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  1. Article ; Online: Clonal cytopenia of undetermined significance presenting with multiple duplications of chromosome 1q.

    Wang, Panhong / Yang, Shaobin

    International journal of hematology

    2023  Volume 118, Issue 3, Page(s) 307–308

    MeSH term(s) Humans ; Clonal Hematopoiesis ; Myelodysplastic Syndromes/genetics ; Multiple Myeloma/genetics ; Chromosomes, Human, Pair 1/genetics ; Anemia ; Chromosome Aberrations
    Language English
    Publishing date 2023-07-14
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1076875-0
    ISSN 1865-3774 ; 0917-1258 ; 0925-5710
    ISSN (online) 1865-3774
    ISSN 0917-1258 ; 0925-5710
    DOI 10.1007/s12185-023-03641-8
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 269: Show issues Location:
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  2. Article: Insight into the Desolvation of Quaternary Ammonium Cation with Acetonitrile as a Solvent in Hydroxyl-Flat Pores: A First-Principles Calculation.

    Liu, Fudong / Yang, Shaobin / Zhang, Xu / Tang, Shuwei / Xia, Yingkai

    Materials (Basel, Switzerland)

    2023  Volume 16, Issue 10

    Abstract: Supercapacitors have a wide range of applications in high-technology fields. The desolvation of organic electrolyte cations affects the capacity size and conductivity of supercapacitors. However, few relevant studies have been published in this field. In ...

    Abstract Supercapacitors have a wide range of applications in high-technology fields. The desolvation of organic electrolyte cations affects the capacity size and conductivity of supercapacitors. However, few relevant studies have been published in this field. In this experiment, the adsorption behavior of porous carbon was simulated with first-principles calculations using a graphene bilayer with a layer spacing of 4-10 Å as a hydroxyl-flat pore model. The reaction energies of quaternary ammonium cations, acetonitrile, and quaternary ammonium cationic complexes were calculated in a graphene bilayer with different interlayer spacings, and the desolvation behavior of TEA
    Language English
    Publishing date 2023-05-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma16103858
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  3. Article: Low Temperature Aluminothermic Reduction of Natural Sepiolite to High-Performance Si Nanofibers for Li-Ion Batteries.

    Zhao, Mingyuan / Yang, Shaobin / Dong, Wei

    Frontiers in chemistry

    2022  Volume 10, Page(s) 932650

    Abstract: Nanostructure silicon is one of the most promising anode materials for the next-generation lithium-ion battery, but the complicated synthesis process and high cost limit its large-scale commercial application. Herein, a simple and low-cost method was ... ...

    Abstract Nanostructure silicon is one of the most promising anode materials for the next-generation lithium-ion battery, but the complicated synthesis process and high cost limit its large-scale commercial application. Herein, a simple and low-cost method was proposed to prepare silicon nanofibers (SNF) using natural sepiolite as a template
    Language English
    Publishing date 2022-06-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2022.932650
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  4. Article ; Online: Emerging functions of neuronostatin in physiology, pathology, and potential therapeutics.

    Yang, Shaobin / Zhao, Xiaoqian / Du, Yaqin / Yu, Peng

    Neuropeptides

    2022  Volume 94, Page(s) 102257

    Abstract: Neuronostatin, a bioactive peptide hormone, was encoded by pro-somatostatin and discovered using a bioinformatic method in 2008. Neuronostatin is widely expressed in the central nervous system (CNS) and peripheral tissues, it is also highly conserved ... ...

    Abstract Neuronostatin, a bioactive peptide hormone, was encoded by pro-somatostatin and discovered using a bioinformatic method in 2008. Neuronostatin is widely expressed in the central nervous system (CNS) and peripheral tissues, it is also highly conserved among humans, rodents, and even goldfish. The 13 and 19 amino acids and the C-terminal amidation type play important roles in physiological and pathological functions. The present study reviews the roles of neuronostatin in food intake and drinking of water, as well as in the neuroendocrine processes, pain regulation, cardiovascular and circulation function, memory and studies, depression-like effect, and energy metabolism in animals. However, the information on the physiology and pathology of neuronostatin, especially the molecular mechanism, remains scarce. Considering the broad functions of neuronostatin, this endogenous neuropeptide could be a promising therapeutic target for future research and drug design if the exact receptor could be found in humans.
    MeSH term(s) Animals ; Heart ; Peptide Hormones
    Chemical Substances Peptide Hormones
    Language English
    Publishing date 2022-05-20
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 9048-7
    ISSN 1532-2785 ; 0143-4179
    ISSN (online) 1532-2785
    ISSN 0143-4179
    DOI 10.1016/j.npep.2022.102257
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1592: Show issues Location:
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  5. Article: Extended Line Defect Graphene Modified by the Adsorption of Mn Atoms and Its Properties of Adsorbing CH

    Zhang, Chenxiaoyu / Yang, Shaobin / Zhang, Xu / Xia, Yingkai / Li, Jiarui

    Nanomaterials (Basel, Switzerland)

    2022  Volume 12, Issue 4

    Abstract: Extended line defect (ELD) graphene is a two-dimensional (2D) topologically defective graphene with alternate octagonal and quadrilateral carbon rings as basic defective units. This paper reports on the ... ...

    Abstract Extended line defect (ELD) graphene is a two-dimensional (2D) topologically defective graphene with alternate octagonal and quadrilateral carbon rings as basic defective units. This paper reports on the CH
    Language English
    Publishing date 2022-02-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano12040697
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  6. Article ; Online: Reducing PDK1/Akt Activity: An Effective Therapeutic Target in the Treatment of Alzheimer's Disease.

    Yang, Shaobin / Du, Yaqin / Zhao, Xiaoqian / Wu, Chendong / Yu, Peng

    Cells

    2022  Volume 11, Issue 11

    Abstract: Alzheimer's disease (AD) is a common age-related neurodegenerative disease that leads to memory loss and cognitive function damage due to intracerebral neurofibrillary tangles (NFTs) and amyloid-β (Aβ) protein deposition. The phosphoinositide-dependent ... ...

    Abstract Alzheimer's disease (AD) is a common age-related neurodegenerative disease that leads to memory loss and cognitive function damage due to intracerebral neurofibrillary tangles (NFTs) and amyloid-β (Aβ) protein deposition. The phosphoinositide-dependent protein kinase (PDK1)/protein kinase B (Akt) signaling pathway plays a significant role in neuronal differentiation, synaptic plasticity, neuronal survival, and neurotransmission via the axon-dendrite axis. The phosphorylation of PDK1 and Akt rises in the brain, resulting in phosphorylation of the TNF-α-converting enzyme (TACE) at its cytoplasmic tail (the C-terminal end), changing its internalization as well as its trafficking. The current review aimed to explain the mechanisms of the PDK1/Akt/TACE signaling axis that exerts its modulatory effect on AD physiopathology. We provide an overview of the neuropathological features, genetics, Aβ aggregation, Tau protein hyperphosphorylation, neuroinflammation, and aging in the AD brain. Additionally, we summarized the phosphoinositide 3-kinase (PI3K)/PDK1/Akt pathway-related features and its molecular mechanism that is dependent on TACE in the pathogenesis of AD. This study reviewed the relationship between the PDK1/Akt signaling pathway and AD, and discussed the role of PDK1/Akt in resisting neuronal toxicity by suppressing TACE expression in the cell membrane. This work also provides a perspective for developing new therapeutics targeting PDK1/Akt and TACE for the treatment of AD.
    MeSH term(s) Alzheimer Disease/metabolism ; Amyloid beta-Peptides/metabolism ; Humans ; Neurodegenerative Diseases ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism
    Chemical Substances Amyloid beta-Peptides ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2022-05-24
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11111735
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  7. Article ; Online: Solubility of graphene-like two-dimensional layered C

    Wang, Wenbo / Dong, Wei / Ji, Lingxiao / Xia, Yingkai / Yang, Shaobin

    Chemical communications (Cambridge, England)

    2022  

    Abstract: As a new type of carbon nitride material with high nitrogen content, g- ... ...

    Abstract As a new type of carbon nitride material with high nitrogen content, g-C
    Language English
    Publishing date 2022-12-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d2cc05003j
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  8. Article ; Online: Insights into the effect of hydroxyl-, epoxy-, and carboxyl-pores on the desolvation of K

    Yang, Shaobin / Liu, Xueli / Zhang, Xu / Tang, Shuwei

    Journal of physics. Condensed matter : an Institute of Physics journal

    2021  Volume 33, Issue 44

    Abstract: The oxygen-containing functional group is particularly effective at the capacity and cycle performance of porous carbon, but there are few reports on the influence of ionic desolvation. The desolvated behavior in porous carbon could be availably ... ...

    Abstract The oxygen-containing functional group is particularly effective at the capacity and cycle performance of porous carbon, but there are few reports on the influence of ionic desolvation. The desolvated behavior in porous carbon could be availably simulated through the bilayer graphene with the interlayer spacings of 4-10 Å as the flat pore model by a first-principles calculation. The desolvated behavior of hydrated potassium ion ([K(H
    Language English
    Publishing date 2021-08-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472968-4
    ISSN 1361-648X ; 0953-8984
    ISSN (online) 1361-648X
    ISSN 0953-8984
    DOI 10.1088/1361-648X/ac1af1
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  9. Article ; Online: The first case of six-way complex translocation of t(4;7;9;22;8;14) in a patient with chronic myeloid leukemia.

    Bi, Xiaoyu / Li, Chao / Shang, Miao / Han, Bingbing / Li, Hongyu / Sun, Lidan / Lin, Yani / Yang, Shaobin

    Journal of hematopathology

    2024  

    Abstract: In chronic myeloid leukemia (CML), patients exhibit the t(9;22)(q34.1;q11.2) translocation, resulting in the formation of a Philadelphia chromosome (Ph). However, a subset of CML patients display variant complex translocations, characterized by three-way, ...

    Abstract In chronic myeloid leukemia (CML), patients exhibit the t(9;22)(q34.1;q11.2) translocation, resulting in the formation of a Philadelphia chromosome (Ph). However, a subset of CML patients display variant complex translocations, characterized by three-way, four-way, and five-way translocations, which have been occasionally associated with a poor prognosis. This case report presents the first case of a t(9;22) variant six-way complex translocation in CML. The R banding chromosome karyotyping technique was used to obtain preliminary karyotyping results, and the multi-probe FISH technique was used to assist in the verification of chromosome results. Both FISH and PCR proved the existence of fusion genes. A 45-year-old male patient admitted to our hospital due to elevated WBC and anemia. Bone marrow smears revealed a significant proliferation of mature granulocytes, accompanied by an increase in eosinophils and basophils. Karyotype analysis indicated abnormalities in six chromosomes, including 4, 7, 8, 9, 14, and 22. Further analysis using FISH technology demonstrated the presence of the BCR::ABL1 fusion gene, as well as the mapping of the BCR (22q11), MYC (8q24), IGH (14q32), D4S163 (4q35.1), and D7S486 (7q31) genes to new chromosomes. Ultimately, the karyotype findings were described as t(4;7;9;22;8;14)(q27;q22;q34;q11;q22;q12). PCR showed that BCR::ABL1 was p210. After treatment with imatinib for 4 months, the patient achieved complete cytogenetic response (CCyR) and early molecular response (EMR). This is the first report of complex chromosomal karyotype involving six-way translocation in CML; the combination of chromosome analysis and FISH techniques is an effective strategy in determining the karyotype result.
    Language English
    Publishing date 2024-03-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2438687-X
    ISSN 1865-5785 ; 1868-9256
    ISSN (online) 1865-5785
    ISSN 1868-9256
    DOI 10.1007/s12308-024-00577-8
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  10. Article ; Online: FOXP4-AS1 promotes CD8

    Shen, Guo-Yi / Zhang, Yi / Huang, Rong-Zhi / Huang, Zhi-Yong / Yang, Le-Yi / Chen, Ding-Zhu / Yang, Shao-Bin

    Immunologic research

    2024  

    Abstract: Esophageal cancer (EC) is the 9th most frequently diagnosed malignancy globally with unfavorable prognosis. Immune escape is one of the principal factors leading to poor survival, however, the mechanism underlying immune escape remains largely ... ...

    Abstract Esophageal cancer (EC) is the 9th most frequently diagnosed malignancy globally with unfavorable prognosis. Immune escape is one of the principal factors leading to poor survival, however, the mechanism underlying immune escape remains largely uninvestigated. The xenograft mouse model and EC cell-CD8
    Language English
    Publishing date 2024-04-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632857-x
    ISSN 1559-0755 ; 0257-277X
    ISSN (online) 1559-0755
    ISSN 0257-277X
    DOI 10.1007/s12026-024-09482-9
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