response. Finally, the challenges but also the potential of mRNA vaccines are considered.
Language	English
Publishing date	2022-10-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2022.1008684
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