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Article ; Online: Molecular basis of Gabija anti-phage supramolecular assemblies.

Yang, Xiao-Yuan / Shen, Zhangfei / Xie, Jiale / Greenwald, Jacelyn / Marathe, Ila / Lin, Qingpeng / Xie, Wen Jun / Wysocki, Vicki H / Fu, Tian-Min

Nature structural & molecular biology

2024

Abstract: As one of the most prevalent anti-phage defense systems in prokaryotes, Gabija consists of a Gabija protein A (GajA) and a Gabija protein B (GajB). The assembly and function of the Gabija system remain unclear. Here we present cryo-EM structures of ... ...

Abstract	As one of the most prevalent anti-phage defense systems in prokaryotes, Gabija consists of a Gabija protein A (GajA) and a Gabija protein B (GajB). The assembly and function of the Gabija system remain unclear. Here we present cryo-EM structures of Bacillus cereus GajA and GajAB complex, revealing tetrameric and octameric assemblies, respectively. In the center of the complex, GajA assembles into a tetramer, which recruits two sets of GajB dimer at opposite sides of the complex, resulting in a 4:4 GajAB supramolecular complex for anti-phage defense. Further biochemical analysis showed that GajA alone is sufficient to cut double-stranded DNA and plasmid DNA, which can be inhibited by ATP. Unexpectedly, the GajAB displays enhanced activity for plasmid DNA, suggesting a role of substrate selection by GajB. Together, our study defines a framework for understanding anti-phage immune defense by the GajAB complex.
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2126708-X
ISSN	1545-9985 ; 1545-9993
ISSN (online)	1545-9985
ISSN	1545-9993
DOI	10.1038/s41594-024-01283-w
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Article ; Online: Assembly-mediated activation of the SIR2-HerA supramolecular complex for anti-phage defense.

Shen, Zhangfei / Lin, Qingpeng / Yang, Xiao-Yuan / Fosuah, Elizabeth / Fu, Tian-Min

Molecular cell

2023 Volume 83, Issue 24, Page(s) 4586–4599.e5

Abstract: SIR2-HerA, a bacterial two-protein anti-phage defense system, induces bacterial death by depleting ... ...

Abstract	SIR2-HerA, a bacterial two-protein anti-phage defense system, induces bacterial death by depleting NAD
MeSH term(s)	Adenosine Triphosphatases/genetics ; Bacterial Proteins/genetics ; NAD ; Sirtuins/metabolism ; Escherichia coli/enzymology ; Escherichia coli/virology ; T-Phages ; Escherichia coli Proteins/metabolism
Chemical Substances	Adenosine Triphosphatases (EC 3.6.1.-) ; Bacterial Proteins ; NAD (0U46U6E8UK) ; Sirtuins (EC 3.5.1.-) ; Escherichia coli Proteins
Language	English
Publishing date	2023-12-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	1415236-8
ISSN	1097-4164 ; 1097-2765
ISSN (online)	1097-4164
ISSN	1097-2765
DOI	10.1016/j.molcel.2023.11.007
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Article ; Online: Oligomerization-mediated activation of a short prokaryotic Argonaute.

Shen, Zhangfei / Yang, Xiao-Yuan / Xia, Shiyu / Huang, Wei / Taylor, Derek J / Nakanishi, Kotaro / Fu, Tian-Min

Nature

2023 Volume 621, Issue 7977, Page(s) 154–161

Abstract: Although eukaryotic and long prokaryotic Argonaute proteins (pAgos) cleave nucleic acids, some short pAgos lack nuclease activity and hydrolyse NAD(P) ...

Abstract	Although eukaryotic and long prokaryotic Argonaute proteins (pAgos) cleave nucleic acids, some short pAgos lack nuclease activity and hydrolyse NAD(P)
MeSH term(s)	Apoproteins/chemistry ; Apoproteins/metabolism ; Argonaute Proteins/chemistry ; Argonaute Proteins/classification ; Argonaute Proteins/metabolism ; DNA/metabolism ; Enzyme Activation ; NAD/metabolism ; Prokaryotic Cells/metabolism ; RNA/metabolism
Chemical Substances	Apoproteins ; Argonaute Proteins ; DNA (9007-49-2) ; NAD (0U46U6E8UK) ; RNA (63231-63-0)
Language	English
Publishing date	2023-07-26
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-023-06456-z
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Article ; Online: Stapled transperineal rectovaginal fistula repair for low- and mid-level rectovaginal fistulas: A comparison study with rectal mucosal advancement flap repair.

Luo, Min-Yi / Chen, Wen-Ping / Chen, Hua-Xian / Yang, Xiao-Yuan / Wan, Xing-Yang / Xiao, Guo-Zhong / Zheng, Yi-Hui / Ren, Dong-Lin / Peng, Hui / Lin, Hong-Cheng

Asian journal of surgery

2024 Volume 47, Issue 4, Page(s) 1756–1762

Abstract: Background: As an innovative treatment, stapled transperineal rectovaginal fistula repair (STR) for rectovaginal fistula (RVF) has demonstrated effectiveness in preliminary reports. This study aims to compare STR with rectal mucosal advancement flap ... ...

Abstract	Background: As an innovative treatment, stapled transperineal rectovaginal fistula repair (STR) for rectovaginal fistula (RVF) has demonstrated effectiveness in preliminary reports. This study aims to compare STR with rectal mucosal advancement flap repair (RAF), a widely utilized surgical procedure, for the surgical outcome of the low- and mid-level RVF. Methods: In this retrospective cohort study, patients with low- and mid-level RVF who underwent STR or RAF were included from both the Sixth Affiliated Hospital of Sun Yat-sen University and Xi'an Daxing Hospital. Among the 99 total patients, 77 underwent STR and 22 underwent RAF. Patient demographics, operative data, and outcomes were collected and analyzed. Recurrence rate and associated risk factors were evaluated. Results: There were no statistically significant differences among patients in terms of clinical characteristics like age, BMI, aetiology, and fistula features. During the follow-up period of 20 months (interquartile range 3.0-41.8 months), a total of 28 patients relapsed, with a significantly lower recurrence rate in the STR group (20.8 %) than in the RAF group (54.6 %) (P = 0.005). In the multivariate Cox analysis, STR was an independent protective factor against recurrence (HR: 0.37, 95%CI: 0.17-0.79, P = 0.01). Logistic regression indicated that there was no statistically significant difference between these two procedures in terms of surgical complications (OR: 0.53, 95%CI: 0.19-1.48, P = 0.23). Conclusion: For low- and mid-level RVF, STR may be an alternative option for treatment modality that offers a lower recurrence rate, without observed disadvantage in terms of surgical complication rates.
MeSH term(s)	Female ; Humans ; Rectovaginal Fistula/etiology ; Rectovaginal Fistula/surgery ; Retrospective Studies ; Rectum/surgery ; Surgical Flaps ; Risk Factors ; Treatment Outcome
Language	English
Publishing date	2024-01-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2023.12.186
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Article ; Online: Fully automated simultaneous peripheral arteriovenous exchange transfusion not seen to aggravate brain function and the disorder of the internal environment in neonates with severe hyperbilirubinemia.

Lu, Wei-Neng / Yang, Xiao-Yuan / Ning, Shu-Yao / Chen, Zhuang-Gui / Pan, Si-Nian

Pediatrics and neonatology

2021 Volume 62, Issue 3, Page(s) 312–320

Abstract: Background: The acute changes in brain function in newborn infants undergoing ET remain unclear. This study aimed to determine whether fully automated simultaneous peripheral arteriovenous ET would influence the brain function.: Methods: A ... ...

Abstract	Background: The acute changes in brain function in newborn infants undergoing ET remain unclear. This study aimed to determine whether fully automated simultaneous peripheral arteriovenous ET would influence the brain function. Methods: A retrospective analysis was conducted on the clinical data of 39 neonates with hyperbilirubinemia who received ET. Seventeen patients were in the encephalopathy group, and the other 22 patients were in the non-encephalopathy group. Changes in amplitude-integrated electroencephalogram (aEEG) during ETs were analyzed, including background activities, sleep-wake cycling (SWC), and seizures. Before and after the ET, routine blood test parameters, electrolytes, blood glucose, and blood gas parameters were measured. Results: After ETs, there were no significant changes in the levels of pH, PaO Conclusion: Fully automated simultaneous peripheral arteriovenous ET is safe and efficient without significant influence on the disorder of the internal environment and electroencephalographic activities after ET in neonates. However, background activities are more significantly depressed in infants of bilirubin encephalopathy than infants of non-encephalopathy during ET.
MeSH term(s)	Brain ; Electroencephalography ; Exchange Transfusion, Whole Blood ; Humans ; Hyperbilirubinemia, Neonatal/therapy ; Infant, Newborn ; Retrospective Studies
Language	English
Publishing date	2021-02-19
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2441816-X
ISSN	2212-1692 ; 1875-9572
ISSN (online)	2212-1692
ISSN	1875-9572
DOI	10.1016/j.pedneo.2021.02.003
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Article ; Online: PtuA and PtuB assemble into an inflammasome-like oligomer for anti-phage defense.

Li, Yuanyuan / Shen, Zhangfei / Zhang, Mengyuan / Yang, Xiao-Yuan / Cleary, Sean P / Xie, Jiale / Marathe, Ila A / Kostelic, Marius / Greenwald, Jacelyn / Rish, Anthony D / Wysocki, Vicki H / Chen, Chong / Chen, Qiang / Fu, Tian-Min / Yu, Yamei

Nature structural & molecular biology

2024 Volume 31, Issue 3, Page(s) 413–423

Abstract: Escherichia coli Septu system, an anti-phage defense system, comprises two components: PtuA and PtuB. PtuA contains an ATPase domain, while PtuB is predicted to function as a nuclease. Here we show that PtuA and PtuB form a stable complex with a 6:2 ... ...

Abstract	Escherichia coli Septu system, an anti-phage defense system, comprises two components: PtuA and PtuB. PtuA contains an ATPase domain, while PtuB is predicted to function as a nuclease. Here we show that PtuA and PtuB form a stable complex with a 6:2 stoichiometry. Cryo-electron microscopy structure of PtuAB reveals a distinctive horseshoe-like configuration. PtuA adopts a hexameric arrangement, organized as an asymmetric trimer of dimers, contrasting the ring-like structure by other ATPases. Notably, the three pairs of PtuA dimers assume distinct conformations and fulfill unique roles in recruiting PtuB. Our functional assays have further illuminated the importance of the oligomeric assembly of PtuAB in anti-phage defense. Moreover, we have uncovered that ATP molecules can directly bind to PtuA and inhibit the activities of PtuAB. Together, the assembly and function of the Septu system shed light on understanding other ATPase-containing systems in bacterial immunity.
MeSH term(s)	Inflammasomes ; Cryoelectron Microscopy ; Bacteriophages/metabolism ; Adenosine Triphosphatases/metabolism ; Escherichia coli/metabolism
Chemical Substances	Inflammasomes ; Adenosine Triphosphatases (EC 3.6.1.-)
Language	English
Publishing date	2024-01-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2126708-X
ISSN	1545-9985 ; 1545-9993
ISSN (online)	1545-9985
ISSN	1545-9993
DOI	10.1038/s41594-023-01172-8
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Book ; Online: Fully Homomorphic Encryption Encapsulated Difference Expansion for Reversible Data hiding in Encrypted Domain

Ke, Yan / Zhang, Min-qing / Liu, Jia / Su, Ting-ting / Yang, Xiao-yuan

2019

Abstract: This paper proposes a fully homomorphic encryption encapsulated difference expansion (FHEE-DE) scheme for reversible data hiding in encrypted domain (RDH-ED). In the proposed scheme, we use key-switching and bootstrapping techniques to control the ... ...

Abstract	This paper proposes a fully homomorphic encryption encapsulated difference expansion (FHEE-DE) scheme for reversible data hiding in encrypted domain (RDH-ED). In the proposed scheme, we use key-switching and bootstrapping techniques to control the ciphertext extension and decryption failure. To realize the data extraction directly from the encrypted domain without the private key, a key-switching based least-significant-bit (KS-LSB) data hiding method has been designed. In application, the user first encrypts the plaintext and uploads ciphertext to the server. Then the server performs data hiding by FHEE-DE and KS-LSB to obtain the marked ciphertext. Additional data can be extracted directly from the marked ciphertext by the server without the private key. The user can decrypt the marked ciphertext to obtain the marked plaintext. Then additional data or plaintext can be obtained from the marked plaintext by using the standard DE extraction or recovery. A fidelity constraint of DE is introduced to reduce the distortion of the marked plaintext. FHEE-DE enables the server to implement FHEE-DE recovery or extraction on the marked ciphertext, which returns the ciphertext of original plaintext or additional data to the user. In addition, we simplified the homomorphic operations of the proposed universal FHEE-DE to obtain an efficient version. The Experimental results demonstrate that the embedding capacity, fidelity, and reversibility of the proposed scheme are superior to existing RDH-ED methods, and fully separability is achieved without reducing the security of encryption.
Keywords	Computer Science - Cryptography and Security
Publishing date	2019-04-29
Publishing country	us
Document type	Book ; Online
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Book ; Online: Steganography Security

Ke, Yan / Liu, Jia / Zhang, Min-qing / Su, Ting-ting / Yang, Xiao-yuan

Principle and Practice

2018

Abstract: This paper focuses on several theoretical issues and principles in steganography security, and defines four security levels by analyzing the corresponding algorithm instances. In the theoretical analysis, we discuss the differences between steganography ... ...

Abstract	This paper focuses on several theoretical issues and principles in steganography security, and defines four security levels by analyzing the corresponding algorithm instances. In the theoretical analysis, we discuss the differences between steganography security and watermarking security. The two necessary conditions for the steganography security are obtained. Under the current technology situation, we then analyze the indistinguishability of the cover and stego-cover, and consider that the steganography security should rely on the key secrecy with algorithms open. By specifying the role of key in steganography, the necessary conditions for a secure steganography algorithm in theory are formally presented. When analyzing the security instances, we have classified the steganalysis attacks according to their variable access to the steganography system, and then defined the four security levels. The higher level security one has, the higher level attacks one can resist. We have also presented algorithm instances based on current technical conditions, and analyzed their data hiding process, security level, and practice requirements.
Keywords	Computer Science - Multimedia ; Computer Science - Cryptography and Security
Subject code	303
Publishing date	2018-06-10
Publishing country	us
Document type	Book ; Online
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Article ; Online: Sleep Duration, Bedtime, and Myopia Progression in a 4-Year Follow-up of Chinese Children: The Anyang Childhood Eye Study.

Wei, Shi-Fei / Li, Shi-Ming / Liu, Luoru / Li, He / Kang, Meng-Tian / Sun, Yun-Yun / Wang, Yi-Peng / Yang, Xiao-Yuan / Wang, Ningli

Investigative ophthalmology & visual science

2020 Volume 61, Issue 3, Page(s) 37

Abstract: Purpose: To investigate the relationship between sleep duration and bedtime with myopia progression and axial elongation during a 4-year follow-up in primary school children.: Methods: This study included 1887 children (aged 7.09 ± 0.41 years) who ... ...

Abstract	Purpose: To investigate the relationship between sleep duration and bedtime with myopia progression and axial elongation during a 4-year follow-up in primary school children. Methods: This study included 1887 children (aged 7.09 ± 0.41 years) who had cycloplegic refractions data at baseline and a fourth visit and 2209 children (aged 7.10 ± 0.41 years) for axial length. All children underwent comprehensive ophthalmologic examinations, including cycloplegic refraction and ocular biometry, and standardized questionnaires, including average night-time sleep duration (h/d) and bedtime (time to bed). Myopia was defined as spherical equivalent < -0.5 diopters. Results: At the last follow-up, the mean myopia progression and axial elongation for all children were -1.89 ± 1.28 diopters and 1.22 ± 0.57 mm. After stratifying the sleep duration into tertile groups, myopia progression and axial elongation were slower in children with highest sleep duration tertile (P = 0.04 and P =0.014) in girls but not in boys, compared with the middle sleep duration tertile. However, after adjusting for potential confounders, no significant association was found for sleep duration with myopia progression and axial elongation for the children (P = 0.255 and P = 0.068), and the association with axial elongation was only of borderline significance in girls (P = 0.045). The bedtime was not associated with myopia progression and axial elongation in the regression analyses (P = 0.538; P = 0.801). Conclusions: These results show that there was no significant association between sleep duration and bedtime with myopia progression and axial elongation among children. The findings in girls might be related to the earlier onset of puberty.
MeSH term(s)	Asian Continental Ancestry Group/ethnology ; Axial Length, Eye/pathology ; Child ; Child, Preschool ; China/epidemiology ; Disease Progression ; Female ; Follow-Up Studies ; Humans ; Male ; Myopia/diagnosis ; Myopia/ethnology ; Myopia/physiopathology ; Refraction, Ocular/physiology ; Risk Factors ; Sleep/physiology ; Surveys and Questionnaires
Language	English
Publishing date	2020-02-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	391794-0
ISSN	1552-5783 ; 0146-0404
ISSN (online)	1552-5783
ISSN	0146-0404
DOI	10.1167/iovs.61.3.37
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Article: Cost efficiency of electric grid utilities in China

Li, Hong-Zhou / Kopsakangas-Savolainen, Maria / Tian, Zhen-Zhen / Wang, Jian-Lin / Xiao, Xing-Zhi / Yang, Xiao-Yuan

Energy economics Vol. 55 , p. 272-283

a comparison of estimates from SFA–MLE, SFA–Bayes and StoNED–CNLS

2016 Volume 55, Page(s) 272–283

Author's details	Hong-Zhou Li, Maria Kopsakangas-Savolainen, Xing-Zhi Xiao, Zhen-Zhen Tian, Xiao-Yuan Yang, Jian-Lin Wang
Keywords	Electric grid utilities in China ; Cost efficiency ; SFA-MLESFA-Bayes ; StoNED-CNLS
Language	English
Publisher	Elsevier
Publishing place	Amsterdam
Document type	Article
ZDB-ID	795279x ; 2000893-4
ISSN	0140-9883
ISSN	0140-9883
Database	ECONomics Information System

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