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Article: [The holistic assessment and individualized precision therapy for chronic rhinosinusitis with nasal polyps].

Yang, Y C / Zhang, Y

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery

2022 Volume 57, Issue 2, Page(s) 217–221

MeSH term(s)	Chronic Disease ; Humans ; Nasal Polyps/therapy ; Rhinitis/therapy ; Sinusitis/therapy
Language	Chinese
Publishing date	2022-02-23
Publishing country	China
Document type	Journal Article
ZDB-ID	2195655-8
ISSN	1673-0860
ISSN	1673-0860
DOI	10.3760/cma.j.cn115330-20210707-00435
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Zs.A 3733: Show issues

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Article: [Progress in application of aspirin desensitization and maintenance therapy in aspirin-exacerbated respiratory disease].

Zhao, Q Y / Xu, X Q / Shen, Y / Yang, Y C / Hong, S L / Ke, X

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases

2024 Volume 47, Issue 3, Page(s) 286–291

Abstract: Aspirin-exacerbated respiratory disease (AERD) is a clinical syndrome characterized by chronic rhinosinusitis with nasal polyps, asthma and the development of significant airway symptoms following the ingestion of aspirin and other nonsteroid anti- ... ...

Abstract	Aspirin-exacerbated respiratory disease (AERD) is a clinical syndrome characterized by chronic rhinosinusitis with nasal polyps, asthma and the development of significant airway symptoms following the ingestion of aspirin and other nonsteroid anti-inflammatory drugs (NSAIDs). At present, aspirin challenge is the gold standard for diagnosis. Aspirin desensitization and aspirin therapy after desensitization (ATAD) is one of the classical therapies. This paper described the application of aspirin desensitization and ATAD in AERD and provided the reference for the comprehensive treatment of AERD.
MeSH term(s)	Humans ; Aspirin/adverse effects ; Asthma ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Syndrome
Chemical Substances	Aspirin (R16CO5Y76E) ; Anti-Inflammatory Agents, Non-Steroidal
Language	Chinese
Publishing date	2024-03-06
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1027965-9
ISSN	1001-0939
ISSN	1001-0939
DOI	10.3760/cma.j.cn112147-20230803-00043
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Zs.B 2465: Show issues

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Article: Investigating uncertainties in human adaptation and their impacts on water scarcity in the Colorado river Basin, United States

Hung, Fengwei / Son, Kyongho / Yang, Y. C. Ethan

Journal of hydrology. 2022 Sept., v. 612

2022

Abstract: The Colorado River Basin (CRB) supports the water supply for seven states and forty million people in the Western United States (US) and has been suffering an extensive drought for more than two decades. As climate change continues to reshape water ... ...

Abstract	The Colorado River Basin (CRB) supports the water supply for seven states and forty million people in the Western United States (US) and has been suffering an extensive drought for more than two decades. As climate change continues to reshape water resources distribution in the CRB, its impact can differ in intensity and location, resulting in variations in human adaptation behaviors. The feedback from human systems in response to the environmental changes and the associated uncertainty is critical to water resources management, especially for water-stressed basins. This paper investigates how human adaptation affects water scarcity uncertainty in the CRB and highlights the uncertainties in human behavior modeling. Our focus is on agricultural water consumption, as approximately 80% of the water consumption in the CRB is used in agriculture. We adopted a coupled agent-based and water resources modeling approach for exploring human-water system dynamics, in which an agent is a human behavior model that simulates a farmer’s water consumption decisions. We examined uncertainties at the system, agent, and parameter levels through uncertainty, clustering, and sensitivity analyses. The uncertainty analysis results suggest that the CRB water system may experience 13 to 30 years of water shortage during the 2019–2060 simulation period, depending on the paths of farmers’ adaptation. The clustering analysis identified three decision-making classes: bold, prudent, and forward-looking, and quantified the probabilities of an agent belonging to each class. The sensitivity analysis results indicated agents whose decision-making models require further investigation and the parameters with the higher uncertainty reduction potentials. By conducting numerical experiments with the coupled model, this paper presents quantitative and qualitative information about farmers’ adaptation, water scarcity uncertainties, and future research directions for improving human behavior modeling.
Keywords	climate change ; decision making ; drought ; farmers ; human behavior ; humans ; hydrology ; models ; uncertainty ; uncertainty analysis ; water shortages ; water stress ; watersheds ; Colorado River
Language	English
Dates of publication	2022-09
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1473173-3
ISSN	1879-2707 ; 0022-1694
ISSN (online)	1879-2707
ISSN	0022-1694
DOI	10.1016/j.jhydrol.2022.128015
Database	NAL-Catalogue (AGRICOLA)

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Article: [Promoting the colorectal surgery in virtue of new theories and techniques].

Zhang, Z T / Yang, Y C

Zhonghua wai ke za zhi [Chinese journal of surgery

2020 Volume 58, Issue 8, Page(s) 586–588

Abstract: Since the 21st century, with the development of minimally invasive surgical technology, the update of comprehensive treatment strategies and the progress of clinical research, colorectal surgery has developed rapidly. However, in recent years, some ... ...

Abstract	Since the 21st century, with the development of minimally invasive surgical technology, the update of comprehensive treatment strategies and the progress of clinical research, colorectal surgery has developed rapidly. However, in recent years, some disputable issues still exist in colorectal surgery, such as transanal total mesorectal excision, pelvic cavity lateral lymph node dissection, the "wait and observe" strategy for clinical complete remission of rectal cancer after neoadjuvant therapy, and robotic colorectal surgical operation. In addition, the application of three dimensions imaging, 4K resolution, 5th generation wireless systems, virtual reality, artificial intelligence and other new techniques may provide extensive space and new opportunity for the development of colorectal surgery. The therapic outcome could be optimized by more relevant clinical research and evidence, which contribute to the standardization of surgical treatment of colorectal cancer.
MeSH term(s)	Artificial Intelligence ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/surgery ; Colorectal Neoplasms/therapy ; Colorectal Surgery/trends ; Combined Modality Therapy/trends ; Digestive System Surgical Procedures/methods ; Digestive System Surgical Procedures/trends ; Health Promotion ; Humans ; Imaging, Three-Dimensional ; Inventions ; Lymph Node Excision ; Minimally Invasive Surgical Procedures/methods ; Minimally Invasive Surgical Procedures/trends ; Rectal Neoplasms/diagnosis ; Rectal Neoplasms/surgery ; Rectal Neoplasms/therapy ; Robotic Surgical Procedures/trends ; Watchful Waiting
Language	Chinese
Publishing date	2020-07-29
Publishing country	China
Document type	Journal Article
ZDB-ID	604573-x
ISSN	0529-5815
ISSN	0529-5815
DOI	10.3760/cma.j.cn112139-20200521-00404
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Zs.B 2469: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 218: Show issues

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Article ; Online: Pay-for-practice or Pay-for-performance? A coupled agent-based evaluation tool for assessing sediment management incentive policies

Lin, Chung-Yi / Yang, Y.C. Ethan / Kumar Chaudhary, Anil

Journal of Hydrology. 2023 Sept., v. 624 p.129959-

2023

Abstract: Cost-shared programs have been applied to incentivize the adoption of agricultural best management practices (BMPs) to address the long-standing water quality issue in the Chesapeake Bay watershed, US. However, the business-as-usual (BAU) incentive ... ...

Abstract	Cost-shared programs have been applied to incentivize the adoption of agricultural best management practices (BMPs) to address the long-standing water quality issue in the Chesapeake Bay watershed, US. However, the business-as-usual (BAU) incentive program (i.e., pay-for-practice, paying cost share for implementing BMPs) is likely to miss the Total Maximum Daily Load target to reduce 20% of the total suspended sediment (TSS) in 2010 by 2025. Some field experiments indicate that pay-by-performance (PFP; paying lower cost share but with additional bonus payment per unit sediment reduction) can better motivate community involvement leading to greater water quality control outcomes. However, the effectiveness of different incentive policies is still unclear at a basin scale. We propose a coupled agent-based modeling tool to quantify the performance of different incentive policies. The tool considers farmers’ (i.e., agents’) BMP adoption dynamics affected by the social norm and the potential bonus payment. Specifically, we compare individual-based PFP (PFPᵢ) and group-based PFP (PFPg) with BAU. Results of our proposed model applied to the selected study area, the Susquehanna River Basin, Chesapeake Bay’s largest tributary watershed, suggest that PFP can achieve higher TSS reduction with less cost. PFPg shows the best basin-wide TSS reduction associated with the least uncertainty among all tested policies. Also, the performance of PFPg is less impacted by the change in the bonus payment compared to PFPᵢ attributed to farmers’ collaboration efforts. Potentially, the proposed policy evaluation tool can better inform an achievable target with policy suggestions in assistance with social studies (e.g., surveys and behavioral experiments).
Keywords	basins ; community service ; models ; policy analysis ; quality control ; sediments ; suspended sediment ; total maximum daily load ; uncertainty ; water quality ; watersheds ; Chesapeake Bay ; Water quality management ; Chesapeake Bay Watershed ; Sediment modeling ; Cost-share program ; Behavioral sensitivity analysis ; Best management practice
Language	English
Dates of publication	2023-09
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	1473173-3
ISSN	1879-2707 ; 0022-1694
ISSN (online)	1879-2707
ISSN	0022-1694
DOI	10.1016/j.jhydrol.2023.129959
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: 17β-estradiol regulates adenosine triphosphate-binding cassette transporters A1 expression via estrogen receptor A to increase macrophage cholesterol efflux.

Bao, Z / Liu, Z-Q / He, P-Y / Adali, J / Yang, Y-C / Wulasihan, M

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society

2023 Volume 74, Issue 5

Abstract: The liver is the focus of research on the effects of estrogen on cholesterol metabolism. Few studies have investigated the effects of estrogen on macrophages despite the significance of cells in atherosclerosis. The purpose of this study is to examine ... ...

Abstract	The liver is the focus of research on the effects of estrogen on cholesterol metabolism. Few studies have investigated the effects of estrogen on macrophages despite the significance of cells in atherosclerosis. The purpose of this study is to examine the effect of estrogen on macrophage cholesterol efflux. Macrophage cholesterol efflux, oil red O staining, RT-qPCR, Western blotting analyses were used to determine cholesterol metabolize and the expressions of adenosine triphosphate (ATP)-binding cassette transporter G1 (ABCG1) and ATP-binding cassette transporter A1 (ABCA1) in J774A.1 cells, and the effect of these treatments was compared to without adding 17β-estradiol (E2). Gain and loss of estrogen receptor alpha (ERα), liver X receptor α (LXRα) were conducted to study interactions between E2, ERα, LXRα and ABCA. Finally, in mice, we validate the relationship between ERα and ABCA1. E2 increases cholesterol efflux from macrophages and decreases the formation of lipid droplets and positively regulates the expression of ABCA1. This suggests that estrogen receptors (ERs) directly regulate ABCA1 translation. We suppressed ERα, which decreased the mRNA and protein expression of ABCA1. At the mRNA level, E2 treatment could partially counteract these phenomena, but not at the protein level. ABCA1 expression decreased after LXRα was inhibited. This suggests that ABCA1 translation is directly regulated by ERα. In the ovariectomized mouse model of ABCA1 protein expression was significantly reduced in the peritoneal macrophages of the ovariectomy (OVX) group. ABCA1 protein expression was greater in the E2+OVX group than in the OVX group. E2 contributes to the positive regulation of ABCA1 expression and promotes cholesterol efflux in macrophages by binding to ERα. The effect is independent of ABCA1 transcription regulation by LXRα.
MeSH term(s)	Female ; Animals ; Mice ; ATP Binding Cassette Transporter 1/genetics ; ATP Binding Cassette Transporter 1/metabolism ; Receptors, Estrogen/metabolism ; Estrogen Receptor alpha/genetics ; Estrogen Receptor alpha/metabolism ; Macrophages ; Cholesterol/metabolism ; Liver X Receptors/metabolism ; Estradiol/pharmacology ; Estrogens/metabolism ; RNA, Messenger/metabolism
Chemical Substances	ATP Binding Cassette Transporter 1 ; Receptors, Estrogen ; Estrogen Receptor alpha ; Cholesterol (97C5T2UQ7J) ; Liver X Receptors ; Estradiol (4TI98Z838E) ; Estrogens ; RNA, Messenger
Language	English
Publishing date	2023-12-06
Publishing country	Poland
Document type	Journal Article
ZDB-ID	1125221-2
ISSN	1899-1505 ; 0867-5910 ; 0044-6033
ISSN (online)	1899-1505
ISSN	0867-5910 ; 0044-6033
DOI	10.26402/jpp.2023.5.05
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Article: [The prevention and treatment of severe adverse reactions to specific subcutaneous immunotherapy for allergic rhinitis].

Zheng, B W / Shen, Y / Guan, D Y / Gu, Y / Li, C X / Yang, Y C

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery

2023 Volume 58, Issue 9, Page(s) 941–944

MeSH term(s)	Humans ; Immunotherapy ; Rhinitis, Allergic/therapy
Language	Chinese
Publishing date	2023-07-26
Publishing country	China
Document type	Journal Article
ZDB-ID	2195655-8
ISSN	1673-0860
ISSN	1673-0860
DOI	10.3760/cma.j.cn115330-20230403-00153
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Zs.A 3733: Show issues

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Article: Assessing Adaptive Irrigation Impacts on Water Scarcity in Nonstationary Environments—A Multi‐Agent Reinforcement Learning Approach

Hung, Fengwei / Yang, Y. C. Ethan

Water resources research. 2021 Sept., v. 57, no. 9

2021

Abstract: One major challenge in water resource management is to balance the uncertain and nonstationary water demands and supplies caused by the changing anthropogenic and hydroclimate conditions. To address this issue, we developed a reinforcement learning agent‐ ...

Abstract	One major challenge in water resource management is to balance the uncertain and nonstationary water demands and supplies caused by the changing anthropogenic and hydroclimate conditions. To address this issue, we developed a reinforcement learning agent‐based modeling (RL‐ABM) framework where agents (agriculture water users) are able to learn and adjust water demands based on their interactions with the water systems. The intelligent agents are created by a reinforcement learning algorithm adapted from the Q‐learning algorithm. We illustrated this framework in a case study where the RL‐ABM is two‐way coupled with the Colorado River Simulation System (CRSS), a long‐term planning model used for the administration of the Colorado River Basin, for assessing agriculture water uses impacts on water scarcity. Seventy‐eight intelligent agents are simulated, which can be grouped into three categories based on their parameter values: the “aggressive” (swift actions; low regrets), the “forward‐looking conservative” (mild actions; high regrets; fast learning), and the “myopic conservative” (mild actions; median regrets; slow learning). The ABM‐CRSS results showed that the major reservoirs in the Upper Colorado Basin might experience more frequent water shortages due to the increasing water uses compared to the original CRSS results. If the drought continues, the case study also demonstrates that agents can learn and adjust their demands.
Keywords	algorithms ; basins ; case studies ; drought ; irrigation ; models ; research ; water ; water management ; water shortages ; watersheds ; Colorado ; Colorado River
Language	English
Dates of publication	2021-09
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	5564-5
ISSN	1944-7973 ; 0043-1397
ISSN (online)	1944-7973
ISSN	0043-1397
DOI	10.1029/2020WR029262
Database	NAL-Catalogue (AGRICOLA)

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Article: [Surgical treatment of cronic rhinosinusitis with nasal polyps].

Yang, Y C / Zou, C

Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery

2018 Volume 32, Issue 5, Page(s) 328–331

Language	Chinese
Publishing date	2018-05-25
Publishing country	China
Document type	Journal Article
ISSN	1001-1781
ISSN	1001-1781
DOI	10.13201/j.issn.1001-1781.2018.05.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: An investigation of coupled natural human systems using a two-way coupled agent-based modeling framework

Lin, Chung-Yi / Yang, Y.C. Ethan / Malek, Keyvan / Adam, Jennifer C.

Environmental modelling & software. 2022 June 20,

2022

Abstract: Improving the understanding of coupled natural human systems (CNHS) can better inform environmental policymaking. We investigated the co-evolution (i.e., bidirectional interactions) issues in CNHS via two-way coupling RiverWare (RW; a river-reservoir ... ...

Abstract	Improving the understanding of coupled natural human systems (CNHS) can better inform environmental policymaking. We investigated the co-evolution (i.e., bidirectional interactions) issues in CNHS via two-way coupling RiverWare (RW; a river-reservoir routing model) with agent-based models (ABMs, human decision models) in the Yakima River Basin in Washington, US. Results show that coupled models can better capture the historical irrigation diversion (human) and streamflow (nature) dynamics. We further demonstrated the effect of social norms (i.e., the influence of neighbors) among farmers and tested a “water reallocation” scenario to evaluate the influence of water policies on irrigation diversion behaviors. Detailed model structure and parameter uncertainty analysis are suggested to further quantify the benefit of CNHS models in multi-level water resources governance.
Keywords	coevolution ; computer software ; governance ; humans ; irrigation ; parameter uncertainty ; stream flow ; uncertainty analysis ; watersheds
Language	English
Dates of publication	2022-0620
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ISSN	1364-8152
DOI	10.1016/j.envsoft.2022.105451
Database	NAL-Catalogue (AGRICOLA)

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