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  1. Article ; Online: From Womb to Tomb: In Utero Exposure to Tobacco Smoke and Adult Cancers.

    Yang, Ping

    Mayo Clinic proceedings

    2023  Volume 98, Issue 8, Page(s) 1116–1117

    MeSH term(s) Humans ; Adult ; Female ; Tobacco Smoke Pollution/adverse effects ; Smoking/adverse effects ; Prenatal Exposure Delayed Effects ; Uterus ; Neoplasms/epidemiology ; Neoplasms/etiology
    Chemical Substances Tobacco Smoke Pollution
    Language English
    Publishing date 2023-08-04
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2023.06.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.183: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Evolutionary graph theory beyond pairwise interactions: Higher-order network motifs shape times to fixation in structured populations.

    Kuo, Yang Ping / Carja, Oana

    PLoS computational biology

    2024  Volume 20, Issue 3, Page(s) e1011905

    Abstract: To design population topologies that can accelerate rates of solution discovery in directed evolution problems or for evolutionary optimization applications, we must first systematically understand how population structure shapes evolutionary outcome. ... ...

    Abstract To design population topologies that can accelerate rates of solution discovery in directed evolution problems or for evolutionary optimization applications, we must first systematically understand how population structure shapes evolutionary outcome. Using the mathematical formalism of evolutionary graph theory, recent studies have shown how to topologically build networks of population interaction that increase probabilities of fixation of beneficial mutations, at the expense, however, of longer fixation times, which can slow down rates of evolution, under elevated mutation rate. Here we find that moving beyond dyadic interactions in population graphs is fundamental to explain the trade-offs between probabilities and times to fixation of new mutants in the population. We show that higher-order motifs, and in particular three-node structures, allow the tuning of times to fixation, without changes in probabilities of fixation. This gives a near-continuous control over achieving solutions that allow for a wide range of times to fixation. We apply our algorithms and analytic results to two evolutionary optimization problems and show that the rate of solution discovery can be tuned near continuously by adjusting the higher-order topology of the population. We show that the effects of population structure on the rate of evolution critically depend on the optimization landscape and find that decelerators, with longer times to fixation of new mutants, are able to reach the optimal solutions faster than accelerators in complex solution spaces. Our results highlight that no one population topology fits all optimization applications, and we provide analytic and computational tools that allow for the design of networks suitable for each specific task.
    MeSH term(s) Biological Evolution ; Mutation Rate ; Mutation ; Algorithms ; Mathematics
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2193340-6
    ISSN 1553-7358 ; 1553-734X
    ISSN (online) 1553-7358
    ISSN 1553-734X
    DOI 10.1371/journal.pcbi.1011905
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  3. Article ; Online: Evolutionary graph theory beyond single mutation dynamics: on how network structured populations cross fitness landscapes.

    Kuo, Yang Ping / Carja, Oana

    Genetics

    2024  

    Abstract: Spatially-resolved datasets are revolutionizing knowledge in molecular biology, yet are under-utilized for questions in evolutionary biology. To gain insight from these large-scale datasets of spatial organization, we need mathematical representations ... ...

    Abstract Spatially-resolved datasets are revolutionizing knowledge in molecular biology, yet are under-utilized for questions in evolutionary biology. To gain insight from these large-scale datasets of spatial organization, we need mathematical representations and modeling techniques that can both capture their complexity, but also allow for mathematical tractability. Evolutionary graph theory utilizes the mathematical representation of networks as a proxy for heterogeneous population structure and has started to reshape our understanding of how spatial structure can direct evolutionary dynamics. However, previous results are derived for the case of a single new mutation appearing in the population and the role of network structure in shaping fitness landscape crossing is still poorly understood. Here we study how network structured populations cross fitness landscapes and show that even a simple extension to a two-mutational landscape can exhibit complex evolutionary dynamics that cannot be predicted using previous single-mutation results. We show how our results can be intuitively understood through the lens of how the two main evolutionary properties of a network, the amplification and acceleration factors, change the expected fate of the intermediate mutant in the population and further discuss how to link these models to spatially-resolved datasets of cellular organization.
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2167-2
    ISSN 1943-2631 ; 0016-6731
    ISSN (online) 1943-2631
    ISSN 0016-6731
    DOI 10.1093/genetics/iyae055
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 767: Show issues Location:
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  4. Article ; Online: Clinical characteristics and pharmacokinetics of PAXLOVID in COVID-19 patients with hematological tumor.

    Liu, Wei / Yang, Ping / Yang, Ping / Yang, Li / Jing, Hongmei / Zhao, Libo / Zhao, Rongsheng

    Medical review (2021)

    2024  Volume 4, Issue 2, Page(s) 169–171

    Language English
    Publishing date 2024-03-04
    Publishing country Germany
    Document type Journal Article
    ISSN 2749-9642
    ISSN (online) 2749-9642
    DOI 10.1515/mr-2023-0068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Lorenz-Mie theory-type solution for light scattering by spheroids with small-to-large size parameters and aspect ratios.

    Ding, Jiachen / Yang, Ping

    Optics express

    2023  Volume 31, Issue 24, Page(s) 40937–40951

    Abstract: There has been a long-term endeavor in the light-scattering research community to develop a Lorenz-Mie theory-type method for simulating light scattering by spheroidal particles with small-to-large sizes. A spheroid is a very important nonspherical shape ...

    Abstract There has been a long-term endeavor in the light-scattering research community to develop a Lorenz-Mie theory-type method for simulating light scattering by spheroidal particles with small-to-large sizes. A spheroid is a very important nonspherical shape in modeling the optical properties of many natural particles. For the first time, we develop a computationally feasible separation of variables method (SVM) in spheroidal coordinates to compute optical properties of spheroids with small-to-large sizes compared to the wavelength of the incident light (λ). The method is applicable to spheroids with size parameters (2π/λ times the major semiaxis) up to at least 600, and is not restricted by particle aspect ratios. Therefore, the work reported here represents a breakthrough in solving the optical properties of a nonspherical particle in an analytical form.
    Language English
    Publishing date 2023-12-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.505416
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  6. Article ; Online: [Retracted] MicroRNA‑203 inhibits malignant melanoma cell migration by targeting versican.

    Bu, Pingyuan / Yang, Ping

    Experimental and therapeutic medicine

    2023  Volume 27, Issue 1, Page(s) 21

    Abstract: This retracts the article DOI: 10.3892/etm.2014.1708.]. ...

    Abstract [This retracts the article DOI: 10.3892/etm.2014.1708.].
    Language English
    Publishing date 2023-11-20
    Publishing country Greece
    Document type Retraction of Publication
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2023.12308
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  7. Article ; Online: CsPbX

    Zhang, Xiao / Yang, Ping

    Langmuir : the ACS journal of surfaces and colloids

    2023  Volume 39, Issue 32, Page(s) 11188–11212

    Abstract: Cesium lead halide ( ... ...

    Abstract Cesium lead halide (CsPbX
    Language English
    Publishing date 2023-08-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.3c01848
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  8. Article ; Online: B, N, and Si Single-Doping at Graphene/Cu (111) Interfaces to Adjust Electrical Properties.

    Li, Dongbo / Yang, Ping

    Langmuir : the ACS journal of surfaces and colloids

    2023  Volume 39, Issue 26, Page(s) 9172–9179

    Abstract: We investigated the structural and electrical properties of B-, N-, and Si-doped graphene/Cu interfaces through density functional theory. B-doping enhances the interfacial bonding strength, N-doping has little effect on the interfacial interaction, and ... ...

    Abstract We investigated the structural and electrical properties of B-, N-, and Si-doped graphene/Cu interfaces through density functional theory. B-doping enhances the interfacial bonding strength, N-doping has little effect on the interfacial interaction, and Si-Cu bonds are formed in the Si-doped interface. The energy bands and density of states show that the pristine and N-doped graphene/Cu interfaces exhibit n-type semiconductor properties, and the B-doped and Si-doped graphene/Cu interfaces exhibit p-type semiconductor properties. According to the Mulliken charge populations and charge properties, B-doping and Si-doping improve the ability of charge transport and orbital hybridization at the interface. Graphene doping has a significant effect on the interfacial work function. This result will help to understand the contact between B-, N-, and Si-doped graphene and Cu surfaces and to predict the performance of related micro-nano electronic devices.
    Language English
    Publishing date 2023-06-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.3c00952
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  9. Article ; Online: Maximizing quality of life remains an ultimate goal in the era of precision medicine: exemplified by lung cancer.

    Yang, Ping

    Precision clinical medicine

    2019  Volume 2, Issue 1, Page(s) 8–12

    Abstract: An ultimate goal of precision medicine in lung cancer treatment is to restore patient health with maximized quality of life (QOL). Results from Mayo Clinic studies show that a significant improvement in fatigue, dyspnea, and pain scales could lead to ... ...

    Abstract An ultimate goal of precision medicine in lung cancer treatment is to restore patient health with maximized quality of life (QOL). Results from Mayo Clinic studies show that a significant improvement in fatigue, dyspnea, and pain scales could lead to better overall QOL. Although treatments and guidelines for clinical implementation to alleviate these key symptoms are available, few cancer patients receive adequate therapy, mostly because of limitations in current care delivery systems and unclear clinicians' roles. For optimal care of lung cancer survivors in different subpopulations, three barriers must be overcome: physicians' lack of knowledge, unwarranted practice variation, and uncertainty regarding care provider roles. Appropriate culturally adapted, tested and validated tools for QOL measures must be developed, rather than directly translating existing tools between different languages and across cultures or diverse subpopulations. Finally, lack of sensitive, adequate, and relevant tools in measuring health-related QOL (HRQOL) has long been an issue for effective data collection, demanding a global consensus on a set of core components that reflect the needs of all critical parties for the best cure and care, supporting patients to achieve optimal HRQOL.
    Language English
    Publishing date 2019-03-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2948341-4
    ISSN 2516-1571 ; 2096-5303
    ISSN (online) 2516-1571
    ISSN 2096-5303
    DOI 10.1093/pcmedi/pbz001
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  10. Article ; Online: Tuning Rashba-Dresselhaus effect with ferroelectric polarization at asymmetric heterostructural interface.

    Zhang, Bangmin / Tang, Chunhua / Yang, Ping / Chen, Jingsheng

    Materials horizons

    2024  Volume 11, Issue 1, Page(s) 262–270

    Abstract: The spin-orbit interaction (SOI) plays an essential role in materials properties, and controlling its intensity has great potential in the design of materials. In this work, asymmetric [( ... ...

    Abstract The spin-orbit interaction (SOI) plays an essential role in materials properties, and controlling its intensity has great potential in the design of materials. In this work, asymmetric [(La
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2744250-0
    ISSN 2051-6355 ; 2051-6347
    ISSN (online) 2051-6355
    ISSN 2051-6347
    DOI 10.1039/d3mh00635b
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