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  1. AU="Yang, Ting-Ting"
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  1. Article: The Latest Research Progress on Cell-Free DNA and Prospects of Its Forensic Application.

    Hu, Wen-Jing / Yang, Ting-Ting / Wang, Ya-Ya / Yan, Jiang-Wei

    Fa yi xue za zhi

    2024  Volume 40, Issue 1, Page(s) 70–76

    Abstract: In recent years, with the continuous progress of DNA extraction and detection technology, cell-free DNA(cfDNA)has been widely used in the life science field, and its potential application value in forensic identification is becoming more and more obvious. ...

    Abstract In recent years, with the continuous progress of DNA extraction and detection technology, cell-free DNA(cfDNA)has been widely used in the life science field, and its potential application value in forensic identification is becoming more and more obvious. This paper reviews the concept, formation mechanism, and classification of cfDNA, etc., and describes the latest research progress of cfDNA in personal identification of crime scene touch DNA samples and non-invasive prenatal paternity testing (NIPPT). Meanwhile, this paper summarizes the potential application of cfDNA in injury inference, and discusses the advantages and disadvantages of common cfDNA analysis methods and techniques, and its application prospects, to provide a new idea for the wide application of cfDNA in the field of forensic science.
    MeSH term(s) Pregnancy ; Female ; Humans ; Cell-Free Nucleic Acids/genetics ; Paternity ; Forensic Sciences ; Touch ; DNA/genetics
    Chemical Substances Cell-Free Nucleic Acids ; DNA (9007-49-2)
    Language Chinese
    Publishing date 2024-03-08
    Publishing country China
    Document type Review ; Journal Article
    ISSN 1004-5619
    ISSN 1004-5619
    DOI 10.12116/j.issn.1004-5619.2022.521001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Genomic Landscape of Melanoma and Its Therapeutic Implications.

    Yang, Ting-Ting / Yu, Sebastian / Ke, Chiao-Li Khale / Cheng, Shih-Tsung

    Genes

    2023  Volume 14, Issue 5

    Abstract: Melanoma is one of the most aggressive malignancies of the skin. The genetic composition of melanoma is complex and varies among different subtypes. With the aid of recent technologies such as next generation sequencing and single-cell sequencing, our ... ...

    Abstract Melanoma is one of the most aggressive malignancies of the skin. The genetic composition of melanoma is complex and varies among different subtypes. With the aid of recent technologies such as next generation sequencing and single-cell sequencing, our understanding of the genomic landscape of melanoma and its tumor microenvironment has become increasingly clear. These advances may provide explanation to the heterogenic treatment outcomes of melanoma patients under current therapeutic guidelines and provide further insights to the development of potential new therapeutic targets. Here, we provide a comprehensive review on the genetics related to melanoma tumorigenesis, metastasis, and prognosis. We also review the genetics affecting the melanoma tumor microenvironment and its relation to tumor progression and treatment.
    MeSH term(s) Humans ; Melanoma/genetics ; Melanoma/therapy ; Melanoma/pathology ; Genomics ; Prognosis ; Treatment Outcome ; Immunotherapy ; Tumor Microenvironment/genetics
    Language English
    Publishing date 2023-04-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14051021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Impact of Vitiligo on Life Quality of Patients: Assessment of Currently Available Tools.

    Yang, Ting-Ting / Lee, Chien-Hung / Lan, Cheng-Che E

    International journal of environmental research and public health

    2022  Volume 19, Issue 22

    Abstract: Background: How different tools for evaluating health-related quality of life (QoL) reflect the burden of vitiligo has rarely been compared. In this study, we aim to evaluate the impact of vitiligo on QoL using currently available tools.: Methods: A ... ...

    Abstract Background: How different tools for evaluating health-related quality of life (QoL) reflect the burden of vitiligo has rarely been compared. In this study, we aim to evaluate the impact of vitiligo on QoL using currently available tools.
    Methods: A single-center, cross-sectional study of vitiligo patients was performed. QoL was evaluated using the dermatology life quality index (DLQI), short form-36 (SF-36), and willingness to pay (WTP). As the original DLQI cutoff score (>10) indicating aginificantly impated QoL was found to underestimate QoL, receiver operating characteristic (ROC) curve was use to determine a new cutoff point discriminating vitiligo patients with positive mental stress (SF-36 mental health ≤ 52).
    Results: Of the 143 patients enrolled, 24.5% were identified having significant mental stress by SF-36 mental health domain score ≤ 52 while there were only 13.3% patients with significantly hampered QoL indicated by DLQI >10. Using ROC analysis, DLQI ≥ 7 was found to be a more appropriate DLQI cutoff value for identifying mental stress in vitiligo patients. Additionally, the median WTP for treating vitiligo was comparable to other inflammatory skin diseases.
    Conclusions: There exist discrepancies in the outcomes identifying significant disease burden of vitiligo using DLQI and SF-36, making the current DLQI cutoff score (>10) for identifying significantly affected QoL inappropriate for these patients.
    MeSH term(s) Humans ; Quality of Life/psychology ; Vitiligo ; Surveys and Questionnaires ; Cross-Sectional Studies ; Cost of Illness
    Language English
    Publishing date 2022-11-13
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph192214943
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  4. Article ; Online: Effect of cryotherapy on paclitaxel-induced peripheral neuropathy of the hand in female breast cancer patients: A prospective self-controlled study.

    Yang, Ting-Ting / Pai, Hsiang-Chu / Chen, Chiung-Yao

    International journal of nursing practice

    2022  Volume 29, Issue 4, Page(s) e13094

    Abstract: Aims: The purpose of this study was to examine the efficacy of cryotherapy with frozen gloves for the prevention of the chemotherapy-induced peripheral neuropathy of the hand.: Background: Most breast cancer patients receive chemotherapy; ... ...

    Abstract Aims: The purpose of this study was to examine the efficacy of cryotherapy with frozen gloves for the prevention of the chemotherapy-induced peripheral neuropathy of the hand.
    Background: Most breast cancer patients receive chemotherapy; consequently, patients frequently experience adverse effects of chemotherapy-induced peripheral neuropathy.
    Methods: A quasi-experimental and prospective self-controlled study was conducted. Breast cancer patients wore frozen glove on the dominant hand for 90 min during their weekly treatment with paclitaxel (80 mg/m
    Results: A total of 22 patients participated in this study, and only one patient did not reach the cumulative dose (960 mg/m
    Conclusion: Cryotherapy with frozen gloves is useful in reducing both the sensory and motor symptoms of the chemotherapy-induced peripheral neuropathy of the hands.
    MeSH term(s) Humans ; Female ; Paclitaxel/adverse effects ; Breast Neoplasms/drug therapy ; Peripheral Nervous System Diseases/therapy ; Peripheral Nervous System Diseases/drug therapy ; Prospective Studies ; Cryotherapy/adverse effects ; Antineoplastic Agents/adverse effects
    Chemical Substances Paclitaxel (P88XT4IS4D) ; Antineoplastic Agents
    Language English
    Publishing date 2022-08-15
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1381116-2
    ISSN 1440-172X ; 1322-7114
    ISSN (online) 1440-172X
    ISSN 1322-7114
    DOI 10.1111/ijn.13094
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4740: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: The Genomic Landscape of Melanoma and Its Therapeutic Implications

    Yang, Ting-Ting / Yu, Sebastian / Ke, Chiao-Li Khale / Cheng, Shih-Tsung

    Genes (Basel). 2023 Apr. 29, v. 14, no. 5

    2023  

    Abstract: Melanoma is one of the most aggressive malignancies of the skin. The genetic composition of melanoma is complex and varies among different subtypes. With the aid of recent technologies such as next generation sequencing and single-cell sequencing, our ... ...

    Abstract Melanoma is one of the most aggressive malignancies of the skin. The genetic composition of melanoma is complex and varies among different subtypes. With the aid of recent technologies such as next generation sequencing and single-cell sequencing, our understanding of the genomic landscape of melanoma and its tumor microenvironment has become increasingly clear. These advances may provide explanation to the heterogenic treatment outcomes of melanoma patients under current therapeutic guidelines and provide further insights to the development of potential new therapeutic targets. Here, we provide a comprehensive review on the genetics related to melanoma tumorigenesis, metastasis, and prognosis. We also review the genetics affecting the melanoma tumor microenvironment and its relation to tumor progression and treatment.
    Keywords carcinogenesis ; genome ; melanoma ; metastasis ; neoplasm progression ; prognosis ; therapeutics
    Language English
    Dates of publication 2023-0429
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2527218-4
    ISSN 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14051021
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: Common pitfalls and bias learned from the COVID-19 pandemic: Keeping a clear mind of judgment.

    Sun, Yng / Lan, Cheng-Che E / Yang, Ting-Ting / Chiu, Szu-Hao

    JAAD case reports

    2022  Volume 27, Page(s) 1–2

    Language English
    Publishing date 2022-07-02
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2022.06.021
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  7. Article ; Online: Substrate-Dependent Regioselectivity: Pd/PTC Cooperatively Catalyzed Domino Heck/Allylation of Allenamides with α-Carbon of Carbonyl Compounds.

    Wang, Dong-Chao / Yang, Ting-Ting / Qu, Gui-Rong / Guo, Hai-Ming

    The Journal of organic chemistry

    2022  Volume 87, Issue 21, Page(s) 14284–14298

    Abstract: A Pd/phase-transfer catalyst cooperatively catalyzed domino Heck/allylation reaction is first reported, which represents interesting substrate-dependent regioselectivity. Under the same conditions, Ts- ... ...

    Abstract A Pd/phase-transfer catalyst cooperatively catalyzed domino Heck/allylation reaction is first reported, which represents interesting substrate-dependent regioselectivity. Under the same conditions, Ts-protected
    MeSH term(s) Palladium/chemistry ; Molecular Structure ; Carbon ; Cyclization ; Catalysis ; Organic Chemicals
    Chemical Substances Palladium (5TWQ1V240M) ; Carbon (7440-44-0) ; Organic Chemicals
    Language English
    Publishing date 2022-10-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.2c01768
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4473: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article ; Online: Self-assembled surgical headlights in dermatologic procedures.

    Fang, Wei-Cheng / Chiu, Li-Wen / Sun, Yng / Yang, Ting-Ting

    Journal of the American Academy of Dermatology

    2022  Volume 89, Issue 4, Page(s) e149–e150

    MeSH term(s) Humans ; Visual Perception ; Lighting ; Dermatologic Surgical Procedures
    Language English
    Publishing date 2022-09-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2022.09.042
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1540: Show issues Location:
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  9. Article: Role of glycolysis in retinal vascular endothelium, glia, pigment epithelium, and photoreceptor cells and as therapeutic targets for related retinal diseases.

    Yang, Ting-Ting / Li, Hui / Dong, Li-Jie

    International journal of ophthalmology

    2021  Volume 14, Issue 9, Page(s) 1302–1309

    Abstract: Glycolysis produces large amounts of adenosine triphosphate (ATP) in a short time. The retinal vascular endothelium feeds itself primarily through aerobic glycolysis with less ATP. But when it generates new vessels, aerobic glycolysis provides rapid and ... ...

    Abstract Glycolysis produces large amounts of adenosine triphosphate (ATP) in a short time. The retinal vascular endothelium feeds itself primarily through aerobic glycolysis with less ATP. But when it generates new vessels, aerobic glycolysis provides rapid and abundant ATP support for angiogenesis, and thus inhibition of glycolysis in endothelial cells can be a target for the treatment of neovascularization. Aerobic glycolysis has a protective effect on Müller cells, and it can provide with a target for visual protection and maintenance of the blood-retinal barrier. Under physiological conditions, the mitochondria of RPE can use lactic acid produced by photoreceptor cells as an energy source to provide ATP for survival. In pathological conditions, because RPE cells avoid their oxidative damage by increasing glycolysis, a large number of glycolysis products accumulate, which in turn has a toxic effect on photoreceptor cells. This shows that stabilizing the function of RPE mitochondria may become a target for the treatment of diseases such as retinal degeneration. The decrease of aerobic glycolysis leads to the decline of photoreceptor cell function and impaired vision; therefore, aerobic glycolysis of stable photoreceptor cells provides a reliable target for delaying vision loss. It is of great significance to study the role of glycolysis in various retinal cells for the targeted treatment of ocular fundus diseases.
    Language English
    Publishing date 2021-09-18
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2663246-9
    ISSN 2227-4898 ; 2222-3959
    ISSN (online) 2227-4898
    ISSN 2222-3959
    DOI 10.18240/ijo.2021.09.02
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Yellowish papules and plaques in the periocular area.

    Wang, Wei-Yao / Su, Yue-Chiu / Yang, Ting-Ting / Lan, Cheng-Che E / Sun, Yng

    Clinical and experimental dermatology

    2023  Volume 48, Issue 10, Page(s) 1202–1204

    MeSH term(s) Humans ; Skin Abnormalities ; Face
    Language English
    Publishing date 2023-05-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 195504-4
    ISSN 1365-2230 ; 0307-6938
    ISSN (online) 1365-2230
    ISSN 0307-6938
    DOI 10.1093/ced/llad187
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