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  1. AU="Yang, Qizhang"
  2. AU=Wilt Timothy J
  3. AU="Dene R. Littler" AU="Dene R. Littler"
  4. AU="Petrenko, Andrei"
  5. AU=Valentino Kristin
  6. AU=Swash M
  7. AU="Adedipe, Ifeoluwa"
  8. AU=Shen Hongcheng
  9. AU="Padhy, Biswajit"
  10. AU="Kruglikov, Alibek"
  11. AU="Tasu, Jean Pierre"
  12. AU="Floate, Kevin D"
  13. AU="Mark Rijpkema"
  14. AU="Gjeloshi, Klodian"
  15. AU="Lucie Beaudoin"

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  1. Artikel ; Online: Explore the durability of repetitive transcranial magnetic stimulation in treating post-traumatic stress disorder: An updated systematic review and meta-analysis.

    Xu, Guobin / Li, Geng / Yang, Qizhang / Li, Chao / Liu, Chengzhen

    Stress and health : journal of the International Society for the Investigation of Stress

    2023  Band 40, Heft 1, Seite(n) e3292

    Abstract: The objective was to synthesize results from studies that assessed symptom relief after repetitive transcranial magnetic stimulation (rTMS) treatment for post-traumatic stress disorder (PTSD) and investigate the long-term effectiveness of rTMS for ... ...

    Abstract The objective was to synthesize results from studies that assessed symptom relief after repetitive transcranial magnetic stimulation (rTMS) treatment for post-traumatic stress disorder (PTSD) and investigate the long-term effectiveness of rTMS for treating PTSD. We searched multiple databases for relevant randomized controlled trials of rTMS for PTSD treatment up to 1 January 2023. Two researchers evaluated the studies and focused on the CAPS and PCL as outcome indicators. We used STATA17 SE software for the data analysis. Eight articles involving 309 PTSD patients were analysed in a meta-analysis, which found that rTMS had a significant and large effect on reducing core post-traumatic symptoms [Hedges'g = 1.75, 95% CI (1.18, 2.33)]. Both low and high-frequency rTMS also significantly reduced symptoms, with the latter having a greater effect. rTMS was shown to have a long-term effect on PTSD, with all three subgroup analyses demonstrating significant results. Interestingly, no significant difference in symptom relief was found between the follow-up and completion of treatments [Hedges'g = 0.01, 95% CI (-0.30, 0.33)], suggesting that the treatment effect of rTMS is stable. The meta-analysis provides strong evidence that rTMS is effective in reducing the severity and symptoms of PTSD in patients, and follow-up studies confirm its long-term stability.
    Mesh-Begriff(e) Humans ; Transcranial Magnetic Stimulation/methods ; Stress Disorders, Post-Traumatic/diagnosis ; Treatment Outcome
    Sprache Englisch
    Erscheinungsdatum 2023-07-15
    Erscheinungsland England
    Dokumenttyp Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 2042041-9
    ISSN 1532-2998 ; 1532-3005
    ISSN (online) 1532-2998
    ISSN 1532-3005
    DOI 10.1002/smi.3292
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Multifunctional Surface with Enhanced Angiogenesis for Improving Long-Term Osteogenic Fixation of Poly(ether ether ketone) Implants

    Dong, Taosheng / Duan, Chunyan / Wang, Song / Gao, Xiangyu / Yang, Qizhang / Yang, Weizhong / Deng, Yi

    ACS applied materials & interfaces. 2020 Mar. 11, v. 12, no. 13

    2020  

    Abstract: Poly(ether ether ketone) (PEEK) is a biocompatible polymer, but the lack of angiogenesis makes the long-term osteogenic fixation of PEEK implants challenging, which has hampered their wider application in orthopedics. Herein, we develop a multifunctional ...

    Abstract Poly(ether ether ketone) (PEEK) is a biocompatible polymer, but the lack of angiogenesis makes the long-term osteogenic fixation of PEEK implants challenging, which has hampered their wider application in orthopedics. Herein, we develop a multifunctional micro-/nanostructured surface presenting hydroxyapatite (HA) nanoflowers and nickel hydroxide (Ni(OH)2) nanoparticles on PEEK implants (sPEEK-Ni-HA) to tackle the problem. The results show that the reasonable release of Ni2+ from sPEEK-Ni-HA significantly facilitates the migration, tube formation, and angiogenic gene expression of human umbilical vein endothelial cells (HUVECs). In addition to angiogenesis, the sPEEK-Ni-HA displays enhanced cytocompatibility and osteogenicity in terms of cell proliferation, spreading, alkaline phosphatase activity, matrix mineralization, and osteogenesis-related gene secretion, exceeding pure and other multifunctional sPEEK samples. Importantly, in vivo evaluations employing a rabbit femoral condyle implantation model confirm that such dual decoration of Ni elements and HA nanoflowers boosts bone remodeling/osseointegration, which dramatically promotes the in vivo osteogenic fixation of implants. Therefore, this work not only sheds light on the significance of angiogenesis on the osteogenic fixation of an implant but also presents a facile strategy to empower bioinert PEEK with a well-orchestrated feature of angiogenesis and osteogenesis.
    Schlagwörter alkaline phosphatase ; angiogenesis ; bone formation ; cell proliferation ; enzyme activity ; gene expression ; genes ; human umbilical vein endothelial cells ; hydroxyapatite ; in vivo studies ; mineralization ; models ; nanoflowers ; nanoparticles ; nickel ; orthopedics ; polymers ; rabbits ; secretion
    Sprache Englisch
    Erscheinungsverlauf 2020-0311
    Umfang p. 14971-14982.
    Erscheinungsort American Chemical Society
    Dokumenttyp Artikel
    ISSN 1944-8252
    DOI 10.1021/acsami.0c02304
    Datenquelle NAL Katalog (AGRICOLA)

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  3. Artikel ; Online: Multifunctional Surface with Enhanced Angiogenesis for Improving Long-Term Osteogenic Fixation of Poly(ether ether ketone) Implants.

    Dong, Taosheng / Duan, Chunyan / Wang, Song / Gao, Xiangyu / Yang, Qizhang / Yang, Weizhong / Deng, Yi

    ACS applied materials & interfaces

    2020  Band 12, Heft 13, Seite(n) 14971–14982

    Abstract: Poly(ether ether ketone) (PEEK) is a biocompatible polymer, but the lack of angiogenesis makes the long-term osteogenic fixation of PEEK implants challenging, which has hampered their wider application in orthopedics. Herein, we develop a multifunctional ...

    Abstract Poly(ether ether ketone) (PEEK) is a biocompatible polymer, but the lack of angiogenesis makes the long-term osteogenic fixation of PEEK implants challenging, which has hampered their wider application in orthopedics. Herein, we develop a multifunctional micro-/nanostructured surface presenting hydroxyapatite (HA) nanoflowers and nickel hydroxide (Ni(OH)
    Mesh-Begriff(e) Animals ; Benzophenones ; Biocompatible Materials/chemistry ; Biocompatible Materials/pharmacology ; Biocompatible Materials/therapeutic use ; Bone Diseases/drug therapy ; Bone Diseases/pathology ; Bone Regeneration/drug effects ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Disease Models, Animal ; Durapatite/chemistry ; Human Umbilical Vein Endothelial Cells ; Humans ; Hydroxides/chemistry ; Ketones/chemistry ; Mice ; Nanoparticles/chemistry ; Neovascularization, Physiologic/drug effects ; Nickel/chemistry ; Osteoblasts/cytology ; Osteoblasts/metabolism ; Osteogenesis/drug effects ; Polyethylene Glycols/chemistry ; Polymers ; Prostheses and Implants ; Rabbits ; Surface Properties
    Chemische Substanzen Benzophenones ; Biocompatible Materials ; Hydroxides ; Ketones ; Polymers ; nickel hydroxide (12054-48-7) ; polyetheretherketone (31694-16-3) ; Polyethylene Glycols (3WJQ0SDW1A) ; Nickel (7OV03QG267) ; Durapatite (91D9GV0Z28)
    Sprache Englisch
    Erscheinungsdatum 2020-03-20
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.0c02304
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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