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Article ; Online: Oxidation of Methanesulfinate by Hexachloroiridate(IV) and the Standard Electrode Potential of the Aqueous Methanesulfonyl Radical.

Yang, Yixuan / Stanbury, David M

2024 Volume 63, Issue 3, Page(s) 1625–1632

Abstract: The aqueous reaction of [ ... ...

Abstract	The aqueous reaction of [IrCl
Language	English
Publishing date	2024-01-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.3c03796
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Article ; Online: Current status of controlled onco-therapies based on metal organic frameworks.

Yang, Yixuan / Dai, Xiaofeng

RSC advances

2024 Volume 14, Issue 18, Page(s) 12817–12828

Abstract: Despite consecutive efforts devoted to the establishment of innovative therapeutics for cancer control, cancer remains as a primary global public health concern. Achieving controlled release of anti-cancer agents may add great value to the field of ... ...

Abstract	Despite consecutive efforts devoted to the establishment of innovative therapeutics for cancer control, cancer remains as a primary global public health concern. Achieving controlled release of anti-cancer agents may add great value to the field of oncology that requires the involvement of nanotechnologies. Metal organic frameworks (MOFs) hold great promise in this regard owing to their unique structural properties. MOFs can act as superior candidates for drug delivery given their porous structure and large loading area, and can be prepared into anti-cancer therapeutics by incorporating stimuli-sensitive components into the ligands or nodes of the framework. By combing through chemical and physical features of MOFs favorable for onco-therapeutic applications and current cancer treatment portfolios taking advantages of these characteristics, this review classified MOFs feasible for establishing controlled anti-cancer modalities into 6 categories, outlined the corresponding strategies currently available for each type of MOF, and identified understudied areas and future opportunities towards innovative MOF design for improved or expanded clinical anti-cancer applications.
Language	English
Publishing date	2024-04-19
Publishing country	England
Document type	Journal Article ; Review
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d4ra00375f
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Article ; Online: Clinical decision support system based on deep learning for evaluating implantable collamer lens size and vault after implantable collamer lens surgery: a retrospective study.

Yang, Yixuan / Long, Zhengqin / Lei, Bo / Liu, Wei / Ye, Jian

BMJ open

2024 Volume 14, Issue 2, Page(s) e081050

Abstract: Objectives: To aid doctors in selecting the optimal preoperative implantable collamer lens (ICL) size and to enhance the safety and surgical outcomes of ICL procedures, a clinical decision support system (CDSS) is proposed in our study.: Design: A ... ...

Abstract	Objectives: To aid doctors in selecting the optimal preoperative implantable collamer lens (ICL) size and to enhance the safety and surgical outcomes of ICL procedures, a clinical decision support system (CDSS) is proposed in our study. Design: A retrospective study of patients after ICL surgery. Setting: China Tertiary Myopia Prevention and Control Center. Participants: 2772 eyes belonging to 1512 patients after ICL surgery. Data were collected between 2018 and 2022. Outcome measures: A CDSS is constructed and used to predict vault at 1 month postoperatively and preoperative ICL dimensions using various artificial intelligence methods. Accuracy metrics as well as area under curve (AUC) parameters are used to determine the CDSS prediction methods. Results: Among the ICL size prediction models, conventional neural networks (CNNs) achieve the best prediction accuracy at 91.37% and exhibit the highest AUC of 0.842. Regarding the prediction model for vault values 1 month after surgery, CNN surpasses the other methods with an accuracy of 85.27%, which has the uppermost AUC of 0.815. Thus, we select CNN as the prediction algorithm for the CDSS. Conclusions: This study introduces a CDSS to assist doctors in selecting the optimal ICL size for patients while improving the safety and postoperative outcomes of ICL surgery.
MeSH term(s)	Humans ; Retrospective Studies ; Lens Implantation, Intraocular/methods ; Visual Acuity ; Artificial Intelligence ; Decision Support Systems, Clinical ; Deep Learning
Language	English
Publishing date	2024-02-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-081050
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Article ; Online: Myoglobin improves doxycycline sensitivity in pancreatic cancer through promoting heme oxygenase-1-mediated ferroptosis.

Zhang, Lun / Yang, Liuxu / Du, Keyuan / Yang, Yixuan

Environmental toxicology

2023 Volume 39, Issue 4, Page(s) 2166–2181

Abstract: Ferroptosis is expected to be a therapeutic target for cancers including pancreatic cancer. We aimed to screen genes that regulate ferroptosis and doxycycline resistance in pancreatic cancer and to explore the underlying mechanisms. Bioinformatics ... ...

Abstract	Ferroptosis is expected to be a therapeutic target for cancers including pancreatic cancer. We aimed to screen genes that regulate ferroptosis and doxycycline resistance in pancreatic cancer and to explore the underlying mechanisms. Bioinformatics analysis was performed to identify genes that respond to ferroptosis in two human pancreatic cancer cells with GOT1 knocked down or not. 325 and 842 genes were upregulated in MiaPaCa and Tu8902 cells in response to GOT1 knockdown, with 43 genes shared. Among the 43 genes, 14 genes were identified to interact with ferroptosis key genes. MB and HMOX1 were the genes most sensitive to Erastin and doxycycline. Moreover, MB and HMOX1 expression was higher in human normal pancreatic duct epithelial cells than in pancreatic cancer cells. MB and HMOX1 proteins physically bound and promoted each other's expression. By interacting with HMOX1, MB suppressed pancreatic cancer cell proliferation, colony formation and invasion, and promoted cell ferroptosis and sensitivity to erastin and doxycycline. Silencing HMOX1 reversed the promoting effect of MB on cell ferroptosis and sensitivity to doxycycline. A pancreatic cancer xenograft model was established by subcutaneous injection of Panc-1 cells transfected with or without Ad-MB, and doxycycline was administered intraperitoneally. Overexpression of MB enhanced the inhibitory effect of doxycycline on xenograft growth. In conclusion, MB facilitated doxycycline sensitivity in pancreatic cancer cells through promoting HMOX1-mediated ferroptosis.
MeSH term(s)	Humans ; Heme Oxygenase-1/genetics ; Myoglobin ; Doxycycline/pharmacology ; Ferroptosis ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/genetics
Chemical Substances	Heme Oxygenase-1 (EC 1.14.14.18) ; Myoglobin ; Doxycycline (N12000U13O)
Language	English
Publishing date	2023-12-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1463449-1
ISSN	1522-7278 ; 1520-4081
ISSN (online)	1522-7278
ISSN	1520-4081
DOI	10.1002/tox.24078
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Article ; Online: Influencing factors of the supply-demand relationships of carbon sequestration and grain provision in China: Does land use matter the most?

Xia, Fan / Yang, Yixuan / Zhang, Shiqin / Yang, Yixuan / Li, Dehuan / Sun, Wei / Xie, Yujing

The Science of the total environment

2022 Volume 832, Page(s) 154979

Abstract: The provision of ecosystem services (ESs) such as carbon sequestration and grain provision are critical components to sustainable development. Reaching carbon neutrality generally requires the growing carbon sequestration of forest land, and feeding a ... ...

Abstract	The provision of ecosystem services (ESs) such as carbon sequestration and grain provision are critical components to sustainable development. Reaching carbon neutrality generally requires the growing carbon sequestration of forest land, and feeding a growing population needs an expansion of cultivated land. However, limited land resources may lead to a contradiction between the carbon sequestration and grain provision. China has proposed long-term and large-scale land use programs, and exploring whether these land use policies are effective for ES sustainable provision would be instructive for future policy implications. This study integrated multi-source data in the socioecological dimension to determine the extent by which land use and land use change influence the supply-demand mismatches of carbon (carbon sequestration and emission) and grain (grain provision and consumption) in China at the provincial level. The result showed that the total quantity of carbon emissions surpassed carbon sequestration and the grain provision could cover the consumption from 2000 to 2015. Spatially, southeastern coastal provinces had higher grain deficits and northeast provinces had higher carbon deficits. This study further detected the influencing factors of the mismatches between the supply and demand of the two ESs. Excluding land use factors, our results showed that social factors contributed 38% and 47% to the supply-demand mismatches of carbon and grain, respectively, and natural factors contributed 39% and 15%, respectively. During 2000-2005, 2005-2010, and 2010-2015, cropland changes significantly affected grain balance, while forest land changes did not significantly affect carbon balance. These results indicated that cropland protections are vital to food safety, and carbon emission reductions should be the focus for carbon balance. Finally, this study makes policy suggestions for land use and ecosystem management, and a future research framework was proposed to help mitigate ES supply-demand imbalance.
MeSH term(s)	Carbon ; Carbon Sequestration ; China ; Conservation of Natural Resources/methods ; Ecosystem ; Edible Grain
Chemical Substances	Carbon (7440-44-0)
Language	English
Publishing date	2022-04-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.154979
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Article ; Online: Immunological effects of recombinant Lactobacillus casei expressing pilin MshB fused with cholera toxin B subunit adjuvant as an oral vaccine against Aeromonas veronii infection in crucian carp.

Song, Hai-Chao / Yang, Yi-Xuan / Lan, Qi-Guan / Cong, Wei

Fish & shellfish immunology

2023 Volume 139, Page(s) 108934

Abstract: Aeromonas veronii is a zoonotic agent capable of infecting fish and mammals, including humans, posing a serious threat to the development of aquaculture and public health safety. Currently, few effective vaccines are available through convenient routes ... ...

Abstract	Aeromonas veronii is a zoonotic agent capable of infecting fish and mammals, including humans, posing a serious threat to the development of aquaculture and public health safety. Currently, few effective vaccines are available through convenient routes against A. veronii infection. Herein, we developed vaccine candidates by inserting MSH type VI pili B (MshB) from A. veronii as an antigen and cholera toxin B subunit (CTB) as a molecular adjuvant into Lactobacillus casei and evaluated their immunological effect as vaccines in a crucian carp (Carassius auratus) model. The results suggested that recombinant L. casei Lc-pPG-MshB and Lc-pPG-MshB-CTB can be stably inherited for more than 50 generations. Oral administration of recombinant L. casei vaccine candidates stimulated the production of high levels of serum-specific immunoglobulin M (IgM) and increased the activity of acid phosphatase (ACP), alkaline phosphatase (AKP) superoxide dismutase (SOD), lysozyme (LZM), complement 3 (C3) and C4 in crucian carp compared to the control group (Lc-pPG612 group and PBS group) without significant changes. Moreover, the expression levels of interleukin-10 (IL-10), interleukin-1β (IL-1β), tumour necrosis factor-α (TNF-α) and transforming growth factor-β (TGF-β) genes in the gills, liver, spleen, kidney and gut of crucian carp orally immunized with recombinant L. casei were significantly upregulated compared to the control groups, indicating that recombinant L. casei induced a significant cellular immune response. In addition, viable recombinant L. casei can be detected and stably colonized in the intestine tract of crucian carp. Particularly, crucian carp immunized orally with Lc-pPG-MshB and Lc-pPG-MshB-CTB exhibited higher survival rates (48% for Lc-pPG-MshB and 60% for Lc-pPG-MshB-CTB) and significantly reduced loads of A. veronii in the major immune organs after A. veronii challenge. Our findings indicated that both recombinant L. casei strains provide favorable immune protection, with Lc-pPG-MshB-CTB in particular being more effective and promising as an ideal candidate for oral vaccination.
MeSH term(s)	Humans ; Animals ; Lacticaseibacillus casei ; Cholera Toxin ; Fimbriae Proteins ; Aeromonas veronii ; Carps ; Bacterial Vaccines ; Vaccines, Synthetic ; Fish Diseases/prevention & control ; Mammals
Chemical Substances	Cholera Toxin (9012-63-9) ; Fimbriae Proteins (147680-16-8) ; Bacterial Vaccines ; Vaccines, Synthetic
Language	English
Publishing date	2023-07-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1067738-0
ISSN	1095-9947 ; 1050-4648
ISSN (online)	1095-9947
ISSN	1050-4648
DOI	10.1016/j.fsi.2023.108934
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Article: A comprehensive perspective for exploring the trade-offs and synergies between carbon sequestration and grain supply in China based on the production possibility frontier

Yang, Yixuan / Zhang, Shiqin / Xia, Fan / Li, Dehuan / Sun, Wei / Wang, Yuan / Xie, Yujing

Journal of cleaner production. 2022 June 20, v. 354

2022

Abstract: The growth of grain supply (GS) is generally achieved through production intensification, cropland expansion, or both, which have significant direct or indirect effects on carbon sequestration (CS). However, the comprehensive benefits of the two ... ...

Abstract	The growth of grain supply (GS) is generally achieved through production intensification, cropland expansion, or both, which have significant direct or indirect effects on carbon sequestration (CS). However, the comprehensive benefits of the two ecosystem services (ESs), determined by biophysical constraints and management conditions in specific regions, have not yet been thoroughly explored. In this study, the dynamic benefits of the two ESs was quantified by production possibility frontier (PPF) considering the biophysical constraints and management conditions in China during the years 2000–2015. An evaluation matrix combined with spatial analysis method was used to examine the spatiotemporal variations of the ES relationship, and a multiple logistic regression model was adopted to investigate the influencing mechanism that shape ES relationship. The results demonstrated that the ES relationship had considerable spatial heterogeneities in China, and synergy and trade-off were the dominant relationships during the study period. The further trade-off analyses of PPFs suggested that the fitting curve shape was concave trade-off type in 2000, backward S-type in 2005, and to a pattern between inverted backward S-type trade-off and convex trade-off type in 2015. Meanwhile, the threshold of the total benefits of the two ESs, which determines the influence degree that GS brings to bear on CS, decreased from 0.36 to approximately 0.07 kg/m² in 2000–2015. Cropland area, topography, soil texture, soil organic carbon, and chemical fertilizer use were important factors influencing the synergy and trade-off of ESs. This study provides a comprehensive perspective to explore the spatial-temporal dynamic characteristics and the influencing mechanism of ES relationship. Our findings could serve as a basis for the multi-objective optimal management of ESs, considering both biophysical constraints and management conditions.
Keywords	carbon sequestration ; cropland ; ecosystems ; fertilizer application ; mineral fertilizers ; regression analysis ; soil organic carbon ; soil texture ; topography ; China
Language	English
Dates of publication	2022-0620
Publishing place	Elsevier Ltd
Document type	Article
ISSN	0959-6526
DOI	10.1016/j.jclepro.2022.131725
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Article: Danhong injection alleviates cerebral ischemia-reperfusion injury by inhibiting autophagy through miRNA-132-3p/ATG12 signal axis

Zhang, Hongrui / Wang, Xinyi / Chen, Weiwei / Yang, Yixuan / Wang, Yu / Wan, Haitong / Zhu, Zhenhong

Journal of ethnopharmacology. 2023 Jan. 10, v. 300

2023

Abstract: Danhong injection (DHI) is a renowned traditional Chinese medicine often used clinically to treat cardiovascular and cerebrovascular diseases. Studies have shown that DHI can significantly alter microRNA (miRNA) expression in the brain tissue. Therefore, ...

Abstract	Danhong injection (DHI) is a renowned traditional Chinese medicine often used clinically to treat cardiovascular and cerebrovascular diseases. Studies have shown that DHI can significantly alter microRNA (miRNA) expression in the brain tissue. Therefore, exploring specific miRNAs’ regulatory mechanisms during treatment with DHI is essential. To investigate DHI's regulatory mechanism on cerebral autophagy in rats with cerebral ischemia-reperfusion injury (CIRI). Rats were randomly divided into the sham, middle cerebral artery occlusion (MCAO) model, and DHI-treatment groups. The extent of brain damage was evaluated using triphenyl tetrazolium chloride and hematoxylin-eosin staining. Hippocampal cell autophagy was observed using transmission electron microscopy. Autophagy-related proteins were analyzed using western blotting. Differentially expressed miRNAs were screened using high-throughput and real-time quantitative reverse transcription PCR. The relationship between miR-132-3p and ATG12 was confirmed using a dual-luciferase assay. The miR-132-3p mimics and inhibitors were transfected into PC12 cells subjected to oxygen-glucose deprivation (OGD) in vitro and MCAO model rats in vivo. DHI significantly altered the miRNA expression profile in rat brain tissues. The pathological changes in the brain tissues were improved, and the autophagic hippocampal cell vehicles were significantly reduced after DHI treatment. miRNA-132-3p, one of the miRNAs with a significantly different expression, was screened. Kyoto Encyclopedia of Genes and Genomes signal pathway analysis showed that its target genes were closely related to autophagy. Western blotting revealed that the p-PI3K, p-AKT, and mTOR expression increased significantly; AMPK, ULK1, ATG12, ATG16L1, and LC3II/I were downregulated in the DHI group. Dual-luciferase reporter gene experiments showed that miRNA-132-3p could target the ATG12 3′-UTR region directly. In vitro, miRNA-132-3p had a protective effect on OGD/R-induced oxidative stress injury in PC12 cells, improving cell viability, and affecting the expression of autophagy pathway-related proteins. In vivo transfection experiments showed that miR-132-3p could regulate ATG12 expression in CIRI rats' lateral brain tissue, affecting the autophagy signaling pathway. miR-132-3p overexpression reduces CIRI-induced autophagy and protects neurons. This study showed that DHI inhibits neuronal autophagy after cerebral ischemia-reperfusion. This may have resulted from miR-132-3p targeting ATG12 and regulating the autophagy signaling pathway protein expression.
Keywords	Oriental traditional medicine ; autophagy ; brain ; brain damage ; cell viability ; chlorides ; microRNA ; models ; neurons ; oxidative stress ; protective effect ; protein synthesis ; rats ; reporter genes ; reverse transcriptase polymerase chain reaction ; signal transduction ; tetrazolium ; transfection ; transmission electron microscopy
Language	English
Dates of publication	2023-0110
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115724
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Article ; Online: Immunological effects of recombinant Lactobacillus casei expressing pilin MshB fused with cholera toxin B subunit adjuvant as an oral vaccine against Aeromonas veronii infection in crucian carp

Song, Hai-Chao / Yang, Yi-Xuan / Lan, Qi-Guan / Cong, Wei

Fish and Shellfish Immunology. 2023 Aug., v. 139 p.108934-

2023

Abstract	Aeromonas veronii is a zoonotic agent capable of infecting fish and mammals, including humans, posing a serious threat to the development of aquaculture and public health safety. Currently, few effective vaccines are available through convenient routes against A. veronii infection. Herein, we developed vaccine candidates by inserting MSH type VI pili B (MshB) from A. veronii as an antigen and cholera toxin B subunit (CTB) as a molecular adjuvant into Lactobacillus casei and evaluated their immunological effect as vaccines in a crucian carp (Carassius auratus) model. The results suggested that recombinant L. casei Lc-pPG-MshB and Lc-pPG-MshB-CTB can be stably inherited for more than 50 generations. Oral administration of recombinant L. casei vaccine candidates stimulated the production of high levels of serum-specific immunoglobulin M (IgM) and increased the activity of acid phosphatase (ACP), alkaline phosphatase (AKP) superoxide dismutase (SOD), lysozyme (LZM), complement 3 (C3) and C4 in crucian carp compared to the control group (Lc-pPG612 group and PBS group) without significant changes. Moreover, the expression levels of interleukin-10 (IL-10), interleukin-1β (IL-1β), tumour necrosis factor-α (TNF-α) and transforming growth factor-β (TGF-β) genes in the gills, liver, spleen, kidney and gut of crucian carp orally immunized with recombinant L. casei were significantly upregulated compared to the control groups, indicating that recombinant L. casei induced a significant cellular immune response. In addition, viable recombinant L. casei can be detected and stably colonized in the intestine tract of crucian carp. Particularly, crucian carp immunized orally with Lc-pPG-MshB and Lc-pPG-MshB-CTB exhibited higher survival rates (48% for Lc-pPG-MshB and 60% for Lc-pPG-MshB-CTB) and significantly reduced loads of A. veronii in the major immune organs after A. veronii challenge. Our findings indicated that both recombinant L. casei strains provide favorable immune protection, with Lc-pPG-MshB-CTB in particular being more effective and promising as an ideal candidate for oral vaccination.
Keywords	Aeromonas veronii ; Carassius auratus ; Lactobacillus casei ; acid phosphatase ; adjuvants ; alkaline phosphatase ; antigens ; aquaculture ; cell-mediated immunity ; cholera toxin ; complement ; edible vaccines ; fimbriae ; fish ; immunoglobulins ; interleukin-10 ; intestines ; kidneys ; liver ; lysozyme ; models ; necrosis ; neoplasms ; oral administration ; oral vaccination ; public health ; shellfish ; spleen ; superoxide dismutase ; Cholera toxin B subunit ; Pilin MshB ; Immunopotentiation
Language	English
Dates of publication	2023-08
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	1067738-0
ISSN	1095-9947 ; 1050-4648
ISSN (online)	1095-9947
ISSN	1050-4648
DOI	10.1016/j.fsi.2023.108934
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Article ; Online: How can trees protect us from air pollution and urban heat? the association and pathways at the neighborhood scale

Yang, Yixuan / Xu, Yan / Duan, Yusen / Zhang, Shiqin / Zhang, Yi / Xie, Yujing

Landscape and Urban Planning. 2023, p.104779-

2023 , Page(s) 104779–

Abstract: With rapidly increasing urbanization, cities frequently suffer from the development of urban pollution and heat islands, the co-occurrence of which increases the vulnerability of cities and threatens public health. Greening practices, particularly the ... ...

Abstract	With rapidly increasing urbanization, cities frequently suffer from the development of urban pollution and heat islands, the co-occurrence of which increases the vulnerability of cities and threatens public health. Greening practices, particularly the plantation of trees, have become an effective strategy for enhancing the quality of urban environments. However, extensive studies examining the effects of urban greening tend to focus on the singular contribution of trees to mitigating either urban air pollution or heat. In this study, the metropolis of Shanghai, China was selected as a study case to explore associations between particulate matters with aerodynamic diameters ≤10 μm (PM₁₀) and heat mitigation by urban trees. During the summer months, we obtained hourly PM₁₀ concentration and meteorological data from environmental monitoring stations in Shanghai, and land cover data were derived from 0.8-m-resolution GF-2 satellite images. Regression analysis indicated a negative non-linear logarithmic pattern between canopy cover and PM₁₀ or heat indicators within neighborhoods. Mediation analysis confirmed the significant mediatory role of heat mitigation pathways, particularly extreme heat mitigation on PM₁₀ reduction from urban trees. The proportion of indirect PM₁₀ₘₑₐₙ mitigation effects of urban trees associated with reductions in average temperature, maximum temperature, extreme heat days, and extreme heat hours amounted to 27.11%, 27.59%, 30.61%, and 39.76%, respectively. Different results were obtained when using PM₁₀ₘₐₓ as the dependent variable, with only extreme heat events (EHEs) pathways being significant, whereas the proportion of indirect effects associated with extreme heat days and extreme heat hours accounted for 25.89% and 37.08%, respectively. Overall, mitigating extreme heat events makes a larger contribution to air purification than temperature regulation. Our findings enrich and extend the current understanding of associations between the air purification and cooling effects of urban trees, and highlight the potential co-benefits for effectively dealing with air pollution and urban heat in high-density cities.
Keywords	aerodynamics ; air ; air pollution ; canopy ; heat ; land cover ; landscapes ; meteorological data ; public health ; regression analysis ; satellites ; summer ; temperature ; urbanization ; China ; Urban trees ; Air purification ; Cooling effect ; Neighborhood scale ; Mediation analysis
Language	English
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	742504-1
ISSN	1872-6062 ; 0169-2046
ISSN (online)	1872-6062
ISSN	0169-2046
DOI	10.1016/j.landurbplan.2023.104779
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