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Article ; Online: ASO Author Reflections: Safety of Elective Esophagectomy Performed on Weekend for Patients with Esophageal Carcinoma.

Yang, Tzu-Yi / Chao, Yin-Kai

2023 Volume 30, Issue 6, Page(s) 3799

MeSH term(s)	Humans ; Esophagectomy/adverse effects ; Esophageal Neoplasms/surgery ; Esophageal Neoplasms/pathology ; Esophageal Squamous Cell Carcinoma/surgery ; Carcinoma/surgery ; Patients
Language	English
Publishing date	2023-03-11
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-023-13331-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Impact of Weekend Effect on Short- and Long-Term Survival of Patients Undergoing Esophagectomy for Cancer: A Population-Based, Inverse Probability of Treatment-Weighted Analysis.

Yang, Tzu-Yi / Wen, Yu-Wen / Chao, Yin-Kai

Annals of surgical oncology

2023 Volume 30, Issue 6, Page(s) 3790–3798

Abstract: Background: We examined the impact of the weekend effect on the survival outcomes of patients undergoing elective esophagectomy for cancer.: Methods: This was a retrospective analysis of a nationwide, health administrative dataset that included all ... ...

Abstract	Background: We examined the impact of the weekend effect on the survival outcomes of patients undergoing elective esophagectomy for cancer. Methods: This was a retrospective analysis of a nationwide, health administrative dataset that included all patients (n = 3235) who had undergone elective esophagectomy for cancer in Taiwanese hospitals between 2008 and 2015. Patients were categorized according to the day of surgery (weekday group: surgical procedures starting Monday through Friday, n = 3148; weekend group: surgical procedures starting on Saturday or Sunday, n = 87). Inverse probability of treatment weighting (IPTW) using the propensity score was used to account for selection bias due to baseline differences. Results: After IPTW, patients undergoing esophagectomy on weekends had a higher 90-days mortality rate compared with those undergoing surgery on a weekday (10.5% vs. 5.5%, respectively, P < 0.001). After controlling for potential confounders, weekend surgery was identified as an independent adverse predictor of 2-years, overall survival [hazard ratio (HR) = 1.38, P < 0.001]. Importantly, inferior weekend outcomes were especially evident in certain subgroups, including patients aged > 60 years (HR = 1.61, P < 0.001), as well as those with a high burden of comorbidities (HR = 1.32, P < 0.001), advanced tumor stage (HR = 1.50, P < 0.001), histological diagnosis of squamous cell carcinoma (HR = 1.20, P < 0.001), and treated with minimally invasive esophagectomy (HR = 1.26, P < 0.001). Conclusions: Elective esophagectomy for cancer during weekends has an adverse impact on short- and long-term survival.
MeSH term(s)	Humans ; Esophagectomy ; Retrospective Studies ; Carcinoma, Squamous Cell/surgery ; Proportional Hazards Models ; Propensity Score ; Treatment Outcome ; Esophageal Neoplasms/surgery ; Esophageal Neoplasms/pathology
Language	English
Publishing date	2023-02-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-023-13280-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Dynamic effect of economic growth on the persistence of suicide rates.

Yang, Tzu-Yi / Yang, Yu-Tai / Chen, Ssu-Han / Lan, Yu-Ting / Peng, Chia-Jui

Geospatial health

2023 Volume 18, Issue 1

Abstract: Positive and negative economic growth is closely related to the suicide rate. To answer the question whether economic development has a dynamic impact on this rate, we used a panel smooth transition autoregressive model to evaluate the threshold effect ... ...

Abstract	Positive and negative economic growth is closely related to the suicide rate. To answer the question whether economic development has a dynamic impact on this rate, we used a panel smooth transition autoregressive model to evaluate the threshold effect of economic growth rate on the persistence of suicide. The research period was from 1994 to 2020, and the results show that the suicide rate had a persistent effect, which varied over time depending on the transition variable within different threshold intervals. However, the persistent effect was manifested in different degrees with the change in the economic growth rate and as the lag period of the suicide rate increased, the effect of the influence gradually decreased. We investigated different lag periods and noted that the impact on the suicide rate was the strongest in the first year after an economic change and then reduced to be only marginal after three years. This means that the growth momentum of the suicide rate within the first two years after a change in the economic growth rate, should be included in policy considerations of how to prevent suicides.
MeSH term(s)	Humans ; Suicide ; Economic Development ; Economic Recession
Language	English
Publishing date	2023-05-25
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2276179-2
ISSN	1970-7096 ; 1827-1987
ISSN (online)	1970-7096
ISSN	1827-1987
DOI	10.4081/gh.2023.1201
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Preoperative Transient Elastography in Patients with Esophageal Cancer.

Yang, Tzu-Yi / Shih, Chia-Pang / Huang, Pei-Ching / Tsai, Chun-Yi / Chao, Yin-Kai

Diagnostics (Basel, Switzerland)

2022 Volume 12, Issue 12

Abstract: Since excessive alcohol consumption is a shared risk factor for esophageal cancer and liver fibrosis, it is possible that patients with esophageal cancer may develop unknown liver fibrosis or cirrhosis. We applied preoperative transient elastography (TE) ...

Abstract	Since excessive alcohol consumption is a shared risk factor for esophageal cancer and liver fibrosis, it is possible that patients with esophageal cancer may develop unknown liver fibrosis or cirrhosis. We applied preoperative transient elastography (TE) to patients without recorded cirrhosis undergoing esophagectomy to clarify the validity in predicting postesophagectomy hepatic failure. The cohort consisted of 107 patients who received TE before esophagectomy between June 2018 and December 2021. Patients were categorized into two groups based on the fibrosis score yielded by preoperative TE (mild group: 0~2, n = 92; severe group: 3~4, n = 15). There was no significant difference in demographic data nor surgical variables between the two groups. None of the cohort encountered hepatic failure, yet the severe fibrosis group had a significantly higher rate of pleural effusion (40.0% versus 15.2%,
Language	English
Publishing date	2022-12-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics12123194
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Article ; Online: Natural aging and ovariectomy induces parallel phosphoproteomic alterations in skeletal muscle of female mice.

Peyton, Mina P / Yang, Tzu-Yi / Higgins, LeeAnn / Markowski, Todd W / Murray, Kevin / Vue, Cha / Parker, Laurie L / Lowe, Dawn A

Aging

2023 Volume 15, Issue 15, Page(s) 7362–7380

Abstract: The loss of skeletal muscle strength mid-life in females is associated with the decline of estrogen. Here, we questioned how estrogen deficiency might impact the overall skeletal muscle phosphoproteome after contraction, as force production induces ... ...

Abstract	The loss of skeletal muscle strength mid-life in females is associated with the decline of estrogen. Here, we questioned how estrogen deficiency might impact the overall skeletal muscle phosphoproteome after contraction, as force production induces phosphorylation of several muscle proteins. Phosphoproteomic analyses of the tibialis anterior muscle after contraction in two mouse models of estrogen deficiency, ovariectomy (Ovariectomized (Ovx) vs. Sham) and natural aging-induced ovarian senescence (Older Adult (OA) vs. Young Adult (YA)), identified a total of 2,593 and 3,507 phosphopeptides in Ovx/Sham and OA/YA datasets, respectively. Further analysis of estrogen deficiency-associated proteins and phosphosites identified 66 proteins and 21 phosphosites from both datasets. Of these, 4 estrogen deficiency-associated proteins and 4 estrogen deficiency-associated phosphosites were significant and differentially phosphorylated or regulated, respectively. Comparative analyses between Ovx/Sham and OA/YA using Ingenuity Pathway Analysis (IPA) found parallel patterns of inhibition and activation across IPA-defined canonical signaling pathways and physiological functional analysis, which were similarly observed in downstream GO, KEGG, and Reactome pathway overrepresentation analysis pertaining to muscle structural integrity and contraction, including AMPK and calcium signaling. IPA Upstream regulator analysis identified MAPK1 and PRKACA as candidate kinases and calcineurin as a candidate phosphatase sensitive to estrogen. Our findings highlight key molecular signatures and pathways in contracted muscle suggesting that the similarities identified across both datasets could elucidate molecular mechanisms that may contribute to skeletal muscle strength loss due to estrogen deficiency.
MeSH term(s)	Mice ; Female ; Animals ; Humans ; Muscle, Skeletal/metabolism ; Estrogens/metabolism ; Muscle Contraction/physiology ; Aging/metabolism ; Proteins/metabolism ; Ovariectomy
Chemical Substances	Estrogens ; Proteins
Language	English
Publishing date	2023-08-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.204959
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Tuberculous peritonitis in patients on peritoneal dialysis: a 35-year experience from a large medical center in Northern Taiwan.

Yang, Tzu-Yi / Tian, Ya-Chung / Yen, Tzung-Hai / Chang, Ming-Yang / Lin, Chan-Yu / Liu, Shou-Hsuan

Renal failure

2023 Volume 45, Issue 1, Page(s) 2153064

Abstract: Introduction: Tuberculous peritonitis (TBP) is a rare but fatal complication in patients on peritoneal dialysis (PD). In this study, we aimed to determine the demographic features, clinical features, laboratory parameters, and clinical outcomes of PD ... ...

Abstract	Introduction: Tuberculous peritonitis (TBP) is a rare but fatal complication in patients on peritoneal dialysis (PD). In this study, we aimed to determine the demographic features, clinical features, laboratory parameters, and clinical outcomes of PD patients with TBP and to clarify possible risk factors for mortality. Materials and methods: We retrospectively reviewed 2084 PD patients from January 1985 to December 2019. The diagnosis of TBP was established by positive peritoneal fluid culture for Results: 18 patients were diagnosed with TBP. The incidence was 2.029 episodes per 1000 patient-years. The most common symptom was fever (94.4%), followed by cloudy effluent (83.3%) and abdominal pain (83.3%). The average peritoneal dialysis effluent (PDE) white blood cell (WBC) count was 172.7 cells/μL. Nine patients (50%) had WBC counts lower than 100 cells/μL and 13 patients (72.2%) had neutrophilic predominant WBC counts. Acid fast stain (AFS) was positive in 7 patients (38.9%). Only 2 patients (11.1%) continued with PD after TB infection, while 10 patients (55.6%) changed to hemodialysis. Seven patients (38.9%) died within 1 year. Significant differences were observed in sex ( Conclusion: Physicians should pay attention to the unusual presentations of peritonitis, especially if symptoms include fever or an initial low PDE WBC count. Catheter removal is not mandatory if early diagnosis and appropriate therapy are available.
MeSH term(s)	Humans ; Retrospective Studies ; Taiwan/epidemiology ; Peritoneal Dialysis/adverse effects ; Peritonitis/etiology ; Peritonitis/microbiology ; Peritoneum ; Peritonitis, Tuberculous/diagnosis ; Peritonitis, Tuberculous/epidemiology ; Peritonitis, Tuberculous/etiology
Language	English
Publishing date	2023-01-09
Publishing country	England
Document type	Journal Article
ZDB-ID	632949-4
ISSN	1525-6049 ; 0886-022X
ISSN (online)	1525-6049
ISSN	0886-022X
DOI	10.1080/0886022X.2022.2153064
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Article: Atomically Thin Tin Monoxide-Based p-Channel Thin-Film Transistor and a Low-Power Complementary Inverter

Huang, Chi-Hsin / Tang, Yalun / Yang, Tzu-Yi / Chueh, Yu-Lun / Nomura, Kenji

ACS applied materials & interfaces. 2021 Nov. 01, v. 13, no. 44

2021

Abstract: Atomically thin oxide semiconductors are significantly expected for next-generation cost-effective, energy-efficient electronics. A high-performance p-channel oxide thin-film transistor (TFT) was developed using an atomically thin p-type tin monoxide, ... ...

Abstract	Atomically thin oxide semiconductors are significantly expected for next-generation cost-effective, energy-efficient electronics. A high-performance p-channel oxide thin-film transistor (TFT) was developed using an atomically thin p-type tin monoxide, SnO channel with a thickness of ∼1 nm, which was grown by a vacuum-free, solvent-free, metal-liquid printing process at low temperatures, as low as 250 °C in an ambient atmosphere. By performing oxygen-vacancy defect termination for the bulk-channel and back-channel surface of the ultrathin SnO channel, the presented p-channel SnO TFT exhibited good device performances with a reasonable TFT mobility of ∼0.47 cm² V–¹ s–¹, a high on/off current ratio of ∼10⁶, low off current of <10–¹² A, and a subthreshold swing of ∼2.5 V decade–¹, which was improved compared with the conventional p-channel SnO TFTs. We also fabricated metal-liquid printing-based n-channel oxide TFTs such as n-channel SnO₂ and In₂O₃-TFTs and developed ultrathin-channel oxide-TFT-based low-power complementary inverter circuits with the developed p-channel SnO TFTs. The full swing of voltage-transfer characteristics with a voltage gain of ∼10 and a power dissipation of <4 nW for p-SnO/n-SnO₂ and ∼120 and <2 nW for p-SnO/n-In₂O₃-CMOS inverters were successfully demonstrated.
Keywords	cost effectiveness ; electric potential difference ; electronics ; energy efficiency ; tin ; tin monoxide ; transistors
Language	English
Dates of publication	2021-1101
Size	p. 52783-52792.
Publishing place	American Chemical Society
Document type	Article
ISSN	1944-8252
DOI	10.1021/acsami.1c15990
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Atomically Thin Tin Monoxide-Based p-Channel Thin-Film Transistor and a Low-Power Complementary Inverter.

Huang, Chi-Hsin / Tang, Yalun / Yang, Tzu-Yi / Chueh, Yu-Lun / Nomura, Kenji

ACS applied materials & interfaces

2021 Volume 13, Issue 44, Page(s) 52783–52792

Abstract	Atomically thin oxide semiconductors are significantly expected for next-generation cost-effective, energy-efficient electronics. A high-performance p-channel oxide thin-film transistor (TFT) was developed using an atomically thin p-type tin monoxide, SnO channel with a thickness of ∼1 nm, which was grown by a vacuum-free, solvent-free, metal-liquid printing process at low temperatures, as low as 250 °C in an ambient atmosphere. By performing oxygen-vacancy defect termination for the bulk-channel and back-channel surface of the ultrathin SnO channel, the presented p-channel SnO TFT exhibited good device performances with a reasonable TFT mobility of ∼0.47 cm
Language	English
Publishing date	2021-11-01
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.1c15990
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Artificial Synapse Based on a 2D-SnO

Huang, Chi-Hsin / Chang, Hsuan / Yang, Tzu-Yi / Wang, Yi-Chung / Chueh, Yu-Lun / Nomura, Kenji

ACS applied materials & interfaces

2021 Volume 13, Issue 44, Page(s) 52822–52832

Abstract: A new type of two-dimensional (2D) ... ...

Abstract	A new type of two-dimensional (2D) SnO
Language	English
Publishing date	2021-10-29
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.1c18329
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Article ; Online: Global phosphoproteomic profiling of skeletal muscle in ovarian hormone-deficient mice.

Peyton, Mina P / Yang, Tzu-Yi / Higgins, LeeAnn / Markowski, Todd W / Vue, Cha / Parker, Laurie L / Lowe, Dawn A

Physiological genomics

2022 Volume 54, Issue 11, Page(s) 417–432

Abstract: Protein phosphorylation is important in skeletal muscle development, growth, regeneration, and contractile function. Alterations in the skeletal muscle phosphoproteome due to aging have been reported in males; however, studies in females are lacking. We ... ...

Abstract	Protein phosphorylation is important in skeletal muscle development, growth, regeneration, and contractile function. Alterations in the skeletal muscle phosphoproteome due to aging have been reported in males; however, studies in females are lacking. We have demonstrated that estrogen deficiency decreases muscle force, which correlates with decreased myosin regulatory light chain phosphorylation. Thus, we questioned whether the decline of estrogen in females that occurs with aging might alter the skeletal muscle phosphoproteome. C57BL/6J female mice (6 mo) were randomly assigned to a sham-operated (Sham) or ovariectomy (Ovx) group to investigate the effects of estrogen deficiency on skeletal muscle protein phosphorylation in a resting, noncontracting condition. After 16 wk of estrogen deficiency, the tibialis anterior muscle was dissected and prepped for label-free nano-liquid chromatography-tandem mass spectrometry phosphoproteomic analysis. We identified 4,780 phosphopeptides in tibialis anterior muscles of ovariectomized (Ovx) and Sham-operated (Sham) control mice. Further analysis revealed 647 differentially regulated phosphopeptides (Benjamini-Hochberg adjusted
MeSH term(s)	Animals ; Female ; Mice ; Estrogens/metabolism ; Mice, Inbred C57BL ; Muscle, Skeletal/metabolism ; Myosin Light Chains/metabolism ; Myosin Light Chains/pharmacology ; Phosphopeptides/metabolism
Chemical Substances	Estrogens ; Myosin Light Chains ; Phosphopeptides
Language	English
Publishing date	2022-09-05
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial, Veterinary ; Research Support, N.I.H., Extramural
ZDB-ID	2038823-8
ISSN	1531-2267 ; 1094-8341
ISSN (online)	1531-2267
ISSN	1094-8341
DOI	10.1152/physiolgenomics.00104.2022
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