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Article ; Online: Rate of adverse cardiovascular events in breast cancer patients receiving chemotherapy and targeted therapy: Impact of frailty.

Yang, Shuang / Guo, Yi

American heart journal plus : cardiology research and practice

2023 Volume 38, Page(s) 100353

Language	English
Publishing date	2023-12-07
Publishing country	United States
Document type	Journal Article
ISSN	2666-6022
ISSN (online)	2666-6022
DOI	10.1016/j.ahjo.2023.100353
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Trends in prevalence of esophageal adenocarcinoma: Findings from a statewide database of over 6 million patients.

Qumseya, Bashar / Yang, Shuang / Guo, Yi

Endoscopy international open

2024 Volume 12, Issue 2, Page(s) E218–E226

Abstract: Esophageal cancer (EC) is a leading cause of cancer-related death in the west 1 . Esophageal squamous cell carcinoma (SCC) is the most common type of EC worldwide. However, in Western countries, including the United States, esophageal adenocarcinoma (EAC) ...

Abstract	Esophageal cancer (EC) is a leading cause of cancer-related death in the west 1 . Esophageal squamous cell carcinoma (SCC) is the most common type of EC worldwide. However, in Western countries, including the United States, esophageal adenocarcinoma (EAC) is the most common 2 . EAC is most common in the lower esophagus whereas SCC is most common in the middle and upper esophagus 3 . The incidence of EAC has increased dramatically in western countries over the past few decades. 2 3 The exact reason for this rise in EAC has not been clearly understood. However, an increase in the prevalence of EAC risk factors is postulated as a potential explanation 4 . Although there are many identifiable EAC risk factors, including gastroesophageal reflux disease (GERD), obesity, male sex, White race, and smoking 5 6 7 , Barrett's esophagus (BE) remains the major precursor lesion of esophageal adenocarcinoma. BE develops when there is a change in the normal squamous lining of the esophageal mucosa into intestinal metaplasia 8 9 . The incidence has also increased in the population over the past few decades 10 11 . There is a well-described progression within BE from non-dysplastic BE (NDBE), low-grade dysplasia (LGD), high-grade dysplasia (HGD), intramucosal carcinoma (IMC), to invasive EAC 12 13 . Recent data suggest that the increased incidence of EAC may have plateaued 1 . However, we questioned whether the prevalence of EAC is still increasing, especially at younger ages in lieu of recent trends showing an increase in the prevalence of colorectal cancer in younger patients. These findings resulted in a lowering of the colorectal cancer screening age cutoff to 45 years from 50 years 14 15 16 . Therefore, we aimed to assess the time trends in the prevalence and incidence of EAC and some of its risk factors in a large population of patients in Florida and to assess these trends based on age categories. We hypothesized that the prevalence of EAC and BE has increased over time at younger age groups.
Language	English
Publishing date	2024-02-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2761052-4
ISSN	2196-9736 ; 2364-3722
ISSN (online)	2196-9736
ISSN	2364-3722
DOI	10.1055/a-2221-7974
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Association between serum anion gap and risk of in-hospital mortality in patients with acute heart failure.

Huang, Zilun / Wang, Shanjie / Yang, Shuang

Scientific reports

2024 Volume 14, Issue 1, Page(s) 4858

Abstract: A high serum anion gap (AG) at the time of patient admission can lead to the deterioration or even death; data are lacking for patients who suffer acute heart failure (AHF). The present study aimed at exploring the impact of serum AG (SAG) levels on the ... ...

Abstract	A high serum anion gap (AG) at the time of patient admission can lead to the deterioration or even death; data are lacking for patients who suffer acute heart failure (AHF). The present study aimed at exploring the impact of serum AG (SAG) levels on the in-hospital mortality in AHF patients. The study conducted retrospective analysis on the data from the medical information mart for intensive care (MIMIC-IV) database in severe AHF cases. Serum AG, age, sex, concomitant diseases and laboratory tests were collected from patients at admission. Multivariate Cox proportional hazard regression model together with Kaplan Meier (K-M) survival curve served for analyzing the relationship of serum AG with the hospital all-cause mortality (ACM). In addition, subgroup analysis assisted in assessing the concordance. Data from 2774 AHF patients were collected in the study. The hospital ACM rate was 9.2% (254/2774). After correcting potential confounders, multivariate analysis compared the high serum AG level (≥ 16 mmol/L) and the low serum AG level (< 16 mmol/L) (hazard ratio (HR): 1.89 [95% CI 1.42-2.51]). In a similar way, K-M survival curve indicated that hospital survival was lower in patients with high serum, suggesting that high serum AG level could lead to poor AHF prognosis. In patients with AHF, high serum AG level could increase the hospital ACM.
MeSH term(s)	Humans ; Retrospective Studies ; Acid-Base Equilibrium ; Hospital Mortality ; Prognosis ; Heart Failure
Language	English
Publishing date	2024-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-55658-6
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Article: Opinion leaders and crisis communication during the COVID-19 pandemic: A study of theme evolution and emotional impact on Twitter.

Wang, Yan / Yang, Shuang / An, Xinying

Digital health

2024 Volume 10, Page(s) 20552076241234619

Abstract: This study uses Twitter data from the early stages of the pandemic to analyze the evolution of topics during different time periods and attempts to investigate the content and emotional impact of opinion leaders on public opinion evolution under ... ...

Abstract	This study uses Twitter data from the early stages of the pandemic to analyze the evolution of topics during different time periods and attempts to investigate the content and emotional impact of opinion leaders on public opinion evolution under different themes, in order to understand their role in shaping public discourse and emotions. Divide the life cycle into three stages; NLTK emotional analysis and dynamic topic models (DTMs) are employed to extract and analyze topic words. The results showed that there were significant differences between opinion leaders and followers in terms of hot topics and their evolution trends: (1) In terms of hot topics, opinion leaders have always been paying attention to measures and methods aimed at the public, while followers usually have persist in seeking information and dissatisfaction. (2) In terms of identifying and evolving hot topics, opinion leaders have shifted from the impact of the epidemic on individuals and resources to government responses and policies, while followers are more inclined to express people's growing concerns and dissatisfaction with crisis management. The content of opinion leaders has a significant relationship with evolving public opinion, highlighting the importance of understanding their role in crisis communication. Opinion leaders are also categorized into five types, each with different audience sizes, contents, emotions, and network structures, and they impact public opinion differently. This study identifies and analyzes the characteristics and impact mechanisms of opinion leaders in crisis communication. It hopes to contribute to understanding crisis communication dynamics in the digital era and provide insights into effective communication strategies during crises.
Language	English
Publishing date	2024-03-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2819396-9
ISSN	2055-2076
ISSN	2055-2076
DOI	10.1177/20552076241234619
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Article ; Online: Congenital hepatic fibrosis complicated with Caroli’s disease

Yang Shuang / Liu Yaping / Gao Lili / Duan Xuefei

Xin yixue, Vol 54, Iss 9, Pp 687-

a case report

2023 Volume 690

Abstract: Congenital hepatic fibrosis （CHF） complicated with Caroli’s disease is a rare autosomal recessive genetic disease with non-specific clinical and imaging manifestations， mainly including portal hypertension and complications， which is likely to be missed ... ...

Abstract	Congenital hepatic fibrosis （CHF） complicated with Caroli’s disease is a rare autosomal recessive genetic disease with non-specific clinical and imaging manifestations， mainly including portal hypertension and complications， which is likely to be missed and misdiagnosed. In this article， a 32-year-old male patient developed unexplained cirrhosis on physical examination， and he was diagnosed with Caroli’s disease confirmed by histopathological examination of liver puncture and genetic testing. This case suggests the importance of liver puncture for the diagnosis of CHF.
Keywords	congenital hepatic fibrosis\|caroli’s disease\|diagnosis ; Medicine ; R
Language	Chinese
Publishing date	2023-09-01T00:00:00Z
Publisher	Editorial Office of Journal of New Medicine
Document type	Article ; Online
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Article ; Online: Systematic analysis of olfactory protein-protein interactions network of fruitfly, Drosophila melanogaster.

Yang, Shuang / Zhang, WenJun

Archives of insect biochemistry and physiology

2022 Volume 110, Issue 2, Page(s) e21882

Abstract: Olfaction is one of the physiological traits of insect behavior. Insects have evolved a sophisticated olfactory system and use a combined coding strategy to process general odor. Drosophila melanogaster is a powerful model to reveal the molecular and ... ...

Abstract	Olfaction is one of the physiological traits of insect behavior. Insects have evolved a sophisticated olfactory system and use a combined coding strategy to process general odor. Drosophila melanogaster is a powerful model to reveal the molecular and cellular mechanisms of odor detection. Identifying new olfactory targets through complex interactions will contribute to a better understanding of the functions, interactions, and signaling pathways of olfactory proteins. However, the mechanism of D. melanogaster olfaction is still unclear, and more olfactory proteins are required to be discovered. In this study, we tried to explore essential proteins in the olfactory system of D. melanogaster and conduct protein-protein interactions (PPIs) analysis. We constructed the PPIs network of the olfactory system of D. melanogaster, consisting of 863 proteins and 18,959 interactions. Various methods were used to perform functional enrichment analysis, topological analysis and cluster analysis. Our results confirmed that Class B scavenger receptors (SR-Bs), glutathione S-transferases (GSTs), and UDP-glycosyltransferases (UGTs) play an essential role in olfaction of D. melanogaster. The proteins obtained in this study can be used for subsequent functional identification in D. melanogaster olfactory.
MeSH term(s)	Animals ; Drosophila ; Drosophila Proteins/genetics ; Drosophila melanogaster ; Insecta ; Odorants ; Protein Interaction Maps ; Smell/physiology
Chemical Substances	Drosophila Proteins
Language	English
Publishing date	2022-03-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	11323-2
ISSN	1520-6327 ; 0739-4462
ISSN (online)	1520-6327
ISSN	0739-4462
DOI	10.1002/arch.21882
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Article ; Online: Adsorption of triblock copolymers confined between two plates: An analytical approach.

Chen, Ji-Yu / Zhong, Lu-Wei / Chen, Er-Qiang / Yang, Shuang

The Journal of chemical physics

2024 Volume 160, Issue 6

Abstract: We present an approximate analytical approach to the adsorption problem of ABA triblock copolymers confined between two parallel plates in a θ solvent and give the expression of the propagator q(x, t) as a piece-wise function by solving the modified ... ...

Abstract	We present an approximate analytical approach to the adsorption problem of ABA triblock copolymers confined between two parallel plates in a θ solvent and give the expression of the propagator q(x, t) as a piece-wise function by solving the modified diffusion equation. In this way, the role of separation between the two plates, adsorption energy and block lengths on segment concentration profile, chain conformations, and interaction potential is then investigated, which agrees well with the numerical results. It is demonstrated that there are parallels between lengthening adsorbing A blocks and increasing surface affinity: strong adsorption and long adsorbing blocks favor the formation of loops and bridges, whereas more tails and free chains exist in the case of weak adsorption and short A blocks at large separations. For moderate and strong adsorptions, the bridging fraction begins to plummet at a separation larger than the end-to-end distance of non-adsorbing B block RB and becomes negligible at above 2RB owing to the entropy effect. The depth of the potential well in the interaction potential profile depends on the adsorption energy and A block length, while the location of the potential minimum corresponds to the onset of the sharp decrease in bridges.
Language	English
Publishing date	2024-02-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/5.0190074
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Article ; Online: Crown-Assisted CsCu

Yang, Shuang / Tang, Zhenyu / Qu, Bo / Xiao, Lixin / Chen, Zhijian

ACS applied materials & interfaces

2024

Abstract: Copper (Cu)-based perovskites are promising for lead-free perovskite light-emitting diodes (PeLEDs). However, it remains a significant challenge to achieve high performance devices due to the nonradiative loss caused by the disordered crystallization and ...

Abstract	Copper (Cu)-based perovskites are promising for lead-free perovskite light-emitting diodes (PeLEDs). However, it remains a significant challenge to achieve high performance devices due to the nonradiative loss caused by the disordered crystallization and lack of passivation. Crown ethers are known to form host-guest complexes by the interaction between C-O-C groups and certain cations, and 18-crown-6 (18C6) with an appropriate complementary size can interact with Cs
Language	English
Publishing date	2024-04-12
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.4c01048
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Article: Systematic analysis of olfactory protein–protein interactions network of fruitfly, Drosophila melanogaster

Yang, Shuang / Zhang, WenJun

Archives of insect biochemistry and physiology. 2022 June, v. 110, no. 2

2022

Abstract	Olfaction is one of the physiological traits of insect behavior. Insects have evolved a sophisticated olfactory system and use a combined coding strategy to process general odor. Drosophila melanogaster is a powerful model to reveal the molecular and cellular mechanisms of odor detection. Identifying new olfactory targets through complex interactions will contribute to a better understanding of the functions, interactions, and signaling pathways of olfactory proteins. However, the mechanism of D. melanogaster olfaction is still unclear, and more olfactory proteins are required to be discovered. In this study, we tried to explore essential proteins in the olfactory system of D. melanogaster and conduct protein–protein interactions (PPIs) analysis. We constructed the PPIs network of the olfactory system of D. melanogaster, consisting of 863 proteins and 18,959 interactions. Various methods were used to perform functional enrichment analysis, topological analysis and cluster analysis. Our results confirmed that Class B scavenger receptors (SR‐Bs), glutathione S‐transferases (GSTs), and UDP‐glycosyltransferases (UGTs) play an essential role in olfaction of D. melanogaster. The proteins obtained in this study can be used for subsequent functional identification in D. melanogaster olfactory.
Keywords	Drosophila melanogaster ; cluster analysis ; fruit flies ; glutathione transferase ; insect behavior ; insect biochemistry ; models ; odors ; smell ; topology
Language	English
Dates of publication	2022-06
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	11323-2
ISSN	1520-6327 ; 0739-4462
ISSN (online)	1520-6327
ISSN	0739-4462
DOI	10.1002/arch.21882
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Article ; Online: Bimetallic CoCu nanoparticles anchored on COF/SWCNT for electrochemical detection of carbendazim.

Wang, Xue / Yang, Shuang / Bai, Xuting / Shan, Jiajia

The Science of the total environment

2023 Volume 902, Page(s) 166530

Abstract: Carbendazim (CBZ) is a widespread fungicide used in crop protection, but the CBZ residues in drinking water, fruits, and vegetables can also cause adverse impacts on public health due to direct exposure. In this paper, a ternary synergistic composite of ... ...

Abstract	Carbendazim (CBZ) is a widespread fungicide used in crop protection, but the CBZ residues in drinking water, fruits, and vegetables can also cause adverse impacts on public health due to direct exposure. In this paper, a ternary synergistic composite of bimetallic CoCu nanoparticles anchored on covalent organic framework/single-walled carbon nanotube (CoCu/COF/SWCNT) was prepared and further applied as an electrochemical sensing platform for detecting CBZ. The sensor showed a sensitive response performance toward CBZ oxidation, as a result of the enhanced charge transfer ability, large electrochemically active surface area, and high electro-catalytic activity from the rational integration of the ternary components in CoCu/COF/SWCNT. Under the optimal conditions, the proposed sensor exhibited a detection range of 0.001 to 10 μM and a limit detection of 0.65 nM for CBZ detection. In addition, the sensor displayed practical feasibility for the determination of CBZ in water and pear samples with a recovery of 96.1 % to 102.1 %.
Language	English
Publishing date	2023-08-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.166530
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