Article ; Online: Supramolecular fluorescence sensor array used for the analysis of tyrosine kinase inhibitors in biological fluids and cell imaging.
2023 Volume 1287, Page(s) 342124
Abstract: Tyrosine kinase inhibitors (TKIs) are commonly used in tumor targeting therapy. However, the rapid analysis of TKIs remains a significant challenge, especially in complex biological fluid environments. In this work, we have constructed a supramolecular ... ...
| Abstract | Tyrosine kinase inhibitors (TKIs) are commonly used in tumor targeting therapy. However, the rapid analysis of TKIs remains a significant challenge, especially in complex biological fluid environments. In this work, we have constructed a supramolecular fluorescence sensor array based on a cucurbituril-dye host-guest complex. The binding affinity between the three complexes and each TKI is different, resulting in different cross-response signals of the complexes to the fluorescence of each TKI. Combined with linear discriminant analysis(LDA), five kinds of TKIs can be well identified. The supramolecular fluorescence sensor array could accurately identify and distinguish the five TKIs in water and could classify mixtures containing different concentrations of TKIs in serum. The concentration and Factor 1 exhibited a good linear relationship and the detection limit (LOD) was as low as 10 |
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| MeSH term(s) | Reproducibility of Results ; Tyrosine Kinase Inhibitors ; Cell Differentiation ; Discriminant Analysis ; Drug Monitoring |
| Chemical Substances | Tyrosine Kinase Inhibitors |
| Language | English |
| Publishing date | 2023-12-09 |
| Publishing country | Netherlands |
| Document type | Journal Article |
| ZDB-ID | 1483436-4 |
| ISSN | 1873-4324 ; 0003-2670 |
| ISSN (online) | 1873-4324 |
| ISSN | 0003-2670 |
| DOI | 10.1016/j.aca.2023.342124 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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