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Article: [Similarities and differences of myocardial metabolic characteristics between HFpEF and HFrEF mice based on LC-MS/MS metabolomics].

Zhang, Z Y / Feng, X Y / Wang, Z H / Huang, Y Z / Yang, W B / Zhang, W J / Zhou, J / Yuan, Z Y

2022 Volume 51, Issue 7, Page(s) 722–730

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Mice ; Animals ; Heart Failure/metabolism ; Stroke Volume ; Chromatography, Liquid ; Tandem Mass Spectrometry ; Metabolomics ; Arachidonic Acids ; Proline
Chemical Substances	Arachidonic Acids ; Proline (9DLQ4CIU6V)
Language	Chinese
Publishing date	2022-11-08
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	603425-1
ISSN	0253-3758
ISSN	0253-3758
DOI	10.3760/cma.j.cn112148-20230329-00182
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Book ; Online: PLANNING BY USING DIGITAL TECHNOLOGY IN THE RECONSTRUCTION OF CULTURAL HERITAGE SITES – A CASE STUDY OF QIONG-LIN SETTLEMENT IN KINMEN AREA

Yang, W. B. / Ye, Y. N.

eISSN: 2194-9034

2017

Abstract: ICOMOS Florence Declaration in 2014, encourages an in-depth reflection on human values through cultural heritage and landscapes, which emphasizes the importance of historical heritage sites, in order to achieve the application of cultural heritage ... ...

Abstract	ICOMOS Florence Declaration in 2014, encourages an in-depth reflection on human values through cultural heritage and landscapes, which emphasizes the importance of historical heritage sites, in order to achieve the application of cultural heritage records through the public participation, sharing new technology platform and facilitation tools for knowledge diffusion, for instance. Nikos adopted digitized intangible cultural heritage within i-Treasures project to create a novel digital platform in 2016. Nowadays, the display platform developed based on geographic information system has been gradually accepted and widely used to distribute cultural heritage information, aiming to combine geography, time, events, issues, trends with the interactive maps to show the context of data changes from the consideration of planarity; for example, Burnaby City in Canada has cooperated with the Columbia University to create a navigation platform for guidance of tangible cultural heritage based on story maps in order to provide public recognition function. In this study, Qiong-Lin Settlement in Kinmen Area was taken as an example to illustrate the developing process of an overall planning framework for reappearing the glory of historic settlements of cultural heritage sites with digital technology, which included tangible and intangible cultural heritage preservation and transmission planning, community participation and digital navigation programs. The digital technology with the GIS-based digital platform can provide more diverse and interesting information while using an intuitive, graphical user story mapping interface. So that tangible cultural heritage can be effectively understood, interpreted and preserved with the value-added methods, and also intangible cultural heritage can be continuously transmitted to establish a complete system of cultural heritage preservation. The main contents include several navigation technologies, such as 3D laser scanning, UAV images, photogrammetry, panorama, audio/video, geographic information systems etc.
Subject code	302
Language	English
Publishing date	2017-08-23
Publishing country	de
Document type	Book ; Online
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Article ; Online: MiR-4299 suppresses non-small cell lung cancer cell proliferation, migration and invasion through modulating PTEN/AKT/PI3K pathway.

Yang, W-B / Zhang, W-P / Shi, J-L / Wang, J-W

European review for medical and pharmacological sciences

2018 Volume 22, Issue 11, Page(s) 3408–3414

Abstract: Objective: The aim of the present study was to investigate clinical significances and biological roles of miR-4299 in non-small cell lung cancer (NSCLC) PATIENTS AND METHODS: Expression of miR-4299 in NSCLC tissues and matched non-tumor tissues was ... ...

Abstract	Objective: The aim of the present study was to investigate clinical significances and biological roles of miR-4299 in non-small cell lung cancer (NSCLC) PATIENTS AND METHODS: Expression of miR-4299 in NSCLC tissues and matched non-tumor tissues was determined by quantitative real-time PCR (qRT-PCR). The correlations between miR-4299 expression and clinicopathological characteristics and prognosis were also analyzed. MTT assay and Transwell assay were performed to determine the proliferation, migration and invasion. Western blotting was used to examine the expressing patterns of PTEN/AKT/PI3K signaling pathway-related proteins. Results: We found that the expression level of miR-4299 was downregulated in NSCLC tissues and cell lines. Low miR-4299 expression was positively correlated with TNM stage (p=0.002), histological grade (p=0.002) and lymph node metastasis (p=0.028). Moreover, Kaplan-Meier survival analysis showed that the patients with low miR-4299 expression had shorter survival time than those with high miR-4299 expression (p=0.0011). More importantly, multivariate analysis suggested that decreased miR-4299 expression was a poor independent prognostic predictor for NSCLC patients (p=0.009). Functionally, overexpression of miR-4299 inhibited the proliferation, migration and invasion in A549 cells. Mechanistically, the results of Western blot showed that miR-4299 exhibited its tumor-suppressive role by modulating PTEN/AKT/PI3K signaling pathway. Conclusions: We firstly indicated that miR-4299 may be a candidate independent marker for NSCLC prognosis and suppressed the progression of NSCLC by modulating the activation of PTEN/AKT/PI3K signaling pathway, suggesting that miR-4299 could be a potential target for developing therapies in treating NSCLC.
MeSH term(s)	Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Down-Regulation ; Female ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Male ; MicroRNAs/biosynthesis ; MicroRNAs/genetics ; MicroRNAs/physiology ; Middle Aged ; Neoplasm Invasiveness/genetics ; PTEN Phosphohydrolase/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Prognosis ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction
Chemical Substances	MIR4299 microRNA, human ; MicroRNAs ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; PTEN Phosphohydrolase (EC 3.1.3.67) ; PTEN protein, human (EC 3.1.3.67)
Language	English
Publishing date	2018-06-19
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_201806_15163
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Article: [Establishment of a mutation prediction model for evaluating the efficacy of immunotherapy in renal carcinoma].

Qin, C P / Song, Y X / Ding, M T / Wang, F / Lin, J X / Yang, W B / DU, Y Q / Li, Q / Liu, S J / Xu, T

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences

2022 Volume 54, Issue 4, Page(s) 663–668

Abstract: Objective: To establish a mutation prediction model for efficacy assessment, the genomic sequencing data of renal cancer patients from the MSKCC (Memorial Sloan Kettering Cancer Center) pan-cancer immunotherapy cohort was used.: Methods: The genomic ... ...

Abstract	Objective: To establish a mutation prediction model for efficacy assessment, the genomic sequencing data of renal cancer patients from the MSKCC (Memorial Sloan Kettering Cancer Center) pan-cancer immunotherapy cohort was used. Methods: The genomic sequencing data of 121 clear cell renal cell carcinoma patients treated with immune checkpoint inhibitors (ICI) in the MSKCC pan-cancer immunotherapy cohort were obtained from cBioPortal database (http://www.cbioportal.org/) and they were analyzed by univariate and multivariate Cox regression analysis to identify mutated genes associated with ICI treatment efficacy, and we constructed a comprehensive prediction model for drug efficacy of ICI based on mutated genes using nomogram. Survival analysis and time-dependent receiver operator characteristic curves were performed to assess the prognostic value of the model. Transcriptome and genomic sequencing data of 538 renal cell carcinoma patients were obtained from the TCGA database (https://portal.gdc.cancer.gov/). Gene set enrichment analysis was used to identify the potential functions of the mutated genes enrolled in the nomogram. Results: We used multivariate Cox regression analysis and identified mutations in Conclusion: PBRM1
MeSH term(s)	Biomarkers, Tumor/genetics ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/therapy ; Humans ; Immunotherapy/methods ; Kidney Neoplasms/genetics ; Kidney Neoplasms/therapy ; Mutation
Chemical Substances	Biomarkers, Tumor
Language	Chinese
Publishing date	2022-08-07
Publishing country	China
Document type	Journal Article
ZDB-ID	2452593-5
ISSN	1671-167X
ISSN	1671-167X
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Application value of non-invasive ventilation combined with high flow nasal cannula oxygen therapy in sequential treatment of patients with chronic obstructive pulmonary disease after mechanical ventilation].

Yang, S Q / Liu, Z / Meng, S Q / Yang, W B / Zhang, G Z / Shi, Q B / Zhang, K

Zhonghua yi xue za zhi

2020 Volume 100, Issue 27, Page(s) 2116–2120

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Airway Extubation ; Cannula ; Humans ; Noninvasive Ventilation ; Oxygen/administration & dosage ; Oxygen Inhalation Therapy/methods ; Pulmonary Disease, Chronic Obstructive/therapy ; Respiration, Artificial ; Treatment Outcome
Chemical Substances	Oxygen (S88TT14065)
Language	Chinese
Publishing date	2020-07-20
Publishing country	China
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	132513-9
ISSN	0376-2491
ISSN	0376-2491
DOI	10.3760/cma.j.cn112137-20200306-00616
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Article: [Transurethral resection of prostate treatment for recurrence of a multilocular prostatic cystadenoma: a case report].

Yang, W B / Zhang, X W / Yang, J / Li, Q / Xu, T / Bai, W J

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences

2018 Volume 50, Issue 4, Page(s) 740–742

Abstract: Multilocular prostatic cystadenoma (MPC) is a rare benign tumor that originates from the prostate itself. MPC is usually characterized by large multilocular cysts located between the rectum and bladder. The clinical presentation includes obstructive ... ...

Abstract	Multilocular prostatic cystadenoma (MPC) is a rare benign tumor that originates from the prostate itself. MPC is usually characterized by large multilocular cysts located between the rectum and bladder. The clinical presentation includes obstructive voiding symptoms, such as poor stream, intermittency, sensation of incomplete emptying, acute urinary retention and sometimes constipation symptoms due to mechanical compression of the lower intestine. Most of the previously reported patients with MPC underwent open surgery. Although the natural history of MPC remains unknown, surgical excision may not always be necessary. Here we report the case of a 49-year-old male, treated by transurethral electroresection of prostate (TURP) for prostate cyst one and half years before．His biopsy of TURP showed benign prostatic tissue with no evidence of malignancy. However, the symptoms of urinary tract obstruction were obviously aggravated after the operation. Acute urinary retention occurred intermittently 3 times. In our hospital, his total prostate specific antigen (tPSA) was 5.440 μg/L, free prostate specific antigen (fPSA) was 1.528 μg/L. After examination, it was considered as benign lesions clearly. In the operation of TURP, we found that the tumor was multilocular cystic. Histologically, the cell was mucus. Concerning the immunophenotype, CK5/6(+) , p40(+), PSA(+), P504S(+), PAX-2(-), PAX-8(-), MUC1(+), MUC5ac(+), the results of special staining were as follows: AB(+), PAS(+). At the end of the follow up 3 months later, the routine semen analysis results showed that his semen volume was 3 mL and the sperm density and sperm mobility were normal. At the end of the follow up eight months later, the patient remained free of lower urinary tract symptoms and there were no signs of recurrence. His international prostate symptom score (I-PSS) had dropped from 32 to 4, and quality of life score (QOL) had dropped from 6 to 2. MPC is a rare benign tumor originating from the prostate. TURP may aggravate the symptoms of lower urinary tract obstruction in patients with MPC, and may be temporarily observed for some asymptomatic young and middle-aged patients.
MeSH term(s)	Cystadenoma/surgery ; Humans ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Prostatic Hyperplasia ; Prostatic Neoplasms/surgery ; Quality of Life ; Transurethral Resection of Prostate ; Treatment Outcome
Language	Chinese
Publishing date	2018-08-20
Publishing country	China
Document type	Case Reports ; Journal Article
ISSN	1671-167X
ISSN	1671-167X
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Application of flurbiprofen axetil in pain management associated during transrectal ultrasound-guided prostate biopsy].

Lan, K / Yang, W B / Zhang, X W / Bai, W J / Li, Q / Xu, T

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences

2017 Volume 49, Issue 4, Page(s) 643–647

Abstract: Objective: To examine the effects of perioperative intravenous administration of flurbiprofen axetil (FA) on pain associated with transrectal ultrasound-guided prostate biopsy.: Methods: This was a randomized,controlled study. Eighty-one patients who ...

Abstract	Objective: To examine the effects of perioperative intravenous administration of flurbiprofen axetil (FA) on pain associated with transrectal ultrasound-guided prostate biopsy. Methods: This was a randomized,controlled study. Eighty-one patients who underwent 12 core prostate biopsy were included in the study. The patients were randomly assigned to one of three groups (n=27 in each) by type of procedure during prostate biopsy. Group intrarectal local anesthesia (IRLA) received intrarectal 5% (0.05 g/L) lidocaine gel 60 mg, 5 minutes before the procedure alone; Group FA received intravenous flurbiprofen axetil (1 mg/kg) 1 hour before the procedure; Group IRLA+FA received intrarectal 5% lidocaine gel 60 mg, 5 minutes before the procedure and intravenous flurbiprofen axetil (1 mg/kg) 1 hour before the procedure. The patients were asked to score the pain by using visual analogue scale (VAS) in 4 situations,including when the probe was inserted (VASI),during anesthesia (VAS II),during biopsy (VAS III) and 20 minutes after biopsy (VAS IV). The findings were evaluated with analysis of variance,and the Tukey post hoc test was followed with an overall 2-tailed significance level at α =0.05. P1, P value between Group IRLA and Group FA; P2, P value between Group FA and Group IRLA +FA, P3, P value between Group IRLA and Group IRLA +FA. The bonferroni method was used to adjust the test level, α=0.017,a P value of less than 0.017 was accepted as the threshold for statistical significance. Results: No major complications,including sepsis and severe rectal bleeding,were noted in any patient. There were no differences in general condition of the patients before procedure among the 3 groups. There were statistically significant differences in VAS scores among the 3 groups in VAS II (5.7±2.2, 3.0±1.5,3.3±1.9,respectively,P=0.012) and VAS III (6.7±2.3,3.0±2.1,2.9±1.6,respectively,P=0.001). There were no differences in the pain scores among the 3 groups during probe insertion (VAS I, 3.2±1.0,4.1±2.1,4.2±1.7, respectively,P=5.752) and 20 minutes after biopsy (VAS IV, 1.4±2.1,1.0±0.9,1.1±0.7,respectively,P=3.772). Between-column differences among the 3 groups were VAS II (P1=0.007,P2=5.655,P3=0.001,respectively) and VAS III(P1=0.008,P2=7.517,P3=0.001,respectively),the differences between Group IRLA and Group FA,Group IRLA and Group IRLA +FA in VAS II and VAS III were statistically significant. Conclusion: The intravenous flurbiprofen axetil was found to be more effective than intrarectal lidocaine gel alone.
MeSH term(s)	Anesthetics, Local ; Biopsy/adverse effects ; Flurbiprofen/analogs & derivatives ; Humans ; Lidocaine ; Male ; Nerve Block ; Pain Management ; Prostatic Neoplasms/diagnosis
Chemical Substances	Anesthetics, Local ; Flurbiprofen (5GRO578KLP) ; Lidocaine (98PI200987) ; flurbiprofen axetil (I0OU31PUI5)
Language	Chinese
Publishing date	2017-08-30
Publishing country	China
Document type	Journal Article ; Randomized Controlled Trial
ISSN	1671-167X
ISSN	1671-167X
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: Digitalized preservation and presentation of historical building – taking traditional temples and dougong as examples

Yang, W. B. / Yen, Y. N. / Cheng, H. M.

eISSN: 2194-9050

2015

Abstract: The integration of preservation of heritage and the digital technology is an important international trend in the 21st century. The digital technology not only is able to record and preserve detailed documents and information of heritage completely, but ... ...

Abstract	The integration of preservation of heritage and the digital technology is an important international trend in the 21st century. The digital technology not only is able to record and preserve detailed documents and information of heritage completely, but also brings the value-added features effectively. In this study, 3D laser scanning is used to perform the digitalized archives for the interior and exterior body work of the building which contains integration of 3D scanner technology, mobile scanning collaboration and multisystem reverse modeling and integration technology. The 3D model is built by combining with multi-media presentations and reversed modeling in real scale to perform the simulation of virtual reality (VR). With interactive teaching and presentation of augmented reality to perform the interaction technology to extend the continuously update in traditional architecture information. With the upgrade of the technology and value-added in digitalization, the cultural asset value can be experienced through 3D virtual reality which makes the information presentation from the traditional reading in the past toward user operation with sensory experience and keep exploring the possibilities and development of cultural asset preservation by using digital technology makes the presentation and learning of cultural asset information toward diversification.
Subject code	302
Language	English
Publishing date	2015-08-12
Publishing country	de
Document type	Book ; Online
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Article ; Online: Evaluation of the application of high volume hemofiltration in sepsis combined with acute kidney injury.

Meng, S-Q / Yang, W-B / Liu, J-G / Yuan, J-Y / Zhang, K / Ding, W-Y / Yang, S-Q / Liu, J-H

European review for medical and pharmacological sciences

2018 Volume 22, Issue 3, Page(s) 715–720

Abstract: Objective: To investigate the safety and effectiveness of the application of high-volume hemofiltration (HVHF) in children with sepsis combined with acute kidney injury.: Patients and methods: A total of 76 child patients were enrolled and randomly ... ...

Abstract	Objective: To investigate the safety and effectiveness of the application of high-volume hemofiltration (HVHF) in children with sepsis combined with acute kidney injury. Patients and methods: A total of 76 child patients were enrolled and randomly divided equally (n=38) into control and the observation groups respectively. The control group received conventional volume hemofiltration (the ultrafiltration rate of 35-50 ml/kg/h), and the observation group received HVHF (50-100 ml/kg/h). Results: The serum Interleukin-6 (IL-6), Tumor Necrosis Factor-a (TNF-α) and creatinine levels were significantly lower in the observation group than the control group at 6 h, 12 h, 24 h and 48 h of hemofiltration (p<0.05). The efficacy rate of treatment was improved. The mortality rate and incidence rate of complications were decreased, and the treatment course was significantly shortened (p<0.05). Conclusions: The application of HVHF in children with sepsis combined with acute kidney injury has a better safety and effectiveness.
MeSH term(s)	Acute Kidney Injury/therapy ; Child ; Child, Preschool ; Female ; Hemofiltration/methods ; Humans ; Interleukin-6/blood ; Male ; Sepsis/therapy ; Tumor Necrosis Factor-alpha/blood
Chemical Substances	Interleukin-6 ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2018-02-19
Publishing country	Italy
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_201802_14298
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Article: Soil water threshold for the growth of Haloxylon ammodendron in the Ulan Buh desert in arid northwest China

Yang, W.B / J.Y. Guo / W. Feng / Y.J. Zhu / Z.Q. Jia

South African Association of Botanists South African journal of botany. 2014 May, v. 92

2014

Abstract: An experiment was conducted over a 3-year period to investigate the aeolian soil water dynamics and ecophysiological characteristics of Haloxylon ammodendron in Ulan Buh Desert, northwest China. Three different communities of H. ammodendron, which ... ...

Abstract	An experiment was conducted over a 3-year period to investigate the aeolian soil water dynamics and ecophysiological characteristics of Haloxylon ammodendron in Ulan Buh Desert, northwest China. Three different communities of H. ammodendron, which consist of two 8- to 10-year plantations and one natural stand, were selected in this study. As a result, the âeconomic water thresholdâ of H. ammodendron was expressed at about 2.0% of the absorbed water content. Above this threshold, the aeolian soil water potential decreased by â0.18MPa with a 1.0% decrease in the water content. Below this threshold, the aeolian soil water potential decreased by â2.09MPa with a 1.0% decrease in the water content. The predawn water potential of the shoot can recover to an above zero turgor pressure when the aeolian soil water content exceeded the âeconomic water thresholdâ. However, the predawn water potential of the shoot became â3.50MPa, which was lower than that at zero turgor (â3.41MPa) when the aeolian soil water content was about 1.0%. This results indicated that the shoot cannot recover its turgor. Therefore, 1.0% of the aeolian soil water content was defined as the âsurvival water thresholdâ of the growth of H. ammodendron.
Keywords	ecophysiology ; Haloxylon ammodendron ; plantations ; soil water ; soil water content ; soil water potential ; turgor ; water content ; China
Language	English
Dates of publication	2014-05
Size	p. 53-58.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2126918-X
ISSN	0254-6299
ISSN	0254-6299
DOI	10.1016/j.sajb.2014.02.001
Database	NAL-Catalogue (AGRICOLA)

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