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Artikel: [Role of the ES-62 protein derived from

Hu, Q / Xing, J Y / Wu, P / Huang, T T / Yang, X D

Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control

2022 Band 34, Heft 2, Seite(n) 204–211

Abstract: ES-62 is a phosphorylcholine-containing, 62 kDa glycoprotein derived from the excretory-secretory product ... ...

Abstract	ES-62 is a phosphorylcholine-containing, 62 kDa glycoprotein derived from the excretory-secretory product of
Mesh-Begriff(e)	Acanthocheilonema/metabolism ; Animals ; Dipetalonema/metabolism ; Glycoproteins ; Helminth Proteins ; Phosphorylcholine/metabolism
Chemische Substanzen	Glycoproteins ; Helminth Proteins ; Phosphorylcholine (107-73-3)
Sprache	Chinesisch
Erscheinungsdatum	2022-05-10
Erscheinungsland	China
Dokumenttyp	Journal Article ; Review
ISSN	1005-6661
ISSN	1005-6661
DOI	10.16250/j.32.1374.2021141
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: [Effects of intranasal dexmedetomidine for children undergoing dental rehabilitation under general anesthesia: a double-blinded randomized controlled trial].

Gao, L / Liu, Y / Yang, X D

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences

2018 Band 50, Heft 6, Seite(n) 1078–1082

Abstract: Objective: To observe the preoperative sedation, the status of separation from parents, compliance with the mask, hemodynamic parameters and postoperative agitation of intranasal dexmedetomidine (DEX) premedication on children undergoing dental ... ...

Abstract	Objective: To observe the preoperative sedation, the status of separation from parents, compliance with the mask, hemodynamic parameters and postoperative agitation of intranasal dexmedetomidine (DEX) premedication on children undergoing dental rehabilitation under general anesthesia. Methods: In the study, 60 children of American Society of Anesthesiology classification (ASA I-II), aged 2-9 years, were randomly assigned to one of two equal groups. Thirty minutes before operation, control group received intranasal placebo (0.9% saline) 0.02 mL/kg, and DEX group received intranasal DEX 2 μg/kg. The preoperative sedation score, the status of separation from parents, compliance with the mask and hemodynamic parameters were recorded by an anesthesiologists until anesthesia induction. Recovery conditions, postoperative agitation were also recorded. Results: There was no significant difference between the two groups in patient characteristics, operation time, extubation time and recovery time. Compared with the children in control group, those in DEX group were significantly more sedated when they were separated from their parents (56.7% vs. 26.7%, P<0.05). Satisfactory compliance with mask application was 40% in control group vs. 73.3% in DEX group (P<0.05). There was no significant difference between the two groups regarding the incidences of postoperative agitation and oxygen saturation (SpO Conclusion: Premedication with intranasal DEX 2 μg/kg for children undergoing dental rehabilitation under general anesthesia produces good preoperative sedation. The levels of sedation, scores of parental separation and compliance with the mask were satisfied. The children have good recovery conditions, and no obvious postoperative agitation and respiratory depression after DEX administration. Intranasal DEX 2 μg/kg is an effective and safe alternative for premedication in children.
Mesh-Begriff(e)	Administration, Intranasal ; Anesthesia, General ; Child ; Child, Preschool ; Dental Restoration, Permanent/methods ; Dexmedetomidine/administration & dosage ; Double-Blind Method ; Heart Rate ; Humans ; Hypnotics and Sedatives/administration & dosage
Chemische Substanzen	Hypnotics and Sedatives ; Dexmedetomidine (67VB76HONO)
Sprache	Chinesisch
Erscheinungsdatum	2018-12-18
Erscheinungsland	China
Dokumenttyp	Journal Article ; Randomized Controlled Trial
ISSN	1671-167X
ISSN	1671-167X
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Preoperative oral carbohydrates in elderly patients undergoing free flap surgery for oral cancer: randomized controlled trial.

Wu, H-Y / Yang, X-D / Yang, G-Y / Cai, Z-G / Shan, X-F / Yang, Y

International journal of oral and maxillofacial surgery

2022 Band 51, Heft 8, Seite(n) 1010–1015

Abstract: The aim of this study was to evaluate the safety of carbohydrate intake 2 hours before surgery in elderly patients undergoing free flap surgery for oral cancer. Elderly patients undergoing free flap surgery between September 2019 and January 2021 were ... ...

Abstract	The aim of this study was to evaluate the safety of carbohydrate intake 2 hours before surgery in elderly patients undergoing free flap surgery for oral cancer. Elderly patients undergoing free flap surgery between September 2019 and January 2021 were randomly divided into control (n = 43) and intervention (n = 43) groups. Control group patients fasted for 6 hours and were forbidden from drinking water for 4 hours before surgery. Intervention group patients fasted for 6 hours and were forbidden from drinking after the oral administration of 5 ml/kg carbohydrate (≤400 ml) 2 hours before surgery. The main outcome measures were aspiration, fasting blood glucose level, insulin concentration, insulin resistance index (fasting at admission, prior to anaesthesia induction, immediately after surgery, and at 6 a.m. on postoperative days 1 and 2), and comfort before and after surgery. No aspiration occurred in any of the patients during anaesthesia. There were significant differences in fasting blood glucose, insulin concentration, and insulin resistance index between the control and intervention groups prior to anaesthesia induction, immediately after surgery, and on day 1 after surgery (P < 0.01). Thirst (P = 0.001) and hunger (P = 0.003) differed significantly between the two groups prior to anaesthesia induction. The intake of oral carbohydrate 2 hours before surgery was both safe and effective for elderly patients with oral cancer undergoing free flap surgery and could relieve the physiological stress response.
Mesh-Begriff(e)	Aged ; Blood Glucose ; Free Tissue Flaps ; Humans ; Insulin Resistance ; Insulins ; Mouth Neoplasms/surgery ; Preoperative Care
Chemische Substanzen	Blood Glucose ; Insulins
Sprache	Englisch
Erscheinungsdatum	2022-03-11
Erscheinungsland	Denmark
Dokumenttyp	Journal Article ; Randomized Controlled Trial
ZDB-ID	353721-3
ISSN	1399-0020 ; 0901-5027
ISSN (online)	1399-0020
ISSN	0901-5027
DOI	10.1016/j.ijom.2022.02.014
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: [Joint interpretation of 2017 edition of expert consensus on classification and clinical strategy of constipation and guide for surgical diagnosis and treatment of constipation (2017 edition)].

Wei, Y / Yang, X D / Lan, H B / Fan, W B / Wang, L N

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery

2020 Band 23, Heft 12, Seite(n) 1220–1222

Abstract: ... ...

Abstract	The
Mesh-Begriff(e)	Consensus ; Constipation/classification ; Constipation/diagnosis ; Constipation/psychology ; Constipation/therapy ; Humans ; Mental Disorders/complications ; Practice Guidelines as Topic
Sprache	Chinesisch
Erscheinungsdatum	2020-12-20
Erscheinungsland	China
Dokumenttyp	Journal Article
ISSN	1671-0274
ISSN	1671-0274
DOI	10.3760/cma.j.issn.441530-20200209-00043
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: [Epidemiology, diagnosis, treatment and control measures of trichinellosis in China: an overview].

Yang, X D / Xu, C Y / Wang, S Y / Gao, H Y / Liang, J B

Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control

2020 Band 32, Heft 5, Seite(n) 448–452

Abstract: Trichinellosis is a worldwide zoonotic parasitic disease, which may infect humans and a wide range of animals, including carnivores, herbivores and even birds. Humans get infections through ingestion of raw or semi-cooked meat or meat products containing ...

Abstract	Trichinellosis is a worldwide zoonotic parasitic disease, which may infect humans and a wide range of animals, including carnivores, herbivores and even birds. Humans get infections through ingestion of raw or semi-cooked meat or meat products containing live
Mesh-Begriff(e)	Animals ; China/epidemiology ; Disease Outbreaks/prevention & control ; Humans ; Meat/parasitology ; Trichinella ; Trichinellosis/diagnosis ; Trichinellosis/drug therapy ; Trichinellosis/epidemiology ; Zoonoses
Sprache	Chinesisch
Erscheinungsdatum	2020-11-11
Erscheinungsland	China
Dokumenttyp	Journal Article ; Review
ISSN	1005-6661
ISSN	1005-6661
DOI	10.16250/j.32.1374.2020251
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Molecular characteristics of MC1R gene in tile-grey plumage of domestic chicken

Zhang, L. Y. / Huang, M. Y. / Li, Y. / Yang, X. D. / Luo, Y. S. / Shi, X. W.

British Poultry Science. 2020 July 03, v. 61, no. 4 p.382-389

2020

Abstract: 1. Tile-grey plumage is a unique and rare feather type of local chicken breeds in China, but its genetic mechanism and corresponding genes remain unknown. 2. In order to identify the genetic basis and molecular characteristics of tile-grey plumage, this ... ...

Abstract	1. Tile-grey plumage is a unique and rare feather type of local chicken breeds in China, but its genetic mechanism and corresponding genes remain unknown. 2. In order to identify the genetic basis and molecular characteristics of tile-grey plumage, this experiment investigated variations of melanocortin 1 receptor (MC1R) gene in Yunnan Piao chickens with typical tile-grey plumage characteristics in contrast with three Yunnan local breeds as well as two standard breeds with different plumage colour, and analysed the association between genic variation and tile-grey plumage. 3. Through sequencing and comparison of the entire coding region of the MC1R gene, a total of 10 SNP loci were detected, of which eight were non-synonymous mutations that cause amino acid changes. The gene frequency and genotype frequency of the MC1R mutation sites in different breeds and different plumage colour groups revealed that C69T, T212C and A274G were significantly associated with tile-grey plumage. Eighteen haplotypes of the MC1R gene were constructed based on 10 nucleotide variations and eight amino acid variations. Haplotype distribution and the median joining network in breeds and plumage colour groups revealed a main haplotype (hap2) for tile-grey plumage. Hap2 is unique to the tile-grey feather of Piao chicken, and the individuals carrying this haplotype account for 62.96% of the whole tile-grey chicken. 4. The results of this study are of significance for further analysis of the molecular basis of tile-grey plumage and the selective breeding of tile-grey plumage.
Schlagwörter	alpha-melanocyte-stimulating hormone ; amino acids ; chickens ; color ; gene frequency ; genes ; haplotypes ; mutation ; plumage ; China ; Tile-grey plumage ; MC1R ; variation ; haplotype ; association
Sprache	Englisch
Erscheinungsverlauf	2020-0703
Umfang	p. 382-389.
Erscheinungsort	Taylor & Francis
Dokumenttyp	Artikel ; Online
ZDB-ID	956653-3
ISSN	1466-1799 ; 0007-1668
ISSN (online)	1466-1799
ISSN	0007-1668
DOI	10.1080/00071668.2020.1751804
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: Role of E3 ubiquitin ligases in insulin resistance.

Yang, X-D / Xiang, D-X / Yang, Y-Y

Diabetes, obesity & metabolism

2016 Band 18, Heft 8, Seite(n) 747–754

Abstract: E3 ubiquitin ligases are a large family of proteins that catalyse the ubiquitination of many proteins for degradation by the 26S proteasome. E3 ubiquitin ligases play pivotal roles in the process of insulin resistance and diabetes. In this review, we ... ...

Abstract	E3 ubiquitin ligases are a large family of proteins that catalyse the ubiquitination of many proteins for degradation by the 26S proteasome. E3 ubiquitin ligases play pivotal roles in the process of insulin resistance and diabetes. In this review, we summarize the currently available studies to analyse the potential role of E3 ubiquitin ligases in the development of insulin resistance. We propose two mechanisms by which E3 ubiquitin ligases can affect the process of insulin resistance. First, E3 ubiquitin ligases directly degrade the insulin receptor, insulin receptor substrate and other key insulin signalling molecules via the UPS. Second, E3 ubiquitin ligases indirectly regulate insulin signalling by regulating pro-inflammatory mediators that are involved in the regulation of insulin signalling molecules, such as tumour necrosis factor-α, interleukin (IL)-6, IL-4, IL-13, IL-1β, monocyte chemoattractant protein-1 and hypoxia-inducible factor 1α. Determining the mechanism by which E3 ubiquitin ligases affect the development of insulin resistance can identify a novel strategy to protect against insulin resistance and diabetes.
Mesh-Begriff(e)	Animals ; Chemokine CCL2/metabolism ; Cytokines/metabolism ; Diabetes Mellitus, Type 2/metabolism ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Inflammation ; Insulin Receptor Substrate Proteins/metabolism ; Insulin Resistance/physiology ; Interleukin-13/metabolism ; Interleukin-1beta/metabolism ; Interleukin-4/metabolism ; Interleukin-6/metabolism ; Proteasome Endopeptidase Complex/metabolism ; Receptor, Insulin/metabolism ; Signal Transduction ; Tumor Necrosis Factor-alpha/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination
Chemische Substanzen	Chemokine CCL2 ; Cytokines ; Hypoxia-Inducible Factor 1, alpha Subunit ; Insulin Receptor Substrate Proteins ; Interleukin-13 ; Interleukin-1beta ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Interleukin-4 (207137-56-2) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Receptor, Insulin (EC 2.7.10.1) ; Proteasome Endopeptidase Complex (EC 3.4.25.1) ; ATP dependent 26S protease (EC 3.4.99.-)
Sprache	Englisch
Erscheinungsdatum	2016-08
Erscheinungsland	England
Dokumenttyp	Journal Article ; Review
ZDB-ID	1454944-x
ISSN	1463-1326 ; 1462-8902
ISSN (online)	1463-1326
ISSN	1462-8902
DOI	10.1111/dom.12677
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Inhibition of autophagy by 3-MA promotes hypoxia-induced apoptosis in human colorectal cancer cells.

Dong, Y / Wu, Y / Zhao, G-L / Ye, Z-Y / Xing, C-G / Yang, X-D

European review for medical and pharmacological sciences

2019 Band 23, Heft 3, Seite(n) 1047–1054

Abstract: Objective: Cell autophagy reduces the sensitivity of cancer cells to therapeutic reagents in various types of human cancer. Therefore, the aim of our study was to use human colorectal cancer HCT116 cells to explore whether inhibition of autophagy by 3- ... ...

Abstract	Objective: Cell autophagy reduces the sensitivity of cancer cells to therapeutic reagents in various types of human cancer. Therefore, the aim of our study was to use human colorectal cancer HCT116 cells to explore whether inhibition of autophagy by 3-Methyladenine (3-MA, an autophagy inhibitor) is able to enhance hypoxia-induced apoptosis in vitro. Materials and methods: HCT116 cells were treated with 3-MA, hypoxia, or 3-MA plus hypoxia, and the autophagy, apoptosis and proliferation of the HCT116 cells were investigated. Western blot analysis was used to detect autophagy specificity protein microtubule-associated protein light chain 3 (LC3) expression. Effects on apoptosis were evaluated by using flow cytometry (JC-1 staining to measure mitochondrial membrane potential) and annexin V-propidium iodide (PI) staining. Results: The results showed that the treatment of HCT116 cells in vitro with hypoxia alone increased autophagy as well as apoptosis, whereas combination treatment with 3-MA and hypoxia markedly inhibited hypoxia-induced autophagy, but increased hypoxia-induced cell apoptosis. Conclusions: Autophagy might play a role as a self-defense mechanism in hypoxia-treated colon cancer cells, and its inhibition could be a promising strategy for the adjuvant chemotherapy of colon cancer.
Mesh-Begriff(e)	Adenine/analogs & derivatives ; Adenine/pharmacology ; Annexin A5/metabolism ; Apoptosis/drug effects ; Autophagy/drug effects ; Autophagy/physiology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/physiology ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Humans ; Hypoxia/physiopathology ; Membrane Potential, Mitochondrial/drug effects ; Microtubule-Associated Proteins/biosynthesis
Chemische Substanzen	Annexin A5 ; Microtubule-Associated Proteins ; 3-methyladenine (5142-23-4) ; Adenine (JAC85A2161)
Sprache	Englisch
Erscheinungsdatum	2019-02-19
Erscheinungsland	Italy
Dokumenttyp	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_201902_16992
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: [Effect of

Gao, H Y / Wan, C / Sun, F D / Wang, S Y / Chu, L / Yuan, Y / Wang, P / Yu, X Q / Liu, W Y / Dong, H F / Yang, X D

Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control

2022 Band 34, Heft 2, Seite(n) 158–162

Abstract: Objective: To investigate the protective effect of : Methods: Twenty-four BALB/c mice at ages of 8 to 10 weeks, each weighing approximately 20 g, were randomly divided into four groups, including groups A (blank control group), B (blank intervention ... ...

Abstract	Objective: To investigate the protective effect of Methods: Twenty-four BALB/c mice at ages of 8 to 10 weeks, each weighing approximately 20 g, were randomly divided into four groups, including groups A (blank control group), B (blank intervention group), C (AR model group) and D (AR+HCFP intervention group), with 6 mice in each group. On days 0, 2, 4, 6, 8, 10 and 12, mice in groups A, B, C and D were injected with 200 μL sterile phosphate buffered saline (PBS), 200 μL sterile PBS containing 20 μg HCFP, 200 μL sterile PBS containing 50 μg OVA and 5 mg Al(OH) Results: The mean behavioral score was significantly greater in Group C (6.83 ± 0.50) than in groups A (1.17 ± 0.52) and B (1.33 ± 0.52) ( Conclusions: E. granulosus
Mesh-Begriff(e)	Animals ; Cytokines ; Disease Models, Animal ; Echinococcosis ; Echinococcus ; Echinococcus granulosus ; Interleukin-10 ; Interleukin-4/adverse effects ; Interleukin-5/adverse effects ; Mice ; Mice, Inbred BALB C ; Ovalbumin/adverse effects ; Rhinitis, Allergic ; Transforming Growth Factor beta
Chemische Substanzen	Cytokines ; Interleukin-5 ; Transforming Growth Factor beta ; Interleukin-10 (130068-27-8) ; Interleukin-4 (207137-56-2) ; Ovalbumin (9006-59-1)
Sprache	Chinesisch
Erscheinungsdatum	2022-05-10
Erscheinungsland	China
Dokumenttyp	Journal Article
ISSN	1005-6661
ISSN	1005-6661
DOI	10.16250/j.32.1374.2021276
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: [Gene expression signature analysis of peripheral blood mononuclear cells from patients with for high altitude pulmonary hypertension and value for potential drug selection].

Wu, X H / Chen, Z R / He, Z Y / Dong, Y / Yang, Y / Zhao, Q Y / Yang, W / Wang, L Y / Fu, C J / Yang, X D / Liu, H

Zhonghua xin xue guan bing za zhi

2022 Band 50, Heft 6, Seite(n) 577–584

Abstract: Objective: ...

Abstract	Objective:
Mesh-Begriff(e)	Aged ; Altitude ; Altitude Sickness/genetics ; Case-Control Studies ; China ; Familial Primary Pulmonary Hypertension/genetics ; Humans ; Hydroxamic Acids/pharmacology ; Hydroxamic Acids/therapeutic use ; Hypertension, Pulmonary/drug therapy ; Hypertension, Pulmonary/genetics ; Inflammation ; Leukocytes, Mononuclear/metabolism ; Leukocytes, Mononuclear/pathology ; Male ; Middle Aged ; Transcription Factors ; Transcriptome/genetics ; Vorinostat/pharmacology ; Vorinostat/therapeutic use
Chemische Substanzen	Hydroxamic Acids ; Transcription Factors ; trichostatin A (3X2S926L3Z) ; Vorinostat (58IFB293JI)
Sprache	Chinesisch
Erscheinungsdatum	2022-06-15
Erscheinungsland	China
Dokumenttyp	Journal Article
ZDB-ID	603425-1
ISSN	0253-3758
ISSN	0253-3758
DOI	10.3760/cma.j.cn112148-20220328-00215
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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