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  1. Article ; Online: Pseudo Label Association and Prototype-Based Invariant Learning for Semi-Supervised NIR-VIS Face Recognition.

    Hu, Weipeng / Yang, Yiming / Hu, Haifeng

    IEEE transactions on image processing : a publication of the IEEE Signal Processing Society

    2024  Volume 33, Page(s) 1448–1463

    Abstract: Remarkable success of the existing Near-InfraRed and VISible (NIR-VIS) approaches owes to sufficient labeled training data. However, collecting and tagging data from different domains is a time-consuming and expensive task. In this paper, we tackle the ... ...

    Abstract Remarkable success of the existing Near-InfraRed and VISible (NIR-VIS) approaches owes to sufficient labeled training data. However, collecting and tagging data from different domains is a time-consuming and expensive task. In this paper, we tackle the NIR-VIS face recognition problem in a semi-supervised manner, termed as semi-supervised NIR-VIS Heterogeneous Face Recognition (NIR-VIS-sHFR). To cope with this problem, we propose a novel pseudo Label association and Prototype-based invariant Learning (LPL), consisting of three key components, i.e., Cross-domain pseudo Label Association (CLA), Intra-domain Compact Representation learning (ICR), and Prototype-based Inter-domain Invariant learning (PII). Firstly, the CLA iteratively builds inter-domain association graphs for pseudo-label association, subsequently facilitating cross-domain model development based on the generated pseudo-labels. Furthermore, the ICR is proposed to achieve the separation of in-domain features from different clusters and the aggregation of features from the same cluster, by performing cluster adaptation learning with prototype-based initialization. Finally, with the cross-domain pseudo-label training data produced by CLA, the PII explores potential domain-invariant and identity-related features, which employs cross-domain prototypes with identity-associated momentum updating to effectively guide inter-domain instances learning. The semi-supervised LPL method achieves comparable performance to recent supervised learning methods on multiple challenging NIR-VIS datasets, which demonstrates that the LPL is capable of learning robust cross-domain representations even without identity label information.
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article
    ISSN 1941-0042
    ISSN (online) 1941-0042
    DOI 10.1109/TIP.2024.3364530
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Developing Biarylhemiboronic Esters for Biaryl Atropisomer Synthesis via Dynamic Kinetic Atroposelective Suzuki-Miyaura Cross-Coupling.

    Yang, Yiming / Wu, Changhui / Xing, Junhao / Dou, Xiaowei

    Journal of the American Chemical Society

    2024  Volume 146, Issue 9, Page(s) 6283–6293

    Abstract: We herein introduce biarylhemiboronic esters as a new type of bridged biaryl reagent for asymmetric synthesis of axially chiral biaryl structures, and the palladium-catalyzed asymmetric Suzuki-Miyaura cross-coupling of biarylhemiboronic esters is ... ...

    Abstract We herein introduce biarylhemiboronic esters as a new type of bridged biaryl reagent for asymmetric synthesis of axially chiral biaryl structures, and the palladium-catalyzed asymmetric Suzuki-Miyaura cross-coupling of biarylhemiboronic esters is developed. This dynamic kinetic atroposelective coupling reaction exhibits high enantioselectivity, good functional group tolerance, and a broad substrate scope. The synthetic application of the current method was demonstrated by transformations of the product and a programmed synthesis of chiral polyarene. Preliminary mechanistic studies suggested that the reaction proceeded via an enantio-determining dynamic kinetic atroposelective transmetalation step.
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c14450
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Abnormal methylation mediated upregulation of LINC00857 boosts malignant progression of lung adenocarcinoma by modulating the miR-486-5p/NEK2 axis.

    Fu, Haoyu / Zhang, Mingming / Liu, Xiaohui / Yang, Yiming / Xing, Ying

    The clinical respiratory journal

    2024  Volume 18, Issue 5, Page(s) e13765

    Abstract: LINC00857 is frequently dysregulated in varying cancers, which in turn exerts carcinogenic effects; however, its DNA methylation status in promoter region and molecular mechanisms underlying the progression of lung adenocarcinoma (LUAD) remain rarely ... ...

    Abstract LINC00857 is frequently dysregulated in varying cancers, which in turn exerts carcinogenic effects; however, its DNA methylation status in promoter region and molecular mechanisms underlying the progression of lung adenocarcinoma (LUAD) remain rarely understood. Through bioinformatics analysis, we examined the expression state and methylation site of LINC00857 in LUAD and further investigated the properties of LINC00857 as a competitive endogenous RNA in the cancer progression. The current study revealed that the overexpression of LINC00857 in LUAD tissue and cells was mainly caused by the hypomethylation of the promoter region. LINC00857 knockdown prominently reduced cell proliferation, impeded cell migration and invasion, and restrained lymph node metastasis, with enhancing radiosensitivity. The effects of LINC00857 on tumor growth were also investigated in nude mice models. Subsequently, the downstream factors, miR-486-5p and NEK2, were screened, and the putative regulatory axis was examined. Overall, the regulatory effect of methylation-mediated LINC00857 overexpression on miR-486-5p/NEK2 axis may be a new mechanism for LUAD progression.
    MeSH term(s) MicroRNAs/genetics ; MicroRNAs/metabolism ; Humans ; Animals ; Mice ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Lung Neoplasms/metabolism ; Adenocarcinoma of Lung/genetics ; Adenocarcinoma of Lung/pathology ; Adenocarcinoma of Lung/metabolism ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Disease Progression ; DNA Methylation ; Gene Expression Regulation, Neoplastic ; Up-Regulation ; Cell Proliferation/genetics ; NIMA-Related Kinases/genetics ; NIMA-Related Kinases/metabolism ; Cell Line, Tumor ; Mice, Nude ; Cell Movement/genetics ; Male
    Chemical Substances MicroRNAs ; MIRN486 microRNA, human ; RNA, Long Noncoding ; NIMA-Related Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2024-02-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2442214-9
    ISSN 1752-699X ; 1752-6981
    ISSN (online) 1752-699X
    ISSN 1752-6981
    DOI 10.1111/crj.13765
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online: DIFUSCO

    Sun, Zhiqing / Yang, Yiming

    Graph-based Diffusion Solvers for Combinatorial Optimization

    2023  

    Abstract: Neural network-based Combinatorial Optimization (CO) methods have shown promising results in solving various NP-complete (NPC) problems without relying on hand-crafted domain knowledge. This paper broadens the current scope of neural solvers for NPC ... ...

    Abstract Neural network-based Combinatorial Optimization (CO) methods have shown promising results in solving various NP-complete (NPC) problems without relying on hand-crafted domain knowledge. This paper broadens the current scope of neural solvers for NPC problems by introducing a new graph-based diffusion framework, namely DIFUSCO. Our framework casts NPC problems as discrete {0, 1}-vector optimization problems and leverages graph-based denoising diffusion models to generate high-quality solutions. We investigate two types of diffusion models with Gaussian and Bernoulli noise, respectively, and devise an effective inference schedule to enhance the solution quality. We evaluate our methods on two well-studied NPC combinatorial optimization problems: Traveling Salesman Problem (TSP) and Maximal Independent Set (MIS). Experimental results show that DIFUSCO strongly outperforms the previous state-of-the-art neural solvers, improving the performance gap between ground-truth and neural solvers from 1.76% to 0.46% on TSP-500, from 2.46% to 1.17% on TSP-1000, and from 3.19% to 2.58% on TSP10000. For the MIS problem, DIFUSCO outperforms the previous state-of-the-art neural solver on the challenging SATLIB benchmark.

    Comment: Accepted at NeurIPS 2023 (Spotlight)
    Keywords Computer Science - Machine Learning
    Subject code 006
    Publishing date 2023-02-16
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Impact of local governments’ construction land allocation strategies on innovation-driven development of China

    WANG Jian / PENG Shangui / FENG Yuhao / YANG Yiming / WU Qun

    Ziyuan Kexue, Vol 45, Iss 6, Pp 1153-

    2023  Volume 1167

    Abstract: Objective] This study aimed to explore whether the local governments’ construction land allocation strategies, which once promoted China’s high-speed economic growth, can continue to support the country’s innovation-driven development, to realize the ... ...

    Abstract [Objective] This study aimed to explore whether the local governments’ construction land allocation strategies, which once promoted China’s high-speed economic growth, can continue to support the country’s innovation-driven development, to realize the goal of precisely optimizing the allocation of construction land and improving the urban innovation ability according to local conditions. [Methods] Based on the perspective of prices, this study constructed an analytical framework for the impact of local governments’ construction land allocation strategies on urban innovation, and then used the panel data of 278 prefecture-level cities from 2007 to 2019 to construct a spatial econometric model for empirical analysis. [Results] (1) The impact of local governments’ construction land allocation strategies on urban innovation presented an inverted U-shaped characteristic in both the national and regional samples. The inflection points of the sample at the national level, eastern, central and western regions occurred when the ratio of the price of commercial and residential land to the price of industrial land were 7.89, 8.56, 7.81, and 7.11, respectively; (2) The impact of industrial land price on urban innovation showed an inverted N-shape in the whole country and the eastern region, and an positive U-shape in the central and western regions; the impact of commercial and residential land price on urban innovation showed an inverted U-shape in the whole country and all regions; (3) The local governments’ construction land allocation strategies had different degrees of influence on urban innovation by affecting the scale and efficiency of industrial development, innovation expenditure, and innovative talents, and there were different mechanisms of influence between industrial land prices and commercial and residential land prices. [Conclusion] It is difficult for local governments’ construction land allocation strategies to continuously promote China’s innovation-driven development, so it is urgent to explore more ...
    Keywords |land economy|resource allocation|construction land allocation|urban innovation|high-quality development|impact mechanism|spatial econometrics ; Environmental sciences ; GE1-350 ; Biology (General) ; QH301-705.5
    Subject code 710
    Language Chinese
    Publishing date 2023-06-01T00:00:00Z
    Publisher Science Press, PR China
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Experimental Study on Secondary Anchorage Bond Performance of Residual Stress after Corrosion Fracture at Ends of Prestressed Steel Strands.

    Yang, Rihua / Yang, Yiming / Zhang, Xuhui / Wang, Xinzhong

    Materials (Basel, Switzerland)

    2023  Volume 16, Issue 23

    Abstract: In order to explore the secondary bond anchorage performance between prestressed tendons and concrete after the fracture of steel strands in post-tensioned, prestressed concrete (PPC) beams, a total of seven post-tensioned, prestressed concrete specimens ...

    Abstract In order to explore the secondary bond anchorage performance between prestressed tendons and concrete after the fracture of steel strands in post-tensioned, prestressed concrete (PPC) beams, a total of seven post-tensioned, prestressed concrete specimens with a size of 3 × 7ϕ15.2 mm were constructed firstly, and the steel strands at the anchorage end were subjected to corrosion fracture. Then, the pull-out test of the specimens was conducted to explore the secondary anchorage bond mechanism of the residual stress of prestressed tendons experiencing local fracture. Moreover, the influences of factors such as the embedded length, release-tensioning speed, concrete strength, and stirrup configuration on anchorage bond performance were analyzed. Finally, the test results were further verified via finite element analysis. The results show that the failure of pull-out specimens under different parameters can be divided into two types: bond anchorage failure induced by the entire pull-out of steel strands and material failure triggered by the rupture of steel strands. The bond anchorage failure mechanism between steel strands and the concrete was revealed by combining the failure characteristics and pull-out load-slippage relation curves. The bond strength between prestressed steel strands and concrete can be enhanced by increasing the embedded length of steel strands, elevating the concrete strength grade, and enlarging the diameter of stirrups so that the specimens are turned from bond anchorage failure into material failure.
    Language English
    Publishing date 2023-11-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma16237441
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Robust Cross-Domain Pseudo-Labeling and Contrastive Learning for Unsupervised Domain Adaptation NIR-VIS Face Recognition.

    Yang, Yiming / Hu, Weipeng / Lin, Haiqi / Hu, Haifeng

    IEEE transactions on image processing : a publication of the IEEE Signal Processing Society

    2023  Volume 32, Page(s) 5231–5244

    Abstract: Near-infrared and visible face recognition (NIR-VIS) is attracting increasing attention because of the need to achieve face recognition in low-light conditions to enable 24-hour secure retrieval. However, annotating identity labels for a large number of ... ...

    Abstract Near-infrared and visible face recognition (NIR-VIS) is attracting increasing attention because of the need to achieve face recognition in low-light conditions to enable 24-hour secure retrieval. However, annotating identity labels for a large number of heterogeneous face images is time-consuming and expensive, which limits the application of the NIR-VIS face recognition system to larger scale real-world scenarios. In this paper, we attempt to achieve NIR-VIS face recognition in an unsupervised domain adaptation manner. To get rid of the reliance on manual annotations, we propose a novel Robust cross-domain Pseudo-labeling and Contrastive learning (RPC) network which consists of three key components, i.e., NIR cluster-based Pseudo labels Sharing (NPS), Domain-specific cluster Contrastive Learning (DCL) and Inter-domain cluster Contrastive Learning (ICL). Firstly, NPS is presented to generate pseudo labels by exploring robust NIR clusters and sharing reliable label knowledge with VIS domain. Secondly, DCL is designed to learn intra-domain compact yet discriminative representations. Finally, ICL dynamically combines and refines intrinsic identity relationships to guide the instance-level features to learn robust and domain-independent representations. Extensive experiments are conducted to verify an accuracy of over 99% in pseudo label assignment and the advanced performance of RPC network on four mainstream NIR-VIS datasets.
    MeSH term(s) Facial Recognition ; Learning
    Language English
    Publishing date 2023-09-20
    Publishing country United States
    Document type Journal Article
    ISSN 1941-0042
    ISSN (online) 1941-0042
    DOI 10.1109/TIP.2023.3309110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A Brain-Inspired Approach for Probabilistic Estimation and Efficient Planning in Precision Physical Interaction.

    Xing, Dengpeng / Yang, Yiming / Zhang, Tielin / Xu, Bo

    IEEE transactions on cybernetics

    2023  Volume 53, Issue 10, Page(s) 6248–6262

    Abstract: This article presents a novel structure of spiking neural networks (SNNs) to simulate the joint function of multiple brain regions in handling precision physical interactions. This task desires efficient movement planning while considering contact ... ...

    Abstract This article presents a novel structure of spiking neural networks (SNNs) to simulate the joint function of multiple brain regions in handling precision physical interactions. This task desires efficient movement planning while considering contact prediction and fast radial compensation. Contact prediction demands the cognitive memory of the interaction model, and we novelly propose a double recurrent network to imitate the hippocampus, addressing the spatiotemporal property of the distribution. Radial contact response needs rich spatial information, and we use a cerebellum-inspired module to achieve temporally dynamic prediction. We also use a block-based feedforward network to plan movements, behaving like the prefrontal cortex. These modules are integrated to realize the joint cognitive function of multiple brain regions in prediction, controlling, and planning. We present an appropriate controller and planner to generate teaching signals and provide a feasible network initialization for reinforcement learning, which modifies synapses in accordance with reality. The experimental results demonstrate the validity of the proposed method.
    MeSH term(s) Brain/physiology ; Learning ; Neural Networks, Computer ; Cerebellum/physiology
    Language English
    Publishing date 2023-09-15
    Publishing country United States
    Document type Journal Article
    ISSN 2168-2275
    ISSN (online) 2168-2275
    DOI 10.1109/TCYB.2022.3164750
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Structural Insights into Membrane Fusion Mediated by Convergent Small Fusogens.

    Yang, Yiming / Margam, Nandini Nagarajan

    Cells

    2021  Volume 10, Issue 1

    Abstract: From lifeless viral particles to complex multicellular organisms, membrane fusion is inarguably the important fundamental biological phenomena. Sitting at the heart of membrane fusion are protein mediators known as fusogens. Despite the extensive ... ...

    Abstract From lifeless viral particles to complex multicellular organisms, membrane fusion is inarguably the important fundamental biological phenomena. Sitting at the heart of membrane fusion are protein mediators known as fusogens. Despite the extensive functional and structural characterization of these proteins in recent years, scientists are still grappling with the fundamental mechanisms underlying membrane fusion. From an evolutionary perspective, fusogens follow divergent evolutionary principles in that they are functionally independent and do not share any sequence identity; however, they possess structural similarity, raising the possibility that membrane fusion is mediated by essential motifs ubiquitous to all. In this review, we particularly emphasize structural characteristics of small-molecular-weight fusogens in the hope of uncovering the most fundamental aspects mediating membrane-membrane interactions. By identifying and elucidating fusion-dependent functional domains, this review paves the way for future research exploring novel fusogens in health and disease.
    MeSH term(s) Amino Acid Motifs ; Animals ; Bacteriophages/metabolism ; Cell Fusion ; Cell Membrane/metabolism ; GTP-Binding Proteins/metabolism ; Humans ; Hydrophobic and Hydrophilic Interactions ; Inflammation ; Membrane Fusion ; Membrane Proteins/metabolism ; Mice ; Muscle, Skeletal/metabolism ; Mutation ; Myoblasts/metabolism ; Protein Domains ; Protein Structure, Secondary
    Chemical Substances MYMX protein, human ; Membrane Proteins ; ATL1 protein, human (EC 3.6.1.-) ; GTP-Binding Proteins (EC 3.6.1.-)
    Language English
    Publishing date 2021-01-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10010160
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Diffuse large B-cell lymphoma: the significance of CD8

    Zhu, Qiqi / Yang, Yiming / Chen, Kexin / Zhang, Qiaoyu / Huang, Yifan / Jian, Shunhai

    Journal of translational medicine

    2024  Volume 22, Issue 1, Page(s) 174

    Abstract: Background: Overexpression of T-cell immunoglobulin and mucin domain-containing protein 3 (TIM3) is related to the exhaustion of CD8: Methods: The expression of TIM3 and its correlation with CD8: Results: Our results demonstrated that CD8: ... ...

    Abstract Background: Overexpression of T-cell immunoglobulin and mucin domain-containing protein 3 (TIM3) is related to the exhaustion of CD8
    Methods: The expression of TIM3 and its correlation with CD8
    Results: Our results demonstrated that CD8
    Conclusions: Our study highlights that TIM3/Galectin-9 pathway plays a crucial role in CD8
    MeSH term(s) Humans ; CD8-Positive T-Lymphocytes ; Hepatitis A Virus Cellular Receptor 2/metabolism ; Ligands ; Lymphocytes, Tumor-Infiltrating ; Lymphoma, Large B-Cell, Diffuse/pathology ; Tumor Microenvironment ; Galectins/metabolism
    Chemical Substances Hepatitis A Virus Cellular Receptor 2 ; Ligands ; HAVCR2 protein, human ; LGALS9 protein, human ; Galectins
    Language English
    Publishing date 2024-02-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2118570-0
    ISSN 1479-5876 ; 1479-5876
    ISSN (online) 1479-5876
    ISSN 1479-5876
    DOI 10.1186/s12967-024-05002-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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