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Article ; Online: The Associations between Glenohumeral Range of Motion (ROM) during Off-Season and On-Season and the Ball Speed among Collegiate Baseball Pitchers.

Yang, Seung-Won / Kwon, Se-Jeong

2022 Volume 51, Issue 12, Page(s) 2835–2837

Language	English
Publishing date	2022-12-07
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2240935-X
ISSN	2251-6093 ; 2251-6093
ISSN (online)	2251-6093
ISSN	2251-6093
DOI	10.18502/ijph.v51i12.11477
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Article ; Online: Impact of pharmacist-led medication management in care transitions.

Yang, Seungwon

BMC health services research

2017 Volume 17, Issue 1, Page(s) 722

Abstract: Background: When patients are discharged from hospital to home, it is a highlighted vulnerable period for which medication - related problems are prevalent. Researchers have proposed a telephone follow-up intervention as a means to reduce hospital ... ...

Abstract	Background: When patients are discharged from hospital to home, it is a highlighted vulnerable period for which medication - related problems are prevalent. Researchers have proposed a telephone follow-up intervention as a means to reduce hospital readmissions. However, the outcome of the intervention with the engagement of pharmacists in managing patients' medicines after discharge has not been well explored. The objectives of this study were (1) to determine whether a pharmacist telephone follow-up intervention focusing on patients' medicines management support is associated with a reduction in 30-day readmission rates and (2) to describe the number and types of pharmacist interventions in care transitions. Methods: This was a case-cohort study conducted in two acute hospitals in the UK. Pharmacists performed a telephone follow-up intervention to discharged patients to provide medicines management support. Patients who received pharmacist telephone follow-up calls within 14 days of discharge formed the intervention group. A subset of medical patient population discharged in the month of May 2013 formed the comparison group. During a series of two-telephone follow-up, pharmacists identified post-discharge pharmaceutical problems and provided patient-tailored interventions accordingly. The impact of pharmacist interventions was assessed using a risk assessment matrix tool by two senior pharmacists. Overall 30-day readmission rates in the intervention group were measured and compared with the comparison group using a chi-square test. Results: Between 5 Conclusions: A pharmacist TFU intervention did not show a benefit in 30-day hospital readmissions. However, a pharmacist TFU intervention was an effective method to solve or avoid critical pharmaceutical problems. A future study using a larger scale trial is warranted.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Continuity of Patient Care/standards ; Female ; Follow-Up Studies ; Humans ; Male ; Medication Adherence ; Middle Aged ; Patient Discharge ; Patient Readmission ; Pharmacists ; Pharmacy Service, Hospital ; Prospective Studies ; Quality of Health Care ; Telephone ; Transitional Care/organization & administration ; United Kingdom ; Young Adult
Language	English
Publishing date	2017-11-13
Publishing country	England
Document type	Journal Article
ISSN	1472-6963
ISSN (online)	1472-6963
DOI	10.1186/s12913-017-2684-3
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Article ; Online: The m

Yang, Zizhao / Verghese, Michelle / Yang, Seungwon / Shah, Palak / He, Yu-Ying

Photochemistry and photobiology

2024

Abstract: Ultraviolet B (UVB) radiation represents a major carcinogen for the development of all skin cancer types. Mechanistically, UVB induces damage to DNA in the form of lesions, including cyclobutane pyrimidine dimers (CPDs). Disruption of the functional ... ...

Abstract	Ultraviolet B (UVB) radiation represents a major carcinogen for the development of all skin cancer types. Mechanistically, UVB induces damage to DNA in the form of lesions, including cyclobutane pyrimidine dimers (CPDs). Disruption of the functional repair processes, such as nucleotide excision repair (NER), allows persistence of DNA damage and contributes to skin carcinogenesis. Recent work has implicated m
Language	English
Publishing date	2024-01-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	123540-0
ISSN	1751-1097 ; 0031-8655
ISSN (online)	1751-1097
ISSN	0031-8655
DOI	10.1111/php.13904
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Zs.B 1686: Show issues

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Article ; Online: GridSet: Visualizing Individual Elements and Attributes for Analysis of Set-Typed Data.

Chung, Haeyong / Nandhakumar, Santhosh / Yang, Seungwon

IEEE transactions on visualization and computer graphics

2022 Volume 28, Issue 8, Page(s) 2983–2998

Abstract: We present GridSet, a novel set visualization for exploring elements, their attributes, intersections, as well as entire sets. In this set visualization, each set representation is composed of glyphs, which represent individual elements and their ... ...

Abstract	We present GridSet, a novel set visualization for exploring elements, their attributes, intersections, as well as entire sets. In this set visualization, each set representation is composed of glyphs, which represent individual elements and their attributes utilizing different visual encodings. In each set, elements are organized within a grid treemap layout that can provide space-efficient overviews of the elements structured by set intersections across multiple sets. These intersecting elements can be connected among sets through visual links. These visual representations for the individual set, elements, and intersection in GridSet facilitate novel interaction approaches for undertaking analysis tasks by utilizing both macroscopic views of sets, as well as microscopic views of elements and attribute details. In order to perform multiple set operations, GridSet supports a simple and straightforward process for set operations through dragging and dropping set objects. Our use cases involving two large set-typed datasets demonstrate that GridSet facilitates the exploration and identification of meaningful patterns and distributions of elements with respect to attributes and set intersections for solving complex analysis problems in set-typed data.
Language	English
Publishing date	2022-06-30
Publishing country	United States
Document type	Journal Article
ISSN	1941-0506
ISSN (online)	1941-0506
DOI	10.1109/TVCG.2020.3047111
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Article ; Online: Antihypertensive effects of rosuvastatin in patients with hypertension and dyslipidemia: A systemic review and meta-analysis of randomized studies.

Lee, Sungjae / Yang, Seungwon / Chang, Min Jung

PloS one

2021 Volume 16, Issue 11, Page(s) e0260391

Abstract: Some studies have suggested the antihypertensive effects of statins, a class of lipid-lowering agents, particularly in patients with hypertension. However, the evidence for the role of statins in blood pressure (BP) lowering is controversial, and no meta- ...

Abstract	Some studies have suggested the antihypertensive effects of statins, a class of lipid-lowering agents, particularly in patients with hypertension. However, the evidence for the role of statins in blood pressure (BP) lowering is controversial, and no meta-analysis of rosuvastatin therapy has been conducted to assess its BP-lowering effects. Therefore, the aim of this meta-analysis of randomized controlled trials (RCTs) was to investigate the effects of rosuvastatin on systolic blood pressure (SBP) and diastolic blood pressure (DBP) in patients with hypertension. We systematically searched the electronic databases MEDLINE, EMBASE, and Cochrane Library to identify RCTs in which patients were assigned to groups of rosuvastatin plus antihypertensive agents vs. antihypertensive agents. The three authors independently selected the studies, extracted data, and assessed methodological quality. We included five RCTs in this meta-analysis with 288 patients treated with rosuvastatin and 219 patients without rosuvastatin. The mean DBP in the rosuvastatin group was significantly lower than that in the non-rosuvastatin group by -2.12 mmHg (95% confidence interval (CI) -3.72 to -0.52; Pfixed-effects model = 0.009; I2 = 0%, Pheterogeneity = 0.97). Rosuvastatin treatment also lowered the mean SBP compared with the non-rosuvastatin treatment by -2.27 mmHg, but not significantly (95% CI - 4.75 to 0.25; Pfixed-effects model = 0.08; I2 = 0%, Pheterogeneity = 0.82). In this study, we reviewed the antihypertensive effects of rosuvastatin in patients with hypertension and dyslipidemia. We demonstrated a modest significant reduction of DBP and a trend toward a lowered SBP in patients with hypertension with rosuvastatin therapy. Rosuvastatin could be beneficial to control hypertension and, consequently, contribute toward reducing the risk of cardiovascular events in patients with hypertension and dyslipidemia.
MeSH term(s)	Anticholesteremic Agents/therapeutic use ; Antihypertensive Agents/therapeutic use ; Dyslipidemias/complications ; Dyslipidemias/drug therapy ; Humans ; Hypertension/complications ; Hypertension/drug therapy ; Randomized Controlled Trials as Topic ; Rosuvastatin Calcium/therapeutic use
Chemical Substances	Anticholesteremic Agents ; Antihypertensive Agents ; Rosuvastatin Calcium (83MVU38M7Q)
Language	English
Publishing date	2021-11-24
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0260391
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Article ; Online: Assessment of professional baseball players aerobic exercise performance depending on their positions.

Yang, Seung-Won

Journal of strength and conditioning research

2014 Volume 28, Issue 11, Page(s) 3289–3292

Abstract: This study reports the average and SD of professional baseball players' cardiorespiratory endurance, maximum oxygen consumption, oxygen consumption during anaerobic threshold, maximum oxygen consumption of anaerobic threshold %, maximum heart rate, and ... ...

Abstract	This study reports the average and SD of professional baseball players' cardiorespiratory endurance, maximum oxygen consumption, oxygen consumption during anaerobic threshold, maximum oxygen consumption of anaerobic threshold %, maximum heart rate, and heart rate of anaerobic threshold. We also report the comparison between pitchers and fielders. Considering the total number of results, percentile was used and results were classified into 5 grades. One professional baseball players' organization with more than 14 years of experience participated in this study. First, we observed that the average pitchers' V[Combining Dot Above]O2max was 53.64 ml·kg·min, whereas the average fielders' was 52.30 ml·kg·min. These values were lower than other sports players. Second, in case of the V[Combining Dot Above]O2AT, pitchers showed 39.35 ml·kg·min and fielders showed 39.96 ml·kg·min. %V[Combining Dot Above]O2AT showed a significant difference of 71.13% between pitchers and fielders-pitchers, whereas fielders showed 73.89% (p < 0.01). Third, maximal heart rates were measured at 188.69 b·min (pitchers) and 187.79 b·min (fielders). These were lower than college baseball players and higher than other sports players. In conclusion, both professional baseball pitchers and fielders should be aware of the necessity of systematic cardiorespiratory endurance data analysis. Moreover, baseball teams, athletic trainers, and coaches should also be aware of the importance of cardiorespiratory endurance.
MeSH term(s)	Adult ; Anaerobic Threshold ; Baseball/classification ; Baseball/physiology ; Exercise/physiology ; Exercise Test ; Heart Rate ; Humans ; Male ; Oxygen Consumption ; Republic of Korea ; Young Adult
Language	English
Publishing date	2014-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	1156349-7
ISSN	1533-4287 ; 1064-8011
ISSN (online)	1533-4287
ISSN	1064-8011
DOI	10.1519/JSC.0000000000000527
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Article ; Online: Population pharmacokinetics and dose optimization of vancomycin in neonates.

Lee, Soon Min / Yang, Seungwon / Kang, Soyoung / Chang, Min Jung

Scientific reports

2021 Volume 11, Issue 1, Page(s) 6168

Abstract: The pharmacokinetics of vancomycin vary among neonates, and we aimed to conduct population pharmacokinetic analysis to determine the optimal dosage of vancomycin in Korean neonates. From a retrospective chart review, neonates treated with vancomycin from ...

Abstract	The pharmacokinetics of vancomycin vary among neonates, and we aimed to conduct population pharmacokinetic analysis to determine the optimal dosage of vancomycin in Korean neonates. From a retrospective chart review, neonates treated with vancomycin from 2008 to 2017 in a neonatal intensive care unit (NICU) were included. Vancomycin concentrations were collected based on therapeutic drug monitoring, and other patient characteristics were gathered through electronic medical records. We applied nonlinear mixed-effect modeling to build the population pharmacokinetic model. One- and two-compartment models with first-order elimination were evaluated as potential structural pharmacokinetic models. Allometric and isometric scaling was applied to standardize pharmacokinetic parameters for clearance and volume of distribution, respectively, using fixed powers (0.75 and 1, respectively, for clearance and volume). The predictive performance of the final model was developed, and dosing strategies were explored using Monte Carlo simulations with AUC
MeSH term(s)	Anti-Bacterial Agents/pharmacokinetics ; Drug Monitoring ; Female ; Gestational Age ; Humans ; Infant, Newborn ; Infant, Premature ; Male ; Republic of Korea/epidemiology ; Retrospective Studies ; Vancomycin/pharmacokinetics
Chemical Substances	Anti-Bacterial Agents ; Vancomycin (6Q205EH1VU)
Language	English
Publishing date	2021-03-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-85529-3
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Article ; Online: A prospective cohort study evaluating m

Lazaroff, Jake / Duan, Grace Y / Verghese, Michelle / Bertacchi, Breanna / Yang, Seungwon / He, Yu-Ying / Bolotin, Diana

Journal of the American Academy of Dermatology

2023 Volume 89, Issue 5, Page(s) 1083–1084

MeSH term(s)	Humans ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/pathology ; Skin Neoplasms/genetics ; Skin Neoplasms/pathology ; Methylation ; Prospective Studies ; RNA
Chemical Substances	RNA (63231-63-0)
Language	English
Publishing date	2023-07-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603641-7
ISSN	1097-6787 ; 0190-9622
ISSN (online)	1097-6787
ISSN	0190-9622
DOI	10.1016/j.jaad.2023.07.1017
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Article ; Online: Keratinocyte autophagy enables the activation of keratinocytes and fibroblastsand facilitates wound healing.

Qiang, Lei / Yang, Seungwon / Cui, Yan-Hong / He, Yu-Ying

Autophagy

2020 Volume 17, Issue 9, Page(s) 2128–2143

Abstract: Macroautophagy/autophagy is a cellular catabolic process that is implicated in several physiological and pathological processes. However, the role of epidermal autophagy in wound healing remains unknown. Here, using mice with genetic ablation of the ... ...

Abstract	Macroautophagy/autophagy is a cellular catabolic process that is implicated in several physiological and pathological processes. However, the role of epidermal autophagy in wound healing remains unknown. Here, using mice with genetic ablation of the essential
MeSH term(s)	Animals ; Autophagy/physiology ; Autophagy-Related Protein 5/metabolism ; Beclin-1 ; Keratinocytes/metabolism ; Mice ; Wound Healing
Chemical Substances	Autophagy-Related Protein 5 ; Beclin-1
Language	English
Publishing date	2020-09-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2454135-7
ISSN	1554-8635 ; 1554-8627
ISSN (online)	1554-8635
ISSN	1554-8627
DOI	10.1080/15548627.2020.1816342
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Article ; Online: Influence of shoulder coverage difference of abutment on stress distribution and screw stability in tissue-level internal connection implants: A finite element analysis and in vitro study.

Lee, Hag-Young / Yang, Seung-Won / Kang, You-Jung / Oh, Kyung Chul / Kim, Jee-Hwan

The Journal of prosthetic dentistry

2021 Volume 125, Issue 4, Page(s) 682.e1–682.e10

Abstract: Statement of problem: Tissue-level internal connection implants are widely used, but the difference in abutment screw stability because of the shoulder coverage formed by the contact between the shoulder of the implant collar and the abutment remains ... ...

Abstract	Statement of problem: Tissue-level internal connection implants are widely used, but the difference in abutment screw stability because of the shoulder coverage formed by the contact between the shoulder of the implant collar and the abutment remains unclear. Purpose: The purpose of this finite element analysis (FEA) and in vitro study was to investigate stress distribution and abutment screw stability as per the difference in shoulder coverage of the abutment in tissue-level internal connection implants. Material and methods: Abutments were designed in 3 groups as per the shoulder coverage of the implant collar, yielding complete coverage (complete group), half coverage (half group), no coverage (no group) groups. In the FEA, a tightening torque of 30.0 Ncm was applied to the abutment screw, a force of 250 N was applied to the crown at a 30-degree angle, and the von Mises stresses and the stress distribution patterns were evaluated. In the in vitro study, the groups were tested (n=12). A total of 200 000 cyclic loads were applied at 250 N, 14 Hz, and at a 30-degree angle. Removal torque values and scanning electron microscopy (SEM) images were assessed. Removal torque values were analyzed by ANOVA and paired t tests. Results: The maximum von Mises stress of the abutment screw was the lowest in the complete group, slightly higher in the half group, and highest in the no group. High stresses were concentrated in 1 location in the implant abutment connection area of the no group. The removal torque values after loading were significantly lower in the no group than in the complete group (P=.047). The SEM images revealed concentrated structural loss and wear in 1 location of the no group. Conclusions: FEA and in vitro studies confirmed that the shoulder coverage of the abutment in the tissue-level internal connection implant helped improve screw stability. Cyclic loading reduced the removal torque of the abutment screw.
MeSH term(s)	Bone Screws ; Dental Abutments ; Dental Implant-Abutment Design ; Dental Implants ; Dental Stress Analysis ; Finite Element Analysis ; Torque
Chemical Substances	Dental Implants
Language	English
Publishing date	2021-02-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	218157-5
ISSN	1097-6841 ; 0022-3913
ISSN (online)	1097-6841
ISSN	0022-3913
DOI	10.1016/j.prosdent.2020.08.022
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