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Article: Study on molecular mechanisms of nattokinase in pharmacological action based on label‐free liquid chromatography–tandem mass spectrometry

YANG, YAN

Food Science & Nutrition, 7(10):3185-3193

2019

Abstract: Cardiovascular diseases (CVDs) are the leading causes of premature death and disability in people around the world. Therefore, the prevention and treatment of CVDs has become an important subject. In this study, we verified the thrombolytic activities of ...

Abstract	Cardiovascular diseases (CVDs) are the leading causes of premature death and disability in people around the world. Therefore, the prevention and treatment of CVDs has become an important subject. In this study, we verified the thrombolytic activities of a nattokinase‐like protease named NK‐01 in vivo. Label‐free liquid chromatography–tandem mass spectrometry (LC‐MS/MS) technique was used in our study. NK‐01 could inhibit the activity of coagulation factors though the up‐regulation of proteinase C inhibitors and protein S. NK‐01 also could inhibit the angiotensinogen conversion to AngII and promote the degradation of kininogen to reduce the blood pressure. In addition, NK‐01 could increase the content of paraoxonase 1, which could prevent atherosclerosis. In our study, we found that NK‐01 cloud effect some key proteins which participant in CVDs associated metabolic processes such as coagulation system, blood pressure, and atherosclerosis. Taken together, the underlying molecular mechanisms for the biological beneficial of NK‐01 were investigated. Our proteomic study will provide further theoretical basis for application of NK in prevention or adjuvant treatment in biomedicine areas.
Keywords	cardiovascular disease ; disease prevention ; label free ; nattokinase
Language	English
Document type	Article
Database	Repository for Life Sciences

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Article ; Online: Research progress of metallothionein in metabolic diseases

YANG Yan

Jichu yixue yu linchuang, Vol 42, Iss 3, Pp 498-

2022 Volume 501

Abstract: Metallothionein (MT) is a kind of low molecular metal binding proteins rich in cysteine. It plays a protective role in obesity, non-alcoholic fatty liver disease (NAFLD), diabetes mellitus(DM) and its complications. It has many functions such as anti- ... ...

Abstract	Metallothionein (MT) is a kind of low molecular metal binding proteins rich in cysteine. It plays a protective role in obesity, non-alcoholic fatty liver disease (NAFLD), diabetes mellitus(DM) and its complications. It has many functions such as anti-oxidative stress, anti-inflammatory, and inhibiting cell apoptosis.
Keywords	metallothionein\|metabolic disease\|progress ; Medicine ; R
Language	Chinese
Publishing date	2022-03-01T00:00:00Z
Publisher	Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Correlation between a low serum free triiodothyronine level and mortality of severe pulmonary tuberculosis patients.

Yang, Yan / Huang, Xiaoqing

BMC infectious diseases

2024 Volume 24, Issue 1, Page(s) 202

Abstract: Background: This study aimed to assess the relationship between a low serum free triiodothyronine (FT3) level and the mortality of severe pulmonary tuberculosis (TB) patients.: Methods: We performed a retrospective study and reviewed the medical ... ...

Abstract	Background: This study aimed to assess the relationship between a low serum free triiodothyronine (FT3) level and the mortality of severe pulmonary tuberculosis (TB) patients. Methods: We performed a retrospective study and reviewed the medical records of patients with severe pulmonary TB between January 2016 and June 2022. The patient demographics, Acute Physiology and Chronic Health Evaluation (APACHE) II score, survival or death at 28 and 90 days after hospital admission, and serum FT3 level were recorded. Bivariate regression analysis was performed to study the relationship between mortality and the FT3 level. The Kaplan-Meier method and the log-rank test were used to compare the survival rates between patients with different serum FT3 levels. Results: Our study included 495 severe pulmonary TB patients, with 383 (77.4%) patients having a low serum FT3 level. The low-serum FT3 group had high 28-day and 90-day mortalities. The patients who had died by 28 or 90 days after hospital admission had a low FT3 level. Survival analysis showed that the patients with a low serum FT3 level had a low probability of survival at 28 days and at 90 days after hospital admission. Conclusion: The serum FT3 level was correlated with the 28-day and 90-day mortalities in patients with severe pulmonary TB. The serum FT3 level should be monitored in these patients to help manage their disease.
MeSH term(s)	Humans ; Triiodothyronine ; Retrospective Studies ; Regression Analysis ; Survival Analysis ; Tuberculosis, Pulmonary ; Prognosis
Chemical Substances	Triiodothyronine (06LU7C9H1V)
Language	English
Publishing date	2024-02-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-024-09099-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Diffusion-weighted imaging in methanol poisoning: beyond the lentiform fork sign.

Yang, Yan / Zhao, Hongwei

Clinical toxicology (Philadelphia, Pa.)

2024 Volume 62, Issue 1, Page(s) 61–63

Abstract: Introduction: Methanol poisoning is a life-threatening emergency, in which the presence of a lentiform fork sign on magnetic resonance imaging, although not exclusive to methanol poisoning, can be of diagnostic assistance. This report highlights the ... ...

Abstract	Introduction: Methanol poisoning is a life-threatening emergency, in which the presence of a lentiform fork sign on magnetic resonance imaging, although not exclusive to methanol poisoning, can be of diagnostic assistance. This report highlights the additional value of diffusion-weighted imaging in methanol poisoning. Case summary: A 38-year-old man was admitted to the hospital with severe metabolic acidosis, coma and visual disturbances due to methanol poisoning. Images: Initial computed tomography of the brain was unremarkable. However, magnetic resonance imaging revealed the lentiform fork sign, with diffusion-weighted imaging changes in the lentiform nuclei. Conclusion: Diffusion-weighted imaging sequences provide additional information compared to traditional magnetic resonance imaging in assessing methanol poisoning. Systematic evaluation is needed to fully understand and utilize the potential predictive value of diffusion-weighted imaging in this context.
MeSH term(s)	Male ; Humans ; Adult ; Methanol ; Diffusion Magnetic Resonance Imaging ; Magnetic Resonance Imaging/methods ; Brain/pathology ; Alcoholism ; Poisoning/diagnosis
Chemical Substances	Methanol (Y4S76JWI15)
Language	English
Publishing date	2024-01-17
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	204476-6
ISSN	1556-9519 ; 0009-9309 ; 0731-3810 ; 1556-3650
ISSN (online)	1556-9519
ISSN	0009-9309 ; 0731-3810 ; 1556-3650
DOI	10.1080/15563650.2024.2302452
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Article: Holistic Nursing Intervention Versus Routine Nursing on Nursing Quality and Satisfaction After PCI in Patients With Acute Myocardial Infarction: A Randomized Controlled Trial.

Ji, Ying'jie / Yang, Yan

Alternative therapies in health and medicine

2024

Abstract: Objective: To analyze the effect of holistic nursing intervention on the nursing quality and satisfaction of patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI).: Methods: This is a retrospective study. 148 ... ...

Abstract	Objective: To analyze the effect of holistic nursing intervention on the nursing quality and satisfaction of patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). Methods: This is a retrospective study. 148 AMI patients admitted to the Department of Cardiovascular Medicine in our hospital were divided into a conventional group and an experimental group according to different nursing methods, with 74 patients in each group. Patients in the routine group were given routine nursing care, while those in the experimental group were given holistic nursing interventions. The nursing quality, the incidence of complications and nursing satisfaction were compared between the two groups. Results: One year after discharge, the experimental group achieved a significantly higher LVEF than the routine group (P < .05). After nursing intervention, the Morisky scores in both groups were increased, and the increase values was greater in the experimental group vs. routine group with respect to body mass index (BMI) control, medication adherence prescribed by a doctor, proper exercise, diet control (all P < .05); the experimental group exhibited superior performance in terms of disease, physical, medical, general life, social and psychological status, and work conditions than the routine group (all P < .05). After nursing intervention, the GSES score of the experimental group (29.14±2.56) was significantly higher than that of the routine group (21.35±2.74) (P < .05). Furthermore, the incidences of AMI and stent thrombosis in the experimental group (1.35%, 1.35%) were lower than they were in the routine group (9.46%, 14.87%); higher total satisfaction was observed in the experimental group vs. the routine group [71 (95.95%) vs. 53 (71.62%)] (P < .05). Conclusion: Holistic nursing intervention emerges as a promising care strategy for AMI patients, demonstrating potential in enhancing treatment adherence, improving quality of life, fostering self-efficacy, and making positive contributions to prognosis and cardiac function. The observed effectiveness and safety profiles highlight the feasibility of this approach. In real-world clinical settings, the implementation of holistic nursing interventions may lead to improved adherence to treatment plans and an overall elevation in healthcare quality.
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1225073-9
ISSN	1078-6791
ISSN	1078-6791
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Article ; Online: Progress of plant polyphenol extracts in treating depression by anti-neuroinflammatory mechanism: A review.

Guo, Yuting / Yang, Yan

Medicine

2024 Volume 103, Issue 5, Page(s) e37151

Abstract: There is a growing body of evidence supporting the involvement of central nervous system inflammation in the pathophysiology of depression. Polyphenols are a diverse group of compounds known for their antioxidative and anti-inflammatory properties. They ... ...

Abstract	There is a growing body of evidence supporting the involvement of central nervous system inflammation in the pathophysiology of depression. Polyphenols are a diverse group of compounds known for their antioxidative and anti-inflammatory properties. They offer a promising and effective supplementary approach to alleviating neuropsychiatric symptoms associated with inflammation-induced depression. This paper provides a summary of the potential anti-neuroinflammatory mechanisms of plant polyphenol extracts against depression. This includes direct interference with inflammatory regulators and inhibition of the expression of pro-inflammatory cytokines. Additionally, it covers downregulating the expression of pro-inflammatory cytokines by altering protein kinases or affecting the activity of the signaling pathways that they activate. These pathways interfere with the conduction of signaling molecules, resulting in the destruction and reduced synthesis of all inflammatory mediators and cytokines. This reduces the apoptosis of neurons and plays a neuroprotective role. This paper provides a theoretical basis for the clinical application of plant polyphenols.
MeSH term(s)	Humans ; Polyphenols/pharmacology ; Polyphenols/therapeutic use ; Depression/drug therapy ; Signal Transduction ; Cytokines/metabolism ; Inflammation/drug therapy ; Inflammation/metabolism ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use
Chemical Substances	Polyphenols ; Cytokines ; Plant Extracts
Language	English
Publishing date	2024-02-02
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000037151
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Article: What are the roles of positive psychological construct in blended learning contexts? Integrating academic buoyancy into the Community of Inquiry framework.

Yang, Yan / Lay, Yoon Fah

Frontiers in psychology

2024 Volume 15, Page(s) 1354156

Abstract: Introduction: In the post-epidemic era, blended learning has become a social trend for the future of higher education, and scholars have endeavored to understand the factors that influence student learning in these blended communities. Communities of ... ...

Abstract	Introduction: In the post-epidemic era, blended learning has become a social trend for the future of higher education, and scholars have endeavored to understand the factors that influence student learning in these blended communities. Communities of Inquiry is a conceptual framework that describes the components of blended learning environments, indicating teaching presence, social presence, and cognitive presence. However, the framework fails to adequately explore how individual learning motivational factors influence student learning. Therefore, this study extends the Community of Inquiry framework by drawing on a positive psychological construct-academic buoyancy to reveal the relationship between academic buoyancy and the three presences through empirical research. Methods: The theoretical model was validated by SPSS 26.0 and smartPLS4.0. To evaluate the measurement and structural models, structural equation modeling (SEM) was carried out using the partial least squares (PLS) method. Findings: (a) Teaching presence positively predicts academic buoyancy, and academic buoyancy positively predicts social presence and cognitive presence; (b) academic buoyancy mediates teaching presence and social presence, as well as teaching presence and cognitive presence; and (c) academic buoyancy acts as a chain mediator between teaching presence and cognitive presence through social presence. Discussion: The results of this study fill a gap in the multiple roles of individual positive psychological construct-academic buoyancy in blended learning communities, extend the Community of Inquiry theoretical framework, and provide empirical evidence for blended learning quality and practical improvement strategies.
Language	English
Publishing date	2024-04-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2024.1354156
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Method Prediction for the Environment of Vibration Structure in Consideration with Elastic Joint

Yang Yan

E3S Web of Conferences, Vol 165, p

2020 Volume 02009

Abstract: In order to accurately and efficiently predict the environment of vibration structures with elastic joints, the BUSH equivalent elastic joints unit of MSC. Nastran software was used to deduce the natural frequencies of structures with elastic joints by ... ...

Abstract	In order to accurately and efficiently predict the environment of vibration structures with elastic joints, the BUSH equivalent elastic joints unit of MSC. Nastran software was used to deduce the natural frequencies of structures with elastic joints by using the Fixed Interface Mode Synthesis Method (FIMSM).An example structure with elastic joint is designed, and both FIMSM and traditional FEM are used to calculate the first 30 order natural frequencies of the example structure. The results show that, compared with FEM, the relative calculation error of FIMSM is within ±1.31%. Consequently, via using BUSH element to simulate the elastic joint, FIMSM possesses the ability to predict the Environment of Vibration Structure considering elastic joint precisely and efficiently.
Keywords	Environmental sciences ; GE1-350
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Prognostic and immunological role of adaptor related protein complex 3 subunit mu2 in colon cancer

Qianqian Jin / Jiahao Feng / Yang Yan / Yong Kuang

Scientific Reports, Vol 14, Iss 1, Pp 1-

2024 Volume 16

Abstract: Abstract The expression levels and prognostic role of AP3M2 in colorectal adenocarcinoma (CRAC) have yet to be fully unveiled. Our study comprehensively investigated the clinical significance of AP3M2 in colorectal cancer through an extensive ... ...

Abstract	Abstract The expression levels and prognostic role of AP3M2 in colorectal adenocarcinoma (CRAC) have yet to be fully unveiled. Our study comprehensively investigated the clinical significance of AP3M2 in colorectal cancer through an extensive bioinformatics data mining process (TCGA, GEO, GEPIA, Timer, Ualcan, ROCPLOT, and David), followed by experimental validation. We found AP3M2 is a cancer gene, which can be used to distinguish between colorectal cancer and colorectal adenomas, liver metastasis, lung metastasis, colorectal polyp. Higher AP3M2 expression levels were associated with longer overall survival in colon adenocarcinoma. AP3M2 might be the primary biomarker for oxaliplatin in colon cancer and an acquired resistance biomarker for oxaliplatin and 5-fu. AP3M2 was positively associated with CD274, CTLA4. AP3M2 might be associated with T-cell, NF-kappaB transcription factor activity, and response to hypoxia. AP3M2 could predict chemotherapy effectiveness and prognosis for colon cancer patients. AP3M2 might inhibit tumor growth via influencing tumor-infiltrating immune cells in the context of Tumor microenvironment. AP3M2 plays as an oncogene in CRAC and is suggested as a new potential biotarget for therapy.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Exploration and Practice of Maker Education Mode in Innovation and Entrepreneurship Education.

Yang, Yan

Frontiers in psychology

2020 Volume 11, Page(s) 1626

Abstract: This study was conducted with the purpose of exploring the impact of positive entrepreneurial psychological quality in innovation and entrepreneurship education, as well as the development of maker education in colleges and universities. The ... ...

Abstract	This study was conducted with the purpose of exploring the impact of positive entrepreneurial psychological quality in innovation and entrepreneurship education, as well as the development of maker education in colleges and universities. The questionnaire survey method -
Language	English
Publishing date	2020-09-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2020.01626
Database	MEDical Literature Analysis and Retrieval System OnLINE

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