Article: Antidiabetic and hypolipidemic effects of Collybia confluens mycelia produced by submerged culture in streptozotocin-diabetic rats.
Archives of pharmacal research
2006 Volume 29, Issue 1, Page(s) 73–79
Abstract: This investigation was undertaken to study the effects of oral administration (3 weeks) of Collybia confluens mycelial powder (CCMP) produced by a submerged culture on plasma glucose and other biochemical parameters in streptozotocin (STZ)-induced ... ...
Abstract | This investigation was undertaken to study the effects of oral administration (3 weeks) of Collybia confluens mycelial powder (CCMP) produced by a submerged culture on plasma glucose and other biochemical parameters in streptozotocin (STZ)-induced diabetic rats. Antidiabetic and hypolipidemic effects were proportionally increased with the increasing concentration of the CCMP for oral administration. The CCMP, at the dose of 400 mg/kg BW, substantially reduced the plasma glucose level by as much as 33.1% as compared to the STZ-induced diabetic rats group. It also lowered the plasma total cholesterol, triglyceride, and low density lipoprotein (LDL) cholesterol by 22.9%, 19.9%, and 37.3%, respectively. The levels of total cholesterol and triglyceride in liver were reduced to the extent of by 13.5% and 18.8%, and the activity of alanine transaminase (ALT) and aspartate transaminase (AST) was decreased by 48.8% and 37.2%, respectively, under the influence of CCMP. The general components of CCMP were found to contain 26.18% carbohydrate, 3.67% crude ash, 4.02% crude fat, 22.55% crude protein, and 43.58% dietary fiber. The amino acid composition of the CCMP was also analyzed in detail. |
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MeSH term(s) | Agaricales/chemistry ; Alanine Transaminase/blood ; Amino Acids/metabolism ; Animals ; Aspartate Aminotransferases/blood ; Blood Glucose/metabolism ; Cholesterol/blood ; Diabetes Mellitus, Experimental/blood ; Diabetes Mellitus, Experimental/metabolism ; Hypoglycemic Agents/pharmacology ; Hypolipidemic Agents/pharmacology ; Lipids/blood ; Male ; Mycelium/chemistry ; Mycelium/growth & development ; Phospholipids/blood ; Rats ; Rats, Sprague-Dawley ; Triglycerides/blood |
Chemical Substances | Amino Acids ; Blood Glucose ; Hypoglycemic Agents ; Hypolipidemic Agents ; Lipids ; Phospholipids ; Triglycerides ; Cholesterol (97C5T2UQ7J) ; Aspartate Aminotransferases (EC 2.6.1.1) ; Alanine Transaminase (EC 2.6.1.2) |
Language | English |
Publishing date | 2006-01-23 |
Publishing country | Korea (South) |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 447623-2 |
ISSN | 1976-3786 ; 0253-6269 |
ISSN (online) | 1976-3786 |
ISSN | 0253-6269 |
DOI | 10.1007/bf02977472 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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