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Article: [Clinicopathological analysis of 4 cases of lung cancer with concomitant EGFR mutation and ROS1 fusion].

Yao, M H / Yang, Y H

Zhonghua bing li xue za zhi = Chinese journal of pathology

2023 Volume 52, Issue 6, Page(s) 615–617

MeSH term(s)	Humans ; Protein-Tyrosine Kinases/genetics ; Proto-Oncogene Proteins/genetics ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Mutation ; ErbB Receptors/genetics ; Oncogene Proteins, Fusion/genetics ; Gene Rearrangement
Chemical Substances	Protein-Tyrosine Kinases (EC 2.7.10.1) ; Proto-Oncogene Proteins ; ErbB Receptors (EC 2.7.10.1) ; Oncogene Proteins, Fusion ; ROS1 protein, human (EC 2.7.10.1) ; EGFR protein, human (EC 2.7.10.1)
Language	Chinese
Publishing date	2023-06-01
Publishing country	China
Document type	Journal Article
ZDB-ID	784533-9
ISSN	0529-5807
ISSN	0529-5807
DOI	10.3760/cma.j.cn112151-20221031-00903
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Article: [Atypical adenomyoepitheloma of the breast: report of a case].

Ye, Z T / Yang, Y H / Zheng, Q L

Zhonghua bing li xue za zhi = Chinese journal of pathology

2023 Volume 52, Issue 5, Page(s) 521–523

MeSH term(s)	Humans ; Female ; Breast/pathology ; Hyperplasia/pathology ; Breast Neoplasms/surgery ; Breast Neoplasms/pathology
Language	Chinese
Publishing date	2023-04-28
Publishing country	China
Document type	Case Reports ; Journal Article
ZDB-ID	784533-9
ISSN	0529-5807
ISSN	0529-5807
DOI	10.3760/cma.j.cn112151-20230111-00027
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Article: [Strengthening the construction of standardized system to enhance the standard diagnosis, treatment and comprehensive management of pulmonary hypertension in China].

Zhai, Z G / Yang, Y H / Wang, C

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases

2023 Volume 46, Issue 6, Page(s) 553–557

Abstract: In recent years, there has been rapid progress in the field of pulmonary hypertension (PH). With the deeper understanding of the pathogenesis of PH, the increase of evidence-based medical evidence, the continuous updating of PH clinical classification, ... ...

Abstract	In recent years, there has been rapid progress in the field of pulmonary hypertension (PH). With the deeper understanding of the pathogenesis of PH, the increase of evidence-based medical evidence, the continuous updating of PH clinical classification, the hemodynamic diagnostic boundaries, and the emergence of new targeted drugs and interventions, the guidelines are constantly being updated. It brings new challenges to the standard diagnosis, treatment and comprehensive management of PH in China. Compared with the world, there are still many problems in the field of PH in China. The heterogeneity of PH causes the complexity of the disease and the difficulty of clinical management, and the early identification and diagnosis of pH face great challenges. Individualized and precise treatment needs to be further optimized, and standardized diagnosis and treatment strategies need to be popularized and promoted. In recent years, rapid progress has been made in the field of PH, including its pathogenesis, diagnostic thresholds, classification and comprehensive treatment methods, prompting an update of the guidelines, which brings a new level of standardized diagnosis and comprehensive management of PH in China. This guideline brings new challenges to the standardized diagnosis and treatment and comprehensive management of PH in China. Here, we discussed in depth the current situation of diagnosis and treatment in the field of PH, as well as the development of a standardized system for PH in China.
MeSH term(s)	Humans ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/therapy ; Hypertension, Pulmonary/etiology ; China ; Hemodynamics
Language	Chinese
Publishing date	2023-06-06
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1027965-9
ISSN	1001-0939
ISSN	1001-0939
DOI	10.3760/cma.j.cn112147-20230418-00185
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Article: [A case with tetralogy of Fallot and thymus hypoplasia found by ultrasound was eventually diagnosed as DiGeorge syndrome].

Gong, X Y / Yang, Z H / Li, W / Yang, Y H

Zhonghua er ke za zhi = Chinese journal of pediatrics

2023 Volume 61, Issue 8, Page(s) 733–735

MeSH term(s)	Humans ; DiGeorge Syndrome/diagnostic imaging ; Tetralogy of Fallot/diagnostic imaging ; Tetralogy of Fallot/surgery ; Ultrasonography
Language	Chinese
Publishing date	2023-04-13
Publishing country	China
Document type	Journal Article
ZDB-ID	784523-6
ISSN	0578-1310
ISSN	0578-1310
DOI	10.3760/cma.j.cn112140-20230511-00328
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Article: [Research progress of thrombolytic therapy for high risk and intermediate-high risk pulmonary thromboembolism].

Yang, J J / Zhang, Y / Zhai, Z G / Yang, Y H

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases

2023 Volume 46, Issue 7, Page(s) 720–725

Abstract: Acute pulmonary thromboembolism (PTE) is a highly fatal disease. Fibrinolytic therapy can rapidly improve pulmonary hemodynamics and is an important life-saving treatment. How to screen patients who may benefit from thrombolytic therapy and how to reduce ...

Abstract	Acute pulmonary thromboembolism (PTE) is a highly fatal disease. Fibrinolytic therapy can rapidly improve pulmonary hemodynamics and is an important life-saving treatment. How to screen patients who may benefit from thrombolytic therapy and how to reduce the complications of major bleeding are still the focus of PTE treatment. In addition, as our understanding of post-PE syndrome (PPES) has improved, much attention has been paid to whether thrombolytic therapy has any benefit in preventing PPES. This article reviewed the research progress of early risk stratification and prognosis assessment, early major bleeding risk assessment, thrombolytic drug dose reduction, interventional thrombolysis and the long-term prognosis of PTE thrombolysis in recent years.
MeSH term(s)	Humans ; Thrombolytic Therapy ; Pulmonary Embolism/drug therapy ; Pulmonary Embolism/etiology ; Fibrinolytic Agents/therapeutic use ; Hemorrhage/chemically induced ; Hemorrhage/drug therapy ; Prognosis
Chemical Substances	Fibrinolytic Agents
Language	Chinese
Publishing date	2023-07-04
Publishing country	China
Document type	Review ; English Abstract ; Journal Article
ZDB-ID	1027965-9
ISSN	1001-0939
ISSN	1001-0939
DOI	10.3760/cma.j.cn112147-20221102-00866
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Article: [A case of heritable pulmonary arterial hypertension treated with long-term oral low-dose imatinib].

Gao, A L / Gong, J N / Li, J F / Yang, Y H

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases

2023 Volume 47, Issue 1, Page(s) 36–38

Abstract: Heritable pulmonary arterial hypertension (HPAH) is a rare type of pulmonary arterial hypertension that often presents with progressive exertional dyspnea and for which there is no significant effective drug. A HPAH patient was admitted to our hospital ... ...

Abstract	Heritable pulmonary arterial hypertension (HPAH) is a rare type of pulmonary arterial hypertension that often presents with progressive exertional dyspnea and for which there is no significant effective drug. A HPAH patient was admitted to our hospital more than three years ago, and the gene mutation was bone morphogenetic protein 2 (BMPR2). For the first 45 months, she was given oral imatinib 100 mg once daily, and her symptoms and hemodynamics improved significantly, with no apparent side effects. It is reported that, in combination with the characteristics of the case and related literatures, it provides clinicians with other feasible treatment options for HPAH.
MeSH term(s)	Humans ; Female ; Familial Primary Pulmonary Hypertension/genetics ; Hypertension, Pulmonary/drug therapy ; Hypertension, Pulmonary/genetics ; Imatinib Mesylate/therapeutic use ; Mutation ; Bone Morphogenetic Protein Receptors, Type II/genetics ; Bone Morphogenetic Protein Receptors, Type II/metabolism
Chemical Substances	Imatinib Mesylate (8A1O1M485B) ; hydralazine 4-anisaldehyde hydrazone (61641-43-8) ; Bone Morphogenetic Protein Receptors, Type II (EC 2.7.11.30)
Language	Chinese
Publishing date	2023-12-07
Publishing country	China
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	1027965-9
ISSN	1001-0939
ISSN	1001-0939
DOI	10.3760/cma.j.cn112147-20230918-00165
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Article: [Hemodynamic changes with serial balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension].

Wang, W / Gong, J N / Wang, J F / Ding, Y / Zhang, Y X / Liu, J Y / Yang, Y H

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases

2024 Volume 47, Issue 2, Page(s) 120–125

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Humans ; Hypertension, Pulmonary/diagnosis ; Pulmonary Artery ; Pulmonary Embolism/diagnosis ; Angioplasty, Balloon/methods ; Hemodynamics ; Chronic Disease ; Treatment Outcome
Language	Chinese
Publishing date	2024-01-11
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1027965-9
ISSN	1001-0939
ISSN	1001-0939
DOI	10.3760/cma.j.cn112147-20231016-00237
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Article: Application of machine learning techniques in the diagnostic approach of PTSD using MRI neuroimaging data: A systematic review.

Jia, Y L / Yang, B N / Yang, Y H / Zheng, W M / Wang, L / Huang, C Y / Lu, J / Chen, N

Heliyon

2024 Volume 10, Issue 7, Page(s) e28559

Abstract: Background: At present, the diagnosis of post-traumatic stress disorder（PTSD） mainly relies on clinical symptoms and psychological scales, and finding objective indicators that are helpful for diagnosis has always been a challenge in clinical practice ... ...

Abstract	Background: At present, the diagnosis of post-traumatic stress disorder（PTSD） mainly relies on clinical symptoms and psychological scales, and finding objective indicators that are helpful for diagnosis has always been a challenge in clinical practice and academic research. Neuroimaging is a useful and powerful tool for discovering the biomarkers of PTSD,especially functional MRI (fMRI), structural MRI (sMRI) and Diffusion Weighted Imaging（DTI）are the most commonly used technologies, which can provide multiple perspectives on brain function, structure and its connectivity. Machine learning (ML) is an emerging and potentially powerful method, which has aroused people's interest because it is used together with neuroimaging data to define brain structural and functional abnormalities related to diseases, and identify phenotypes, such as helping physicians make early diagnosis. Objectives: According to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) declaration, a systematic review was conducted to assess its accuracy in distinguishing between PTSD patients, TEHC(Trauma-Exposed Healthy Controls), and HC(healthy controls). Methods: We searched PubMed, Embase, and Web of Science using common words for ML methods and PTSD until June 2023, with no language or time limits. This review includes 13 studies, with sensitivity, specificity, and accuracy taken from each publication or acquired directly from the authors. Results: All ML techniques have an diagnostic accuracy rate above 70%，and support vector machine（SVM） are the most commonly used techniques. This series of studies has revealed significant neurobiological differences in key brain regions among individuals with PTSD, TEHC, and HC. The connectivity patterns of regions such as the Insula and Amygdala hold particular significance in distinguishing these groups. TEHC exhibits more normal connectivity patterns compared to PTSD, providing valuable insights for the application of machine learning in PTSD diagnosis. Conclusion: In contrast to any currently available assessment and clinical diagnosis, ML techniques can be used as an effective and non-invasive support for early identification and detection of patients as well as for early screening of high-risk populations.
Language	English
Publishing date	2024-03-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e28559
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Article: [Atypical extraosseous Ewing's sarcoma of sinonasal cranial base: a case report].

Wei, C B / He, F / Tang, J C / Yang, Y H / Deng, X L / Liu, F X

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery

2024 Volume 59, Issue 3, Page(s) 256–259

MeSH term(s)	Humans ; Sarcoma, Ewing/surgery
Language	Chinese
Publishing date	2024-04-01
Publishing country	China
Document type	Case Reports ; Journal Article
ZDB-ID	2195655-8
ISSN	1673-0860
ISSN	1673-0860
DOI	10.3760/cma.j.cn115330-20230811-00040
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Article ; Online: Targeting miR-106-3p facilitates functional recovery via inactivating inflammatory microglia and interfering glial scar component deposition after neural injury.

Yang, Y-H / Zhu, J

European review for medical and pharmacological sciences

2019 Volume 23, Issue 20, Page(s) 9000–9008

Abstract: Objective: The aim of this study was to elucidate whether the knockdown of microRNA-106-3p (miR-106-3p) could mediate the nerve regeneration and functional recovery after the spinal cord injury (SCI) and its potential mechanism.: Materials and methods! ...

Abstract	Objective: The aim of this study was to elucidate whether the knockdown of microRNA-106-3p (miR-106-3p) could mediate the nerve regeneration and functional recovery after the spinal cord injury (SCI) and its potential mechanism. Materials and methods: Microglia were extracted from the cerebral cortex of the neonatal rats and cultured in vitro. Subsequently, biomarkers of M1-type and M2-type in microglia transfected with miR-106-3p inhibitor were measured. Furthermore, in vivo SCI model in rats was successfully constructed, and SCI rats were intrathecally injected with miR-106-3p inhibitor or negative control. The expressions of the pro-inflammatory factors in the SCI rats or controls were detected by the enzyme-linked immunosorbent assay (ELISA). The glial scar marker and extracellular matrix were visualized by Western blotting and immunofluorescence, respectively. To observe the nerve function in rats, the movement evaluation was conducted using Basso-Beattie-Bresnahan (BBB) locomotor rating scale. Results: In the inflammatory microglia, miR-106-3p was markedly up-regulated. Western blotting exhibited the downregulation of M1-type cells and the upregulation of M2-type cells after silencing miR-106-3p. In SCI rats, we discovered that the miR-106-3p level in the injured spinal cord was up-regulated within one week following injury. Meanwhile, the levels of the pro-inflammatory factors were significantly reduced in SCI rats with the miR-106-3p knockdown. At 7 days after the injury, the area of the astrocyte scar in the injured spinal cord was remarkably reduced by in vivo knockdown of miR-106-3p. Moreover, the extracellular matrix components secreted in the scar were also significantly inhibited. However, the glial secretion of the neurotrophic factors relatively increased in the SCI rats with the miR-106-3p knockdown. Neurological function recovery was pronounced in SCI rats with the miR-106-3p knockdown relative to controls. Conclusions: The silence of miR-106-3p promotes the recovery of the locomotor function and protects the environment of the neurotization by inactivating inflammatory microglia and reducing the scar formation following SCI.
MeSH term(s)	Animals ; Cells, Cultured ; Cerebral Cortex/cytology ; Disease Models, Animal ; Gene Knockdown Techniques/methods ; Male ; MicroRNAs/antagonists & inhibitors ; MicroRNAs/genetics ; Microglia/cytology ; Microglia/drug effects ; Oligonucleotides/administration & dosage ; Oligonucleotides/pharmacology ; Rats ; Rats, Sprague-Dawley ; Recovery of Function ; Spinal Cord Injuries/genetics ; Spinal Cord Injuries/physiopathology ; Spinal Cord Injuries/therapy ; Up-Regulation/drug effects
Chemical Substances	MicroRNAs ; Oligonucleotides
Language	English
Publishing date	2019-11-06
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_201910_19300
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