LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Zurück zur letzten Suche Suchhistorie
Erweiterte Suche

Ihre letzten Suchen

  1. AU="Yang, Shaofan"
  2. AU="Cucui, Andrea"
  3. AU="Sarma, Birinchi Kumar"
  4. AU="Schrader, Thomas"
  5. AU="Macleod, Kay F"
  6. AU="Vishnuprabha, R. Sangeetha"
  7. AU=Singh B N
  8. AU="Shahir Asfahan"
  9. AU="A.E.Pace, "
  10. AU="Scharbert, J"
  11. AU=Alganabi Mashriq
  12. AU=Balthazar Emil J
  13. AU="Pallos, Debora"
  14. AU="Tatsuya Igarashi"
  15. AU="Martinez, Randy"
  16. AU="Fu, Yayan"
  17. AU=Hertel Laura
  18. AU="Sasivimolrattana, Thanayod"
  19. AU="McAuley, Arnold" AU="McAuley, Arnold"
  20. AU="Reithmeier, Reinhart A F"
  21. AU="Ma, Dongmei"
  22. AU="Suh, M. H"
  23. AU="Xiao-Cheng Sun"
  24. AU="Belizario Quispe, Germán"

Suchergebnis

Treffer 1 - 3 von insgesamt 3

Suchoptionen

  1. Artikel ; Online: Growth hormone promotes myelin repair after chronic hypoxia via triggering pericyte-dependent angiogenesis.

    Ren, Shu-Yu / Xia, Yu / Yu, Bin / Lei, Qi-Jing / Hou, Peng-Fei / Guo, Sheng / Wu, Shuang-Ling / Liu, Wei / Yang, Shao-Fan / Jiang, Yi-Bin / Chen, Jing-Fei / Shen, Kai-Feng / Zhang, Chun-Qing / Wang, Fei / Yan, Mi / Ren, Hong / Yang, Nian / Zhang, Jun / Zhang, Kuan /
    Lin, Sen / Li, Tao / Yang, Qing-Wu / Xiao, Lan / Hu, Zhang-Xue / Mei, Feng

    Neuron

    2024  

    Abstract: White matter injury (WMI) causes oligodendrocyte precursor cell (OPC) differentiation arrest and functional deficits, with no effective therapies to date. Here, we report increased expression of growth hormone (GH) in the hypoxic neonatal mouse brain, a ... ...

    Abstract White matter injury (WMI) causes oligodendrocyte precursor cell (OPC) differentiation arrest and functional deficits, with no effective therapies to date. Here, we report increased expression of growth hormone (GH) in the hypoxic neonatal mouse brain, a model of WMI. GH treatment during or post hypoxic exposure rescues hypoxia-induced hypomyelination and promotes functional recovery in adolescent mice. Single-cell sequencing reveals that Ghr mRNA expression is highly enriched in vascular cells. Cell-lineage labeling and tracing identify the GHR-expressing vascular cells as a subpopulation of pericytes. These cells display tip-cell-like morphology with kinetic polarized filopodia revealed by two-photon live imaging and seemingly direct blood vessel branching and bridging. Gain-of-function and loss-of-function experiments indicate that GHR signaling in pericytes is sufficient to modulate angiogenesis in neonatal brains, which enhances OPC differentiation and myelination indirectly. These findings demonstrate that targeting GHR and/or downstream effectors may represent a promising therapeutic strategy for WMI.
    Sprache Englisch
    Erscheinungsdatum 2024-04-16
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2024.03.026
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 2496: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 92: Hefte anzeigen

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  2. Artikel ; Online: Engrafted glial progenitor cells yield long-term integration and sensory improvement in aged mice.

    Yang, Zhiqi / Gong, Mingyue / Jian, Tingliang / Li, Jin / Yang, Chuanyan / Ma, Qinlong / Deng, Ping / Wang, Yuxia / Huang, Mingzhu / Wang, Haoyu / Yang, Shaofan / Chen, Xiaowei / Yu, Zhengping / Wang, Manxia / Chen, Chunhai / Zhang, Kuan

    Stem cell research & therapy

    2022  Band 13, Heft 1, Seite(n) 285

    Abstract: Aging causes astrocyte morphological degeneration and functional deficiency, which impairs neuronal functions. Until now, whether age-induced neuronal deficiency could be alleviated by engraftment of glial progenitor cell (GPC) derived astrocytes ... ...

    Abstract Aging causes astrocyte morphological degeneration and functional deficiency, which impairs neuronal functions. Until now, whether age-induced neuronal deficiency could be alleviated by engraftment of glial progenitor cell (GPC) derived astrocytes remained unknown. In the current study, GPCs were generated from embryonic cortical neural stem cells in vitro and transplanted into the brains of aged mice. Their integration and intervention effects in the aged brain were examined 12 months after transplantation. Results indicated that these in-vitro-generated GPC-derived astrocytes possessed normal functional properties. After transplantation they could migrate, differentiate, achieve long-term integration, and maintain much younger morphology in the aged brain. Additionally, these GPC-derived astrocytes established endfeet expressing aquaporin-4 (AQP4) and ameliorate AQP4 polarization in the aged neocortex. More importantly, age-dependent sensory response degeneration was reversed by GPC transplantation. This work demonstrates that rejuvenation of the astrocyte niche is a promising treatment to prevent age-induced degradation of neuronal and behavioral functions.
    Mesh-Begriff(e) Animals ; Astrocytes/metabolism ; Mice ; Neural Stem Cells ; Neuroglia ; Neurons ; Stem Cell Transplantation
    Sprache Englisch
    Erscheinungsdatum 2022-06-28
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2548671-8
    ISSN 1757-6512 ; 1757-6512
    ISSN (online) 1757-6512
    ISSN 1757-6512
    DOI 10.1186/s13287-022-02959-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  3. Artikel: Astrocytes exhibit diverse Ca

    Ding, Fusheng / Liang, Shanshan / Li, Ruijie / Yang, Zhiqi / He, Yong / Yang, Shaofan / Duan, Qingtian / Zhang, Jianxiong / Lyu, Jing / Zhou, Zhenqiao / Huang, Mingzhu / Wang, Haoyu / Li, Jin / Yang, Chuanyan / Wang, Yuxia / Gong, Mingyue / Chen, Shangbin / Jia, Hongbo / Chen, Xiaowei /
    Liao, Xiang / Fu, Ling / Zhang, Kuan

    Frontiers in aging neuroscience

    2022  Band 14, Seite(n) 1029533

    Abstract: Astrocytic ... ...

    Abstract Astrocytic Ca
    Sprache Englisch
    Erscheinungsdatum 2022-10-28
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2022.1029533
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

Zum Seitenanfang