Article: [Occurrence and recurrence of hepatitis C-related hepatocellular carcinoma after direct antiviral treatment].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology
2022 Volume 30, Issue 1, Page(s) 103–106
Abstract: Hepatitis C virus (HCV) RNA can be cleared from the blood circulation by direct antiviral treatment to achieve sustained virologic response (SVR). Studies have shown that SVR after direct antiviral therapy can reduce the incidence of hepatocellular ... ...
Abstract | Hepatitis C virus (HCV) RNA can be cleared from the blood circulation by direct antiviral treatment to achieve sustained virologic response (SVR). Studies have shown that SVR after direct antiviral therapy can reduce the incidence of hepatocellular carcinoma; however, monitoring for hepatocellular carcinoma is still needed. This review briefly summarizes and discusses the existing studies on the possible causes of hepatitis C secondary to HCC after antiviral therapy, which is mainly divided into epigenetic alterations and abnormal DNA methylation, HCV-related cirrhosis and abnormal DNA amplification, HBV reactivation, several aspects of occult HCV infection, and the effect of direct antiviral treatment on hepatocellular carcinoma recurrence. In few cases, direct antiviral treatment cannot completely prevent the occurrence and recurrence of hepatitis C-related hepatocellular carcinoma. Therefore, its mechanism needs to be studied and explored, and clinicians should also approach it with caution. |
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Language | Chinese |
Publishing date | 2022-02-14 |
Publishing country | China |
Document type | English Abstract ; Journal Article |
ISSN | 1007-3418 |
ISSN | 1007-3418 |
DOI | 10.3760/cma.j.cn501113-20210119-00032 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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