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Article ; Online: Epidemiologic analysis of antimicrobial resistance in hospital departments in China from 2022 to 2023.

Bai, Hui-Jun / Geng, Qing-Feng / Jin, Fang / Yang, Yong-Li

Journal of health, population, and nutrition

2024 Volume 43, Issue 1, Page(s) 39

Abstract: Bacterial drug resistance monitoring in hospitals is a crucial aspect of healthcare management and a growing concern worldwide. In this study, we analysed the bacterial drug resistance surveillance in our hospital from 2022 Q1 to 2023 Q2. The main ... ...

Abstract	Bacterial drug resistance monitoring in hospitals is a crucial aspect of healthcare management and a growing concern worldwide. In this study, we analysed the bacterial drug resistance surveillance in our hospital from 2022 Q1 to 2023 Q2. The main sampling sources were respiratory, blood, and urine-based, and the main clinical infections were respiratory and genitourinary in nature. Specimens were inoculated and cultured; bacterial strains were isolated using a VITEK® 2 Compact 60-card automatic microorganism identifier (bioMerieux, Paris, France) and their matching identification cards were identified, and manual tests were supplemented for strain identification. The most common Gram-positive bacteria detected were Staphylococcus aureus, followed by Enterococcus faecalis (E. faecalis), Staphylococcus epidermidis (S. epidermidis), and Staphylococcus haemolyticus (S. haemolyticus). The most common Gram-negative bacteria detected were Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. The most prevalent multidrug-resistant bacteria were those producing extended-spectrum beta-lactamases, followed by methicillin-resistant Staphylococcus aureus, followed by carbapenem-resistant Enterobacterales. This study suggests that the prevention and control of infections in the respiratory and genitourinary systems should be the focus of anti-infective work and that the use of antimicrobials should be reduced and regulated to prevent the emergence and spread of resistant bacteria.
MeSH term(s)	Humans ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Methicillin-Resistant Staphylococcus aureus ; Drug Resistance, Bacterial ; Hospital Departments ; China/epidemiology ; Escherichia coli
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2024-03-06
Publishing country	Bangladesh
Document type	Journal Article
ZDB-ID	2025045-9
ISSN	2072-1315 ; 1606-0997
ISSN (online)	2072-1315
ISSN	1606-0997
DOI	10.1186/s41043-024-00526-2
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Article ; Online: Poly[[(μ(2)-di-3-pyridyl-methanone-κN:N')(μ(2)-hexa-fluoro-silicato-κF:F')copper(II)] dihydrate].

Yang, Yong-Li

Acta crystallographica. Section E, Structure reports online

2012 Volume 68, Issue Pt 2, Page(s) m209

Abstract: In the title complex, {[Cu(SiF(6))(C(11)H(8)N(2)O)(2)]·2H(2)O}(n), the Cu(II) atom adopts an N(4)F(2)-octa-hedral coordination geometry with four pyridine N atoms in the equatorial sites and two F atoms in the axial sites. The di-3-pyridyl-methanone and ... ...

Abstract	In the title complex, {[Cu(SiF(6))(C(11)H(8)N(2)O)(2)]·2H(2)O}(n), the Cu(II) atom adopts an N(4)F(2)-octa-hedral coordination geometry with four pyridine N atoms in the equatorial sites and two F atoms in the axial sites. The di-3-pyridyl-methanone and hexa-fluoro-silicate ligands act as bidentate ligands, linking symmetry-related Cu(II) atoms. Water mol-ecules form O-H⋯O and O-H⋯F hydrogen bonds with the di-3-pyridyl-methanone and hexa-fluoro-silicate ligands. The Cu(2+) and SiF(6) (2-) ions are each located on a twofold axis.
Language	English
Publishing date	2012-01-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2041947-8
ISSN	1600-5368 ; 1600-5368
ISSN (online)	1600-5368
ISSN	1600-5368
DOI	10.1107/S1600536812002267
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Article ; Online: Evaluation of inflammation of perirenal adipose tissue in C57BL/6J mice with high-fat diet

YANG Yong, LI Zi-yu, YANG Wei, LIU Yong

Jichu yixue yu linchuang, Vol 41, Iss 9, Pp 1318-

2021 Volume 1322

Abstract: Objective To evaluate the inflammation of perirenal adipose tissue induced by high-fat diet in C57BL/6J mice. Methods Mice were randomly divided into normal diet group (control group, n=6) and high-fat diet group (HFD group, n=6). The mRNA expression of ... ...

Abstract	Objective To evaluate the inflammation of perirenal adipose tissue induced by high-fat diet in C57BL/6J mice. Methods Mice were randomly divided into normal diet group (control group, n=6) and high-fat diet group (HFD group, n=6). The mRNA expression of TNF-α, CD11c, IL-1β, IL-10, TGF-β1, CD206 in perirenal adipocytes were detected by RT-qPCR. The expressions of F4/80, CD68 and LCA in perirenal adipose tissue and renal parenchyma were detected by immunohistochemistry method. Results Compared with the control group, the mRNA expression by TNF-α and IL-1β in perirenal adipose tissue of mice in HFD group was increased(P＜0.05); The expression of F4/80, CD68 and LCA in perirenal fat increased in HFD group(P＜0.05). Conclusions High-fat diet induces inflammation in perirenal adipose tissue of C57BL/6J mice.
Keywords	adipose tissue\|high-fat diet\|inflammation\|kidney\|macrophages ; Medicine ; R
Language	Chinese
Publishing date	2021-09-01T00:00:00Z
Publisher	Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: 高海拔地区健康足月新生儿脑氧代谢及脑电活动差异的多中心临床研究方案.

Ze, Bi / Gao, Jin / Zhao, Xiao-Fen / Li, Yang-Fang / Zhang, Tie-Song / Liu, Xiao-Mei / Mao, Hui / Qin, Ming-Cai / Zhang, Yi / Yang, Yong-Li / He, Chun-Ye / Zhao, Yan / DU, Kun / Liu, Lin / Zhou, Wen-Hao

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics

2024 Volume 26, Issue 4, Page(s) 403–409

Abstract: Further evidence is needed to explore the impact of high-altitude environments on the neurologic function of neonates. Non-invasive techniques such as cerebral near-infrared spectroscopy and amplitude-integrated electroencephalography can provide data on ...

Title translation	Cerebral oxygen metabolism and brain electrical activity of healthy full-term neonates in high-altitude areas: a multicenter clinical research protocol.
Abstract	Further evidence is needed to explore the impact of high-altitude environments on the neurologic function of neonates. Non-invasive techniques such as cerebral near-infrared spectroscopy and amplitude-integrated electroencephalography can provide data on cerebral oxygenation and brain electrical activity. This study will conduct multiple cerebral near-infrared spectroscopy and amplitude-integrated electroencephalography monitoring sessions at various time points within the first 3 days postpartum for healthy full-term neonates at different altitudes. The obtained data on cerebral oxygenation and brain electrical activity will be compared between different altitudes, and corresponding reference ranges will be established. The study involves 6 participating centers in the Chinese High Altitude Neonatal Medicine Alliance, with altitude gradients divided into 4 categories: 800 m, 1 900 m, 2 400 m, and 3 500 m, with an anticipated sample size of 170 neonates per altitude gradient. This multicenter prospective cohort study aims to provide evidence supporting the impact of high-altitude environments on early brain function and metabolism in neonates.
MeSH term(s)	Humans ; Altitude ; Infant, Newborn ; Brain/metabolism ; Electroencephalography ; Oxygen/metabolism ; Spectroscopy, Near-Infrared ; Prospective Studies
Chemical Substances	Oxygen (S88TT14065)
Language	Chinese
Publishing date	2024-04-25
Publishing country	China
Document type	Journal Article ; Multicenter Study ; English Abstract
ISSN	1008-8830
ISSN	1008-8830
DOI	10.7499/j.issn.1008-8830.2310102
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Article ; Online: Necessity and evaluation of teaching for medical postgraduates in the view point of knowledge needed as physician-scientists

WANG Yi / YANG Ai-rong / YANG Yong-li / YU Zhang-bin / ZHANG Ying / MA Xin-chun

Jichu yixue yu linchuang, Vol 41, Iss 6, Pp 927-

2021 Volume 930

Abstract: Objective To evaluate the necessity and effect of knowledge needed for research in the education of research-oriented medical graduates. Methods In March 2021, medical experts introduced the knowledge needed for the first-year medical graduates in ... ...

Abstract	Objective To evaluate the necessity and effect of knowledge needed for research in the education of research-oriented medical graduates. Methods In March 2021, medical experts introduced the knowledge needed for the first-year medical graduates in Qinghai University Affiliated Hospital. Questionnaire survey was conducted to understand the current situation of graduates' understanding of the aim of training for the physician-scientists before the training and evaluate its necessity. The learning outcomes were evaluated by the comparison before and after the training. Results Only 55.16% of graduates understood the difference between traditional clinicians and physician-scientists before training, and 54.37% knew the difference between traditional clinical reasoning and clinical research logics, which indicated that it was very necessary to carry out teaching of knowledge as physician-scientists to medical graduates. After training, 95.78% of graduate students knew the difference between traditional clinicians and physician-scientists, and 86.75% of them knew the difference between traditional clinical reasoning and physician-scientists logics, which was significantly higher than that before training (P＜0.01). Conclusions Medical graduates have insufficient knowledge needed by physician-scientists. Training can significantly improve their understanding of physician-scientists.
Keywords	medical postgraduates\|physician-scientists\|training\|questionnaire ; Medicine ; R
Subject code	370
Language	Chinese
Publishing date	2021-06-01T00:00:00Z
Publisher	Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Benchmark Dose Assessment for Coke Oven Emissions-Induced Mitochondrial DNA Copy Number Damage Effects.

Yan, Zhao Fan / Gu, Zhi Guang / Fan, Ya Hui / Li, Xin Ling / Niu, Ze Ming / Duan, Xiao Ran / Mallah, Ali Manthar / Zhang, Qiao / Yang, Yong Li / Yao, Wu / Wang, Wei

Biomedical and environmental sciences : BES

2023 Volume 36, Issue 6, Page(s) 490–500

Abstract: Objective: The study aimed to estimate the benchmark dose (BMD) of coke oven emissions (COEs) exposure based on mitochondrial damage with the mitochondrial DNA copy number (mtDNAcn) as a biomarker.: Methods: A total of 782 subjects were recruited, ... ...

Abstract	Objective: The study aimed to estimate the benchmark dose (BMD) of coke oven emissions (COEs) exposure based on mitochondrial damage with the mitochondrial DNA copy number (mtDNAcn) as a biomarker. Methods: A total of 782 subjects were recruited, including 238 controls and 544 exposed workers. The mtDNAcn of peripheral leukocytes was detected through the real-time fluorescence-based quantitative polymerase chain reaction. Three BMD approaches were used to calculate the BMD of COEs exposure based on the mitochondrial damage and its 95% confidence lower limit (BMDL). Results: The mtDNAcn of the exposure group was lower than that of the control group (0.60 ± 0.29 Conclusion: Based on our conservative estimate, the BMDL of mitochondrial damage caused by COEs is 0.002 mg/m
MeSH term(s)	Male ; Female ; Animals ; Coke ; Polycyclic Aromatic Hydrocarbons ; DNA Copy Number Variations ; Benchmarking ; Occupational Exposure/adverse effects ; Occupational Exposure/analysis ; DNA, Mitochondrial/genetics ; DNA Damage
Chemical Substances	Coke ; Polycyclic Aromatic Hydrocarbons ; DNA, Mitochondrial
Language	English
Publishing date	2023-07-10
Publishing country	China
Document type	Journal Article
ZDB-ID	645083-0
ISSN	2214-0190 ; 0895-3988
ISSN (online)	2214-0190
ISSN	0895-3988
DOI	10.3967/bes2023.060
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Article ; Online: Relationship between

Cheng, Shuai / Liu, Bin / Guo, Zhi Feng / Duan, Xiao Ran / Liu, Su Xiang / Li, Lei / Yao, Wu / Yang, Yong Li / Wang, Wei

Biomedical and environmental sciences : BES

2021 Volume 34, Issue 10, Page(s) 838–841

MeSH term(s)	Adult ; China ; Dimethoate/adverse effects ; Dimethoate/analogs & derivatives ; Farmers/statistics & numerical data ; Female ; Humans ; Male ; Middle Aged ; Occupational Exposure ; Pesticides/adverse effects ; Polymorphism, Single Nucleotide ; Telomerase/genetics ; Telomere/drug effects ; Telomere/physiology
Chemical Substances	Pesticides ; dimethoxon (28U28EWE79) ; TERT protein, human (EC 2.7.7.49) ; Telomerase (EC 2.7.7.49) ; Dimethoate (W6U08B045O)
Language	English
Publishing date	2021-10-29
Publishing country	China
Document type	Letter
ZDB-ID	645083-0
ISSN	2214-0190 ; 0895-3988
ISSN (online)	2214-0190
ISSN	0895-3988
DOI	10.3967/bes2021.115
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Article ; Online: Association and Prediction of Influenza-like Illness with Meteorological Factors in Mississippi, USA.

Shi, Xue Zhong / Song, Zhi Juan / Yang, Yong Li / Bao, Jun Zhe / Zhu, Hui Li / Luo, Zi Xiao / Wang, Yu Ping / Wu, Mei Na / Jia, Xiao Can

Biomedical and environmental sciences : BES

2022 Volume 35, Issue 10, Page(s) 962–967

MeSH term(s)	Humans ; Mississippi/epidemiology ; Influenza, Human/epidemiology ; Meteorological Concepts ; Virus Diseases
Language	English
Publishing date	2022-11-25
Publishing country	China
Document type	Letter
ZDB-ID	645083-0
ISSN	2214-0190 ; 0895-3988
ISSN (online)	2214-0190
ISSN	0895-3988
DOI	10.3967/bes2022.123
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Article ; Online: (Nitrato-κO)bis-[5-(pyridin-2-yl)pyrazine-2-carbonitrile-κN,N]silver(I).

Zhang, Fan / Yang, Yong-Li

Acta crystallographica. Section E, Structure reports online

2011 Volume 67, Issue Pt 12, Page(s) m1863

Abstract: In the mononuclear title complex, [Ag(NO(3))(C(10)H(6)N(4))(2)], two κ(2)N:N'-chelating 5-(pyridin-2-yl)pyrazine-2-carbonitrile ligands surround the Ag(I) atom, forming an N(4)O square-pyramidal coordination geometry with one nitrate anion bonding at the ...

Abstract	In the mononuclear title complex, [Ag(NO(3))(C(10)H(6)N(4))(2)], two κ(2)N:N'-chelating 5-(pyridin-2-yl)pyrazine-2-carbonitrile ligands surround the Ag(I) atom, forming an N(4)O square-pyramidal coordination geometry with one nitrate anion bonding at the apical site. The two heterocyclic rings of the 5-(2-pyridin-2--yl)pyrazine-2-carbonitrile ligand are almost coplanar [dihedral angle = 5.63 (8)°], and the two chelating ligands are in an anti relationship. The mononuclear units are inter-connected along [010] through C-H⋯O(nitrate) and C-H⋯N(cyano) inter-actions, forming an infinite chain. The mononuclear units are stacked along the a axis and inter-connected via inter-molecular π-π stacking inter-actions between adjacent pyridine and pyrazine rings [centroid-centroid distances = 3.984 (2) and 3.595 (3) Å], thus forming a three-dimensional supra-molecular structure.
Language	English
Publishing date	2011-11-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2041947-8
ISSN	1600-5368 ; 1600-5368
ISSN (online)	1600-5368
ISSN	1600-5368
DOI	10.1107/S1600536811049221
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Article: Association of changes in waist circumference with cardiovascular disease and all-cause mortality among the elderly Chinese population: a retrospective cohort study.

Zhang, Xue-Ning / Zhao, Hao / Shi, Zhan / Yin, Ling / Zhao, Xiao-Yan / Yin, Chun-Yu / Yang, Yong-Li / Shi, Song-He

Journal of geriatric cardiology : JGC

2019 Volume 18, Issue 3, Page(s) 185–195

Abstract: Background: To examine the association of baseline waist circumference (WC) and changes in WC with cardiovascular disease (CVD) and all-cause mortality among elderly people.: Methods: A total of 30,041 eligible participants were included from a ... ...

Abstract	Background: To examine the association of baseline waist circumference (WC) and changes in WC with cardiovascular disease (CVD) and all-cause mortality among elderly people. Methods: A total of 30,041 eligible participants were included from a retrospective cohort in China. The same questionnaire, anthropometric and laboratory measurements were performed at baseline (2010) and the first follow-up (2013). The percent change in WC between baseline and the first follow-up was calculated to evaluate three years change of WC. We collected the occurrence of CVD and all-cause death from the first follow-up to December 31, 2018. Restricted cubic splines and Cox proportional-hazards regression models were used to evaluate the relationship between baseline WC/ changes in WC and mortality. Results: The dose-response relationships between baseline WC and CVD mortality were U- or J-shaped. In low WC group, compared with stable group, the fully adjusted hazard ratio (aHR) for CVD mortality was 1.60 (95% CI: 1.24-2.06) in WC gain group among men. In normal WC group, the CVD mortality risk increased with WC gain (men: aHR = 1.86, 95% CI: 1.36-2.56; women: aHR = 1.83, 95% CI: 1.29-2.58). In moderate-high WC group, the CVD mortality risk increased with WC gain (men: aHR = 1.76, 95% CI: 1.08-2.88; women: aHR = 1.46, 95% CI: 1.04-2.05) and risk decreased with WC loss (men: aHR = 0.54, 95% CI: 0.30-0.98; women: aHR = 0.59, 95% CI: 0.37-0.96). Conclusions: For the elderly population, WC gain may increase CVD mortality risk regardless of baseline WC, whereas WC reduction could decrease the risk only in the moderate-high WC group.
Language	English
Publishing date	2019-05-28
Publishing country	China
Document type	Journal Article
ZDB-ID	2421391-3
ISSN	1671-5411
ISSN	1671-5411
DOI	10.11909/j.issn.1671-5411.2021.03.001
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